Clinical trials: Infant, Newborn, Pain
Hypoxic-Ischemic Encephalopathy, Pain
Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)
Management of neonatal pain and sedation often includes opioid therapy. A growing body of evidence suggests long-term harm associated with neonatal opioid exposure.
- Trial name
- DICE (NCT04772222)
- Testing
- Dexmedetomidine Hydrochloride, Morphine Sulfate
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Inguinal Hernia, Femoral Hernia
Factors Influencing the Results of Treatment in Patients With Hernias of Various Localizations
The study attempts to quantify the relative risks for acute postoperative pain, complications rate, chronic postoperative pain (CPIP) and recurrence rate after different methods of repair of groin, umbilical and incisional hernia…
- Conditions
- Inguinal Hernia, Femoral Hernia, Umbilical Hernia, Ventral Hernia
- Trial name
- NCT05920200
- Testing
- open non-mesh hernia repair, open mesh hernia repair, MIS hernia repair
- Where
- Russia
- Volunteers
- 4,000 people
- Sponsor
- Immanuel Kant Baltic Federal University
Cystic Fibrosis (CF), Pain Management
PACE CF, a 3-session Mind-body Pain Management Program for Adults With Cystic Fibrosis
Many people living with cystic fibrosis (CF) experience pain. However, pain is sometimes unrecognized and under-managed in people with CF.
- Trial name
- NCT06606457
- Testing
- Pain Acknowledgment Coping and Empowerment in CF (PACE CF)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Congenital Heart Surgery
The Effect of Using Multifunctional Baby Carrier With Heart Surgery
The study aims to investigate the effect of using a multifunctional baby carrier with rocking, safe swaddling, and white noise features on physiological parameters, crying, and sleep status in infants aged 0-3 months who have…
- Trial name
- NCT07319858
- Testing
- Multifunctional Baby Carrier
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Istanbul University - Cerrahpasa
Infant, Premature
Nasogastric Tube in Premature Babies - Pain and Treatment
Does sucrose or pacifier influence pain in premature babies when a nasogastric tube is inserted?
- Trial name
- NCT00218946
- Testing
- Sucrose, Pacifier, sterile water
- Where
- Norway
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
İnfant Comfort, Infant
EFFECTS OF TWO PAİN MANAGEMENT EDUCATİON METHODS DURİNG HEEL PRİCK PROCEDURES ON MATERNAL ANXİETY AND NEONATAL PAİN
The aim of this research is to evaluate the effects of two different methods of education (verbal instruction + written brochure and verbal instruction + AI-assisted video presentation) given to new mothers on neonatal pain…
- Conditions
- İnfant Comfort, Infant, Infant Care, Newborn Pain
- Trial name
- NCT07660159
- Testing
- verbal and brochure-based education, verbal and AI-supported video training
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Kocaeli University
Pain
The Effect of Warming and Vibration Applications on Pain in Newborns
This study aimed to determine the effects of warming and vibration applications on pain during heel blood collection in newborns. H1: Warming application has a positive effect on pain during heel blood collection in newborns.
- Trial name
- NCT06607575
- Testing
- Control group, Warming, Vibration
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Congenital Heart Disease (CHD), Chest Tube Removal
The Effect of Music and Musical Mobile Interventions on Pain and Physiological Parameters
Chest tube removal in infants undergoing surgery for congenital heart disease is an invasive procedure associated with significant pain and physiological stress responses.
- Trial name
- Music Pain Inf (NCT07564882)
- Testing
- Music Group, Musical Mobile Group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Baskent University
Post Operative Pain
Does the Newborn Infant Parasympathetic Evaluation (NIPE) Index Predict Postsurgical Pain in Children
An investigation to find out if Newborn Infant Parasympathetic Evaluation (NIPE) index predicts postsurgical pain in children, since NIPE is thought to may be of guide to the appropriate therapy in a timely and objective manner…
- Trial name
- NIPE (NCT04909060)
- Testing
- noninvasive blood pressure, 3 lead ECG, peripheral oxygen saturation
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Neonatal Disease, Neonatal Disorder
Reducing Pain and Promoting Neurodevelopment Among Preterm Neonates
To determine the effects of multisensory stimulation and soft tissue therapy on procedural pain and neurodevelopment among neonates admitted to the NICU is the aim of the study.
- Trial name
- NCT04366102
- Testing
- Multisensory stimulation with soft tissue therapy, Routine hospital care
- Where
- India
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Asir John Samuel
Infant Pain Management, Parent-driven Pain Management
Parents as Pain Management in Swedish Neonatal Care
Parents are a valuable but underused resource in neonatal pain management. In the Nordic countries, family-centred neonatal care has come a long way in welcoming and including parents in the everyday care of their infant.
- Trial name
- NCT04341194
- Testing
- Parent-driven pain management with skin-to-skin contact, Parent-driven pain management with skin-to-skin contact/breastfeeding/parental singing
- Where
- 4 sites in Sweden
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Värmland County Council, Sweden
Nursing Caries
Foot Bath for Heel Warming Before Heel Lance
Foot bath is a simple warm application method that creates a feeling of comfort and positive effects on health have been reported in the literature. There are studies reporting the benefits of footbath for different groups.
- Trial name
- NCT05220930
- Testing
- Foot bath for heel warming, Ineffective heel warming with thermofor
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Isparta University of Applied Sciences
Induced Vaginal Delivery
Newborn Pain and Stress Levels in Oxytocin Induction at Birth
The aim of the study is to compare pain and stress levels in the early neonatal period in newborns with and without oxytocin induction. The research was conducted in a case-control study design.
- Trial name
- NCT06474000
- Testing
- Oxytocin induction group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Analgesia
Analgesic Efficacy of Oral Glucose in Preterm Neonates During Suctioning
Nasopharyngeal suctioning is a painful procedure that often becomes necessary in the care of preterm infants under CPAP therapy several times a day.
- Trial name
- Glucose FG (NCT00761059)
- Testing
- Glucose 20%, Aqua
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Cologne
Buzzy
Buzzy Application During Heel Blood Collection in the Newborn
Objective The aim of this study was to evaluate the effects of Buzzy device application during heel prick blood collection on pain level and comfort in newborns. Method.
- Trial name
- NCT06773325
- Testing
- Buzzy application
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Procedural Pain, Preterm Infants
Effectiveness of Gentle Touch Technique on Pain Level During Painful Procedures in Preterm Infants
Preterm infants in neonatal intensive care units frequently undergo painful procedures that may affect their physiological stability, including pain level and respiratory parameters.
- Trial name
- NCT07470398
- Testing
- Gentle Touch Technique
- Where
- 3 sites in Iraq
- Volunteers
- 60 people
- Sponsor
- Karbala University
Benign Breast Disease, Fibrocystic Disease of Breast
Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer
The purpose of the study is to determine the efficacy and relapse rate of low dose, short duration treatment with tamoxifen in benign breast disease amenable to hormonal therapy with respect to etiology and estrogen receptor…
- Conditions
- Benign Breast Disease, Fibrocystic Disease of Breast, Fibroadenoma, Mastalgia
- Trial name
- NCT00999921
- Testing
- Tamoxifen, Evening Primrose Oil
- Where
- India
- Volunteers
- 256 people
- Sponsor
- Medical College and Hospital Kolkata
Colic
Study to Evaluate Efficacy and Safety of Oral Doses of Hyoscine Butylbromide for the Treatment of Occasional Abdominal Pain, Cramping, and Discomfort
Study to determine whether hyoscine butylbromide can provide adequate symptomatic relief of a single episode - defined as lasting not longer than 1 day - and multiple episodes of abdominal pain or discomfort associated with…
- Trial name
- NCT02242292
- Testing
- Hyoscine butylbromide
- Volunteers
- 527 people
- Sponsor
- Boehringer Ingelheim
Infant Behavior, Pain, Acute
Multiple Sensory Interventions On Infants' Pain and Physiological Distress During Neonatal Screening Procedures
The study purposes are to compare the effects of different combinations of sensory interventions on newborns' pain responses, physiological distress (heart rate and oxygen saturation), and crying event during heel stick…
- Conditions
- Infant Behavior, Pain, Acute, Physiological Stress, Breast Milk
- Trial name
- MSI (NCT04851353)
- Testing
- GT+VC, Smell, Taste
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Extremely Premature Infant, Pain
Creation of a Scale for Assessing Pain and Discomfort in Extremely Premature Infants (EDEX) Hospitalised in Neonatal Intensive Care, Inspired by the Early Infant Pain and Discomfort Scale (EDIN)
The goal of this study is to develop a new scale for assessing prolonged pain, dedicated to extremely premature infants born before 27 weeks of gestation, adapted to their particular ways of expressing pain and discomfort, which…
- Conditions
- Extremely Premature Infant, Pain, Discomfort Symptoms
- Trial name
- DOU-PREMA (NCT07481331)
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion