Clinical trials: Infant, Premature
Wheezing, Allergy
Wheezing in Black Preterm Infants: Impact of Vitamin D Supplementation Strategy
The goal of this study is to identify a vitamin D supplementation strategy that best promotes the lung, immune, and overall health of black infants born preterm (28-36 weeks gestational age).
- Trial name
- D-Wheeze (NCT01601847)
- Testing
- Cholecalciferol
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- Case Western Reserve University
Pulse Oximetry, Disparities
Beyond Race: Objectively Assessed Skin Color and Its Association With Pulse Oximeter Bias in Critically Ill Infants
The overall objective of this proposal is to quantify the bias in pulse oximeter reported oxygen saturation (SpO2) by evaluating its measures compared to the gold standard blood gas measured arterial oxygen saturation (SaO2)…
- Conditions
- Pulse Oximetry, Disparities, Infants
- Trial name
- NCT05994417
- Volunteers
- 200 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Hypothermia, Preterm Infants
Heat Loss Prevention in Delivery Room Using a Polyethylene Cap
It is apparent that the head of a preterm infant should not be left uncovered, however it remains unclear whether covering the head of a preterm baby with plastic wrapping is effective in preventing heat loss.
- Trial name
- NCT00930917
- Testing
- Polyethylene cap, Polyethylene wrap, conventional treatment
- Volunteers
- 96 people
- Sponsor
- University of Padova
Osteopenia (Disorder), Apnea of Prematurity
Effect of Caffeine on Preterm Infants' Bone Mineral Content
The primary objective was to determine whether caffeine therapy is associated with decreases bone mineral content using dual energy x-ray absorptiometry.
- Trial name
- NCT03084432
- Testing
- Dual Energy X-ray Absorptiometry
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Respiratory Distress Syndrome, Newborn
Feasibility Study of Placement and Surfactant Administration Through a Preterm Size Laryngeal Mask Airway in Very Low Birth Weight Neonates With Respiratory Distress Syndrome
Surfactant administration via a supraglottic airway device or laryngeal mask airway (SALSA) is a minimally invasive method of instilling surfactant in the trachea during spontaneous breathing and after applying nasal continuous…
- Trial name
- NCT06606444
- Testing
- Surfactant Administration Through Laryngeal or Supraglottic Airways
- Where
- Vietnam
- Volunteers
- 45 people
- Sponsor
- Karolinska Institutet
Respiratory Distress Syndrome, Chronic Lung Disease of Prematurity
Prevention of Chronic Lung Disease (CLD) in Preterm Infants
Pulmonary inflammation plays an important role in the early development of CLD. Postnatal glucocorticoids have been shown effective in the prevention or treatment of CLD with various success.
- Trial name
- NCT00883532
- Testing
- budesonide
- Where
- China
- Volunteers
- 300 people
- Sponsor
- China Medical University, China
Lung Injury
Adrenomedullin Changes After Sustained Inflation or Positive Pressure Ventilation at Birth
In this clinical trial the Investigators aimed to assess the Adrenomedullin (AM) release in urine and plasma in preterm infants undergoing Sustained Inflation or Positive Pressure Ventilation at birth to manage respiratory…
- Trial name
- NCT03437499
- Testing
- Sustained Inflation, Positive Pressure Ventilation
- Volunteers
- 45 people
- Sponsor
- Vittore Buzzi Children's Hospital
Infant, Very Low Birth Weight, Neonatal Hypoglycemia
Continuous Glucose Monitoring and Preterm Infants
Neonatal hypoglycemia is associated with brain injury and impaired neurodevelopment outcomes in very low birth weight infants (VLBWI).
- Trial name
- CGM&VLBWI (NCT02583776)
- Testing
- Unblinded - CGM, Blinded - CGM
- Where
- 3 sites in United States, Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Lung Diseases
The Effect of Sildenafil in Preterm Infants With Evolving Chronic Lung Disease
The purpose of this pilot study is to investigate in a randomised double-blind trial whether treatment with Sildenafil reduces duration of ventilatory support in preterm infants born at 28 weeks of gestation or less.
- Trial name
- NCT00431418
- Testing
- Sildenafil
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Mercy Hospital for Women, Australia
Apnea, Bradycardia
microEEG for Neonatal Apnea, Bradycardia and Desaturation
The study utilizes microEEG (a novel miniaturized, FDA approved EEG device) to prospectively investigate the cerebral electrical activity of infants with Apnea, Bradycardia and Desaturation events.
- Conditions
- Apnea, Bradycardia, Premature Birth, Seizures
- Trial name
- NCT02436616
- Testing
- microEEG
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Bio-Signal Group Corp.
Respiratory Viral Infections, Adverse Pregnancy Outcomes
APOs Associated With Respiratory Viral Infections Before and During Early Pregnancy
Adverse pregnancy outcomes (APOs) are a collection of conditions that have short-term and long-term effects of complications related to pregnancy and childbirth on pregnant women and their fetuses, including hypertensive…
- Trial name
- APO (NCT07257952)
- Volunteers
- 1,440 people
- Sponsor
- Shanghai General Hospital, China
Very Preterm Maturity of Infant
Prematurity at the Limit of Viability
Advancements in perinatal care have significantly improved the survival of extremely premature infants, establishing a viability threshold below 25 weeks' gestational age (GA).
- Trial name
- PRELIVIA (NCT06391476)
- Testing
- Study of the evolution of a cohort of children born between 22 and 25 weeks gestational age
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Osteopenia of Prematurity
Comparison of Two Different Doses of Vitamin D in Preterm Infants
randomized clinical trial comparing two different doses of vitamin d supplementation in preterm infants
- Trial name
- NCT03889717
- Testing
- vitamin D
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neonatal Sepsis
Oral Lactoferrin Supplementation for Prevention of Sepsis in Preterm Neonate
Hypothesis: Orally ingested lactoferrin has effects on promotion of growth and differentiation of the immature gut; also it has immunomodulatory properties, so it will prevent serious infections in preterm infants.
- Trial name
- NCT01821989
- Testing
- Lactoferrin
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mooselmokadem
Neurodevelopmental Outcome
Iron Status and Myelination in Premature Infants
Premature infants with iron deficiency if supplemented with more elemental iron than the routine 2mg/kg/day will have improved brain development.
- Trial name
- Piron (NCT00684697)
- Testing
- iron
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Rochester
Weight, Birth, Premature Birth
Effects of Olfactory and Gustatory Stimulus on the Nutrition of Premature Babies
The objective of this clinical trial is to test the effects of olfactory and taste stimulation with milk or water in premature newborns with a gestational age between 28 and 32 weeks.
- Trial name
- NCT06305052
- Testing
- Milk, Water
- Where
- Brazil
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Feeding Disorder Neonatal
Effects of PIOMI on Oral Feeding of the Premature Infants
Randomized controlled clinical trial aimed at evaluating the effects of the "Premature infant oral motor intervention" method on the oral feeding skills of the premature infants.
- Trial name
- PIOMI2020 (NCT04290338)
- Testing
- PIOMI
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Infant, Premature, Diseases, Fatty Acid Deficiency
Prospective Evaluation in Older Premature, Untreated Breast Milk and Milk Processed by the Breast-milk Bank
The purpose of this study is to evaluate the impact of the enteral nutrition type (untreated breast milk, or breast milk processed by the breast-milk bank) on the longitudinal evolution of the total content and plasma profile of…
- Trial name
- ADiLL (NCT01626508)
- Where
- 2 sites in France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Preterm Infant
Non-Invasive Monitoring of Partial Pressure of Carbon Dioxide in Mechanically Ventilated Preterm Infants
In mechanically ventilated preterm infants, the ability to monitor carbon dioxide partial pressure (pCO2) values is indispensable. The gold standard for pCO2 measurement is from an arterial blood sample (paCO2).
- Trial name
- NCT03758313
- Testing
- CO2 measurements
- Where
- Austria
- Volunteers
- 27 people
- Sponsor
- Tobias Werther
Premature Birth
Three-Part Program for Parents With Premature Infants
This study evaluated the efficacy of a comprehensive, three-part program for parents of premature infants. This program was designed to improve development in preterm children and includes an educational video, tests to evaluate…
- Trial name
- NCT00056680
- Testing
- Psychoeducational video, Infant massage, Brazelton Neonatal Behavioral Assessment Scale
- Where
- 5 sites in United States
- Volunteers
- 173 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)