Clinical trials: Incretins
Type 2 Diabetes Mellitus, Obesity
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance
Agonistic activation of fat metabolite responsive G-protein-coupled receptors (GPCR) has been linked to improved glucose metabolism through increased glucose-stimulated-insulin-secreting (GSIS) and incretin release, improved…
- Trial name
- NCT03774095
- Testing
- Hydrolyzed pine nut oil, Hydrolyzed pine nut oil and olive oil
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karina Vejrum Sørensen
Diabetes Mellitus, Type 2
Glucose Homeostasis and Incretin Effect T2DM in the Youth- a Study of the Malaysian Population
Early onset type 2 diabetes mellitus among adolescents/youth (YT2DM) is a rising phenomenon. The pathophysiology has been studied primarily on non-Asian populations while literature on incretin effect is scarce.
- Trial name
- NCT02845557
- Testing
- OGTT and IVGTT tests
- Where
- Malaysia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- RCSI & UCD Malaysia Campus
Obesity, Adiposity
GIP/GLP-1 Co-Activity in Subjects With Obesity: Lowering of Food Intake
We aim to delineate the effects of separate and combined infusion of GIP and GLP-1 on food intake, appetite, bone health and fat metabolism in overweight/obese subjects.
- Conditions
- Obesity, Adiposity, Type 2 Diabetes
- Trial name
- GASOLIN (NCT02598791)
- Testing
- IIGI+GIP, IIGI+GLP-1, OGTT
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Healthy Subjects
Incretin and KATP Channels
This study aims to examine the involvement of KATP channels on the microvascular actions of the incretin GLP-1 and its analogues in healthy individuals and to determine whether the acute oral administration of different KATP…
- Trial name
- NCT01934816
- Testing
- Intradermal injections of GLP-1 and its analogues
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Katarina Kos
Cardiovascular Disease, Diabetes Mellitus, Type 2
Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND)
The purpose of this trial is to assess whether dulaglutide can reduce major cardiovascular events and other serious outcomes in persons with type 2 diabetes, when added to their anti-hyperglycemic regimen.
- Trial name
- REWIND (NCT01394952)
- Testing
- Dulaglutide
- Where
- 300 sites in United States, Argentina and 23 more
- Volunteers
- 9,901 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes
Dissection of the Gastrointestinal-mediated Glucose Disposal and Incretin Defect in Patients With Type 2 Diabetes
In patients with type 2 diabetes, the incretin effect is markedly reduced contributing to the relative insulin deficiency that characterizes these patients.
- Trial name
- NCT02669524
- Testing
- LY2409021, OGTT, IIGI
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Chronic Pancreatitis, Type 2 Diabetes Mellitus
The Incretin Effect in Patients With Chronic Pancreatitis
The phenomenon that oral glucose elicits a higher insulin response than does intravenous (iv) glucose, even at identical plasma glucose (PG) profiles (isoglycemia), is called the incretin effect.
- Trial name
- NCT00638573
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 2 Diabetes, Ageing
Effects of Nitrate on Liver Perfusion and Sugar Control
Rationale: Mediterranean style diets and diets rich in green leafy vegetables protect against the risk of developing type 2 diabetes and a wide range of cardiovascular disease. These diets are rich in nitrate.
- Trial name
- DiMPLe (NCT02195856)
- Testing
- Beetroot juice
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Type 1 Diabetes
Incretin-based Therapy in Preclinical Type 1 Diabetes in Adults
The main objectives of the trial are to study whether daily treatment with liraglutide improves insulin secretion and glucose metabolism, and whether liraglutide treatment is tolerable and safe in subjects with preclinical type 1…
- Trial name
- NCT02611232
- Testing
- Victoza®
- Where
- 3 sites in Finland
- Volunteers
- 42 people
- Sponsor
- University of Oulu
Gestational Diabetes
The Incretin Effect in Patients With Gestational Diabetes Mellitus
The aim of this study is to evaluate the reduced incretin effect observed in patients with T2DM in relation to reversibility. The incretin effect will be measured by means of OGTT and iIVGTT in 12 women with GDM during pregnancy…
- Trial name
- NCT01307995
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Type 2 Diabetes
Sitagliptin in the Elderly
Diabetes is common in the elderly; by the age of 70, approximately 25% of the population will have diabetes. Unfortunately, currently available medications are often not as effective or not well tolerated in older adults.
- Trial name
- NCT00451113
- Testing
- Sitagliptin 100 mg
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of British Columbia
Insulin Resistance, Deteriorated Glucose Homeostasis
Insulinotropic Effect of GIP and GLP-1 Before and After Reduced Glucose Tolerance
The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals.
- Conditions
- Insulin Resistance, Deteriorated Glucose Homeostasis, Inactivity
- Trial name
- NCT01173978
- Testing
- Steroid hormone, No intervention
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Type1diabetes, Hypoglycemia
The Effect of Glucose-dependent Insulinotropic Polypeptide on the Alpha Cell Response to Hypoglycaemia in Patients with Type 1 Diabetes
The goal of this clinical trial is to evaluate the effects of the hormone glucose-dependent insulinotropic polypeptide (GIP) and its two isoforms, GIP[1-30] and GIP[1-42], in patients with type 1 diabetes.
- Conditions
- Type1diabetes, Hypoglycemia, Type 1 Diabetes
- Trial name
- GIPHYPO (NCT06137586)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Hyperglycemia, Hypoglycemia
GLP 1 for Intraoperative Glycemic Control
This is a medical research study designed to see if an infusion of a naturally occurring hormone, GLP-1, works when used to decrease blood sugar during cardiac surgery.
- Trial name
- GLP (NCT00882492)
- Testing
- GLP 1
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Diabetes Mellitus, Type 2, Satiety Response
Metabolic Effects of a Pre-meal Protein Drink With or Without Added Amino Acids at a Subsequent Composite Meal
The purpose of the study was to investigate the efficacy of intake of whey or soy protein isolates, respectively, with or without supplementation of amino acids, on post-meal insulin secretion and glycaemic regulation.
- Trial name
- NCT01586780
- Testing
- Protein drink, Reference meal
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Lund University
Pre-diabetes
Incretins in Impaired Fasting Glucose
People with high fasting glucose can develop type 2 diabetes with the passage of time. This study is being done to determine the effect of a novel medication in people with this elevated fasting glucose.
- Trial name
- NCT00364377
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Monogenic Diabetes
Incretin Regulation of Insulin Secretion in Monogenic Diabetes
The purpose of this study is to explore the mechanisms of metabolic control in monogenic diabetes patients treated with sulfonylurea medications.
- Trial name
- NCT01795144
- Testing
- GLP-1, Exendin 9-39
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy, Incretin Effect
Metabolic Differences of an Oral and Intravenous Dose of 3-hydroxybutyrate (3-OHB).
An open-labeled intervention study testing healthy, lean, and male volunteers on two separate occasions: 1. blood sampling after consuming 36 gram 3-Hydroxybutyrate (3-OHB) salt. 2.
- Conditions
- Healthy, Incretin Effect, Ketosis
- Trial name
- NCT03935841
- Testing
- 3-OHB salt (NaCl)
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sarcopenia
Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle
This study has two protocols the aims of which are: 1. To identify age-related effects of AA on incretin secretion and whether and to what extent AA exhibit a true incretin effect (gut- mediated increases in plasma insulin) in…
- Trial name
- Incretin (NCT02370745)
- Testing
- GLP-1, Insulin Actrapid, Oral amino acids
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy Volunteers
Evaluation of Glycemic Index, Glycemic Load and Insulinemic Index of Spanish Breads
The present study was carried out to determine the glycaemic index (GI), glycaemic load (GL), insulinaemic index (InI), appetite ratings and postprandial plasma concentrations of gastrointestinal hormones related to the control…
- Trial name
- BREADGI (NCT02297074)
- Testing
- Ordinary white bread, Precooked-Frozen White Bread, Candeal-flour White Bread
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Organización Interprofesional Agroalimentaria de Cereales Panificables y Derivados