Clinical trials: Infection, COVID-19
Covid19
Role of Famotidine in the Clinical Improvement of COVID-19 Patients.
This study is aimed to investigate the effect of Famotidine in the clinical recovery of COVID-19 patients. COVID19 is a worldwide pandemic. Hence SARS-CoV-2 is a novel virus; there is no specific medication against it.
- Trial name
- NCT04504240
- Testing
- Famotidine 20 MG
- Where
- 2 sites in Bangladesh
- Volunteers
- 208 people
- Sponsor
- Chattogram General Hospital
Covid19, Pneumonia
Use of a Respiratory Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Patients With Severe Confirmed COVID-19 Pneumonia
The novel coronavirus SARS-CoV-2 (COVID-19) is an emerging respiratory virus that causes pneumonia. WHO data reported admission to the intensive care unit (ICU) for 6% of patients, with a mortality rate reaching 45%.
- Trial name
- MultiCov (NCT04334850)
- Testing
- Combined use of a respiratory broad panel multiplex PCR and procalcitonin, Usual antibiotic treatment
- Where
- France
- Volunteers
- 194 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
SARS CoV 2 Infection
Recovering From COVID-19
Following the success of pilot data trialling a virtual community-based remote monitoring model, using Bluetooth enabled pulse oximeters, which demonstrated a saving of 300 bed spaces over a three week period,9 a nationwide…
- Trial name
- OVER-COVID (NCT05302960)
- Testing
- Fitbit
- Sponsor
- Imperial College London
COVID-19
SCALE-UP Utah II: Community-Academic Partnership to Address COVID-19 Conversational Agent Study
The long-term objective of SCALE-UP II is to increase the reach, uptake, and sustainability of COVID-19 testing among underserved populations.
- Trial name
- NCT05533359
- Testing
- Text-Messaging (TM), Conversational Agent (CA), Patient Navigation (PN)
- Where
- United States
- Volunteers
- 2,117 people
- Sponsor
- University of Utah
COVID-19
Predicting the Need for Intubation in Hospitalised COVID-19 Patients (PRED ICU COVID19)
One of the main challenges of the health crisis caused by the COVID-19 epidemic is the availability of beds in intensive care units (ICUs) and, more importantly, the need for invasive mechanical ventilation (IVM) because the ICUs…
- Trial name
- NCT04376879
- Testing
- Data monitoring for 48h within the first 24 hours of admission for COVID-19
- Where
- 2 sites in France
- Volunteers
- 301 people
- Sponsor
- Central Hospital, Nancy, France
COVID-19
Phase 1 Study on Bioavailability, Food Effect, and Drug-Drug Interaction of ALG-097558 Tablets in Healthy Volunteers
The aim of this multi-part Phase 1 study is to evaluate the drug-drug interaction (DDI) potential of ALG-097558 via co-administration with a P-gp substrate (dabigatran) and a CYP3A4 inhibitor/P-gp inhibitor (itraconazole).
- Trial name
- NCT06945276
- Testing
- ALG-097558, Dabigatran, Itraconazole
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19 Infection
Trial to Determine the Efficacy/Safety of Plitidepsin vs Control in Patients With Moderate COVID-19 Infection
Treatment of patients hospitalised for management of moderate COVID-19 infection
- Trial name
- Neptuno (NCT04784559)
- Testing
- Plitidepsin, Dexamethasone, Remdesivir
- Where
- 28 sites in Brazil, Bulgaria and 6 more
- Volunteers
- 205 people
- Sponsor
- PharmaMar
Osteoarthritis
COVID-19 in Osteoarthritis Patients
While the coronavirus pandemic has spread rapidly around the world, it has generated a considerable degree of fear, concern and anxiety among the population in general and among certain groups in particular, such as older…
- Trial name
- NCT04791462
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Glaucoma, Depression
Impact of Breathing Exercises and Meditation on Improving Quality of Life in Glaucoma Patients
Glaucoma is a chronic disease that causes loss of vision and potentially blindness as a result of optic nerve damage, often due to increased intraocular pressure.
- Conditions
- Glaucoma, Depression, Anxiety, Quality of Life
- Trial name
- NCT05960513
- Testing
- Breathing Exercises followed by Meditation
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Long COVID
Effect of Metformin in Reducing Fatigue in Long COVID in Adolescents
Long Covid is a multisystem condition comprising often severe symptoms that follow a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
- Trial name
- REVIVE (NCT06147050)
- Testing
- Metformin
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Purpose Life Sciences
Coronavirus Disease 2019, Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2
Study of Varespladib in Patients Hospitalized With Severe COVID-19
This is a 2-part, multi-center, randomized, double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability, and efficacy of oral varespladib, in addition to standard of care, in patients…
- Trial name
- STAIRS (NCT04969991)
- Testing
- Varespladib
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- Ophirex, Inc.
COVID-19
A Clinical Trial of Mycobacterium w in Critically Ill COVID 19 Patients
The trial is randomized, blinded, two arms, active comparator controlled, clinical trial to evaluate the safety and efficacy of Mycobacterium w in combination with standard care as per hospital practice versus standard care alone…
- Trial name
- NCT04347174
- Testing
- Suspension of heat killed (autoclaved) Mycobacterium w
- Where
- 4 sites in India
- Volunteers
- 40 people
- Sponsor
- Cadila Pharnmaceuticals
SARS-CoV-2 Infection, COVID-19
Effect of COVID-19 Lockdown on Alcohol and Tobacco Use in Two Chilean Universities
This is a longitudinal study of participants from two university communities in Chile. The primary objective is to examine the effect of a regional lockdown on alcohol and tobacco use, using a difference-in-difference analysis to…
- Trial name
- NCT05069090
- Testing
- Lockdown and other social distancing measures
- Where
- 2 sites in Chile
- Volunteers
- 1,038 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
COVID-19 Pandemic, Morality
Evaluation of Corticosteroids Use and Clinical Outcomes in Hospitalized COVID-19 Patients: A Retrospective Study
Despite the recommendations to avoid using corticosteroids systematically for hospitalized coronavirus disease of 2019 (COVID-19) patients, healthcare professionals used personalized treatments, including corticosteroids, as…
- Trial name
- NCT05844410
- Testing
- Corticosteroid
- Where
- Lebanon
- Volunteers
- 422 people
- Sponsor
- Lebanese University
Covid19
The Canadian COVID-19 Prospective Cohort Study
The CANCOV study will be the first Canadian study to provide a comprehensive evaluation of early, and 1-year, outcomes of outpatient and hospitalized COVID-19 survivors and their family caregivers, their varied trajectories and…
- Trial name
- CANCOV (NCT05125510)
- Where
- 14 sites in Canada
- Volunteers
- 2,176 people
- Sponsor
- University Health Network, Toronto
Covid-19, Sars-CoV2
Safety and Efficacy of Viusid and Asbrip in Hospitalized Patients Infected by SARS-Cov-2 With COVID-19
This is a two-arm, open-label, randomized, phase 2, controlled center study to assess the safety and efficacy of Viusid and Asbrip in patients with mild to moderate symptoms of respiratory disease caused by 2019 coronavirus…
- Conditions
- Covid-19, Sars-CoV2, Diabete Mellitus, Cardiopathy
- Trial name
- NCT04407182
- Testing
- Viusid and Asbrip
- Where
- Ecuador
- Volunteers
- 60 people
- Sponsor
- Catalysis SL
COVID-19, Viral Respiratory Illnesses
Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Pre- and Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers and Others at Increased Risk of SARS-CoV-2 Infection
Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Pre- and Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers and Others at Increased Risk of SARS-CoV-2…
- Trial name
- NCT04359680
- Testing
- Nitazoxanide, Vitamin Super B-Complex
- Where
- 26 sites in United States
- Volunteers
- 1,407 people
- Sponsor
- Romark Laboratories L.C.
Long COVID, COVID-19
CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19
The goal of this proof-of-concept clinical trial is to determine whether cardiac rehabilitation improves exercise capacity and chronotropic (heart rate) response to exercise among people with Long COVID.
- Trial name
- CARE BEAR-LC (NCT05530317)
- Testing
- Cardiac Rehabilitation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, San Francisco
COVID-19
COVID-19 Vaccination Using a 2nd Generation (E1/E2B/E3-Deleted) Adenoviral-COVID-19 in Normal Healthy Volunteers
This is a phase 1b, open-label study in adult healthy subjects. This clinical trial is designed to assess the safety, reactogenicity, and immunogenicity of the hAd5-S-Fusion+N-ETSD vaccine and select a dose for future studies.
- Trial name
- NCT04591717
- Testing
- hAd5-S-Fusion+N-ETSD vaccine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- ImmunityBio, Inc.
COVID-19, Myocardial Injury
Joint Use of Electrocardiogram and Transthoracic Echocardiography With Other Clinico-biological Parameters in an Observational Study to Monitor Cardio-vascular Events and Predict Outcomes in Patients Diagnosed With COVID-19
COVID-19 outbreak is often lethal. Mortality has been associated with several cardio-vascular risk factors such as diabetes, obesity, hypertension and tobacco use.
- Conditions
- COVID-19, Myocardial Injury, Myocarditis
- Trial name
- JOCOVID (NCT04320017)
- Testing
- Electrocardiogram, transthoracic echocardiography and clinico-biological parameters in routine care
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
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