Clinical trials: Induction of Ovulation
Ovulatory Dysfunction, Anovulation
Traditional Clomiphene Citrate Administration vs. Stair-step Approach
The purpose of this study is to compare the length of time to achieve ovulation and pregnancy with a traditional protocol administration of clomiphene citrate versus a stair step administration.
- Conditions
- Ovulatory Dysfunction, Anovulation, Ovulation Induction
- Trial name
- Clomid (NCT01008319)
- Testing
- clomiphene citrate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Oklahoma
Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV
Follicular Flushing Using Double Lumen Needle Versus Direct Aspiration in Low Prognosis Patients According to the POSEIDON Criteria
This is a prospective, randomized, controlled clinical trial designed to evaluate whether follicular flushing increases the number of cumulus-oocyte complexes (COCs) retrieved compared to single aspiration in patients with poor…
- Conditions
- Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV, Poor Response to Ovulation Induction
- Trial name
- FLUSHING (NCT07270081)
- Testing
- follicular flushing, follicular aspiration
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Bernabeu
Poor Response to Ovulation Induction, Infertility, Female
Optimal Embryonic Stage for Transfer in Poor Responders
A Prospective cohort study including couples with poor responder females who undergoing ICSI
- Trial name
- NCT04485819
- Testing
- Cleavage stage transfer, Blast stage transfer
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ganin Fertility Center
PCOS (Polycystic Ovary Syndrome)
Letrozole and Cabergoline Versus Letrozole Alone in Ovulation Induction
Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorders in women of reproductive age. According to the World Health Organization (WHO) estimation revealed over 116 million women (3.4%) are affected by PCOS…
- Trial name
- NCT07168837
- Testing
- Letrozole tablets
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Pregnancy
Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established During Phase II Clinical Trials of Org 36286 (Study 38817)(P06054)(COMPLETED)
The objective of this trial was to evaluate whether Org 36286 treatment in any Phase IIa clinical development trial of Org 36286 for OI or COH in assisted reproductive treatment programs was safe for pregnant subjects and their…
- Trial name
- NCT00702195
- Testing
- Org 36286 (corifollitropin alfa), recFSH
- Volunteers
- 29 people
- Sponsor
- Organon and Co
Infertility, Female, Ovulation Induction
Oral GnRH Antagonist (Linzagolix) Versus Injectable GnRH Antagonist in Controlled Ovarian Stimulation for In Vitro Fertilization: A Randomized Controlled Non-Inferiority Trial With a Concurrent Comparator Cohort Undergoing Progestin-Primed Ovarian Stimulation (PPOS)
Women undergoing IVF/ICSI who are candidates for a GnRH-antagonist protocol are randomly assigned 1:1 to oral linzagolix or the standard injectable GnRH antagonist (ganirelix or cetrorelix).
- Trial name
- NCT07732348
- Testing
- Ganirelix ; Cetrorelix, Medroxyprogesterone Acetate ; Micronized Progesterone, Linzagolix
- Volunteers
- 120 people
- Sponsor
- Centro A.M.B.R.A. (Associazione Medici e Biologi per la Riproduzione Assistita)
Ovulation Induction, Polycystic Ovary Syndrome
Myo-inositol Versus Clomiphene Citrate in PCOS
Specific aim: To compare inositol and the golden standard first line treatment of ovulation induction, namely clomiphene citrate.
- Conditions
- Ovulation Induction, Polycystic Ovary Syndrome, Clomiphene, Inositol
- Trial name
- NCT04306692
- Testing
- Myo-inositol, Clomiphene Citrate
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- University Hospital, Ghent
Infertility Indicated for ICSI
Role of Aromatase Inhibitor to Enhance Ovulation in Poor Responder During Induction With Short Antagonist Protocol in Cases of ICSI
study the effect of aromataze inhibitor induction together with short stimulation protocol by gonadotrphin releasing hormon antagonist in cases that expected to be poor responder before ICSI
- Trial name
- AIPRICSI (NCT02741154)
- Testing
- induction with aromataze inhibitor, HMG, GnRh a
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Polycystic Ovary Syndrome
CRD vs. Met in Patients With Obese PCOS Infertility
Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease and a major cause of anovulatory infertility in reproductive-aged women.
- Trial name
- NCT06049186
- Testing
- CRD, Metformin
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Female Infertility, Anovulatory Infertility
Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction
Clomiphene citrate is commonly used for ovulation induction; however, it may negatively affect endometrial development and cervical mucus quality, which can reduce pregnancy rates.
- Conditions
- Female Infertility, Anovulatory Infertility, Unexplained Infertility
- Trial name
- CC-OVI (NCT07398924)
- Testing
- Clomiphene Citrate., Guaifenesin, Estradiol (E2)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Yuzuncu Yil University
Ovulation Induction
Effect of Vitamin D Supplement in Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome
The aim of this work is to evaluate the effect of vitamin D supplementation in overweight infertile women with PCOs undergoing induction of ovulation.
- Trial name
- NCT03396380
- Testing
- Vitamin D with calcium and clomiphene citrate
- Where
- Egypt
- Volunteers
- 186 people
- Sponsor
- Ain Shams University
Clomiphene Citrate Resistance, Ovulation Induction
Letrozole Versus Gonadotropins in Clomiphene Citrate Resistance
Clomiphene citrate resistance (CCR) occur in 15-40% in women with PCOS. Several studies have shown that letrozole is superior to CC regarding side effects, ovulation, and pregnancy rates.
- Conditions
- Clomiphene Citrate Resistance, Ovulation Induction, Letrozole, Gonadotropins
- Trial name
- NCT04834791
- Testing
- Letrozole 2.5mg, Gonadotropin
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Polycystic Ovarian Syndrome
The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS)
As both medications i.e. CC and letrozole have been shown to be effective in inducing ovulation in PCOS patients, this study was performed in order to evaluate which regime (whether CC or letrozole) is the best to be used as the…
- Trial name
- NCT01577017
- Testing
- Letrozole
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Nik Hazlina
Infertility
Induction of Ovulation Using Clomiphene Citrate and N-acetyl Cysteine Versus Letrozole
Infertility is defined as a couple's inability to become pregnant after one year of unprotected intercourse in women 35 years old and younger, and for six months in women over age 35 years.
- Trial name
- NCT03241472
- Testing
- Letrozole, Clomiphene Citrate plus N acetyl cystine
- Volunteers
- 100 people
- Sponsor
- Assiut University
INFERTILITY, Fertility Preservation
Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation
The purpose of this study is to evaluate the clinical pregnancy rate per embryo transfer in oocytes recipients obtained after ovarian stimulation during the luteal phase of oocytes donors .
- Conditions
- INFERTILITY, Fertility Preservation, Ovulation Induction, Vitrification
- Trial name
- NCT01645241
- Testing
- gonadotropins plus GnRH antagonists, ganirelix
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Infertility
Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs
hCG and GnRH agonist can be used to induce final oocyte maturation and ovulation in IVF cycles. These two approaches will be compared in this study in terms of pregnancy rates and embryological data using patients with…
- Trial name
- NCT00415792
- Testing
- Arvekap, Pregnyl
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eugonia
Ovulation Induction, Polycystic Ovary Syndrome
Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation Induction
The goal of this clinical trial is to learn if injection oxytocin can be used as trigger in ovulation induction cycles in infertile women with polycystic ovary syndrome.
- Trial name
- NCT06725004
- Testing
- Oxytocin, Human Chorionic Gonadotropin
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- Shakeela Ishrat
Infertility, Ovulation Induction
A Phase II Study to Assess the Efficacy and Safety of Luveris® (Lutropin Alfa) in Mid Follicular Phase for Controlled Ovarian Stimulation (COS) in Advanced Reproductive Age
Ovarian reserve is related to chronological age; 35 years of age is the accepted threshold for significant decline in assisted reproductive technologies (ART) success with scarce follicular recruitment and poor oocyte retrieval.
- Trial name
- NCT01079949
- Testing
- r-hLH + r-hFSH, r-hFSH, Recombinant Human Choriogonadotropin (r-hCG)
- Where
- Spain
- Volunteers
- 93 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
OHSS (Ovarian Hyperstimulation)
Triggering of Final Oocyte Maturation With GnRHa (Buserelin) in GnRH Antagonist Cycles
The purpose of this study is to possibly further improve the clinical outcome and explore the incidence of OHSS in patients, who have final oocyte maturation with GnRHa (Buserelin) in GnRH antagonist IVF/ICSI cycles
- Trial name
- NCT00627406
- Testing
- Buserelin and Pregnyl, Pregnyl
- Where
- Denmark
- Volunteers
- 384 people
- Sponsor
- Regionshospitalet Viborg, Skive
Unexplained Infertility
The Predictive Value of the Sperm Chromatin Dispersion Test, Halosperm®, Before and After Sperm Preparation for Clinical Pregnancy in Cases of Unexplained Infertility Treated With Intra-uterine Insemination (First Cycle) and Ovulation Induction With Clomiphene Citrate.
Recent research has revealed that subtle abnormalities can be found in sperm samples that seem to be normal with conventional analysis techniques.
- Trial name
- DNAFRAG (NCT02235103)
- Testing
- Sperm Chromatin Dispersion Test
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Ghent