Clinical trials: Infection, COVID-19
Covid19
A Trial Using ANAKINRA, TOCILIZUMAB Alone or in Association With RUXOLITINIB in Severe Stage 2b and 3 of COVID19-associated Disease
COVID19-associated disease may have different clinical aspects classified in 3 stages. Some patients initially presenting with a non-hypoxemic viral pneumonia (stage 2a) may evolve toward a more severe stage 2b or 3 (acute…
- Trial name
- INFLAMMACOV (NCT04424056)
- Testing
- Anakinra +/- Ruxolitinib (stages 2b/3), Anakinra and Ruxolitinib (Advanced stage 3), Tocilizumab +/- ruxolitinib (stages 2b/3)
- Where
- France
- Volunteers
- 216 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
COVID-19
Protecting Native Families From COVID-19
The goal of this study is to increase and hasten testing among those with COVID-19 symptoms and improve adherence to recommended strategies following positive test results in high-risk groups in the White Mountain Apache and…
- Trial name
- NCT04765475
- Testing
- Motivational Interviewing, COVID-19 Symptom Monitoring System, Motivational Interviewing and COVID-19 Symptom Monitoring System
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cardiovascular Diseases
Effects of COVID-19 Pandemic on a Health Care System: Case Study of the CirculatORy System in LiThuania
Coronavirus disease of 2019 (COVID-19) affected the health care systems all around the world. The collateral damage of the pandemic on the cardiovascular (CV) care and CV mortality has been noticed and reported early.
- Trial name
- COVID-COR-LT (NCT05021575)
- Testing
- Data collection on outpatient care, Data collection on hospitalisation, Data collection on cardiovascular mortality
- Where
- 3 sites in Lithuania
- Volunteers
- 839,678 people
- Sponsor
- Vilnius University
Covid19, Covid-19 ARDS
Efficacy and Safety of Remdesivir and Tociluzumab for the Management of Severe COVID-19: A Randomized Controlled Trial
This randomized clinical trial was designed and intended to evaluate the efficacy of Remdesivir and Tocilizumab as a treatment for severe Acute Respiratory Distress Syndrome (ARDS) caused by Coronavirus disease 2019 (COVID-19).
- Trial name
- NCT04678739
- Testing
- Remdesivir, Tocilizumab
- Where
- 4 sites in Bangladesh
- Volunteers
- 205 people
- Sponsor
- M Abdur Rahim Medical College and Hospital
Post Acute Sequelae Covid-19 Hyposmia
Directed Topical Drug Delivery for Treatment for PASC Hyposmia
This is a phase II randomized, double-blinded, placebo-controlled study to evaluate the efficacy of topical intranasal treatment of beclomethasone vs. placebo for improved olfactory function.
- Trial name
- NCT05970731
- Testing
- Beclomethasone, Microsponge
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Chronic Stress, Chronic Fatigue
The Effect of the Human Regenerator Jet Device on the Quality of Life of Adult Individuals [HR-QoL]
This cross-over single-blinded study aims to evaluate the effect of a novel cold atmospheric plasma jet-producing device, the Human Regenerator Power Jet device, for individuals who suffer from chronic stress, chronic pain…
- Conditions
- Chronic Stress, Chronic Fatigue, Chronic Pain, Post-COVID / Long-COVID
- Trial name
- HR-QoL (NCT07279272)
- Testing
- Cold Atmospheric Plasma, Atmospheric Air
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Athens
Coronavirus Disease 2019
Proof of Principle Study to Evaluate the Safety, PK, Viral Shedding and Efficacy of Pentarlandir™ UPPTA for Patients With Early COVID-19
This is a clinical trial to evaluate the safety, PK, viral shedding and clinical effects of Pentarlandir™ UPPTA in patients with early COVID-19.
- Trial name
- NCT04911777
- Testing
- Pentarlandir™ UPPTA
- Where
- 12 sites in United States
- Volunteers
- 90 people
- Sponsor
- SyneuRx International (Taiwan) Corp
Covid19, Hyperactive Delirium
Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium
The primary purpose of this research is to determine whether Valproate alone, and in combination with Quetiapine, lowers confusion and agitation in persons with severe Corona Virus Disease (COVID)19 pneumonia during weaning from…
- Conditions
- Covid19, Hyperactive Delirium, Pneumonia, Viral
- Trial name
- NCT04513314
- Testing
- Valproate, Quetiapine, Standard of Care
- Sponsor
- University of Miami
Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease
Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)
This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection.
- Conditions
- Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease, Chronic Renal Failure, Coronary Artery Disease
- Trial name
- NCT04361552
- Testing
- Best Practice, Tocilizumab
- Where
- United States
- Sponsor
- Emory University
Covid19
Clinical Study Spartan COVID-19 V2 System
This multicentre prospective study will enroll a sufficient number of patients to afford approximately 60 positives and > 40 negatives (as determined by the SOC - Comparator method) in the United States and/or Canada.
- Trial name
- NCT04575168
- Testing
- Spartan COVID-19 Test
- Where
- 3 sites in United States
- Volunteers
- 81 people
- Sponsor
- Spartan Bioscience Inc.
COVID-19, Coronavirus Infections
Humeral Shaft Fractures : Outcomes of Straight Percutaneous Intramedullary Nailing With Dynamic Distal Locking
This study looks at how many healthcare workers at CHSD have developed antibodies against COVID-19 after the second and third waves of the pandemic and following vaccination.
- Conditions
- COVID-19, Coronavirus Infections, Seroprevalence, Vaccination
- Trial name
- NCT06999018
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Centre Hospitalier de Saint-Denis
2019 Novel Coronavirus Infection
Experimental Trial of rhIFNα Nasal Drops to Prevent 2019-nCOV in Medical Staff
The investigators plan to carry out an experimental study on the preventive effect of recombinant human interferon alpha nasal drops on the infection of 2019 new coronavirus in medical staff.
- Trial name
- NCT04320238
- Testing
- recombinant human interferon Alpha-1b, thymosin alpha 1
- Where
- China
- Volunteers
- 2,944 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Infertility, Female, ART
Impact of COVID-19 on Psychological Status in Case of IVF Interrupted or Postponed
Infertility is a severely distressing experience for many couples. Depression and anxiety are psychological disorders associated with infertility, and they may worsen during infertility treatments.
- Conditions
- Infertility, Female, ART, IVF, COVID-19
- Trial name
- NCT04395755
- Testing
- Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9)
- Where
- Italy
- Volunteers
- 503 people
- Sponsor
- Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia
Covid19 Related Anosmia and Aguesia
Cerebrolycin for Treatment of Covid-related Anosmia and Ageusia
The loss of smell and taste is a prominent symptom of COVID-19. Studies found that patterns of smell loss due to Covid-19 infection differ from that of other respiratory viruses being much more profound in the Covid-19 patents…
- Trial name
- NCT04830943
- Testing
- Cerebrolysin
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Assiut University
Covid19, Coronavirus Infection
Efficacy of Ivermectin in Outpatients With Non-severe COVID-19
This is a randomized controlled trial to evaluate the efficacy of ivermectin in reducing the risk of progression to severe disease and hospitalizations in COVID-19 patients.
- Trial name
- NCT04834115
- Testing
- Ivermectin Tablets
- Where
- Paraguay
- Volunteers
- 400 people
- Sponsor
- Universidad Nacional de Asunción
Covid19
Evaluation of SARS-COV-2 Viral Load of Covid-19 Patients After Rinsing With Oral Antimicrobial Mouthwashes
The aim of this study is to analyze the efficacy of oral disinfection with 0.075% Cetylpyridinium Chloride alone and 0.075% Cetylpyridinium Chloride associated with 0.28% zinc lactate in reduction of the viral load of SARS-CoV-2…
- Trial name
- NCT04902976
- Testing
- CPC+ZN, CPC, Negative Control
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Hospital Israelita Albert Einstein
COVID-19, Acute Hypoxemic Respiratory Failure
Helmet Non-Invasive Ventilation for COVID-19 Patients
Study hypothesis: Non-invasive positive pressure ventilation delivered by helmet will reduce 28-day all-cause mortality in patients with suspected or confirmed severe COVID-19 pneumonia and acute hypoxemic respiratory failure
- Trial name
- Helmet-COVID (NCT04477668)
- Testing
- Helmet non-invasive ventilation
- Where
- Saudi Arabia
- Volunteers
- 322 people
- Sponsor
- King Abdullah International Medical Research Center
Coronavirus Disease (COVID-19)
Efficacy and Safety of Molnupiravir (MK-4482) in Hospitalized Adult Participants With COVID-19 (MK-4482-001)
This study aims to evaluate the safety, tolerability and efficacy of molnupiravir (MK-4482) compared to placebo. The primary hypothesis is that molnupiravir is superior to placebo as assessed by the rate of sustained recovery…
- Trial name
- NCT04575584
- Testing
- Molnupiravir
- Where
- 89 sites in United States, Brazil and 15 more
- Volunteers
- 304 people
- Sponsor
- Merck Sharp & Dohme LLC
Covid19
Effectiveness and Safety Study of Specific Hyperimmune Equine Serum for the Treatment of Severe Hospitalized SARS-CoV-2 in Adults: Retrospective Cohort Study
An observational, retrospective, classic cohort study of adult patients hospitalized for severe pneumonia with a diagnosis of SARS-CoV-2 by RT-PCR will be carried out.
- Trial name
- NCT04954235
- Where
- Argentina
- Volunteers
- 847 people
- Sponsor
- Inmunova S.A.
COVID-19
Non Invasive Positive Pressure Ventilation to Minimize Aerosolization for COVID 19
Patients presenting to the emergency department, or needing hospitalization, for a variety of medical conditions often require non-invasive ventilation (breathing support).
- Trial name
- NCT04344925
- Testing
- Aerosol-reducing Mask, Standard Mask
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
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