Clinical trials: Individual Difference
Fibromyalgia (FM)
Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in People With Fibromyalgia
The first goal of this study is to see how brain activity changes in people with fibromyalgia after they get a treatment called rTMS (repetitive transcranial magnetic stimulation).
- Trial name
- rTMS (NCT07260864)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Autism Spectrum Disorder (ASD, Autism
Assessing Outcomes of Three Different Museum-based Social Prescription Programs in Autistic Adults
This study will examine whether visiting the National Taiwan Museum can support the social and emotional well-being of autistic adults.
- Conditions
- Autism Spectrum Disorder (ASD, Autism, Autistic Spectrum Disorder (ASD)
- Trial name
- NCT07768332
- Testing
- Independent museum visit, Guided museum visits and group discussions, Museum visit with a friend
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Opioid Sensitivity, Individual Difference
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans
Within-subject, double-blind, placebo-controlled examination of opioid abuse potential in healthy individuals as a function of A118G SNP on the OPRM1 gene.
- Conditions
- Opioid Sensitivity, Individual Difference, Abuse Opioids
- Trial name
- NCT02360371
- Testing
- Within-subject test of blinded study medication
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Coronavirus
Omicron BA.4/5-Delta Strain Recombinant Novel Coronavirus Protein Vaccine (CHO Cells)
Popular title: Clinical study of Omicron BA.4/5-Delta strain recombinant novel coronavirus protein vaccine (CHO cells). Purpose of the study: Main objectives: To evaluate the immunogenicity and safety of Omicron BA.4/5-Delta…
- Trial name
- NCT05850507
- Testing
- Omicron BA.4/5-Delta strain recombinant novel coronavirus protein vaccine (CHO cells), Recombinant novel coronavirus protein vaccine (CHO cells)
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Non-Communicable Chronic Diseases
Establishing a Physical Activity Referral Scheme for People With Noncommunicable Diseases in the German Healthcare System
The BewegtVersorgt project involved co-producing a physical activity referral scheme (PARS) for inactive persons with underlying non-communicable diseases.
- Trial name
- BewegtVersorgt (NCT04947787)
- Testing
- Physical activity referral scheme (PARS), Physical activity advice (PAA)
- Where
- Germany
- Volunteers
- 168 people
- Sponsor
- University of Erlangen-Nürnberg
Solid Tumor, KRAS Mutation
A Study to Test How Well Different Doses of BI 3706674 Are Tolerated by People With Advanced Cancer in the Stomach and Oesophagus
This study is no longer open to new participants. It was a study in adults with advanced cancer in the stomach and oesophagus. This is a study for people for whom previous treatment was not successful or no treatment exists.
- Trial name
- NCT06056024
- Testing
- BI 3706674
- Where
- 17 sites in United States, Japan and 2 more
- Volunteers
- 47 people
- Sponsor
- Boehringer Ingelheim
Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis
Healthy Eating and Active Living for People Living With Multiple Sclerosis (HEAL MS): A Lifestyle Program for People With Multiple Sclerosis
The goal of this clinical trial is to learn whether a structured lifestyle program can improve health and wellbeing in people living with multiple sclerosis (MS).
- Trial name
- HEAL-MS (NCT07589062)
- Testing
- Multi-Domain Lifestyle Intervention
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- New York University Abu Dhabi
Major Depressive Disorder
EXperimental Paradigm to Investigate Expectation Change in Depression 4
Research has shown that people with depressive symptoms maintain negative expectations even if they have positive experiences that contradict their expectations.
- Trial name
- EXPECD4 (NCT03780881)
- Testing
- Expectation confirmation, Expectation disconfirmation
- Where
- Germany
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Chronic Low Back Pain (CLBP)
Movement Quality and Balance Improvement in People With Chronic Low Back Pain Following Trunk Muscle Training
The goal of this project is to assess if Chronic Low Back Pain (CLBP) participant's movement quality and balance variables can change after training that decreases their pain and disability.
- Trial name
- CLBP (NCT06944730)
- Testing
- Structural Exercise, Isolated Trunk Exercise, Back school
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Parkinson Disease, Gait Disorders, Neurologic
Benefits of Different Exercise Types to Enhance Walking for PD
Background: Gait disturbance is one of the most common complaints from patients with Parkinson's disease (PD). It is well-established that people with PD have motor learning impairments.
- Trial name
- NCT04895787
- Testing
- Gait + aerobic exercise, Gait + resistance exercises, Gait + conventional physical therapy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Depression - Major Depressive Disorder, Anxiety
Comparative Effects of Acceptance and Commitment Therapy, Cognitive Behavioral Therapy, and Treatment-as-Usual on Depression Among People With Marital Crisis
This parallel three-arm, single-blind (assessor-blinded), randomized controlled trial (RCT) aims to compare the effects of ACT, CBT, and treatment-as-usual (TAU) on the severity of depressive symptoms (primary outcome), the…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Marital Conflict
- Trial name
- NCT07808021
- Testing
- Acceptance and Commitment Therapy, Cognitive Behavioral Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Universiti Sains Malaysia
Malaria, Childhood ALL
Field Evaluations of Innovative Tools for Vector-borne Disease Control in Conflict-affected Communities
The aim of this study is to determine the effectiveness of a new spatial repellent (called Mesh) at repelling multiple disease vectors and, reducing clinical malaria rates in temporary shelters and camp settings.
- Conditions
- Malaria, Childhood ALL, Vector Borne Diseases
- Trial name
- NCT06179732
- Testing
- Mesh - spatial repellent impregnated with transfluthrin (2500mg), Information and Education Campaigns (IEC), test and treat malaria cases
- Where
- United Kingdom
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- The Mentor Initiative
Diabetes Mellitus, Type 2
DOORS: A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes Who Change From Dipeptidyl Peptidase-4 Inhibitor (DPP4i) Treatment to Oral Semaglutide in Italy
The purpose of the study is to look at the change in blood sugar levels in people with type 2 diabetes who change their treatment from DPP4i to oral semaglutide.
- Trial name
- DOORS (NCT05755360)
- Testing
- Semaglutide
- Where
- 25 sites in Italy
- Volunteers
- 291 people
- Sponsor
- Novo Nordisk A/S
Polypharmacy
Appropriate Polypharmacy in Older People in Primary Care
In the past, prescribing many medicines (polypharmacy) was seen in a negative light. However, because people are living longer and have several medical conditions at the same time, views on polypharmacy have changed.
- Trial name
- PolyPrime (NCT04181879)
- Testing
- Intervention
- Where
- 2 sites in Ireland, United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Sepsis, Prognostic Model
Artificial Intelligence Prognostic Model for Sepsis Based on Time Series Analysis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is one of the leading causes of death and disability worldwide, with an inpatient mortality rate of 10-20%.
- Conditions
- Sepsis, Prognostic Model, Artificial Intelligence, Individuality
- Trial name
- NCT06724120
- Testing
- No interventions
- Where
- China
- Volunteers
- 3,641 people
- Sponsor
- West China Hospital
Obesity, Cardiometabolic Syndrome
A Study Comparing the Health Effects of Two Diets Following UK Dietary Guidance in People Living With Overweight or Obesity
There are two parts to this study: 1. The investigators will study if the benefit from eating a healthy, balanced diet depends on the types of food processing in the diet.
- Conditions
- Obesity, Cardiometabolic Syndrome, Overweight
- Trial name
- UPDATE (NCT05627570)
- Testing
- Healthy, balanced Diet A, Healthy, balanced Diet B, Behavioural support intervention
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University College, London
Anal Squamous Intraepithelial Neoplasia
Seville Cohort of People Living With HIV at Risk for Anal Cancer
There is increasing awareness of augmenting risk of anal cancer in people living with HIV, especially among men who have sex with men (MSM).
- Trial name
- SeVIHanal (NCT03713229)
- Testing
- Screening for anal squamous intraepithelial lesions
- Where
- Spain
- Volunteers
- 3,000 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Conditionally Healthy Persons, Persons With a High Body Mass Index
Medico-ecological Monitoring ((CSM, MCTQ, SPAQ, PSQI, HRV, Spirometry; Anthropometry, BP) of the Different Population Groups (Students, Schoolchildren, Volunteers) in North Caucasus
Observational Clinical Trial of the chronotype, sleep quality, seasonal pattern, behavioral time preferences, the functional state of the body's regulatory systems and respiratory systems in individuals of different age groups…
- Trial name
- NCT04851080
- Testing
- Heart Rate Variability, Spirometry, Testing of psycho-physiological functions using four questionnaires
- Where
- Russia
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Vladikavkaz Scientific Center of the Russian Academy of Sciences
Kidney Disease, Chronic, Kidney Failure Chronic
Physical Exercise and Biomolecular Analysis to Reduce Uremic Toxins in Chronic Kidney Disease: An Exploratory Study
The accumulation of uremic toxins is detrimental to physiological systems and induces premature biological aging. Renal function assessment methods, such as predictive formulas, may be influenced by ancestry in Brazilians, given…
- Trial name
- DRC_LExS (NCT06910475)
- Testing
- Resistance training, Endurance training, Concurrent training
- Where
- Brazil
- Volunteers
- 1,600 people
- Sponsor
- Catholic University of Brasília
Healthy
A Study in Healthy People to Test How Well Different Doses of BI 3000202 Are Tolerated and How They Affect the Way the Body Handles Midazolam
The aim of this trial is to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) following multiple rising doses of BI 3000202 and to investigate the effect of BI 3000202 on the metabolism of…
- Trial name
- NCT06327256
- Testing
- BI 3000202, Midazolam
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim