Clinical trials: Individuals With Multiple Sclerosis
Multiple Sclerosis
Effects of Functional Electrical Stimulation Cycling Versus Cycling Only on Walking and Quality of Life in MS
This study will seek to determine the benefits that FES-LE cycling has over cycling alone on walking performance and quality of life in people with multiple sclerosis.
- Trial name
- MSCycling (NCT02606604)
- Testing
- RT 300: Lower Extremity Cycling
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stony Brook University
Multiple Sclerosis
Theory Based Intervention Program to Support Physical Activity for Individuals With Multiple Sclerosis: a Case Series
This study evaluates the effectiveness of personalized physical activity coaching combined with the use of a physical activity monitor to support increased levels of daily physical activity in individuals with multiple sclerosis.
- Trial name
- NCT02335450
- Testing
- Motivational Interviewing, Wristband physical activity monitor
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oakland University
Multiple Sclerosis
The Effect of Cognitive Exercise on Upper Extremity Functions, Balance and Cognitive Functions in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic, progressive, demyelinating disease characterized by myelin sheath damage in the central nervous system that affects more than 2.5 million people worldwide and is more common in young adults…
- Trial name
- NCT06511154
- Testing
- Cognitive Rehabilitation, Core-based Upper Extremity Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ankara Yildirim Beyazıt University
Multiple Sclerosis
The Effect of Internal- or External-Focused Exercise Training, Administered in Conjunction With a Cognitive Task, on Walking, Balance, and Cognitive Functions in Individuals With Multiple Sclerosis
This interventional clinical trial aims to investigate the effects of internal and external focus-based exercise training combined with cognitive dual-task training in individuals diagnosed with multiple sclerosis.
- Trial name
- NCT07507084
- Testing
- Internal Focus Dual-Task Training, External Focus Dual-Task Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kutahya Health Sciences University
Multiple Sclerosis
Home-Based Exergame Rehabilitation for Upper Limb Function in People With Multiple Sclerosis
This randomized pilot clinical trial aims to evaluate the effectiveness, feasibility, and cost-effectiveness of a semi-autonomous upper-limb rehabilitation program based on therapeutic exergames in people with Multiple Sclerosis…
- Trial name
- NCT07430462
- Testing
- Exergame-Based Upper Limb Rehabilitation Program, Conventional Home-Based Physiotherapy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Marina Castel Sánchez
Multiple Sclerosis, Rehabilitation
Robot-assisted Arm Training in Multiple Sclerosis
The upper limb (UL) plays an important role in the daily functioning of patients with Multiple Sclerosis (MS) and negatively influences their quality of life. Effective arm-hand training programs are needed.
- Trial name
- RAMSES (NCT03561155)
- Testing
- Robot assisted treatment (Amadeo®), Conventional treatment
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Secondary Progressive Multiple Sclerosis
Functional Electrical Stimulation for Individuals With Secondary Progressive Multiple Sclerosis
Secondary progressive multiple sclerosis (SPMS) is a subtype of multiple sclerosis (MS) for which there are no existing therapies that alter the disease course.
- Trial name
- NCT01647321
- Testing
- Active cycling, Passive cycling
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Multiple Sclerosis
Effect of Training With Wireless Lightning Reaction Systems on Cognitive Functions in Individuals With Multiple Sclerosis
When the literature is examined, balance disorders, walking disorders and cognitive problems are frequently observed in Multiple Sclerosis(MS) patients.
- Trial name
- NCT06874764
- Testing
- Wireless Lighting Reaction System Training(Agility plus Cognitive)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ege University
Multiple Sclerosis, Insomnia
Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis
The incidence of insomnia is estimated to be as high as 90% in individuals with MS due to insomnia being underdiagnosed. Sleep disturbances in people with MS have been associated with reduced cognitive performance, physical…
- Trial name
- CALM (NCT06428006)
- Testing
- Cognitive behavioral therapy for insomnia, Sleep and lifestyle education
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Kansas Medical Center
Multiple Sclerosis
Effects of Home-based Respiratory Muscle Training With New Load Adjustment Test in People With Multiple Sclerosis
The main objective of the present study is to verify whether respiratory muscle training programme (IMT+EMT; included both inspriratory and expiratory muscles with load adjustment based on the principles of the 1-repetition…
- Trial name
- NCT07269054
- Testing
- Respiratory muscle training + 1-repetition maximum test, Respiratory muscle training + reference test
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Tamara del Corral Núñez-Flores
Multiple Sclerosis
Emotion Regulation Skills Training for Individuals With MS and Their Support Partners
This pilot randomized controlled trial investigates a novel, group-based emotion regulation skills training intervention for reducing anxious and depressive symptomatology and improving emotion regulation and problem solving in…
- Trial name
- NCT03934489
- Testing
- PERSIST, Facilitated Peer Support
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Multiple Sclerosis
Self-Directed Positive Psychology Intervention for Newly Diagnosed Multiple Sclerosis
The goal of this clinical trial is to learn whether positive psychology (PP) exercises such as writing a letter of gratitude or remembering a past success can help individuals with newly diagnosed multiple sclerosis (MS) to feel…
- Trial name
- NCT06891937
- Testing
- Positive psychology
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis, Inspiratory Muscle Training
Inspiratory Muscle Training in Individuals With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, characterized by inflammation, demyelination, and axonal degeneration, and primarily affects young adults.
- Trial name
- NCT07672535
- Testing
- High intensity interval IMT, Low intensity IMT, Conventional rehabilitation
- Volunteers
- 48 people
- Sponsor
- Istanbul University - Cerrahpasa
Multiple Sclerosis
Motor Evoked Potentials With Modified Facilitation Technique
Investigating the change in Test- Retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in…
- Trial name
- EP-F (NCT03646929)
- Testing
- MEP using standard facilitation technique, MEP using modified facilitation technique
- Where
- Switzerland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Multiple Sclerosis
Impact of Direct Current Electrical Stimulation on Spasticity Levels and Functional Muscle Use in MS
In an individual with MS the central nervous system (CNS) is over-protective and causes the threshold for stretch reflex and muscle tightness to be set lower than normal.
- Trial name
- NCT04942938
- Testing
- Neubie
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- CommonSpirit Health
Multiple Sclerosis, Relapsing-Remitting, FNDC5
To Investigate the Effect of Aerobic Exercise on Neurophysiological Values and Functionality in Individuals With Multiple Sclerosis.
Multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system, is characterized by myelin, oligodendrocytes and axon damage.
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, FNDC5, Irisin Hormone, Aerobic Exercise
- Trial name
- NCT04121637
- Testing
- Aerobic Exercise, Frenkel coordination exercises
- Volunteers
- 22 people
- Sponsor
- Firat University
Multiple Sclerosis, Quality of Life
Impact of Exercise on "Invisible" Symptoms and Quality of Life in Multiple Sclerosis Individuals
Patients with multiple sclerosis (MS) struggle on a daily basis with accompanying, "Invisible" symptoms like primary fatigue, pain and emotional-cognitive disorders.
- Conditions
- Multiple Sclerosis, Quality of Life, Motivation, Pain
- Trial name
- NCT03768830
- Testing
- Exercise training
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Multiple Sclerosis
An Online Self-Guided Meditation Course for Individuals With Multiple Sclerosis
The aim of this study is to examine whether meditation delivered by the internet improves mood and attention as well as increases levels of dopamine in individuals who have been diagnosed with Multiple Sclerosis.
- Trial name
- NCT02391298
- Testing
- Mindfulness Meditation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Haley Duncanson
Multiple Sclerosis
CONNECT Trial of eSupport Online Health-coach Moderated Support Groups for Multiple Sclerosis
Within-subject waitlist-control group design trial of eSupport health-coach moderated online support group participation to address mental health needs in persons with multiple sclerosis (PwMS) from historically underrepresented…
- Trial name
- CONNECT (NCT04943887)
- Testing
- eSupport Health Weekly Group Sessions for PwMS
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- eSupport Health
Multiple Sclerosis
Applying Speed of Processing Training to Individuals With Multiple Sclerosis
This pilot study will document the efficacy of a behavioral intervention for Processing Speed (PS) in Multiple Sclerosis (MS), Speed of Processing Training (SPT), which has been successful used in the aging population in several…
- Trial name
- SPTMS (NCT01838824)
- Testing
- Speed of Processing Training
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Kessler Foundation