Clinical trials: Infarction
Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis
Timing of FFR-guided PCI for Non-IRA in STEMI and MVD (OPTION-STEMI)
Patients with STEMI (ST-segment elevation myocardial infarction) with multivessel disease which have PCI (percutaneous coronary intervention)-suitable non-IRA (infarct related artery) will be randomized to immediate complete…
- Trial name
- NCT04626882
- Testing
- Staged in-hospital or Immediate complete revascularization
- Where
- 14 sites in South Korea
- Volunteers
- 994 people
- Sponsor
- Chonnam National University Hospital
Stroke, Acute, Stroke
Efficacy of a Telehealth Delivered Group Lifestyle Balance for People Post Stroke (tGLB-CVA)
Investigators will conduct a randomized controlled trial (RCT) to assess intervention efficacy of telehealth delivery of the GLB-CVA (tGLB-CVA) compared to a 6-month wait-list control (WLC) in partnership with a diverse group of…
- Conditions
- Stroke, Acute, Stroke, Stroke, Cardiovascular, Stroke (CVA) or TIA
- Trial name
- tGLB-CVA (NCT06569121)
- Testing
- Group Lifestyle Balance for People Post Stroke (GLB-CVA)
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Baylor Research Institute
Heart Attack, Cardiovascular Diseases
Stress Management and Resiliency Training Following Acute Myocardial Infarction
The goal of this pilot study is to use total body PET/CT imaging to examine the relationships between stress, amygdala activation, and arterial wall inflammation in participants before and after participating in a multi-modal…
- Trial name
- NCT05415735
- Testing
- Stress Management and Resiliency Training Program
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Davis
Stroke, Stroke, Acute
Volumetric Integral Phase-shift Spectroscopy for Noninvasive Detection of Hemispheric Bioimpedance Asymmetry in Acute Brain Pathology
The purpose of this study is to assess the ability of the Fluids Monitor to detect hemispheric bioimpedance asymmetry associated with acute brain pathology in patients presenting with suspected Acute Ischemic Stroke (AIS).
- Conditions
- Stroke, Stroke, Acute, Ischemic Stroke, Hemorrhage
- Trial name
- VITAL (NCT03148340)
- Testing
- VIPS Monitoring
- Where
- 5 sites in United States
- Volunteers
- 287 people
- Sponsor
- Cerebrotech Medical Systems, Inc.
Coronary Artery Disease, Death
Long-term Outcomes of Patients After Coronary Bifurcation Stenting
The purpose of this study is to assess the long-term clinical outcomes after stenting bifurcation coronary artery lesions, and to determine whether simple or more complex techniques are associated with a better clinical outcome.
- Conditions
- Coronary Artery Disease, Death, Myocardial Infarction
- Trial name
- NCT00325884
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- VA Boston Healthcare System
Myocardial Infarction (MI), Cardiovascular Events
Aspirin Continuation or Interruption in Patients at Moderate Risk for Cardiovascular Events Undergoing Colonoscopy and/or Polypectomy
One in 4 adults between 50 and 80 reports taking regular aspirin. The prevalence of aspirin uses increases with age as well as co-morbid vascular diseases.
- Conditions
- Myocardial Infarction (MI), Cardiovascular Events, Post Polypectomy Bleeding in Antiplatelet Patients
- Trial name
- NCT07052799
- Testing
- Aspirin 80mg
- Where
- Hong Kong
- Volunteers
- 2,514 people
- Sponsor
- Chinese University of Hong Kong
Cardiovascular Disease
Cardiovascular Inflammation Reduction Trial
The Cardiovascular Inflammation Reduction Trial (CIRT) is a randomized clinical trial investigating whether taking low-dose methotrexate reduces heart attacks, strokes, or death in people with type 2 diabetes or metabolic…
- Trial name
- CIRT (NCT01594333)
- Testing
- Methotrexate
- Where
- 470 sites in United States, Canada and 1 more
- Volunteers
- 4,786 people
- Sponsor
- Brigham and Women's Hospital
Stable Coronary Artery Disease (CAD), Myocardial Infarction
Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients
THis study is intended to provide contemporary data on the burden of disease in patients 1 to 3 years post-MI, including a description of patient characteristics, current treatment patterns, rate of major CV events, and…
- Trial name
- TIGRIS (NCT01866904)
- Where
- 309 sites in United States, Argentina and 23 more
- Volunteers
- 9,284 people
- Sponsor
- AstraZeneca
Brain Infarction, Hypertension
Angiotensin II Receptor Blockers (ARB) and ACE Inhibitors (ACEI) on Silent Brain Infarction and Cognitive Decline
The purpose of this study is to elucidate whether or not angiotensin II receptor blockers (ARB) are more beneficial or equal to angiotensin converting enzyme inhibitors (ACEI) on development or progression of silent brain…
- Trial name
- NCT00126516
- Testing
- Angiotensin II Receptor Antagonists, Angiotensin-converting Enzyme Inhibitors
- Where
- Japan
- Volunteers
- 395 people
- Sponsor
- Nara Medical University
Myocardial Infarction
Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor represents the standard of care for the long-term secondary prevention of atherothrombotic events in patients with myocardial infarction (MI).
- Trial name
- VORA-PRATIC (NCT02545933)
- Testing
- Prasugrel, Vorapaxar, Aspirin
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Florida
Acute Coronary Syndrome, Myocardial Infarction
Future Optimal Research and Care Evaluation
Rationale: Acute coronary syndrome (ACS) is the leading cause of death worldwide. To improve cardiovascular care, research is needed.
- Trial name
- FORCE-ACS (NCT03823547)
- Where
- 4 sites in Netherlands
- Volunteers
- 99,999 people
- Sponsor
- J.M. ten Berg
Bulbar Palsy
The Effectiveness of Stellate Ganglion Block in Managing Dysphagia in Patients With Medullary Infarction
This is a randomized controlled study, including dysphagic patients with bulbar palsy after ischemic stroke who were received in the department of rehabilitation medicine.
- Trial name
- NCT06301698
- Testing
- Comprehensive rehabilitation, Injection, Lidocaine Hydrochloride
- Volunteers
- 80 people
- Sponsor
- Ahmadu Bello University Teaching Hospital
Sleep Apnea, Obstructive, Sleep Apnea, Central
Early Sleep Apnea Treatment in Stroke
Investigating the interrelation of stroke and sleep-disordered breathing (SDB) is of major importance. First because of the high occurrence rate of stroke and the fact that it is a frequent cause of long-term disability in…
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Central, Stroke
- Trial name
- eSATIS (NCT02554487)
- Testing
- AirCurveTM10 CS PACEWAVE Adaptive-Servo-Ventilator (ResMed Ldt., Australia)
- Where
- 6 sites in France, Germany and 2 more
- Volunteers
- 201 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiovascular Diseases, Atrial Fibrillation
Pharmacogenetics and Cardiovascular Events
To assess interactions between selected cardiovascular medications and genes in the incidence of heart attack, stroke, and atrial fibrillation, an irregular heartbeat.
- Conditions
- Cardiovascular Diseases, Atrial Fibrillation, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00094198
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Stroke
Stroke Research Consortium in Northern Bavaria (STAMINA)
Each year, approximately 15 million people suffer a stroke worldwide of which 80% are due to ischemic cerebral infarction. Based on the results of randomized controlled trials, treatment options and patient outcomes in acute…
- Trial name
- STAMINA (NCT04357899)
- Testing
- thrombolysis therapy, endovascular therapy, decompressive surgery
- Where
- 2 sites in Germany
- Volunteers
- 3,769 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Nicorandil
Oral Nicorandil in ST Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
To study the effects of early oral administration of nicorandil in the setting of PPCI among STEMI patients on early angiographic, electrocardiographic, echocardiographic and hard clinical outcomes.
- Trial name
- NCT04632121
- Testing
- Nicorandil 20 MG
- Volunteers
- 300 people
- Sponsor
- Ahmed Abdel Nasser Abdel Rady
Myocardial Infarction
Gait Speed for Predicting Cardiovascular Events After Myocardial Infarction
There are growing evidences that gait speed is inversely associated with all causes mortality especially cardiovascular mortality among the elderly.
- Trial name
- NCT01484158
- Volunteers
- 450 people
- Sponsor
- Yokohama City University Medical Center
Acute Myocardial Infarction
Glycoprotein IIb/IIIa Inhibitors Versus Standard Therapy in Patients with Myocardial Infarction and No-reflow
Aim of the study is to examine the effects of glycoprotein IIb/IIIa inhibitors on reperfusion success assessed by cardiac magnetic resonance imaging in patients with myocardial infarction and angiographic evidence of no-reflow.
- Trial name
- REVERSE-FLOW (NCT02739711)
- Testing
- Glycoprotein IIb/IIIa inhibitors
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Luebeck
Acute Myocardial Infarction
Efficacy and Safety Study of Thymosin Beta 4 in Patients With Acute Myocardial Infarction
A multicenter randomized double-blind placebo parallel control design was used in this study. The 90 participants were randomly assigned to placebo, 0.5μg/kg dose group, and 1.0μg/kg dose group in a ratio of 1:1:1.
- Trial name
- NCT05984134
- Testing
- NL005 Middle Dose, NL005 High Dose
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing Northland Biotech. Co., Ltd.
Cardiovascular Diseases, Heart Diseases
Electrophysiological Effects of Late PCI After MI
The purpose of this study is to determine if opening blocked arteries with heart balloons and stents prevents heart rhythm problems in individuals 3 to 28 days after a heart attack.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Coronary Disease
- Trial name
- NCT00119847
- Testing
- PCI, Optimal Medical Therapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Maryland, Baltimore