Clinical trials: Infection, Bloodstream
Candidemia, Candidiasis, Invasive
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Fosmanogepix) for the potential treatment of candidemia and/or invasive candidiasis, a life-threatening fungal infection…
- Trial name
- NCT05421858
- Testing
- Fosmanogepix, Caspofungin, Fluconazole
- Where
- 146 sites in United States, Argentina and 18 more
- Volunteers
- 450 people
- Sponsor
- Basilea Pharmaceutica
Septic Shock, Peritonitis
Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis (EPI Study)
The main objective of this study is to describe the pharmacokinetics of the prescribed echinocandins for septic shock with secondary peritonitis for which intra-abdominal fungal infection is suspected or proven.
- Trial name
- NCT02805049
- Testing
- Echinocandins
- Where
- 2 sites in Australia, France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis, Septic Shock
NAI for Sepsis With Persistent Lymphopenia
This is a Phase 2, randomized, open-label study evaluating the safety and efficacy of nogapendekin alfa inbakicept (NAI, ANKTIVA®) in combination with standard of care versus standard of care alone in critically ill adults with…
- Conditions
- Sepsis, Septic Shock, Lymphopenia, Immunosuppression
- Trial name
- NCT07578558
- Testing
- Nogapendekin alfa inbakicept (NAI), Standard of Care (SOC)
- Volunteers
- 50 people
- Sponsor
- ImmunityBio, Inc.
Atrial Fibrillation
Magnesium Sulphate for Treatment of New Onset Atrial Fibrillation in Medical Intensive Care Unit Patient
The purpose of this study is to determine the efficacy of Magnesium sulphate for the rate and rhythm control of the new onset (within 48 hours) atrial fibrillation in the hemodynamically unstable patients, admitted in the medical…
- Trial name
- EMSAF (NCT01049464)
- Testing
- Magnesium sulphate
- Where
- Thailand
- Volunteers
- 128 people
- Sponsor
- Mahidol University
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
Impact of Arterial CO2 Tension on Management and Outcome in Patients With Acute Hypoxemic Respirator Failure and ARDS
There appears to be considerable variability in the approach physicians use to manage arterial carbon dioxide tensions, in patients in the early phases [first 48 hours] of ARDS (Acute hypoxemic respiratory failure and).
- Trial name
- CO2 LUNG SAFE (NCT03415529)
- Where
- Belgium
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- European Society of Intensive Care Medicine
Severe Sepsis, Septic Shock
Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis
The purpose of this study is to determine whether BMS-936559 is safe and has the desired pharmacologic activity in patients who have severe sepsis.
- Trial name
- NCT02576457
- Testing
- BMS-936559
- Where
- 13 sites in United States
- Volunteers
- 35 people
- Sponsor
- Bristol-Myers Squibb
Catecholamine Resistant Hypotension (CRH), Distributive Shock
Expanded Access for LJPC-501
The primary objective of the study is to provide access to LJPC-501 for distributive shock patients who remain hypotensive despite receiving fluid and vasopressor therapy.
- Conditions
- Catecholamine Resistant Hypotension (CRH), Distributive Shock, High Output Shock, Sepsis
- Trial name
- NCT03245528
- Testing
- LJPC-501
- Sponsor
- La Jolla Pharmaceutical Company
Catheter-Related Infections
Impact of Prophylactic Antibiotics on Bloodstream Infections After Liberation From Extracorporeal Membrane Oxygenation
The goal of this prospective interventional study is to evaluate the impact of antibiotic prophylaxis on bloodstream infections after liberation of extracorporeal membrane oxygenation therapy.
- Trial name
- IPANEMA-ECMO (NCT05651464)
- Testing
- Vancomycine
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Universität des Saarlandes
Malaria, Prevention and Control
Experimental PfSPZ Vaccine in Adults Without Malaria
Background: Malaria parasites are carried by mosquitoes, which spread the infection by biting people. Currently, there is no effective malaria vaccine.
- Conditions
- Malaria, Prevention and Control, Acquired Immunity
- Trial name
- NCT01441167
- Testing
- PfSPZ
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis, Bacterial Infections
Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis
As antibiotic resistance increases globally, it becomes more difficult to select empiric antibiotic therapy, particularly in patients with sepsis who stand to benefit from early adequate treatment.
- Conditions
- Sepsis, Bacterial Infections, Community-Acquired Infections, Hospital Infection
- Trial name
- IDEAS-CRXO (NCT06103500)
- Testing
- Clinical Decision Support Algorithm for Empiric Antibiotics in Sepsis
- Where
- 3 sites in Canada
- Volunteers
- 1,478 people
- Sponsor
- Ottawa Hospital Research Institute
Burns, Hemofiltration
Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure)
The purpose of this study is determine if High-Volume Hemofiltration in addition to 'contemporary' care will result in an improvement of select clinical outcomes when compared to 'contemporary' care alone in the treatment of…
- Conditions
- Burns, Hemofiltration, Kidney Failure, Acute, Shock, Septic
- Trial name
- RESCUE (NCT01213914)
- Testing
- An FDA approved continuous renal replacement device, Control Group
- Where
- 9 sites in United States
- Volunteers
- 37 people
- Sponsor
- American Burn Association
Sepsis, Coagulopathy
The Correlation Between The New Sepsis Scores - SOFA, Quick SOFA and Calibrated Automated Thrombogram Values
In total 200 subjects with diagnosis of sepsis, are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant.
- Trial name
- NCT02953002
- Testing
- Calibrated Automated Thrombogram (CAT)
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- HaEmek Medical Center, Israel
Sepsis, Septic Shock
Fluids in Septic Shock (FISSH)
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world.
- Trial name
- FISSH (NCT03677102)
- Testing
- higher chloride crystalloid, lower chloride crystalloid
- Where
- 30 sites in Canada, Saudi Arabia
- Volunteers
- 1,113 people
- Sponsor
- McMaster University
Neonatal Sepsis, Neonatal Infection
Infection, Sepsis and Meningitis in Surinamese Neonates
Suriname is a small developing country in South America with a population of half a million people. Early neonatal death in Suriname is high with 16 per 1000 live births.
- Conditions
- Neonatal Sepsis, Neonatal Infection, Neonatal Meningitis
- Trial name
- InSepSur (NCT02486783)
- Where
- Suriname
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Academic Hospital Paramaribo
Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker
Phoenixin-14 Downregulation in Sepsis
Background: Sepsis is a leading cause of morbidity and mortality in intensive care units (ICUs) worldwide, accounting for millions of deaths annually.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker, Phoenixin-14 Molecular Downregulation
- Trial name
- NCT07356739
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Firat University
Early Goal-Directed Therapy
RCT How an Online Escape Room Game Enhances Nurses' Learning Outcomes Regarding ESW Signs.
Research Objectives: Clinical trial: To develop an online escape room teaching program and instructional materials aimed at enhancing clinical nursing personnel's awareness of early sepsis warning signs, clinical reasoning…
- Trial name
- NCT06475144
- Testing
- online escape room teaching, online video-based teaching
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xin-Ning Lee
Dengue, Sepsis
Immune Responses to Dengue and Sepsis
The goal of this research study is to help the investigators better understand serious dengue disease. The investigators will collect clinical information and up to four blood samples from participants with dengue, influenza…
- Conditions
- Dengue, Sepsis, Influenza
- Trial name
- DEN-SEP (NCT07040202)
- Where
- 4 sites in Cambodia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Sepsis, Septic Shock
Clearance of Antibacterial Agents During Hemoperfusion in Patients With Sepsis
One of the significants health problems in the world is sepsis, with the number of cases reaching 20-30 million per year, according to the WHO.
- Trial name
- NCT06602245
- Where
- 4 sites in Russia
- Volunteers
- 30 people
- Sponsor
- Efferon JSC
Aortic Valve Disease, Surgery--Complications
Immune Responsiveness and Outcome After Aortic Valve Surgery (Measure)
There is considerable morbidity and mortality associated with cardiac surgery. Currently little effort is made to quantify how well the immune system of an individual can cope with inflammation or infection to which they are…
- Conditions
- Aortic Valve Disease, Surgery--Complications, Immune System Disorder
- Trial name
- Measure (NCT04430972)
- Testing
- Aortic valve replacement
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Barts & The London NHS Trust
Sepsis
Efficacy and Safety of Resatorvid in Patients With Sepsis-induced Cardiovascular and Respiratory Failure
The purpose of this study is to determine the effect of resatorvid on subjects with sepsis.
- Trial name
- NCT00633477
- Testing
- Resatorvid
- Where
- Japan
- Volunteers
- 18 people
- Sponsor
- Takeda