Clinical trials: Induced Acute Kidney Injury
Acute Myocardial Infarction, Acute Kidney Injury
Sodium Bicarbonate and N-Acetylcysteine for Nephroprotection in Acute Myocardial Infarction
Contrast-induced nephropathy (CIN) represents a potential complication of diagnostic and therapeutic procedures in interventional cardiology, especially in the acute setting of primary PCI.
- Trial name
- BINARIO (NCT01218178)
- Testing
- Sodium bicarbonate plus NAC, Saline hydration plus NAC
- Where
- Italy
- Volunteers
- 520 people
- Sponsor
- Catholic University of the Sacred Heart
Chronic Kidney Disease stage3, Contrast-induced Nephropathy
Renoprotective Effect of Febuxostat on Contrast Induced Acute Kidney Injury in Chronic Kidney Disease Patients Stage 3
This study will determine the renoprotective effect of febuxostat in prevention of contrast induced acute kidney injury in chronic kidney disease patients Stage 3 undergoing percutaneous coronary intervention.
- Trial name
- NCT05264584
- Testing
- Isotonic saline, N-acetyl cysteine, Febuxostat 80 MG
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Acute Kidney Injury, Hypotension
A Pilot Analysis of the Association Between Anesthesia Induction Dosing and AKI in the Elderly Population
This study proposes to perform a pilot observational study looking at the doses of propofol used for the induction of general anesthesia and its association with the development of hypotension and AKI among elderly patients at…
- Conditions
- Acute Kidney Injury, Hypotension, Anesthesia; Adverse Effect
- Trial name
- NCT03699696
- Testing
- Propofol
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Yale University
Pulmonary Edema, Acute Lung Injury
Fluid Management in the Post-Anesthetic Care Unit (PACU) at Sourasky Medical Center
Peri-operative fluid therapy is a controversial area with few randomized trials to guide practice. Fluid management has a significant influence on outcome following surgery.
- Conditions
- Pulmonary Edema, Acute Lung Injury, Hypertension, Renal Failure
- Trial name
- NCT00995228
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Acute Respiratory Distress Syndrome, Cardiac Failure
Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients
Patients in end-stage cardiac failure and/or respiratory failure may be started on a rescue therapy known as Extracorporeal Membrane Oxygenation (ECMO).
- Conditions
- Acute Respiratory Distress Syndrome, Cardiac Failure, Extracorporeal Membrane Oxygenation Complication, Respiratory Failure
- Trial name
- IGNITE (NCT04669444)
- Testing
- Ventilator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Contrast-Induced Acute Kidney Injury
ImproviNg rEnal Outcomes Following Coronary angiograPhy and/or percuTaneoUs coroNary intErventions
The NEPTUNE triple-blind, active-placebo, adaptive, pragmatic, randomized trial aims to evaluate the effectiveness of a new intra-venous hydration strategy guided by left ventricular end-diastolic pressure (LVEDP), amount of…
- Trial name
- NEPTUNE (NCT04936607)
- Testing
- Personalized hydration strategy, Standard of care
- Where
- Canada
- Volunteers
- 1,158 people
- Sponsor
- Montreal Heart Institute
Acute Coronary Syndrome
Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury (PRATO-ACS 2)
The aim of the project is to compare the nephro-protective effects of high-dose atorvastatin and high-dose rosuvastatin on the incidence of Contrast Induced-Acute Kidney Injury in patients with non-ST-elevation acute coronary…
- Trial name
- PRATO-ACS-2 (NCT01870804)
- Testing
- Rosuvastatin, Atorvastatin
- Where
- Italy
- Volunteers
- 760 people
- Sponsor
- Centro Cardiopatici Toscani
Stable Angina, Acute Kidney Injury
CI-AKI in Patients With Stable CAD and Comorbidities. Are we Doing Better?
Patients aged 18-89 with stable CAD and comorbidities receiving optimal medical treatment requiring PCI with iodinated contrast media.
- Conditions
- Stable Angina, Acute Kidney Injury, Contrast-induced Nephropathy
- Trial name
- NCT04014153
- Testing
- Iodinated contrast media
- Volunteers
- 1,023 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Acute Kidney Failure
The Acetylcysteine for Contrast-Induced Nephropathy Trial
The purpose of this study is to evaluate the efficacy of acetylcysteine compared to placebo for the contrast-induced nephropathy prevention, between 48 and 96 hours after procedures that use contrast.
- Trial name
- ACT (NCT00736866)
- Testing
- Acetylcysteine
- Where
- Brazil
- Volunteers
- 2,300 people
- Sponsor
- Hospital do Coracao
Kidney Failure
PROMISS: Simvastatin Prevents the Contrast Induced Acute Renal Failure in Patients With Renal Insufficiency Undergoing Coronary Angiography
The contrast induced kidney toxicity has been known to affect the mortality and morbidity in the patients undergoing coronary angiography. But the mechanism and therapeutic strategy for it is not well known.
- Trial name
- NCT00259441
- Testing
- Simvastatin
- Where
- South Korea
- Volunteers
- 320 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Injury (Nontraumatic), Contrast-induced Nephropathy
Data on the Prevention of Complications of Prophylactic Intravenous Hydration in Patients With eGFR < 30
At Maastricht University Medical Centre (Maastricht UMC+) a specialised unit was established where a dual screening process including both renal and cardiac parameters is used to minimize the risk of contrast-induced acute kidney…
- Trial name
- CVP (NCT04592406)
- Testing
- CVP screening
- Where
- Netherlands
- Volunteers
- 443 people
- Sponsor
- Maastricht University Medical Center
Chemotherapy Side Effects, Machine Learning
Prospective Validation of Machine Learning Model to Predict Platinum Induced Nephrotoxicity in Cancer Patients
This study aims to investigate the utility of predictive models for chemotherapy-induced nephrotoxicity in the Taiwanese cancer population.
- Conditions
- Chemotherapy Side Effects, Machine Learning, Acute Kidney Injury, Acute Kidney Disease
- Trial name
- NCT07114276
- Testing
- Machine learning models predictions of acute kidney injury and acute kidney disease
- Where
- Taiwan
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Acute Renal Failure
Intravenous High Dose NAC and Sodium Bicarbonate for the Prevention of Contrast-induced Acute Injury
Contrast-induced acute kidney injury is a common cause of acquired in-hospital renal insufficiency and is associated with prolonged hospitalization and unfavorable early and late outcomes.
- Trial name
- NCT01612013
- Testing
- Sodium bicarbonate plus saline, Intravenous NAC plus saline, NAC plus sodium bicarbonate plus saline
- Where
- Brazil
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Acute Ischemic Stroke, Contrast-induced Nephropathy
Serum Electrolytes and Contrast-Induced Nephropathy in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment
This study aims to evaluate the relationship between serum electrolyte levels and the development of contrast-induced acute kidney injury (CI-AKI) in patients with acute ischemic stroke undergoing endovascular therapy (EVT).
- Conditions
- Acute Ischemic Stroke, Contrast-induced Nephropathy, Acute Kidney Injury
- Trial name
- NCT07546448
- Testing
- No intervention (observational cohort study)
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Kidney Diseases, Diabetes Mellitus
Efficacy and Safety of Alprostadil Prevent Contrast Induced Nephropathy
The aim of this prospective, randomized, controlled study is to investigate the effect of pretreatment with intravenous Alprostadil on the incidence of CIN in a high-risk population of patients with both type 2 diabetes mellitus…
- Conditions
- Kidney Diseases, Diabetes Mellitus, Acute Kidney Injury, Kidney Failure, Chronic
- Trial name
- NCT01722513
- Testing
- Alprostadil ﹠control
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
COVID, Coronavirus
Coronavirus Induced Acute Kidney Injury: Prevention Using Urine Alkalinization
Our overarching goal is to improve the outcomes of critically ill COVID-19 patients with or at risk for development of acute kidney injury (AKI).
- Conditions
- COVID, Coronavirus, Coronavirus Infection, AKI
- Trial name
- NCT04530448
- Testing
- Sodium bicarbonate, Standard of Care
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- West Virginia University
Contrast-induced Nephropathy
Use of Urinary Cell-Cycle Arrest Biomarkers in Contrast-Associated Nephropathy After Coronary Angiography
Radiological examinations that require the administration of iodinated contrasts (IC) for diagnostic and therapeutic purposes are essential in current clinical practice, and their use in interventional procedures has been…
- Trial name
- NCT04163250
- Testing
- Urinary determination of TIMP-2/ IGFBP7
- Where
- Spain
- Volunteers
- 194 people
- Sponsor
- Eva de Miguel Balsa
Contrast-induced Nephropathy, Chronic Kidney Diseases
Multi-Center Trial Utilizing Low Frequency Ultrasound in the Prevention of Post-Contrast Acute Kidney Injury
Multi-center randomized trial to assess the safety and performance of low-frequency therapeutic ultrasound for maintaining renal function after contrast exposure.
- Trial name
- LOTUS (NCT04877847)
- Testing
- Low-frequency therapeutic ultrasound (LOTUS), LOTUS System with Ultrasound Disabled
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Sonogenix
Contrast Induced Nephropathy
Erythropoietin in Radiocontrast Induced Nephropathy (ERIN) Trial
Full Title: A Randomized Controlled Trial of Procrit for the Prevention of Acute Renal Failure in Patients Receiving Intravenous Contrast Primary Objective: To evaluate the efficacy of a one-time dose of intravenous…
- Trial name
- ERIN (NCT00476619)
- Testing
- erythropoeitin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brigham and Women's Hospital
Acute Kidney Injury, Renal Tubulopathy
Prevention of Cisplatin-induced Nephrotoxicity
The research design is a prospective, randomized, controlled clinical trial in children to study effect of aminophylline in preserving renal function in oncologic patient received cisplatin either combined with other CMT or used…
- Trial name
- NCT06196853
- Testing
- Aminophylline
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University