Clinical trials: Infant, Moderate Preterm
Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Bronchopulmonary Dysplasia (BPD)
Combined Oscillation-Volume guarantEe Study
Respiratory Distress Syndrome (RDS) remains the most common respiratory complication in the early postnatal period among preterm infants born before 32 weeks' gestational age.
- Trial name
- NCT07377955
- Testing
- HFOV, HFOV+VG
- Volunteers
- 348 people
- Sponsor
- Xingwang Zhu
Preterm Newborns, Skin Integrity
Use of a Silicone Sensor to Protect Fragile Neonatal Skin in Moderately Preterm Infants Needing Continuous Monitoring
Neonates, especially when born prematurely, have an inherently fragile skin, due to the overall prematurity and to the immature composition of epidermidis and skin dermal structures.
- Trial name
- PRO-NEO-SKIN (NCT07753863)
- Testing
- Nellcor™ OxySoft™, MasimoRD SET NeoPt-500
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Paolo Manzoni Study Group
Bronchopulmonary Dysplasia
Human Mesenchymal Stem Cells For Moderate and Severe Bronchopulmonary Dysplasia
This study is an open-label, single-center, dose escalation study to evaluate of safety and efficacy of human umbilical cord -derived mesenchymal stem cells (hUC-MSCs) in children with moderate and severe bronchopulmonary…
- Trial name
- NCT03601416
- Testing
- Transplantation of mesenchymal stem cell, No Transplantation of Mesenchymal Stem Cell
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Wheezing, LRTI
Protecting Preterm Infants From Respiratory Tract Infections and Wheeze by Using Bacterial Lysates.
The primary objective of this study is to reduce respiratory tract infections and wheezing in moderate-late preterms in the first years of life by bacterial lysate administration.
- Conditions
- Wheezing, LRTI, Premature
- Trial name
- PROTEA (NCT05063149)
- Testing
- Broncho-Vaxom
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Franciscus Gasthuis
Newborn Respiratory Distress Syndrome
HHHFNC (Heated Humidified High-Flow Nasal Cannula) Versus NCPAP for Respiratory Distress Syndrome of Prematurity
Preterm infants ranging from 29+0 to 36+6 weeks+days are randomly assigned to one of the following treatments as non invasive respiratory support if they develop mild to moderate Respiratory Distress Syndrome within 72 hrs from…
- Trial name
- NCT02570217
- Testing
- HHHFNC, NCPAP
- Where
- Italy
- Volunteers
- 316 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Neurophysiologic Maturation
Neurophysiological Maturation Correlate With Clinical Milestones
To examine the association of early measures of heart rate variability and amplitude-integrated electroencephalography with time to wean to crib and to achieve full oral feeds among moderate and late preterm infants.
- Trial name
- NEMO (NCT03722901)
- Where
- 2 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Infant, Newborn, Infant, Moderate Preterm
Generic Database of Moderate Preterm Infants
This is a registry of moderate preterm infants, born alive at 29-33 weeks gestational age, in NICHD Neonatal Research Network (NRN) centers.
- Trial name
- NCT01793116
- Where
- 19 sites in United States
- Volunteers
- 7,057 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Bronchopulmonary Dysplasia
Human Mesenchymal Stem Cells For Bronchopulmonary Dysplasia
This study is an open-label, single-center, dose escalation study to evaluate of safety and efficacy of human umbilical cord -derived mesenchymal stem cells (hUC-MSCs) in premature infants for moderate and severe Bronchopulmonary…
- Trial name
- NCT03558334
- Testing
- Transplantation of mesenchymal stem cell, No transplantation of mesenchymal stem cell
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Infant, Newborn, Hypoxia, Brain
Preemie Hypothermia for Neonatal Encephalopathy
This study is a randomized, controlled trial to assess safety and effectiveness of whole body hypothermia for 72 hours in preterm infants 33-35 weeks gestational age (GA) who present at <6 hours postnatal age with moderate to…
- Conditions
- Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic
- Trial name
- NCT01793129
- Testing
- Hypothermia, Normothermic Control
- Where
- 18 sites in United States
- Volunteers
- 168 people
- Sponsor
- NICHD Neonatal Research Network
Complication of Prematurity
Effect of Extensively Hydrolyzed Liquid Human Milk Fortifier on Growth and Tolerance in Moderately Premature Infants
The purpose of this study is for the researchers to examine the safety and efficacy of liquid human milk fortifier (HMF) in moderately preterm infants compared to powdered human milk fortifier.
- Trial name
- NCT02632266
- Testing
- Powder HMF, Liquid HMF
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Preterm Birth, Mother-Infant Interaction
Continuous Delivery Room Skin-to-skin-study for Moderate and Late Preterm Infants
The goal of this randomized controlled trial is to compare the effect of direct skin-to-skin contact in moderate and late preterm infants.
- Conditions
- Preterm Birth, Mother-Infant Interaction, Infant Development
- Trial name
- COSY (NCT05975203)
- Testing
- skin-to-skin contact
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Cologne
Bronchopulmonary Dysplasia
Follow-Up Study of Mesenchymal Stem Cells for Bronchopulmonary Dysplasia
This is a follow-up study to investigate the long-term safety and efficacy of human umbilical cord -derived mesenchymal stem cells (hUC-MSCs), for the treatment of BPD in premature infants.
- Trial name
- NCT03873506
- Testing
- transplantation of hUC-MSCs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Respiratory Distress, Newborn
Effectiveness of HVNI in Preterm Infants With Moderate Respiratory Distress
Neonatal respiratory distress is a common problem in preterm infants. The application of CPAP is widely used in neonatal units as a primary mode of respiratory support for respiratory distress.
- Trial name
- NCT06436222
- Testing
- HVNI
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia