Clinical trials: Index of Microvascular Resistance
ST Elevation Myocardial Infarction
Effect of DLBS1033 After Primary PCI in Patients With STE-ACS
This is a prospective, randomized, double-blind, double-dummy, and controlled clinical study over a total of 4-week therapy with DLBS1033 in the management of STE-ACS after a primary PCI.
- Trial name
- NCT02976701
- Testing
- DLBS1033, Standard therapy
- Where
- Indonesia
- Volunteers
- 23 people
- Sponsor
- Dexa Medica Group
Sepsis, Myocardial Injury
COronary Microcirculation and Troponin Elevation in Septic Shock
Plasma cardiac troponin (cTn) elevation is an indicator of increased mortality in patients with sepsis yet the underlying cause of troponin elevation in sepsis is not known.
- Conditions
- Sepsis, Myocardial Injury, Coronary Microvascular Dysfunction, Endothelial Dysfunction
- Trial name
- COMTESS (NCT06294730)
- Where
- Sweden
- Volunteers
- 62 people
- Sponsor
- Karolinska Institutet
End Stage Renal Disease, Myocardial Microvascular Disease
Myocardial Microvascular Disease in ESRD
Cardiovascular diseases are the leading cause of mortality in patients with end stage renal disease (ESRD). They often have myocardial ischemia (a major predictor of mortality) on non invasive testing (Stress echocardiography…
- Trial name
- MICROCARD (NCT01291771)
- Testing
- Invasive FFR + CFR measurements are performed during coronary angiography using a pressure guide wire
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
ST-segment Elevation Myocardial Infarction (STEMI)
Angio-IMR and Cardiac MR-derived MVO in STEMI Patients
Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of ST-segment elevation myocardial infarction (STEMI) patients.
- Trial name
- NCT04828681
- Testing
- Cardiac magnetic resonance imaging
- Where
- 2 sites in United States, China
- Volunteers
- 324 people
- Sponsor
- Samsung Medical Center
Acute Myocardial Infarction
Index of Microcirculatory Resistance After Immediate Versus Deferred Stenting in Patients With Acute Myocardial Infarction
This study will compare the microcirculatory resistance (IMR) of infarct-related artery (IRA) in patients who underwent immediate versus deferred stenting during percutaneous coronary intervention (PCI) for acute myocardial…
- Trial name
- NCT03238508
- Testing
- Deferred stenting
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Sejong General Hospital
Cardiac Amyloidosis
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis
The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac…
- Trial name
- NCT02798705
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Coronary Microvascular Dysfunction
A Prospective, Multi-center Clinical Trial for Evaluating the Effectiveness and Safety of Online Coronary Angiography-Derived Index of Microcirculatory Resistance (caIMR)
More than 50% of patients with stable or unstable angina pectoris have no obstructive coronary arteries by angiographic visual estimation, in which coronary microvascular dysfunction (CMD) is one of the causes of myocardial…
- Trial name
- Flash III (NCT05009667)
- Testing
- Angiography-derived Index of Microcirculatory Resistance, Pressure wire-based Index of Microcirculatory Resistance
- Where
- 3 sites in China
- Volunteers
- 116 people
- Sponsor
- Ge Junbo
Coronary Microvascular Dysfunction, Myocardial Ischemia
Diagnostic and Prognostic Value of Angiography-derived IMR
The importance of the microvasculature in determining clinical outcomes has been highlighted in patients with coronary artery disease (CAD).
- Trial name
- CHART-MiCro (NCT04825028)
- Testing
- Angiography-drived Index of Microcirculatory Resistance
- Where
- China
- Volunteers
- 271 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiomyopathies, Microcirculation
IMR Assessment in Patients With New Diagnosis of Left Ventricle Dilatation
To establish if, in patients with new diagnosis of left ventricular dilatation without documentation at the coronary artery angiography of significant coronary artery lesions, there is a damage of the coronary microcirculation at…
- Conditions
- Cardiomyopathies, Microcirculation, Microvessels
- Trial name
- IMPAIRED (NCT02705170)
- Testing
- index of microvascular resistance
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University Hospital of Ferrara
Coronary Artery Calcification, Intravascular Lithotripsy
Prognostic Impact of Coronary Microvascular Dysfunction After IVL Versus RA in Patients With Severe Coronary Calcification Undergoing PCI
The goal of this observational study is to lean that whether the distinct mechanisms by which intravascular lithotripsy (IVL) and rotational atherectomy (RA) treat severe coronary calcification differentially affect the…
- Conditions
- Coronary Artery Calcification, Intravascular Lithotripsy, Coronary Microcirculation Dysfunction
- Trial name
- NCT07699965
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Type 2 Diabetes Mellitus
The HOME Trial: Hyperinsulinaemia: the Outcome of Its Metabolic Effects, a Randomized Controlled Trial
The HOME-trial is a prospective, randomized controlled trial. The purpose of this study is to investigate the effects of metformin HCL in patients with type 2 diabetes mellitus intensively treated with insulin on the quality of…
- Trial name
- NCT00375388
- Testing
- Metformin on top of intensive insulin therapy
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Bethesda General Hospital, Hoogeveen
Coronary Artery Disease, STEMI - ST Elevation Myocardial Infarction
AccuIMR Predicts Microvascular Obstruction and Infarct Size in STEMI Patients
In this study, we aimed to investigate the clinical significance of the angiography-based IMR calculation method (AccuIMR) and its prognostic assessment capability by evaluating the concordance or discordance between AccuIMR…
- Conditions
- Coronary Artery Disease, STEMI - ST Elevation Myocardial Infarction, Microvascular Coronary Artery Disease
- Trial name
- NCT06947564
- Testing
- CMR
- Where
- China
- Volunteers
- 843 people
- Sponsor
- RenJi Hospital
Cardiac Allograft Vasculopathy
Early Post Transplant Cardiac Allograft Vasculopathy
Heart transplantation is an effective life-saving treatment for patients with end-stage heart disease. After a transplant, the new heart may develop narrowing in the arteries, causing heart failure, heart attacks and abnormal…
- Trial name
- ECAV (NCT03217786)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Artery Disease, Microvascular Coronary Artery Disease
Impact of Hyperemic State on Angio-IMR Performance
The goal of this observational study is to evaluate the diagnostic performance of angiography-derived microcirculatory indices (Angio-IMR) in assessing patients with stable angina or suspected coronary artery disease.
- Trial name
- NCT07613996
- Testing
- Angiography-derived IMR
- Where
- 2 sites in China
- Volunteers
- 192 people
- Sponsor
- Shanghai Zhongshan Hospital
Angina Patients With Non-obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction
Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease (ANOCA-CMD)
The goal of this observational study is to explore the incidence and effect on prognosis of coronary microvascular dysfunction in patients present of stable anginal symptoms, a clinical indication for invasive coronary…
- Conditions
- Angina Patients With Non-obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Index of Microvascular Resistance
- Trial name
- NCT06503640
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Severe Symptomatic Aortic Stenosis
Change in Coronary Microcirculation and FFR After TAVI in Patients With Cardiovascular Comorbidities
Change in coronary microcirculation and Fractional Flow Reserve after Transcatheter Aortic Valve Implantation in patients with concomitant coronary artery disease and severe aortic stenosis.
- Trial name
- NCT04663334
- Testing
- inverse myocardial remodeling
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Nantes University Hospital
Coronary Artery Disease
Correlation Study of Imaging Data Acquired During CABG With Data Acquired in the Cath Lab
Visual assessment of a coronary artery narrowing (called stenosis) seen on angiography is conventionally used to infer how likely the stenosis will limit blood flow (called ischemia) under conditions of increased demand (e.g…
- Trial name
- PERSEUS (NCT02138305)
- Testing
- ComboMap XT Guidewire, 'SPY' NIRF During CABG
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- East Carolina University
Coronary Microvascular Disease, Coronary Artery Disease
Multicenter Registry of Coronary Flow-Derived Indexes for Coronary Microvascular Disease (Multicenter FLOW-CMD Registry)
Multicenter FLOW-CMD registry is a prospective, multi-center, registry study. The aim of the study is to evaluate prognostic implications of coronary microvascular disease (CMD) in patients with ischemic heart disease (IHD)…
- Conditions
- Coronary Microvascular Disease, Coronary Artery Disease, Ischemic Heart Disease
- Trial name
- NCT05369182
- Testing
- Invasive physiologic assessment, Intravascular imaging
- Where
- 7 sites in South Korea
- Volunteers
- 1,003 people
- Sponsor
- Samsung Medical Center
Ischemic Heart Disease, Microvascular Coronary Artery Disease
Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function
The DIAST-CMD registry (Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function) is prospective registry which enrolled patients who underwent echocardiography, cnically-indicated invasive coronary…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction
- Trial name
- DIAST-CMD (NCT05058833)
- Testing
- Echocardiography, Coronary flow reserve and index of microcirculatory dysfunction
- Where
- 4 sites in United States, South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Coronary Heart Disease
Ticagrelor Versus Clopidogrel for CMD in Patients With AMI: A Retrospective Study Based on the Angio-IMR
Coronary microvascular dysfunction (CMD) is increasingly recognized as an important indicator for long-term prognosis in patients with acute myocardial infarction (AMI).
- Trial name
- NCT05978726
- Testing
- Dual antiplatelet therapy with aspirin and either ticagrelor or clopidogrel
- Where
- China
- Volunteers
- 325 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine