Clinical trials: Infant Respiratory Distress Syndrome
Maternal Attachment, Breastfeeding
Reciprocal Mother-Infant Voice Exposure in the Neonatal Intensive Care Unit
This randomized controlled trial evaluates the effect of reciprocal maternal-infant voice exposure on maternal attachment and breastfeeding outcomes in a neonatal intensive care unit (NICU).
- Conditions
- Maternal Attachment, Breastfeeding, Transient Tachypnea of the Newborn, Neonatal Intensive Care Unit
- Trial name
- NCT07597954
- Testing
- Reciprocal Voice Exposure Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Biruni University
ARDS
Eit in ArdS for Tcav Setting (EAST Study)
Acute respiratory distress syndrome (ARDS) is a severe form of acute respiratory failure. The therapeutic management is currently based on the treatment of the cause of ARDS, and on mechanical ventilation with positive expiratory…
- Trial name
- EAST (NCT06408272)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Central Hospital, Nancy, France
Influenza, Acute Lung Injury
Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage
The influenza A/H1N1v pandemic virus causes severe pneumonia that can lead to acute respiratory distress syndrome and death even in healthy young individuals.
- Conditions
- Influenza, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- FluBAL (NCT01089400)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
COVID-19 Acute Respiratory Distress Syndrome
Interleukine 6 (IL6) Assay for Predicting Failure of Spontaneous Breathing in Patients With COVID-19 Acute Respiratory Distress Syndrome
In the current COVID-19 pandemic, many patients have an acute respiratory distress syndrome (ARDS). Among mechanisms related to COVID-19 acute respiratory distress syndrome, cytokine storm and secretion of IL-6 play a central…
- Trial name
- NCT05330845
- Testing
- IL6 assessment, CRP and PCT assessment
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Henri Duffaut - Avignon
Covid19, Hypoxemia
A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19
Patients with COVID-19 frequently develop lower respiratory complications. Difficulty breathing and a low concentration of oxygen in the blood are of concern in patients with COVID-19, as they indicate that the lungs may be…
- Trial name
- NCT04771000
- Testing
- Ambrisentan
- Where
- 13 sites in Croatia, Spain
- Volunteers
- 88 people
- Sponsor
- Noorik Biopharmaceuticals AG
Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS)
Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia
This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have severe community-acquired pneumonia, especially if they also have sepsis…
- Conditions
- Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS), Sepsis, Lymphopenia
- Trial name
- NCT07492875
- Testing
- Nogapendekin alfa inbakicept (NAI), agenT-797
- Sponsor
- ImmunityBio, Inc.
Transient Tachypnea of the Newborn
High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation
The primary objective is to determine whether High Flow Nasal Cannula (HFNC) is a superior respiratory modality for neonates ≥36 weeks with transient tachypnea of the newborn (TTN) when compared to the standard of care modality…
- Trial name
- NCT01270581
- Testing
- High Flow Nasal Cannula, Bubble Nasal CPAP
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
ARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory Failure
Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure
The goal of this trial is to accelerate the development of pharmacological therapies for critical illness by identifying biological sub phenotypes in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- US-PANTHER (NCT07779642)
- Testing
- Simvastatin, Baricitinib
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Pediatric Acute Respiratory Distress Syndrome (PARDS)
Role of Dyspnea in the Progression of Pediatric Acute Respiratory Distress Syndrome
Pediatric acute respiratory distress syndrome (ARDS) is a life-threatening clinical syndrome, and dyspnea is its key symptom. Strenuous respiratory effort is a "second hit" for ARDS lungs, inducing changes in regional lung…
- Trial name
- NCT07750288
- Testing
- Noninvasive respiratory support, Transition from controlled to assisted mechanical ventilation, Weaning from mechanical ventilation
- Where
- Chile
- Volunteers
- 68 people
- Sponsor
- Universidad Nacional Andres Bello
ARDS, Human
A Clinical Study on Levosimendan Improvement of Prognosis of ARDS Patients by Optimizing Pulmonary Hemodynamics
The purpose of this study was to evaluate the curative effect of Levosimendan on ARDS patients through omni-directional and multi-angle objective quantitative indexes, and to study the responsiveness of ARDS with or without right…
- Trial name
- NCT04020003
- Testing
- Levosimendan
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenzhen Second People's Hospital
Acute Lung Injury(ALI), Liver Cirrhosis
Digital Early Warning System for Acute Lung Injury in Liver Surgery
This study aims to develop an explainable machine learning model that takes into account the characteristics of cardiopulmonary interactions.
- Conditions
- Acute Lung Injury(ALI), Liver Cirrhosis, ARDS, Human, MASLD
- Trial name
- NCT07070362
- Where
- 4 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Acute Respiratory Distress Syndrome, Positive End Expiratory Pressure
Safety of Low PEEP Maneuvers During ARDS Management
Acute Respiratory distress syndrome (ARDS) is a severe condition in which protective ventilation is a critical point in its management.
- Trial name
- DEBAS (NCT05922969)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
Pragmatic Investigation of Volume Targeted Ventilation-1
This proposal will test the feasibility of implementing an assist volume control ventilation protocol in patients receiving mechanical ventilation in the medical intensive care unit.
- Conditions
- Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Ventilator Lung
- Trial name
- PIVOT-1 (NCT03909854)
- Testing
- mode of mechanical ventilation
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Wake Forest University Health Sciences
Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum
Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or Without Sepsis/ARDS)
This Phase 2 study tests whether adding two immune therapies - nogapendekin alfa-inbakicept (NAI) and off-the-shelf iNKT cell infusions - to standard care can safely help critically ill adults with severe community-acquired…
- Conditions
- Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum, Sepsis, Lymphopenia / Immunoparalysis in Critically Ill Adults
- Trial name
- NCT07492888
- Testing
- Nogapendekin Alfa-Inbakicept (NAI), Allogeneic invariant Natural Killer T (iNKT) Cells (AgenT-797)
- Sponsor
- ImmunityBio, Inc.
Acute Respiratory Distress Syndrome
Extrapulmonary Interventional Ventilatory Support in Severe Acute Respiratory Distress Syndrome (ARDS)
A prospective, randomized study will be performed investigating the effects of a pumpless extracorporeal interventional lung assist [iLA] on the implementation of a lung-protective ventilatory strategy in patients with acute…
- Trial name
- Xtravent (NCT00538928)
- Testing
- lung protective ventilation
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Regensburg
Nebulization, Hypertonic Saline
Effect of Nebulized and Intravenous Hypertonic Saline 3% on the Management of Patients With Acute Respiratory Distress Syndrome
The aim of our study is to compare between the effect of nebulized and intravenous injection of hypertonic saline 3% on the outcome of patients with acute respiratory distress syndrome.
- Conditions
- Nebulization, Hypertonic Saline, Acute Respiratory Distress Syndrome
- Trial name
- NCT06226402
- Testing
- Hypertonic saline 3% nebulizer, Intravenous hypertonic saline 3%
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
Acute Respiratory Distress Syndrome
Adaptive Support Ventilation in Acute Respiratory Distress Syndrome
The purpose of this protocol is to compare standard of care lung protective ventilation settings with an automated ventilator setting, called Adaptive Support Ventilation (ASV), in patients with acute respiratory distress…
- Trial name
- ARDS (NCT03715751)
- Testing
- ASV, Lung Protective Ventilation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Respiratory Distress Syndrome in Premature Infant
Pressure HIgh or LOw DElivered to Preterm Newborns in the Delivery ROOM
The aim of this randomized pilot clinical trial of preterm infants requiring noninvasive respiratory support for respiratory distress syndrome (RDS) at birth is to improve short-term respiratory outcomes.
- Trial name
- PHILODENDROOM (NCT06123845)
- Testing
- static CPAP 8 cmH2O, static CPAP 5 cmH2O
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- ASST Fatebenefratelli Sacco
Hyaluronic Acid
The Role and Mechanism of O-GlcNAc Glycosylation Modified HAS2 in the Hyaluronic Acid Synthesis in ARDS
Maintaining the normal function of the pulmonary microvascular barrier is critical for ARDS treatment. To assess the relationship between the HAS2 protein level, HA content and the clinical prognosis of ARDS in patients with…
- Trial name
- NCT05055557
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Respiratory Distress Syndrome in Preterm Infants
LISA Rigid Catheter vs LISA Soft Catheter in a Very Preterm Manikin
Less invasive surfactant administration (LISA) can be provided using rigid or soft catheters, but possible differences in terms of easiness of use and success of the procedure are unknown.
- Trial name
- NCT05388175
- Testing
- Rigid catheter, Soft catheter
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova