Clinical trials: Individual Difference
Healthy
A Study in Healthy People to Compare Two Different Sifrol® Tablets
The main objective of this trial is to establish the bioequivalence of Sifrol® tablets manufactured at two different sites.
- Trial name
- NCT06457204
- Testing
- Pramipexole manufactured in Ingelheim, Pramipexole manufactured in Ennigerloh
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Neoplasm Metastasis, Non-Small Cell Lung Cancer
Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)
The study has 2 parts. The first part is open to adults with different types of advanced cancer (solid tumours with changes in the HER2 gene) for whom previous treatment was not successful.
- Trial name
- NCT04886804
- Testing
- zongertinib
- Where
- 85 sites in United States, Australia and 16 more
- Volunteers
- 554 people
- Sponsor
- Boehringer Ingelheim
PreDiabetes
Efficacy of Physical Exercise on Glucose Control in People With Prediabetes
To assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes.
- Trial name
- GLYCEX (NCT05612698)
- Testing
- Aerobic training, Aerobic training plus resistance training, High intensive interval training
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Dermatitis, Atopic
Different Application Rates of Crisaborole Ointment 2% in Adults With Mild to Moderate Atopic Dermatitis
This study is being conducted to evaluate the efficacy and safety of 3 different application rates of topically applied Crisaborole ointment 2% over vehicle in adults with mild to moderate atopic dermatitis (AD).
- Trial name
- NCT03868098
- Testing
- Crisaborole 2%
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Innovaderm Research Inc.
Hepatic Insufficiency
A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problems
This study is open to adults aged 18 years and older. People without liver problems and people who have mild or moderate liver problems can join the study.
- Trial name
- NCT05661344
- Testing
- BI 1015550
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Gastrointestinal Cancer, Lung Cancer
A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6
This is a study in adults from Asia with different types of advanced cancer (solid tumours). People can join the study if they have cancer of the stomach, large bowel and rectum, pancreas, liver, head and neck or non-small cell…
- Conditions
- Gastrointestinal Cancer, Lung Cancer, Pancreatic Cancer, Colorectal Cancer
- Trial name
- NCT06091930
- Testing
- BI 765049, Ezabenlimab
- Where
- 3 sites in Japan
- Volunteers
- 21 people
- Sponsor
- Boehringer Ingelheim
Surgery, Individuality
The Realtime Detection for Individual Variation of Analgesic ：A Comparison of Sufentanil vs Fentanyl
Purpose: This study aimed to find a quick and timely way to investigate the individual variation of efficacy of opioid analgesic in Chinese patients undergoing elective surgeries.
- Trial name
- NCT01748071
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Multimorbidity
Personal Resources of Elderly People With Multimorbidity
PREFER II aims at developing psychological targeted theory- and evidence-based intervention components, which support older people with multiple illnesses in performing more physical activity.
- Trial name
- PREFER (NCT01577134)
- Testing
- Social-cognitive resource intervention, no intervention
- Where
- Germany
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- German Centre of Gerontology
Pre-diabetes, Pre-diabetic State
VA|PREVENTION: Randomized Controlled Trial of a Person-Centred Digital Intervention to Prevent Diabetes in High-Risk Adults
The goal of this clinical trial is to help prevent the development of type 2 diabetes (T2D) in adults who are at risk. The study will test a digital intervention called VA|PREVENTION, a web application designed to support and…
- Trial name
- VA|PREVENTION (NCT07021144)
- Testing
- VA|PREVENTION web application (digital intervention), Type 2 Diabetes Guidebook
- Where
- 16 sites in Portugal
- Volunteers
- 180 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Solid Tumors, KRAS Mutation
A Study to Test Different Doses of BI 3011441 in Japanese People With Different Types of Advanced Cancer (NRAS/KRAS Mutation Positive)
This study is open to Japanese adults with different types of advanced cancer that are positive for NRAS/KRAS mutations. This is a study in people for whom previous treatment was not successful or no standard treatment exists.
- Trial name
- NCT04742556
- Testing
- BI 3011441
- Where
- 3 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Boehringer Ingelheim
Incomplete Spinal Cord Injury
Effect of Different Support Systems on Gait
Body weight support systems are commonly used for gait training. A new breed of devices for gait training are soft exosuits. To optimize rehabilitation outcomes, it is important to gain deeper insight in the effect of these…
- Trial name
- NCT06214546
- Testing
- Regular walking, Myosuit, ZeroG
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Sint Maartenskliniek
Diabetic Nephropathies
A Study to Test the Effect of Different Doses of BI 685509 on Kidney Function in People With Diabetic Kidney Disease
This study is open to adults with diabetic kidney disease. The purpose of the study is to find out whether a medicine called BI 685509 improves kidney function. Three different doses of BI 685509 are tested in this study.
- Trial name
- NCT04750577
- Testing
- BI 685509
- Where
- 78 sites in United States, Argentina and 14 more
- Volunteers
- 243 people
- Sponsor
- Boehringer Ingelheim
Renal Insufficiency, Healthy
A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Kidney Problems
This study is open to adults aged 18 years and older. People without kidney problems and people who have moderate or severe kidney problems can join the study.
- Trial name
- NCT05718648
- Testing
- BI 1015550
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Nurses, Mindfulness Training
Effects of Mindfulness-Based Program on Individual and Organizational Output of Frontline Manager Nurses:
The purpose of this randomized controlled study is to examine the effects of a mindfulness program applied to nurse managers on individual and organizational results.
- Trial name
- NCT06454526
- Testing
- Mindfulness Based Program
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Long COVID-19, Post-COVID-19 Syndrome
Exercise and Post-COVID/ Long-COVID: Effects of Different Training Modalities on Various Parameters in People Affected by the Sequelae of COVID-19
The current COVID-19 pandemic is the most severe health crisis of the 21st century. This is not only due to the deaths caused by the disease.
- Conditions
- Long COVID-19, Post-COVID-19 Syndrome, COVID-19
- Trial name
- NCT05204511
- Testing
- endurance training, concurrent training
- Where
- Austria
- Volunteers
- 66 people
- Sponsor
- University of Vienna
Type2 Diabetes, NAFLD
Effects of VLCD and Bariatric Surgery in Patients With Type 2 Diabetes
The investigators are therefore interested to explore the effects of VLCD and different bariatric surgery procedures to changes in the physical deposition of fat in organs which regulate glucose metabolism (i.e.
- Conditions
- Type2 Diabetes, NAFLD, Obesity
- Trial name
- BARIATRICMRI (NCT05092399)
- Testing
- Bariatric Surgery
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Nottingham
Solid Tumors
A Study to Evaluate the Safety and Effectiveness of Different Doses of RO7836748 Alone or in Combination With Other Cancer Therapies in People With Solid Tumors With a Rat Sarcoma Viral Oncogene Homolog Glycine 12 Valine (RAS G12V) Mutation
The study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of RO7836748 as monotherapy and in combination with other anti-cancer therapies, including…
- Trial name
- NCT07905924
- Testing
- RO7836748, Pembrolizumab, mFOLFIRINOX
- Volunteers
- 540 people
- Sponsor
- Hoffmann-La Roche
Chronic Pain, Chiari Malformation
Examining Different Components of Online Acceptance and Commitment Therapy for People With Chiari Malformation
Chiari Malformation (CM) is a chronic health condition characterized by brain and spinal malformations and displacements that cause obstruction of cerebrospinal fluid (CSF; Hadley, 2002) circulation.
- Trial name
- NCT05581472
- Testing
- Online Acceptance and Commitment Therapy Intervention + Phone Coaching, Online Acceptance and Commitment Therapy Intervention without phone coaching
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Kent State University
Healthy
This Study in Healthy Men Tests How Different Doses of BI 705564 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 705564 Affects the Way the Body Breaks Down Midazolam
The primary objective of this trial is to investigate safety and tolerability of BI 705564 in healthy male subjects, following oral administration of multiple rising doses.
- Trial name
- NCT03325712
- Testing
- BI 705564, Midazolam
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Chronic Nonspecific Low Back Pain, Elderly (People Aged 65 or More)
Investigation of Different Treatment Approaches in Elderly Individuals With Chronic Low Back Pain
Chronic nonspecific low back pain (CNSLBP) is a common issue among the elderly, affecting their physical health, daily activities, sleep quality, and overall quality of life.
- Trial name
- NCT06835270
- Testing
- Yoga Exercises, Standard physiotherapy approaches, Kinesiology taping
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Uşak University