Clinical trials: Incretins
Diabetes Mellitus, Type 1
Meal-time Administration of Exenatide for Glycaemic Control in Type 1 Diabetic Cases
Patients with type 1 diabetes (T1D) depend on insulin therapy as substitution for the lack of endocrine insulin production due to an autoimmune destruction of beta-cells in the pancreatic inslets.
- Trial name
- MAG1C (NCT03017352)
- Testing
- Exenatide
- Where
- Denmark
- Volunteers
- 108 people
- Sponsor
- Filip Krag Knop
Renal Insufficiency, Chronic
The Incretin Effect in Patients With Kidney Impairment
The current study explores the incretin effect; a central mechanism of sugar metabolism. People with type 2 diabetes have a markedly reduced incretin effect, while the incretin effect never has been studied in patients with…
- Trial name
- UREMINC (NCT01327378)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Type 2
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
The purpose of this study is to investigate the efficacy and safety of retatrutide compared with semaglutide in participants with Type 2 Diabetes and inadequate glycemic control with metformin with or without sodium-glucose…
- Trial name
- NCT06260722
- Testing
- Retatrutide, Semaglutide
- Where
- 77 sites in United States, Argentina and 3 more
- Volunteers
- 1,250 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 2, Metabolic Syndrome
Isomaltulose VS Sucrose - Postprandial Effect on Incretin Profile and Second Meal Effect
This study evaluates the different postprandial effect of isomaltulose and sucrose on the incretin profile and as an determinant for the second meal effect.
- Trial name
- NCT03806920
- Testing
- Intervention A, Intervention B, Intervention C
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Gastroparesis, Diabetes Mellitus
Effects of Sitagliptin on Gastric Emptying, Glycaemia and Blood Pressure in Type 2 Diabetes
The purpose of this study is to evaluate the acute effects of sitagliptin on postprandial glycemia, incretin hormones and blood pressure, and the relationship to gastric emptying, after a mashed potato meal in patients with type…
- Trial name
- NCT02324010
- Testing
- Sitagliptin
- Where
- Australia
- Volunteers
- 14 people
- Sponsor
- Royal Adelaide Hospital
Diabetes Mellitus, Pre-diabetes
Effects of Green Banana BIOmass Consumption in Patients With Pre-diabetes and Diabetes MELlitus (The BIOMEL Study)
Costa ES, Izar MC, Fonseca FAH, França C, Tria H. The benefits of green banana biomass consumption in patients with diabetes mellitus. Federal University of São Paulo, São Paulo, 2015.
- Trial name
- BIOMEL (NCT03230123)
- Testing
- Green banana biomass
- Where
- Brazil
- Volunteers
- 136 people
- Sponsor
- Federal University of São Paulo
Diabetes Mellitus, Type 2
To Assess the Risk of Acute Pancreatitis in Patients With Type 2 Diabetes Mellitus Treated With Empagliflozin
To compare the risk of acute pancreatitis in patients with Type 2 diabetes mellitus (T2DM) newly initiating empagliflozin to that of patients newly initiating other oral non-incretin/non-Sodium glucose co-transporter-2 inhibitor…
- Trial name
- NCT05162014
- Testing
- empagliflozin, Oral non-incretin/non-sodium glucose co-transporter-2 inhibitors (SGLT2)-containing hypoglycaemic agents
- Where
- Germany
- Volunteers
- 494,679 people
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes Mellitus, Congestive Heart Failure
Effects of Exenatide in Type 2 Diabetic Patients With Congestive Heart Failure
The purpose of this study is to determine if exenatide will improve global cardiac function in patients with type 2 diabetes mellitus and congestive heart failure, by favorable effects on cardiac metabolism leading to improvement…
- Trial name
- NCT00766857
- Testing
- exenatide, Insulin glargine
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Obesity, Overweight (BMI > 25)
Impact of Protein Supplementation and Resistance Training on Body Composition, Functional Parameters, Metabolic Adaptation, and Nitrogen Balance in Adults Aged 45 Years and Older With Overweight or Obesity Receiving Incretin-based Medications
This study aim to evaluate the effects of protein supplements and resistance training on body composition, functional parameters, metabolic adaptation, and nitrogen balance in adults (aged ≥45 years) with overweight/obesity…
- Conditions
- Obesity, Overweight (BMI > 25), Weight Loss
- Trial name
- PRIME (NCT06950684)
- Testing
- Whey Protein Supplement, Resistance Training Program
- Volunteers
- 180 people
- Sponsor
- Assuta Medical Center
Type 2 Diabetes, Postprandial Lipemia
Differential Effects of Protein Quality on Postprandial Lipemia in Response to a Fat-Rich Meal in Type 2 Diabetes: Comparison of Whey, Casein, Gluten, and Cod Protein
Enhanced and prolonged postprandial triglyceride responses involve increased cardiovascular risk in type 2 diabetes. It has been demonstrated that dietary fat and carbohydrates profoundly influence postprandial…
- Trial name
- NCT00817973
- Testing
- Casein, Whey, Cod
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Obesity, Overweight
A Study to Investigate the Effect of LY4086940 Versus Placebo in Participants With Obesity or Overweight and Without Type 2 Diabetes
The purpose of this study, performed under the master protocol W8M-MC- CWMM (NCT06143956), is to evaluate the efficacy and safety of LY4086940 compared with placebo in participants without type 2 diabetes who have obesity or who…
- Trial name
- NCT07890376
- Testing
- LY4086940
- Where
- 46 sites in United States, Argentina
- Volunteers
- 460 people
- Sponsor
- Eli Lilly and Company
Gestational Diabetes Mellitus
Study of Postprandial Incretin Response in Women With Gestational Diabetes
The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent…
- Trial name
- NCT01274052
- Testing
- Meal test
- Where
- Denmark
- Volunteers
- 19 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
COVID 19, Coronavirus
Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19
The coronavirus disease 2019 (COVID-19) is an emerging pandemic in 2020 caused by a novel coronavirus named SARS-CoV2. Diabetes confers a significant additional risk for COVID-19 patients.
- Conditions
- COVID 19, Coronavirus, Diabetes Mellitus, Type 2, Diabetes Mellitus
- Trial name
- NCT04371978
- Testing
- Linagliptin 5 MG
- Where
- 3 sites in Israel
- Volunteers
- 64 people
- Sponsor
- Rabin Medical Center
Obesity & Overweight, Weight Loss Maintenance
Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?
So far, treatment with semaglutide (Wegovy) for therapy of obesity demonstrates substantial effects. However, most patients do not desire life-long pharmaceutical therapy or discontinue this treatment regime.
- Trial name
- DIET-SLIM (NCT07711548)
- Testing
- NutriAct plus, Rescue VLCD
- Volunteers
- 292 people
- Sponsor
- Knut Mai
Healthy, PreDiabetes
Efficacy of Milk Product Supplemented With Bioactives in Lowering Post Meal Glucose Response
This is a monocentric, randomized controlled, open-label, 2x2 cross-over study. The main objective of the study is to Evaluate the efficacy of Nestle YIYANG TangLv milk powder in lowering the Post Prandial Glucose Response (PPGR)…
- Conditions
- Healthy, PreDiabetes, Adult, Asian
- Trial name
- NCT05570435
- Testing
- Blood collection
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Diabetes Mellitus, Prediabetes / Type 2 Diabetes
Chronic Dorzagliatin on Insulin and Incretin Function in Intermediate Hyperglycemia and Type 2 Diabetes
A total of 30 subjects will be recruited 15 with intermediate hyperglycemia and 15 in the tyep 2 diabetes group respectively. Eligible participants will undergo hyperglycemic-clamp/oral glucose tolerance at baseline and after 4…
- Trial name
- NCT06671340
- Testing
- Dorzagliatin
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Elaine Chow
Overweight , Obesity, Adults
Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss
A study of ALV-100 to assess efficacy, safety and tolerability among participants with overweight or obesity who have previously achieved a body weight reduction of ≥10% while treated with incretin-based therapies.
- Trial name
- PRESERVE (NCT07837973)
- Testing
- ALV-100
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Alveus Therapeutics, Inc.
STEMI, Coronary Artery Disease
STEMI and Incretins Treatment
ST elevation myocardial infarction (STEMI) patients affected by multivessels coronary artery stenosis, represent a clinical relevant problem. The management and prognosis of these patents are supported by few literature data.
- Conditions
- STEMI, Coronary Artery Disease, Coronary Syndrome, Coronary Arteriosclerosis
- Trial name
- NCT03312179
- Testing
- PCI and DES stenting, Incretins
- Where
- Italy
- Volunteers
- 900 people
- Sponsor
- University of Campania Luigi Vanvitelli
Obesity and Metabolic Syndrome
Comparative Observation of Metabolic and Pharmacologic Adipose Remodeling With Enhanced Incretin AgonisTs
This randomized, open label, head to head clinical trial directly compares tirzepatide and semaglutide in adults with obesity and metabolic syndrome (N=120, age 20-65, 1:1 randomization).
- Trial name
- COMPARE-AT (NCT07589322)
- Testing
- Tirzepatide with lifestyle modification, Semaglutide with lifestyle modification
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Type2 Diabetes Mellitus, Obesity
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation
Several free fatty acids receptors (FFARs) have been discovered. These have been implicated in metabolic processes and inflammation.
- Trial name
- NCT03062592
- Testing
- Pine nut oil
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital