Clinical trials: Infection, COVID-19
SARS-CoV-2 Infection, Acute Kidney Injury
Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection
An interventional clinical trial using oral nicotinamide riboside (NR) in hospitalized patients with COVID-19 infection and acute kidney injury to determine the effect of NR on whole blood nicotinamide adenine dinucleotide (NAD+)…
- Trial name
- NIRVANA (NCT04818216)
- Testing
- Nicotinamide riboside
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI
The overarching goal of this study is to develop PET/MR techniques for the diagnosis of neuropsychiatric post-acute sequelae (PASC) of SARS-CoV-2.
- Trial name
- NCT05615415
- Testing
- PET Tracer, MRI Tracer, 3T PET/MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
COVID-19
ApTOLL for the Treatment of COVID-19
There is a clear and urgent medical need of developing new medicinal products for COVID-19 since there are poor pharmacological tools to block the progression of patients to cytokine storm syndrome (CSS).
- Trial name
- NCT05293236
- Testing
- ApTOLL, Saline
- Where
- 4 sites in Spain
- Volunteers
- 5 people
- Sponsor
- Macarena Hernández Jiménez
Bariatric Surgery Candidate, Covid19
Obesity Surgery During 2020 Italian Pandemic
The first person-to-person Coronavirus disease (COVID-19) transmission in Italy was reported on Feb 21st, 2020, causing one of the most massive outbreak in Europe so far that stopped immediately all elective surgical procedures.
- Conditions
- Bariatric Surgery Candidate, Covid19, Complication of Surgical Procedure, Pneumonia, Viral
- Trial name
- NCT04480034
- Testing
- Bariatric procedures
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- University of Roma La Sapienza
SARS-CoV 2, COVID-19
Test and Treat COVID 65plus+
Patients over equal or older than 65 yearswill be treated with a hydroxychloroquine versus placebo reduced loading dose of 600mg on the first day followed with 400mg/day divided in 2x200mg for 6 more days resulting in a total…
- Trial name
- COVID65plus (NCT04351516)
- Testing
- Hydroxychloroquine
- Where
- 2 sites in Germany
- Sponsor
- University Hospital Tuebingen
SARS-CoV-2
A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)
The purpose of this study is to evaluate the efficacy and safety of mRNA-1283 and mRNA-1273 (variant formulations) in adults 50 to 64 years of age without high risk factors for severe COVID-19.
- Trial name
- NCT07266558
- Testing
- mRNA-1273, mRNA-1283
- Where
- 150 sites in United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Corona Virus Infection, Thromboembolic Disease
Thrombosis Risk Assessment and Clinical Presentation of Covid-19 Pneumonia
Covid-19 mainly affects the respiratory system. Multiple organ dysfunction and a particularly progressive respiratory insufficiency along with a widespread coagulopathy presumed to be due to infection-associated inflammation and…
- Trial name
- Covid-19 (NCT04423315)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Nisantasi University
Diabetes, Covid19
Diabetes Outcomes in COVID-19 Pandemic
Diabetes management and follow-up has become a challenge during the COVID-19 pandemic. Nation-wide lockdowns and social distancing measures adopted in an attempt to break the chain of COVID-19 transmission have significantly…
- Conditions
- Diabetes, Covid19, Isolation, Social
- Trial name
- NCT04573335
- Where
- Pakistan
- Volunteers
- 1,282 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Pneumonitis, Coronavirus Infection
Proflaxis Using Hydroxychloroquine Plus Vitamins-Zinc During COVID-19 Pandemia
Healthcare professionals mainly doctors, nurses and their first degree relatives (spouse, father, mother, sister, brother, child) who have been started hydroxychloroquine(plaquenil) 200mg single dose repeated every three weeks…
- Trial name
- NCT04326725
- Testing
- Plaquenil 200Mg Tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istinye University
Corona Virus Infection
Covid-19 Convalescent Plasma as Prevention and Treatment for Children With Underlying Medical Conditions
This study will provide access to investigational anti-SARS-CoV-2 human convalescent plasma for pediatric patients with underlying medical conditions (cardiovascular disease, lung disease, immunosuppression) who are either…
- Trial name
- NCT04462848
- Testing
- anti-SARS-CoV-2 human convalescent plasma
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
COVID-19 Respiratory Infection
Insight Into the UAE Experience With Monoclonal Antibodies (Sotrovimab )
Sotrovimab is a newly developed monoclonal antibody for the treatment of mild and moderate COVID-19 patient, who are at high risk for progression to severe COVID-19, including hospitalization or death.
- Trial name
- EHS-Strategy (NCT05144178)
- Where
- United Arab Emirates
- Volunteers
- 3,500 people
- Sponsor
- Emirates Health Services (EHS)
Covid19, Breathing Exercise
The Effect of Home-based Exercise on Functional Capacity of Covid-19 Survivor With Cardiovascular Comorbidity
Objective propose: to investigate the effect of home based breathing exercise and chest mobilization on the cardiorespiratory functional capacity of Covid-19 survivors with cardiovascular comorbidity.
- Conditions
- Covid19, Breathing Exercise, Cardiovascular Diseases
- Trial name
- NCT05077943
- Testing
- Breathing and chest mobilization exercises, Second phase cardiac rehabilitation
- Where
- Indonesia
- Volunteers
- 46 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
COVID-19
Heterologous Booster Study of COVID-19 Protein Subunit Recombinant Vaccine in Children 12-17 Years of Age
The goal of this clinical trial is to evaluate immune response and safety of SARS-CoV-2 subunit protein recombinant vaccine (IndoVac) as a heterologous booster dose in healthy children 12-17 years of age.
- Trial name
- NCT05727215
- Testing
- SARS-CoV-2 subunit protein recombinant vaccine
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Covid19, Pulmonary Embolism
Pulmonary Optical Coherence Tomography in COVID-19 Patients
To evaluate by intravascular OCT study the presence of microvascular pulmonary thrombosis in patients with COVID-19, high D-dimer levels and contrast CT scan negative for pulmonary thrombosis.
- Trial name
- NCT04410549
- Testing
- Optical Coherence Tomography (OCT)
- Where
- 2 sites in Brazil, Italy
- Volunteers
- 13 people
- Sponsor
- IRCCS San Raffaele
Influenza, COVID-19
Flu COVID Vaccine Views
This study addresses a critical evidence gap relevant to implementation strategies for combination vaccines in health care settings.
- Conditions
- Influenza, COVID-19, Vaccination Willingness
- Trial name
- NCT07871448
- Testing
- Survey
- Where
- 2 sites in United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- George Washington University
COVID, SARS-CoV 2
COVID-19 Immune Repertoire Sequencing
This concerns a single-center prospective interventional cohort study. Laboratory-confirmed COVID-19 patients will be asked to donate blood at at least two different timepoints.
- Conditions
- COVID, SARS-CoV 2, Corona Virus Infection, RDT
- Trial name
- IMSEQ (NCT04368143)
- Where
- Belgium
- Volunteers
- 84 people
- Sponsor
- Institute of Tropical Medicine, Belgium
COVID-19
A Randomised, Multi-centre, Double-blind, Phase 3 Study to Observe the Effectiveness, Safety and Tolerability of Molnupiravir Compared to Placebo Administered Orally to High-risk Adult Outpatients With Mild COVID-19 Receiving Local Standard of Care in South Africa
This is a multi-centre, double-blind, phase 3 study to observe the effectiveness, safety, and tolerability of molnupiravir 800 mg administered 12-hourly for five days in adult patients with mild COVID-19 at the time of enrolment…
- Trial name
- CoTeT (NCT05459532)
- Testing
- Molnupiravir 200 mg
- Where
- 4 sites in South Africa
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
COVID-19, Kidney Injury
Morphofunctional, Gene, Inflammation Molecules and Oxidative Stress Analysis in Kidney Tissue of COVID-19 Patients
The involvement of the kidneys in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the outset of the pandemic was associated with high mortality rates worldwide.
- Conditions
- COVID-19, Kidney Injury, Gene Amplification, Oxidative Stress
- Trial name
- NCT06444893
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
COVID-19, Fatigue
Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence
The pandemic caused by SARS-CoV-2 infection has resulted, in addition to the well-known acute symptoms, in the emergence of persistent, diffuse and heterogeneous symptoms referred to as persistent COVID.
- Conditions
- COVID-19, Fatigue, Distress Respiratory Syndrome, Cognitive Dysfunction
- Trial name
- DICOPERIA (NCT05629793)
- Testing
- Experimental tests
- Where
- 7 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Covid19, Follow up
Post ICU Follow up in Patients With Severe SARS-CoV-2 Infection (Covid-19)
Patients affected by new coronavirus infectious disease (COVID) were mostly hospitalized in ICU. This infection seems to cause widespread organ injury (i.e acute renal injury, neurological disorders, pulmonary embolism,…).
- Conditions
- Covid19, Follow up, Rehabilitation
- Trial name
- NCT04491214
- Testing
- quality of live assessment
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
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