Clinical trials: Infant Morbidity
Hypertension in Pregnancy, Hypertension
Enhancing Intergenerational Health in Nigeria: Peripartum as Critical Life Stage for Cardiovascular Health
The purpose of the ENHANCE-CVH study is to promote intergenerational cardiovascular health (CVH) of women and children in Abuja and the surrounding Federal Capital Territory of Nigeria.
- Conditions
- Hypertension in Pregnancy, Hypertension, Obesity and Overweight, Maternal Morbidity and Mortality
- Trial name
- ENHANCE-CVH (NCT06773299)
- Testing
- PAT+HEALTH curriculum - Nigeria
- Where
- Nigeria
- Volunteers
- 1,000 people
- Sponsor
- Washington University School of Medicine
Suspected Damage to Fetus From Other Disease in the Mother, Affecting Management of Mother, With Delivery, Patient Death or Serious Disability Associated With A Haemolytic Reaction Due to the Administration of ABO-Incompatible Blood or Blood Products
The Use of Lung Ultrasonography in the Delivery Room in Neonates
Lung ultrasonography has become frequently used in neonatal intensive care units because it is a diagnostic, useful, harmless, radiation-free, bedside, reproducible and practical method.
- Trial name
- LUSIN (NCT06314789)
- Testing
- doing lung ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Feeding Behavior, Nutritional Status
Effectiveness of Behavior Change Communication in Improving Feeding Practices, Nutritional and Health Status of Infants
Child under nutrition is a major risk factor for ill health and mortality, contributes substantially to the burden of disease in low-income and middle-income countries and is associated with close to half of all child deaths.
- Conditions
- Feeding Behavior, Nutritional Status, Morbidity
- Trial name
- NCT03488680
- Testing
- Behavior change communication
- Where
- Ethiopia
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Jimma University
Cerebral Palsy, Pediatric Neurological Disorder
Lung Ultrasound for Infants' Swallowing Disorders
The aim is to test the effectiveness of lung ultrasound (LUS) in the dynamic assessment of aspiration related to abnormal swallowing in infants and young children with neurological impairment (cerebral palsy/developmental…
- Conditions
- Cerebral Palsy, Pediatric Neurological Disorder, Developmental Disability
- Trial name
- LUNCH (NCT04253951)
- Testing
- Lung Ultrasound (LUS)-monitored feeding trial
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Fondazione Stella Maris
Enterocolitis, Necrotizing, Bacteremia
Antibiotic "Dysbiosis" in Preterm Infants
Prolonged antibiotic use in preterm neonates has significant consequences on the developing intestinal microbiome, metabolome and host response, predisposing the neonate to various major morbidities, including necrotizing…
- Conditions
- Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
- Trial name
- NCT02784821
- Testing
- Antibiotic, Gastric fluid, Breast milk
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Florida
Newborn, Extreme Prematurity
Improve the Survival Without Morbidity of Extremely Preterm Infants (PREMEX)
The intervention proposed is a new organization of care, based on the EXPRIM (EXtrem PRematurity Innovative Management) protocol, involving early, standardized, and multidisciplinary management of women hospitalized for a risk of…
- Conditions
- Newborn, Extreme Prematurity, Pretrm Infants
- Trial name
- PREMEX (NCT05248477)
- Testing
- Premex Protocol
- Where
- France
- Volunteers
- 2,377 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Newborn Morbidity, Simulation Training
Educational Strategy in Exchange Transfusion
Abstract Background: Exchange transfusion is a highly complex procedure that requires high levels of expertise. Paediatricians trainees do not have adequate training because opportunities to perform this procedure in practice are…
- Conditions
- Newborn Morbidity, Simulation Training, Telemedicine, Assessment, Self
- Trial name
- INTEXUS (NCT04070066)
- Testing
- Digital didactic environment, • Simulated scenario
- Where
- Colombia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de la Sabana
Transient Tachypnea of the Newborn
Dexamethasone in Prevention of Respiratory Morbidity in Elective Caesarean Section in Term Fetus
Introduction: Babies born at term by elective caesarean section (CS) and before onset of labor are more likely to develop respiratory complications than babies born vaginally.
- Trial name
- NCT01772381
- Testing
- Dexamethasone
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Premature Birth, Premature Lungs
Comparison of Two Strategies for Surfactant Prophylaxis in Premature Infants
The purpose of this study is to determine whether the immediate bolus strategy combined with early nasal CPAP (nCPAP) treatment could decrease the subsequent need for ventilation compared to the administration of surfactant…
- Trial name
- NCT01294852
- Testing
- surfactant prophylaxis
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara University
Diarrhea, Respiratory Infection
Impact of Zinc Supplementation in Low Birth Weight Infants on Severe Morbidity, Mortality and Zinc Status: A Randomized Controlled Trial
There are currently no interventions available to substantially reduce the incidence of low birth weight (LBW) apart from increasing the age at marriage, maternal iron supplementation and possibly improved energy intakes.
- Conditions
- Diarrhea, Respiratory Infection, Low Birth Weight
- Trial name
- NCT00272142
- Testing
- Zinc
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Morality, Morbidity;Newborn
Comparison of Care Practices, Mortality and Morbidity of Very Preterm Infants Between Two Tertiary Centers in Northwest and South of China
Care practices, mortality and morbidity of very premature infants from two different tertiary centers were collected and compared, in order to discover areas for improvement where these two newborn centers can learn from each…
- Conditions
- Morality, Morbidity;Newborn, Very Preterm Maturity of Infant
- Trial name
- NCT05116670
- Where
- China
- Volunteers
- 807 people
- Sponsor
- Nanjing Medical University
Reproductive, Maternal, Newborn, and Child Health, Integrated, Community-Health Systems
Implementing an Integrated RMNCH Intervention by Community Health Workers in Achham and Dolakha: National Pilot
The investigators will conduct a cluster-controlled, stepped wedge implementation science trial of a bundled reproductive, maternal, neonatal, and child healthcare (RMNCH) delivery intervention within an approximate population of…
- Trial name
- NCT03371186
- Testing
- Community Health Worker, Continuous Surveillance, CB-Integrated Management of Newborn and Childhood Illness
- Where
- 2 sites in Nepal
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Possible
Infant, Newborn, Healthy
Investigating the Mortality and the Morbidity Impact of Oral Polio Vaccine at Birth
Our group has discovered that routine vaccinations in childhood may have non-specific and sex-differential effects on overall mortality.
- Trial name
- NCT00710983
- Testing
- Oral polio vaccine
- Where
- Guinea-Bissau
- Sponsor
- Bandim Health Project
Prematurity, Very Low Birth Weight
Impact of Sex and Own Mother's Milk Pasteurization on Morbidity and Mortality of Very Low Birth Weight Infants
In very low birth weight (<1500g) preterm infants, nutrition with mother's own milk, as opposed to formula, is associated with reduced morbidity and mortality.
- Trial name
- G-PAMINEO (NCT07411872)
- Where
- Germany
- Volunteers
- 900 people
- Sponsor
- Charite University, Berlin, Germany
Infant Mortality, Morbidity
Vitamin A Supplementation With Bacille Calmette Guerin (BCG) Vaccine
In the present study the investigators wish to address the effects of different doses of vitamin A supplementation in low and normal birth weight infants.
- Trial name
- NCT00168610
- Testing
- Vitamin A
- Where
- Guinea-Bissau
- Volunteers
- 7,600 people
- Sponsor
- Bandim Health Project
Infant, Premature, Diseases, Airway Morbidity
Optimising Ventilation in Preterms With Closed-loop Oxygen Control
Many premature infants require respiratory support in the newborn period. Mechanical ventilation although life-saving is linked to complications for the lungs and other organs and its duration should be kept to a minimum.
- Conditions
- Infant, Premature, Diseases, Airway Morbidity, Mechanical Ventilation Complication
- Trial name
- NCT05030337
- Testing
- Closed-loop automated oxygen control (Oxygenie, SLE 6000)
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- King's College Hospital NHS Trust
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Malaria, Pregnancy
Impact of IPT With Sulfadoxin Pyrimetamin on Pregnant Women and Their Babies Outcomes in Peri-urban Areas of Bobo-Dioulasso(Burkina Faso)
The purpose of this is to determine the impact of intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) on the morbidities associated with malaria in pregnant women and newborns in rural peri-urban areas of…
- Trial name
- NCT01255605
- Where
- Burkina Faso
- Volunteers
- 772 people
- Sponsor
- Université Polytechnique de Bobo-Dioulasso
Neonatal Respiratory Distress
The Role of ARTificial Uterine CONtractions in Perinatal Respiratory Morbidity of Term Infants Delivered by Elective Caesarean Section
In this study, the investigators aim to investigate if artificial uterine contractions prior to elective caesarean section delivery may have an impact on the respiratory morbidity of term neonates.
- Trial name
- ARTCON (NCT03899597)
- Testing
- Oxytocin, Normal saline
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic
Preterm Birth, Low Birth Weight
Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns
This study focuses on understanding the conditions that affect newborn health and survival from pregnancy to the first weeks of life at the Isidro Ayora Hospital.
- Conditions
- Preterm Birth, Low Birth Weight, Intrauterine Growth Restriction (IUGR), Perinatal Asphyxia
- Trial name
- UCE (NCT06653374)
- Testing
- Infant, Premature
- Where
- Ecuador
- Volunteers
- 26,000 people
- Sponsor
- HOSPITAL GINECO OBSTETRICO ISIDRO AYORA