Clinical trials: Induction of General Anesthesia
Patient With Nasolacrimal Duct Obstruction, External Dacryocystorhinostomy Operation
Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation
Bleeding is one of the important complications during Dacryocystorhinostomy, which dissatisfy ophthalmic surgeon, reduces surgical field visualization, and increases the duration of surgery Thus, the management of this…
- Trial name
- NCT05241054
- Testing
- Bupivacaine, Nitroglycerine, Propofol
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Mansoura University
Propofol Adverse Reaction, Anesthesia
Impact of Propofol Reduction in Anesthesia Induction
Objective: Determine if, by reducing the dose of propofol and increasing the time elapsed between fentanyl and propofol administration, hemodynamic response is improved.
- Trial name
- NCT04194151
- Testing
- Propofol Injection
- Where
- Spain
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Hospital Central de la Defensa Gómez Ulla
Reversing Vecuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery, Reversing Rocuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery
A Dose-Finding Study of Amogammadex Sodium for Reversing Vecuronium and Rocuronium-Induced Neuromuscular Blockade
Background context: Amogammadex sodium has completed Phase I-III clinical studies in China for reversal of rocuronium-induced blockade. No clinical studies have yet been conducted for vecuronium-induced blockade.
- Trial name
- NCT07595393
- Testing
- Rocuronium (0.6mg/kg), vecuronium bromide (0.1mg/kg)
- Volunteers
- 64 people
- Sponsor
- Amckaus PTY LTD.
Anesthesia, Sedation
EEG Signal Correlates During Anesthesia and Sedation in Adults and Children
This prospective, multicenter, non-interventional observational study investigates the correlates between electroencephalographic (EEG) signals and pharmacological/clinical parameters during general anesthesia and procedural…
- Conditions
- Anesthesia, Sedation, Consciousness Monitors
- Trial name
- SPECTRALADUPED (NCT07460414)
- Where
- 2 sites in France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy Complications, Anesthesia
Propofol Anesthesia and Perinatal Outcome
The effects of intravenous propofol administration for general anesthesia in cesarean deliveries on maternal and infant health will be evaluated in relation to maternal and umbilical cord blood propofol levels.
- Trial name
- PA-Perinatal-O (NCT07035899)
- Testing
- Caesarean Section
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Haseki Training and Research Hospital
Surgery
Observation of Atelectasis Using Lung Ultrasonography in Children Undergoing General Anesthesia: the Cohort Study for Evaluation of the Relationship Between the Incidence and Severity of Upper Respiratory Tract Infection and the Magnitude of Anesthesia-induced Atelectasis
Pediatric patients between 6months and 6years old will be included. They are scheduled for elective general or urologic surgery at a single tertiary medical center.
- Trial name
- NCT03355547
- Testing
- questionnaire about the severity of their symptoms of upper respiratory tract infection
- Where
- South Korea
- Volunteers
- 261 people
- Sponsor
- Yonsei University
Hyperparathyroidism
Interaction Between Anaesthetics and Methylene Blue
We hypothesized that pre-treatment with methylene blue could potentiate the effects of general anaesthetic agents in patients undergoing parathyroidectomy
- Trial name
- NCT00513032
- Testing
- methylene blue
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Geneva
Flow Time, Carotid Doppler Ultrasound
Carotis cFT In Prediction Of Hypotension
The aim of our study is to determine the predictive value of pre-anesthesia FTc for hypotension that may develop after general anesthesia induction in patients over 65 years of age and to investigate the correlation between…
- Conditions
- Flow Time, Carotid Doppler Ultrasound, Hypotension, Anesthesia
- Trial name
- NCT05896514
- Testing
- ultrasound-guided carotid artery flow time measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Pediatric, Anesthesia Induction
The ED95 of Ciprofol for Laryngeal Mask Airway Insertion With Fentanyl in Children: A Biased-Coin Dose-Finding Trial
Ciprofol is a novel intravenous anesthetic with a pharmacological profile similar to propofol but with a lower incidence of injection pain, hypotension, and respiratory depression.
- Conditions
- Pediatric, Anesthesia Induction, Ciprofol, Laryngeal Mask Airway
- Trial name
- NCT07697404
- Testing
- Ciprofol, Fentanyl
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Huazhong University of Science and Technology
Surgery, Noise Exposure
The Effect of a Reduced Noise Environment on Induction and Emergence Behavior in Children Undergoing General Anesthesia
This project will investigate whether reduction in ambient light and elimination of noise on induction of anesthesia alters anxiety (modified Yale Preoperative Anxiety Scale or mYPAS) or compliance (induction compliance checklist…
- Trial name
- NCT03504553
- Testing
- Noise reduction
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Joshua Uffman
Anesthesia
Ultrasonic Measurement of IVC and IJV in Predicting Hypotension After Anesthesia Induction
This research is expected to study ultrasonic measurement of internal jugular vein and inferior vena cava, which can be used as a good index to predict hypotension after anesthesia induction, and its measurement method is simple…
- Trial name
- NCT04379141
- Volunteers
- 150 people
- Sponsor
- Jin Dong Liu
Interventional Radiology, Orthopedic Surgery
Change in Brain Perfusion During Induction of General Anesthesia
Arterial hypotension during general anesthesia remains a factor of poor outcomes, increases the risk of myocardial infarction, acute kidney injury and 1-year mortality.
- Trial name
- CERVO2 (NCT04288869)
- Testing
- Continuous monitoring of arterial blood pressure, Transcranial Doppler, Bispectral Index (BIS)
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preoperative Fasting and Hypotension
Effect of the Duration of Preoperative Fasting on Hypotension Induced by General Anesthesia in the Elderly Person
This study aims to determine if prolonged fasting represents an independent risk factor for hypotension during induction of general anesthesia in the elderly.
- Trial name
- JEÛNE PREOP (NCT02891122)
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Brest
Hypotension on Induction
IVC Ultrasonography Versus Plethysmographic Variability Index for Prediction of General Anesthesia Induction Hypotension
This thesis aims to evaluate the ability of preoperative plethysmographic variability index to predict post-induction hypotension in comparison with ultrasound measurements of inferior vena cava (IVC) diameter.
- Trial name
- NCT04238234
- Testing
- IVC Ultrasonography, Plethysmographic variability index (PVI) and perfusion index readings (PI)
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Cerebral Oxygen Saturation
Changes of Cerebral Oxygenation During Anesthesia Induction
The aim of this study was to investigate the changes of cerebral oxygen saturation (rSO2) during anesthesia induction.
- Trial name
- NCT02687334
- Testing
- 100% Oxygen
- Where
- China
- Volunteers
- 33 people
- Sponsor
- China Medical University, China
Opioid Use
Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone
This study aimed to investigate Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone in female patients.
- Trial name
- NCT04396587
- Testing
- Sufentanil, Hydromorphone, Oxycodone
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Pressor Response
Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients
Dexmedetomidine nebulization in sever preeclamptic patients
- Trial name
- NCT07164326
- Testing
- Dexmedetomidine, Saline
- Volunteers
- 100 people
- Sponsor
- Assiut University
The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability
The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability During Anesthesia Induction in Adults.
The aim of our study to compare two different doses of Dexmedetomidine added to anesthetic dose of ketamine in the induction of general anesthesia in adult patients regarding the hemodynamic profile, adequacy of hypnosis…
- Trial name
- NCT05948267
- Testing
- ketamine- dexmeditomidine admixure, Propofol, Lidocaine and fentanyl
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Kasr El Aini Hospital
Anesthesia
Efficacy of Preemptive Volume Loading to Prevent Arterial Hypotension During Induction of General Anesthesia
Induction of general anesthesia induces frequently arterial hypotension. The short term goal of this study is to evaluate if preemptive volume loading prevents such complication.
- Trial name
- NICOM-MAP (NCT01594021)
- Testing
- Gelatin 500 mL, Gelatin 50 mL
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Hopital Foch
Anesthesia
Dose of Remimazolam in Children for Intubation
Remimazolam has demonstrated the potential as a valuable medication for procedural sedation and general anesthesia. However, half effective dose of remimazolam required to prevent cardiovascular response to tracheal intubation…
- Trial name
- DRIP (NCT06170918)
- Testing
- Remimazolam
- Volunteers
- 40 people
- Sponsor
- Zhihong LU