Clinical trials: Induction Chemotherapy
Myocarditis, Myocardial Failure
Monitoring Drug-induced Myocarditis (CardiTOX)
Several drugs and chemotherapies seem to induce myocarditis. This study investigates reports of myocarditis, including the International classification of disease ICD-10 for treatments in the World Health Organization (WHO)…
- Conditions
- Myocarditis, Myocardial Failure, Myocardial Dysfunction
- Trial name
- CardiTOX (NCT03855982)
- Testing
- Drug inducing myocarditis
- Where
- France
- Volunteers
- 6,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Chemotherapy-related Cognitive Impairment
Evaluating Cognitive Changes on Patients in Chemotherapy (ECCPC)
This randomized clinical trial aims to evaluate the impact of a structured low-intensity exercise program on cognitive function in adult cancer patients undergoing chemotherapy.
- Trial name
- (ECCPC) (NCT06950190)
- Testing
- Low-Intensity Walking Intervention, Control Group Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ellis Medicine
Oral Mucositis in Head and Neck Cancer, Chemo-radiotherapy
A Study on the Effectiveness of Olive Oil Mouthwash in Alleviating Chemoradiotherapy-induced Oral Mucositis in Patients With Head and Neck Cancer.
Backgroud: Radiation therapy and concurrent chemoradiotherapy are the main treatment methods for patients with head and neck cancer, which often lead to many severe oral mucositis (OM).
- Trial name
- NCT07293013
- Testing
- olive oil mouthwash
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chiayi Christian Hospital
Chemotherapy-induced Peripheral Neuropathy, Nerve Pain
The Effect of Electroacupuncture on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
This study is a randomized controlled trial of electroacupuncture (referred to as EA) versus sham acupuncture (referred to as EA) as effective treatments for Chemotherapy-Induced Peripheral Neuropathy (CIPN) pain in cancer…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Nerve Pain, Neuropathy, Neuropathy, Painful
- Trial name
- ACT (NCT04917796)
- Testing
- Electroacupuncture
- Where
- 6 sites in United States
- Volunteers
- 255 people
- Sponsor
- Dana-Farber Cancer Institute
Lung Cancer
Docetaxel and Cisplatin in Treating Patients With Untreated Stage IIIA Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005868
- Testing
- cisplatin, docetaxel
- Where
- 23 sites in Germany, Italy and 3 more
- Volunteers
- 47 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Acute Myeloid Leukemia
Elderly Patients With Acute Myeloid Leukemia (AML), Maintenance Phase After Complete Remission (CR)
Phase II Multicentric Trial Open Label, Multicenter, randomized to evaluate the efficacy of a Maintenance Therapy in First Complete Remission After Induction for Elderly (≥ 60) Fit Patients With Poor Prognosis Acute Myeloid…
- Trial name
- NCT01301820
- Testing
- azacitidine, Lenalidomide
- Where
- France
- Volunteers
- 120 people
- Sponsor
- French Innovative Leukemia Organisation
Liver Injury, Drug-Induced
Clarify of Predictive Risk Factors of Chemotherapy-induced Liver Injury
The most common toxicity of TP (docetaxel and cisplatin) chemotherapy is chemotherapy-induced liver injury. However, patients don't always experience same chemotherapy-induced liver injury for the same drugs.
- Trial name
- NCT03069820
- Testing
- docetaxel and cisplatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Nausea and Vomiting, Chemotherapy-Induced, Chemotherapy-Induced Nausea and Vomiting
Study Of Prevention of Chemo-Induced Nausea and Vomiting Caused By Moderately Emetogenic Chemotherapy
This study was designed to assess the safety and efficacy of different dosages and administration schedules of an investigational agent administered over 3 days when added to standard therapy used in the prevention of…
- Trial name
- NCT00104403
- Testing
- GW679769, Dexamethasone, Ondansetron Hydrochloride
- Where
- 113 sites in United States, Argentina and 22 more
- Volunteers
- 722 people
- Sponsor
- GlaxoSmithKline
Chemotherapy-induced Peripheral Neuropathy
Memantine XR and Pregabalin for Chemotherapy-Induced Peripheral Neuropathy
Study is designed to assess the efficacy and safety of memantine XR and pregabalin in reducing neuropathic pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) caused by prior treatment with any chemotherapy as…
- Trial name
- NCT03709888
- Testing
- Memantine XR-pregabalin combination therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Saint John's Cancer Institute
Chemotherapy-induced Peripheral Neuropathy
Menthol In Neuropathy Trial
Patients will be recruited who have peripheral neuropathy due to chemotherapy. They will be given a blinded treatment of gel containing either menthol (3%) or placebo to be applied for 6 weeks, twice a day.
- Trial name
- MINT (NCT04276727)
- Testing
- MINT study IMP
- Where
- 2 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Edinburgh
Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Heat and Cold Therapy for Chemotherapy-Induced Neuropathy
Cancer patients undergoing chemotherapy experience various side effects depending on the treatment protocol used. Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a dose-limiting and quality-of-life-reducing complication…
- Trial name
- NCT06889129
- Testing
- Experimental- Heat application, Experimental-Cold application
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Cocaine Dependence, Opiate Dependence
Cocaine Withdrawal and Pharmacotherapy Response
A total of 120 male and female opioid dependent cocaine users will participate in this study. This study will be a 8-week double-blind, placebo controlled study examining the dose-dependent effects of carvedilol (up to 50 mg/day)…
- Trial name
- Carvedilol (NCT00566969)
- Testing
- sugar pill, Carvedilol 25 mg, Carvedilol 50 mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Yale University
Chemotherapy-induced Peripheral Neuropathy
Acupuncture for Chemo-Induced Peripheral Neuropathy in Multiple Myeloma Patients
This randomized, controlled trial is designed to evaluate the effect of acupuncture on Chemotherapy-Induced Peripheral Neuropathy (CIPN), other symptoms, and potential opioid and concomitant medication sparing effects in…
- Trial name
- NCT04770402
- Testing
- Acupuncture, Standard of Care CIPN management
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Appendix Carcinoma, Colon Carcinoma
Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer
This phase II trial investigates how well oral cryotherapy plus acupressure and acupuncture compared with oral cryotherapy alone work in decreasing chemotherapy-induced peripheral neuropathy in patients with gastrointestinal…
- Conditions
- Appendix Carcinoma, Colon Carcinoma, Esophageal Carcinoma, Gastric Carcinoma
- Trial name
- NCT04505553
- Testing
- Acupuncture Therapy, Acupressure Therapy, Oral Cryotherapy
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Personalized Kinase Inhibitor Therapy Combined With Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia
This phase IB trial studies the feasibility of using a functional laboratory based study to determine how well the test can be used to select personalized kinase inhibitor therapy in combination with standard chemotherapy in…
- Trial name
- NCT02779283
- Testing
- Cyclophosphamide, Cytarabine, Dasatinib
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- OHSU Knight Cancer Institute
Locoregionally Advanced Laryngo-hypopharyngeal Squamous Cell Cancer
Induction Chemotherapy Combined With Toripalimab in Locoregionally-Advanced Laryngo-Hypopharyngeal Squamous Cell Cancer
This is a non-randomized phase 1, open-labeled clinical study, 1-arm, single center, to observe efficacy and safety of chemotherapy plus PD-L1 antibody Toripalimab every 21 days for 2 cycles as induction regimen in…
- Trial name
- NCT04926753
- Testing
- 5-Fluorouracil, Cisplatin, Toripalimab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Chemotherapy-induced Febrile Neutropenia
Prospective Observational Study of Febrile Neutropenia (FN) and Pegfilgrastim Primary Prophylaxis in Breast Cancer and Non-Hodgkin's Lymphoma Patients Receiving High (>20%) FN-risk Chemotherapy
To estimate the incidence of febrile neutropenia in patients with breast cancer and non-Hodgkin's lymphoma receiving high (> 20%) FN-risk chemotherapy and pegfilgrastim primary prophylaxis.
- Trial name
- NCT02178475
- Where
- 74 sites in Austria, Belgium and 7 more
- Volunteers
- 943 people
- Sponsor
- Amgen
Neuropathy, Pain
Pregabalin in CIPN
The investigators seek to investigate certain patient characteristics that would predict the response to a currently approved analgesic, pregabalin, in patients with chronic pain due to nerve damage caused by chemotherapy.
- Trial name
- NCT02394951
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Washington University School of Medicine
AML (Acute Myeloid Leukemia), BMI
Prognostic Impacts of Lipid Profile and BMI in Adult AML
The goal of this observational study is to evaluate the changes in lipid profile parameters (total cholesterol, triglycerides, HDL-C, and LDL-C) in adult AML patients before and after intensive induction chemotherapy.
- Conditions
- AML (Acute Myeloid Leukemia), BMI, Lipid Profile, Induction Chemotherapy
- Trial name
- AML/BMI (NCT07143877)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Chemotherapy Induced Peripheral Neuropathy, Multiple Myeloma
Prevalence, Intensity and Consequences of Bortezomib-induced Neuropathic Disorders.
Cancer-induced peripheral neuropathies (CIPN) remain a real problem in oncology (Balayssac et al., 2011). These CIPN are induced by certain classes of anticancer drugs such as taxanes (paclitaxel and docetaxel), platinum salts…
- Trial name
- PREVIB (NCT03344328)
- Testing
- Bortezomib
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Clermont-Ferrand
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