Clinical trials: Infant, Newborn
Immune System Diseases, Premature Infant Disease
Oral Colostrum and Its Effect on Immune System
The purpose of this project is to increase the serum immunological defenses of premature infants less then 32 weeks of gestation by administrating colostrum in the oropharyngeal mucosa versus placebo
- Conditions
- Immune System Diseases, Premature Infant Disease, Immunoglobulin Deficiency
- Trial name
- NCT03578341
- Testing
- Orally Colostrum
- Where
- 2 sites in Mexico
- Volunteers
- 96 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Omega 3 Supplements During Pregnancy
The Effect of Alpha Linolenic Acid (ALA) Supplementation During Pregnancy
Omega-3 fatty acids are "good fats," and are among the most important nutrients lacking in Western diets today. The average person in developing countries consumes less than 100 mg of DHA daily.
- Trial name
- NCT03040856
- Testing
- Alpha Linolenic Acid, Omega 3 enriched diet ( DHA+EPA)
- Where
- Israel
- Sponsor
- Sheba Medical Center
Hypoglycemia, Infant, Small for Gestational Age
Dextrose Gel Does Not Prevent Neonatal Hypoglycemia
This was a quasi-experimental pilot study comparing blood glucose values 30 minutes after feeding alone or feeding + dextrose gel in newborns at risk for transient neonatal hypoglycemia.
- Conditions
- Hypoglycemia, Infant, Small for Gestational Age, Premature Birth of Newborn, Fetal Macrosomia
- Trial name
- NCT02523222
- Testing
- 40% Dextrose gel
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Baylor College of Medicine
Hirschsprung Disease
A Trial on Conservative Treatment for Infants' Hirschsprung Disease
The present study was designed to compare the efficacy of conservative treatment to operative treatment for improvement of constipation symptoms in infants with short or normal-segment Hirschsprung disease.
- Trial name
- NCT01985646
- Testing
- surgery treatment, anal dilation, colonic lavage
- Volunteers
- 48 people
- Sponsor
- Tongji Hospital
Cystic Fibrosis
Study of Ivacaftor in Cystic Fibrosis Subjects Aged 6 to 11 Years With the G551D Mutation
The purpose of this study was to evaluate the efficacy and safety of ivacaftor in subjects with cystic fibrosis aged 6 to 11 years who have the G551D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR)…
- Trial name
- ENVISION (NCT00909727)
- Testing
- Ivacaftor
- Where
- 29 sites in United States, Australia and 5 more
- Volunteers
- 52 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Graft Versus Host Disease, Hyperkalemia
Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair
Blood transfusions are required for patients undergoing a craniosynostosis repair due to the significant amount of blood loss. Irradiated or non-irradiated transfusions have many risks involved including elevated potassium levels…
- Conditions
- Graft Versus Host Disease, Hyperkalemia, Craniectomy, Synostectomy
- Trial name
- NCT02483702
- Testing
- Irradiated Blood Transfusions, Non-Irradiated Blood Transfusions
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Rare Diseases
NICUSeq: A Trial to Evaluate the Clinical Utility of Human Whole Genome Sequencing (WGS) Compared to Standard of Care in Acute Care Neonates and Infants
Prospective, multi-site, study to evaluate the clinical utility of cWGS in a proband. One group will receive cWGS and a clinical report approximately 15 days after blood samples are received, while the other group will continue…
- Trial name
- NICU-Seq (NCT03290469)
- Testing
- clinical whole genome sequencing (cWGS)
- Where
- 5 sites in United States
- Volunteers
- 355 people
- Sponsor
- Illumina, Inc.
Newborns
Evaluation of the Effect of Duration of Stabilising Tapes on Skin Damage in Neonates
The research was conducted to evaluate the relationship between the duration of the fixing tapes of the probes attached to the chest, abdominal and lower extremity regions of newborns for temperature monitoring and skin damage.
- Trial name
- NCT06944054
- Testing
- Group 1
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi
Intrauterine Growth Restriction, Preterm Birth
Respiratory Morbidity of Late-Preterm Vs Intrauterine Growth Retarded Infants at School Age
Background: It is increasingly recognized that late preterm infants have increased respiratory morbidity in the neonatal period as well as decreased lung function in later life.
- Trial name
- NCT04849494
- Testing
- ATS-DLD-78-C and ISAAC questionnaires
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Marmara University
Pain, Infant ALL
The Effect of Non-pharmacological Methods on Pain
The research will be conducted using a randomized controlled experimental method.The preterm newborns included in the study will be randomized into three groups using the sealed envelope method.
- Conditions
- Pain, Infant ALL, Preterm
- Trial name
- NCT06455631
- Testing
- Facilitated Tucking, Oral Breast Milk , Kangaroo Care
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
Breastfeeding Education, Newborn; Vitality
The Effect of Breastfeeding Education Using a Doll During Pregnancy on Newborn Feeding
This study was planned in a randomized controlled quasi-experimental design to determine the effect of breastfeeding education using a doll during pregnancy on newborn feeding.
- Conditions
- Breastfeeding Education, Newborn; Vitality, Education
- Trial name
- Newborn (NCT05853653)
- Testing
- Using dolls in breastfeeding education
- Where
- Turkey (Türkiye)
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Infant Nutritional Physiological Phenomena, Infant Formula
Gastrointestinal Tolerability of a Partially Hydrolyzed Ready-to-feed Infant Formula in Healthy Newborns
Gastrointestinal tolerability of a partially hydrolyzed, whey-based, ready-to-feed infant formula in healthy newborns during the birth hospitalization period: a post-market study
- Trial name
- NCT05097924
- Testing
- NAN Supreme HypoAllergenic Starter Infant Formula in ready-to-feed format
- Where
- Saudi Arabia
- Volunteers
- 150 people
- Sponsor
- Société des Produits Nestlé (SPN)
Newborn; Infection, Umbilical Cord Infection
The Effect of Umbilical Cord Clamping Distance
A randomized control trial was conducted to test the effect of umbilical cord clamping distance on cord separation time and umbilical cord microbial colonization in neonates.
- Trial name
- NCT04862403
- Testing
- Umbilical cord clamping distance
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
PPROM, Respiratory Distress Syndrome in Premature Infants
Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?
The purpose of this study is to determine if a repeat course of betamethasone given to pregnant women with preterm premature rupture of membranes (PPROM) will decrease the infant's length of stay in the neonatal intensive care…
- Trial name
- NCT02939742
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Maternity, Birth, First
Women's Perception of Respectful Maternity Care, Birth Experiences and Perception of Traumatic Birth
The effect of the ıntrapartum care model given in line with the world health organization (WHO) recommendations on women's perception of respectful maternity care, birth experiences and perception of traumatic birth
- Conditions
- Maternity, Birth, First, Traumatic Birth, Intrapartum Fetal Distress
- Trial name
- NCT06691854
- Testing
- The group that applied the Intrapartum Care Model
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
Respiratory Distress Syndrome, Transient Tachypnea of Newborn
The Possible Effect Of Amniotic Fluid pH On Neonatal Morbidities In Maternal Inflammation/Infection Associated Pregnancies
Amniotic fluid (AF) pH can be affected by the maternal and/or fetal conditions such as PPROM, prematurity or fetal distress. It is known that fetal urine is the major content of AF since 20th gestational week.
- Conditions
- Respiratory Distress Syndrome, Transient Tachypnea of Newborn, Intrauterine Growth Retardation
- Trial name
- NCT02691559
- Testing
- Amniotic fluid analysis by blood gas device
- Where
- Turkey (Türkiye)
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Neonatal Bradycardia, Hypoxemia of Newborn
Bradycardia Recognition and Detection in Young Infants Part-I
This prospective cohort study will determine the diagnostic accuracy of the Owlet OSS 3.0 monitor for the detection of episodes of bradycardia and/or hypoxemia among infants.
- Trial name
- BRADY-I (NCT05774470)
- Testing
- Owlet OSS 3.0
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Alabama at Birmingham
Cystic Fibrosis (CF)
Muscle Fatigue in People With Cystic Fibrosis: Insight From a Mobile App
Muscle fitness is an important component of health. For instance, the ability to resist to muscle fatigue development is important for daily functioning.
- Trial name
- NCT07135869
- Testing
- One minute sit-to-stand test
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Pregnancies
Preterm Delivery Prevention in Twins With Progesterone
Twin pregnancies have very high preterm delivery rate. Until now, no RCT has proven benefit of progesterone in this population. In contrast, singleton pregnancies are treated with this hormone.
- Trial name
- NCT01927029
- Testing
- Progesterone
- Volunteers
- 213 people
- Sponsor
- Universidad del Desarrollo