Clinical trials: Induction of Labor
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Labor Onset and Length Abnormalities, Induced; Birth
Comparison of Misoprostol Ripening Efficacy With Dilapan
The purpose of this study is to find out if Dilapan works as well as Misoprostol for preparing the mouth of the uterus (cervix) for inducing labor in women who need to undergo this procedure.
- Trial name
- COMRED (NCT03670836)
- Testing
- Dilapan, Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Columbia University
Diabetes, Gestational
Outpatient Cervical Ripening With Orally Administered Misoprostol in Diabetics
A. Null Hypothesis: In term pregnancies complicated by diabetes, there is no difference in the time interval from start of induction to delivery when outpatient cervical ripening and labor induction is initiated with orally…
- Trial name
- NCT00514618
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- MemorialCare Health System
Dexamethasone, Pregnancy
Effect of Dexamethasone on Labor Induction
Pregnant women with a gestational age of 38 weeks and older admitted to Labor Of Kamali Hospital, for termination of pregnancy, by accident and based on the a statistician did coding to identify groups of users of pill A or pill…
- Trial name
- NCT05070468
- Testing
- Dexamethasone 0.5mg
- Where
- Iran
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Alborz Medical University
Fetal Membranes, Premature Rupture, Labor, Induced/IS
Foley Catheter for Labor Induction in Women With Term and Near Term Membrane Rupture
In women undergoing labor induction for membrane rupture at or near term, we are investigating the addition of a foley catheter placed in the cervix to standard therapy (oxytocin administration) to decrease the time from the…
- Trial name
- NCT00290199
- Testing
- Transcervical Foley catheter
- Where
- 3 sites in United States
- Volunteers
- 169 people
- Sponsor
- University of Alabama at Birmingham
Pregnancy
Effects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor
The aim of this study is to measure the effects of bupivacaine administered via epidural catheters on indices of motor blockade ascertained during the second stage of labor.
- Trial name
- BUP (NCT01621230)
- Testing
- Epidural Bupivacaine plus fentanyl, Epidural fentanyl
- Where
- United States
- Volunteers
- 481 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Induction of Labor Affected Fetus / Newborn
A Trial of Cervidil for Outpatient Pre-induction of Cervical Ripening
Induction of labor is a frequently planned obstetric procedure. Induction for women with an unfavorable cervix (bishop score <6) increases the risk of cesarean section.
- Trial name
- NCT03806231
- Testing
- Outpatient Dinoprostone 10mg, Inpatient Dinoprostone 10 mg
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Induction of Labor
Cervical Foley Plus Vaginal Misoprostol for Labor Induction
The purpose of this study is to compare the efficacy of the combination of the supracervical foley bulb and vaginal misoprostol to vaginal misoprostol alone for labor induction.
- Trial name
- NCT01279343
- Testing
- Foley bulb
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Intrauterine Fetal Demise, Fetal Death
Mifepristone Induction for Fetal Demise
Methods: Double blinded, randomized controlled trial with 1:1 allocation of mifepristone or placebo at initiation of induction of labor for fetal demise 20 weeks estimated gestational age or greater.
- Trial name
- MIFD (NCT02620904)
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Foley Catheterization, Induction of Labor
Foley Catheter for Induction of Labor
Study Design: Allocation: 2 arms Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment Detailed Description The utilization of a Foley catheter for induction of labor is well established.
- Conditions
- Foley Catheterization, Induction of Labor, 5 French Stylette
- Trial name
- NCT02044458
- Testing
- Stylette
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Wake Forest University Health Sciences
Labor Induction, Cesarean Delivery
Induction of Labor With Oxytocin: When Should Oxytocin be Held?
The investigators propose to perform a prospective randomized control trial to compare the rate of cesarean delivery in women where Oxytocin (OT) is discontinued once active labor begins (5 cm dilation) when compared with women…
- Trial name
- NCT00957593
- Testing
- Oxytocin, Oxytocin discontinuation
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Lehigh Valley Hospital
Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome
The Budesonide in Babies (BiB) Trial
This is a Phase 3, randomized, masked, active-controlled, multicenter trial designed to determine whether early intratracheal administration of a combination of budesonide with surfactant, as compared to surfactant alone, will…
- Conditions
- Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome, Prematurity; Extreme, Neonatal
- Trial name
- BiB (NCT04545866)
- Testing
- budesonide (Pulmicort nebulizing suspension)., surfactant (poractant alfa;Curosurf)
- Where
- 19 sites in United States
- Volunteers
- 642 people
- Sponsor
- NICHD Neonatal Research Network
Infant, Newborn, Infant, Low Birth Weight
Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)
This pilot study is a randomized, placebo-controlled, clinical trial to measure changes in blood and urine levels of inositol in premature infants at high risk for retinopathy of prematurity (ROP) following repeated doses of…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- INS-2 (NCT01030575)
- Testing
- Inositol lower volume, Inositol mid-level volume, Inositol high volume
- Where
- 17 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Psychosis, Substance Abuse
Effect Evaluation of Individual Placement and Support (IPS)
Roughly one third of disability pensions issued in Norway are classified as mental and behavioral disorders. The proposed study aims to evaluate the effect of an innovative intervention for returning people with moderate to…
- Conditions
- Psychosis, Substance Abuse, Depression, Anxiety
- Trial name
- NCT01964092
- Testing
- Individual Placement and Support, Ordinary employment schemes
- Where
- Norway
- Volunteers
- 410 people
- Sponsor
- NORCE Norwegian Research Centre AS
Bronchopulmonary Dysplasia
Trial II of Lung Protection With Azithromycin in the Preterm Infant
The hypothesis of this study is that administration of azithromycin to ventilated premature infants will decrease the incidence and severity of BPD.
- Trial name
- NCT00319956
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Hubert Ballard
Cesarean Section
Ripening Interventions: Prostaglandins vs EASI Catheter
The primary aim of this randomized clinical trial is to compare the effect of misoprostol vs extra amniotic saline infusion via a catheter (EASI) for cervical ripening on the proportion of patients delivered by cesarean section…
- Trial name
- RIPE (NCT00383942)
- Testing
- Misoprostol, Catheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Loyola University
Induced Vaginal Delivery
Tension Versus Tension- Free Foley Balloon for Cervical Ripening
Foley balloons are commonly used as a mechanical method of cervical ripening for induction of labor. Foley balloons may be placed either under tension or without tension (tension-free).
- Trial name
- NCT05404776
- Testing
- Placement of Foley balloon for cervical ripening with tension., Placement of Foley balloon for cervical ripening without tension.
- Where
- United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cocaine Addiction, Cocaine-related Disorder
Prefrontal Cortex Stimulation as Treatment for Crack-cocaine Addiction
The use of crack-cocaine is growing at alarming rate in our country and it is absolutely worrisome the fast establishment of addiction to it.
- Conditions
- Cocaine Addiction, Cocaine-related Disorder, Executive Dysfunction
- Trial name
- NCT01337297
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Espirito Santo
Cervical Ripening, Induction of Labor
Pharmacokinetic (PK) Study of the 200 Microgram (mcg) Misoprostol Vaginal Insert (MVI 200) in Women at Term Gestation (The MVI-PK Study)
The purpose of this study is to determine the pharmacokinetics (PK) of misoprostol acid for the MVI 200 in women requiring cervical ripening and induction of labor.
- Trial name
- NCT01283022
- Testing
- MVI 200
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ferring Pharmaceuticals
Abortion, Induced
Pilot Study of the Addition of Osmotic Dilators to Preparation Prior to Labor Induction Abortion
One the day prior to medical abortion (labor induction) in the second trimester, insertion of osmotic dilators is added to the routine procedures.
- Trial name
- DAIS (NCT00855842)
- Testing
- osmotic dilator insertion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston University