Clinical trials: Individual Difference
Multiple Sclerosis
How to Develop the Highest Possible Leading-edge Interdisciplinary Care Model for People With MS, That Will be Relevant to All Stakeholders and Declinable to Different Local Contexts With the Ultimate Goal of Ensuring the Highest Level of Quality of Care in MS.
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating and degenerative disease of the central nervous system. It is currently not curable, although several disease-modifying treatments (DMT) reduce the occurrence of…
- Trial name
- MUSICALISE (NCT07289724)
- Testing
- Focus group, individual interview
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 2
A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes.
- Trial name
- NCT07668388
- Testing
- UBT251, Semaglutide
- Where
- 70 sites in United States, Australia and 7 more
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Acute Myeloid Leukemia
Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)
This phase II MyeloMATCH treatment trial studies how well ASTX727 and venetoclax plus enasidenib works compared to ASTX727 and venetoclax alone for the treatment of older patients with newly diagnosed acute myeloid leukemia (AML)…
- Trial name
- NCT06672146
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 138 sites in United States, Puerto Rico
- Volunteers
- 93 people
- Sponsor
- National Cancer Institute (NCI)
Solid Tumors
A Study to Evaluate the Safety and Effectiveness of Different Doses of RO7836748 Alone or in Combination With Other Cancer Therapies in People With Solid Tumors With a Rat Sarcoma Viral Oncogene Homolog Glycine 12 Valine (RAS G12V) Mutation
The study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of RO7836748 as monotherapy and in combination with other anti-cancer therapies, including…
- Trial name
- NCT07905924
- Testing
- RO7836748, Pembrolizumab, mFOLFIRINOX
- Volunteers
- 540 people
- Sponsor
- Hoffmann-La Roche
Renal Insufficiency
A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Kidney Problems
This study is open to people with and without kidney problems. People can join the study if they are 18 years or older and have a body mass index (BMI) between 18.5 and 35 kg/m2.
- Trial name
- NCT05718843
- Testing
- BI 425809
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Obesity, Overweight
Weight Regain After Consumption of Food Supplement and Interventional Diet Program
Effect of the dietary supplement (FAT-BINDER DAMM) on weight regain after 9 months of control weight program
- Conditions
- Obesity, Overweight, Weight Loss, Body Weight Changes
- Trial name
- fat-binder (NCT03554525)
- Testing
- Fat-binder damm
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Obesity
Health Benefits of Functional Oil (Mega 3 Fatty Acids From Fish Oil) on Obese People
Examine the effects and safety of functional oil (olive oil with omega 3 fatty acids from fish oil) on different inflammatory markers in obese subjects with dietary intervention for weight lost.
- Trial name
- NOBO (NCT01739998)
- Testing
- functional oil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Pulmonary Disease, Chronic Obstructive
The Prescriptive Validity of a Novel Fall Risk Clinical Prediction Rule for People With COPD
This study has 3 objectives: (1) demonstrate the effectiveness of balance training for people with COPD, (2) determine which patients with COPD respond best to balance training, and (3) calculate clinically meaningful changes in…
- Trial name
- NCT05173532
- Testing
- Balance Training, Breathing and Stretching Exercises
- Where
- 4 sites in United States
- Volunteers
- 88 people
- Sponsor
- Texas Woman's University
Healthy
A Study in Healthy People to Compare How 2 Different Formulations of Vicadrostat / Empagliflozin Tablets Are Taken up in the Body
The main objective of this trial is to establish the bioequivalence of two different formulations of vicadrostat / empagliflozin in healthy male and female trial participants following oral administration.
- Trial name
- NCT07845630
- Testing
- Vicadrostat, Empagliflozin, Vicadrostat + empagliflozin
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Adult Participants
Alcohol Sensitivity Among Older Adults Who Consume Alcohol
This is a proof-of-concept study exploring individual differences in sensitivity to alcohol among older healthy current drinkers aged 65 to 80.
- Trial name
- NCT07636447
- Testing
- Alcohol (Oral)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sedentary Behaviour, Stroke
Effectiveness of the RISE Intervention
Study aim: Primarily, to investigate the effectiveness of the RISE blended behaviour change intervention in people with a first stroke to prevent major adverse cardiovascular events (i.e., recurrent stroke or TIA, acute coronary…
- Trial name
- RISE (NCT06124248)
- Testing
- RISE intervention
- Where
- 21 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Bronchiectasis, Quality of Life
Evaluating the Effects of Traditional Chinese Medicine by N-of-1 Trials
Treatment based on syndrome differentiation is the essence of traditional Chinese Medicine(TCM) and forms the individualized treatment.
- Conditions
- Bronchiectasis, Quality of Life, Traditional Chinese Medicine, Sputum
- Trial name
- NCT03147443
- Testing
- Individualized Decoction, Tested drug minus heat-clearing herbs
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Traumatic Brain Injury, Walking Impairment
Treadmill Training at Constant or Different Speeds for People With Traumatic Brain Injury
Background: Many people who have had a traumatic brain injury have difficulty walking. Training on a treadmill is often used to help people with walking difficulties.
- Conditions
- Traumatic Brain Injury, Walking Impairment, Gait Training
- Trial name
- NCT01419522
- Testing
- Gait Training Method
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Diabetic Nephropathy Type 2
Rotation for Optimal Targeting of Albuminuria and Treatment Evaluation (ROTATE-2)
This project is an intervention study where type 2 diabetic patients will rotate through 4 different albuminuria lowering drugs with the aim to 1) quantify the individual relationship between drug exposure and albumin lowering…
- Trial name
- ROTATE-2 (NCT03504566)
- Testing
- Linagliptin, Empagliflozin, Telmisartan
- Where
- Denmark
- Sponsor
- Steno Diabetes Center Copenhagen
Stroke
Interference During Motor Learning of Different Degrees of Freedom in the Paretic Upper Extremity of People With Stroke
Post-stroke rehabilitation of the upper extremity is a challenge in neurorehabilitation. Selective training of different degrees of freedom (training of specific monoarticular movements and in one plane of movement of the upper…
- Trial name
- NCT06249737
- Testing
- Training
- Where
- 2 sites in Spain
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Subacromial Impingement Syndrome, Apical Shoulder Pain
Comparison of Dynamic Ultrasound Visual Feedback to Manual Feedback on Scapular Stabilizer Activation and Change in the Subacromial Space in Persons With Pain During Shoulder Elevation
Purpose of the Study This study looks at whether using real-time ultrasound images as feedback can help people better activate two important shoulder muscles-the serratus anterior and lower trapezius-compared to standard verbal…
- Conditions
- Subacromial Impingement Syndrome, Apical Shoulder Pain, Rotator Cuff Syndrome
- Trial name
- SCAP-M-RUSI (NCT07464639)
- Testing
- Verbal and tactile feedback with exercise
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- California State University, Long Beach
Sedentary Behavior
A BCT Intervention for an Hourly Activity Habit Among Caregivers for Persons With AD/ADRD
This 12-week trial will test the efficacy of a personalized, multi-component, personalized text-message delivered behavior change technique (BCT) intervention to encourage habitual hourly physical activity among care providers of…
- Trial name
- NCT06801912
- Testing
- Behavior Change Technique Package
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Sarcopenia, Frailty
Resistance Exercise Training at Different Intensities
The aim of the current study, therefore, is to determine the feasibility of recruitment and adherence to resistance exercise training interventions performed at low and high loads, to volitional muscular failure, in a trial…
- Conditions
- Sarcopenia, Frailty, Aging
- Trial name
- NCT04053920
- Testing
- Low Load Resistance exercise, High Load Resistance exercise
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Obesity
A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Help People With Excess Body Weight Lose Weight
This study will look at how a new medicine called NNC0519-0130 helps people with excess body weight lose weight. The study will test up to 6 different doses of NNC0519-0130. Participants will take 1-2 injections once a week.
- Trial name
- NCT06326060
- Testing
- NNC0519-0130, Tirzepatide
- Where
- 70 sites in United States, Australia and 1 more
- Volunteers
- 354 people
- Sponsor
- Novo Nordisk A/S
Fatigue
Individualized Exercise Program Plus Behavioral Change Enhancement Strategies for Managing Fatigue in Frail Older People
This project aims to investigate the effects of an individualized exercise programme with and without BCE strategies for community-dwelling frail older people with general fatigue, so as to reduce their fatigue and improve their…
- Trial name
- NCT03394495
- Testing
- BCE Combination group
- Where
- Hong Kong
- Volunteers
- 184 people
- Sponsor
- The Hong Kong Polytechnic University