Clinical trials: Infection, Surgical Site
Inguinal Hernia, Hydroceles
Prevention of Surgical Site Infection in Open Paediatric Groin Surgeries Using Intravenous Prophylactic Antibiotics and Antimicrobial-coated Sutures
The goal of this clinical trial is to learn if the use of prophylactic antibiotics and antimicrobial-coated sutures can prevent surgical site infection in children undergoing open groin surgeries.
- Conditions
- Inguinal Hernia, Hydroceles, Surgical Site Infection
- Trial name
- NCT07346742
- Testing
- Antimicrobial-coated sutures, Intravenous Cefuroxime
- Where
- Nigeria
- Volunteers
- 174 people
- Sponsor
- Olawumi Olajide
Incisional Hernia/Prevention and Control, Surgical Site Infection (SSI)
Comparison of Small-bite Versus Conventional Midline Fascial Closure in Abdominal Surgeries
This study investigates how different incision and fascial closure (suture) techniques used in abdominal surgery are associated with the development of incisional hernia, a common long-term complication after laparotomy.
- Trial name
- NCT07340918
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Staphylococcus Aureus Colonization, Surgical Site Infections
Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
The purpose of the study is to determine the effectiveness, safety, and health-care utilization and costs of a preoperative Staphylococcus aureus (SA) screening and decolonization bundle, (5 days of nasal mupirocin ointment…
- Conditions
- Staphylococcus Aureus Colonization, Surgical Site Infections, Healthcare Associated Infections
- Trial name
- NCT06378359
- Testing
- Screening and decolonization for SA carriers with the 3 drug bundle, No screening for SA, no screening
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Minnesota
Surgical Site Infection, Cesarean Section; Infection
Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections
This will be a single-center randomized control trial comparing the efficacy of two different formulations of Chlorhexidine surgical skin preparation in preventing cesarean section wound infections.
- Trial name
- NCT05920122
- Testing
- 2% Chlorhexidine gluconate with 70% alcohol, 4% Chlorhexidine Gluconate aqueous solution
- Where
- United States
- Volunteers
- 1,398 people, healthy volunteers welcome
- Sponsor
- Hyagriv Simhan
Surgical Site Infection, Dementia
Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial
Prophylactic TxA administration in patients undergoing major gastrointestinal surgery reduces the incidence of delirium after surgery when compared with placebo.
- Conditions
- Surgical Site Infection, Dementia, Cognition
- Trial name
- TRIGS-D (NCT05470816)
- Testing
- Tranexamic Acid 100Mg/ml Inj Vial 10ml
- Where
- Australia
- Volunteers
- 826 people
- Sponsor
- Bayside Health
Surgical Site Infection
Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation
A surgical site infection (SSI) is an infection that occurs after a surgical procedure. Despite a variety of infection prevention strategies, SSIs still occur often and impose a significant burden on patients and the healthcare…
- Trial name
- NCT04548661
- Testing
- Intraoperative incisional wound irrigation with povidone-iodine solution, Intraoperative incisional wound irrigation with saline
- Where
- 13 sites in Canada
- Volunteers
- 2,701 people
- Sponsor
- Sunnybrook Health Sciences Centre
Incisional Hernia, Surgical Site Infection
Prophylactic Mesh Reinforcement for Stoma Closure
In the current work we are aiming to compare between the mesh-reinforced stoma closure and the anatomical closure in terms of the risk of developing surgical site incisional hernia (SSIH),incidence of surgical site infection …
- Conditions
- Incisional Hernia, Surgical Site Infection, Postoperative Pain, Hospital Stay, Length of Stay in Hospital From Surgery to Discharge
- Trial name
- OASIS (NCT06157645)
- Testing
- Prolene mesh
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Assiut University
Chronic Pain, Wound Dehiscence
Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure
This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy.
- Conditions
- Chronic Pain, Wound Dehiscence, Surgical Site Infection (SSI), Incisional Hernia
- Trial name
- PolySuture (NCT07280975)
- Testing
- Polyglactin 910 (Vicryl) Suture, Polypropylene (Prolene) Suture
- Where
- Pakistan
- Volunteers
- 156 people
- Sponsor
- Lady Reading Hospital, Pakistan
Post-Operative Wound Infection, Surgical Site Infection
Cutibacterium Acnes: Triple Prevention in Shoulder Operations
Patients planned for shoulder surgery will be identified and contacted for participation. After informed consent is provided, patients will be randomised into one of three groups: pre-operative cutaneous disinfection with iodine…
- Trial name
- C3PO (NCT05701475)
- Testing
- Subcutaneous disinfection, Benzoyl peroxide preparation
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Clinique Générale dAnnecy
Peritonitis, Surgical Site Infection
NPWT vs Primary Closure in SSI Prevention for Emergency Laparotomies for Peritonitis
The study aims to evaluate the efficacy of negative pressure wound therapy (NPWT) compared with primary closure (PC) in surgical site infection (SSI) prevention for laparotomy for peritonitis.
- Conditions
- Peritonitis, Surgical Site Infection, Infections, Wound Infection
- Trial name
- PRISTINE (NCT05684198)
- Testing
- subcutaneous NPWT
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Gdansk
Pancreatectomy, Pancreatic Surgery
PAN-ICIS Study: ICIS for Early Detection of Infectious Complications in Pancreatic Surgery
This study examines a new blood test called ICIS, which may help detect infections earlier after pancreatic surgery. Patients will have routine blood samples taken during their hospital stay, with no extra procedures required.
- Conditions
- Pancreatectomy, Pancreatic Surgery, Intensive Care (ICU), Inflamatory Markers
- Trial name
- PAN-ICIS (NCT07248527)
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Charles University, Czech Republic
Surgical Site Infection
Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections
This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to…
- Trial name
- NCT06363877
- Testing
- Povidone-Iodine, Normal Saline
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- Loma Linda University
Surgery, Surgical Site Infection
Efficacy of an Intervention to Improve the Preoperative Shower in Scheduled Surgery
The aim of the project is to evaluate the effectiveness, on the skin cleanliness of the patient on arrival at the operating room, of an intervention aimed at improving the performance of the preoperative shower, for patients…
- Trial name
- PRODOUCH'OP (NCT04820075)
- Testing
- improvement of preoperative shower
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Rouen
Surgical Site Infection
Prophylactic Effects for Preventing Surgical Site Infection in Third Molar Surgery
The purpose of this study is to determine the incidence of surgical site infection (SSIs) after third molar surgery for different duration of intravenous ampicillin administration.
- Trial name
- NCT06368102
- Testing
- Ampicillin
- Where
- Japan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Uji Takeda Hospital
Fractures, Open, Fractures, Closed
LOQTEQ® Antibacterial Pre-Market Study
aap001 is a randomized, controlled, subject-blinded, multi-center study to show the safety of the LOQTEQ® antibacterial silver-coated system is non-inferior in comparison with the uncoated LOQTEQ® system
- Conditions
- Fractures, Open, Fractures, Closed, Surgical Site Infection, Fracture of Fibula
- Trial name
- NCT05260463
- Testing
- Implantation
- Where
- 13 sites in Germany
- Volunteers
- 203 people
- Sponsor
- aap Implantate AG
Surgical Site Infection, Colon Surgery
Gut Decolonisation With Neomycin/Metronidazole or Rifaximin Before Colon Surgery
The goal of this clinical trial is to find out if a gut cleaning using Rifaximin works as well as the usual treatment with Neomycin and Metronidazole to prevent infections after colon surgery.
- Conditions
- Surgical Site Infection, Colon Surgery, Surgical Site Infections
- Trial name
- NeoRiDe (NCT07180615)
- Testing
- Rifaximin (Xifaxan), Metronidazole, Neomycin Sulfate
- Where
- 4 sites in Switzerland
- Volunteers
- 458 people
- Sponsor
- Universität Luzern
Surgical Site Infections, Lumbar Disc Herniation
The Effect of Number of Showers With 4% Chlorhexidine Gluconate on Prevention of Surgical Site Infections
Surgical site infections (SSIs) are the most common type of nosocomial infection in surgical departments. Although lumbar disc herniation (LDH), which is one of the common cases in neurosurgery, is a serious problem affecting…
- Trial name
- SSI (NCT06801275)
- Testing
- 1 shower with 4% chlorhexidine gluconate, 2 shower with 4% chlorhexidine gluconate
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
S. Aureus Transmission, Surgical Site Infection
Reducing Perioperative S. Aureus Transmission Via OR PathTrac
Healthcare-associated infections (HAIs) occur frequently and are associated with patient harm. It is important that healthcare facilities take the necessary steps to prevent the spread of resistant bacteria.
- Trial name
- NCT04657185
- Testing
- OR PathTrac Feedback Optimization
- Where
- United States
- Volunteers
- 804 people
- Sponsor
- Georgetown University
Surgical Site Infection
AI Algorithm for Surveillance of Deep Surgical Site Infections After Elective Colorectal Surgery.
Epidemiological surveillance is one of the eight core components of the World Health Organization Infection Prevention and Control Programmes. These include surveillance programmes for surgical site infection (SSI).
- Trial name
- Infect-IA-2 (NCT07130656)
- Testing
- Diagnosis of SSI
- Where
- Spain
- Volunteers
- 1,200 people
- Sponsor
- Hospital de Granollers
Surgical Site Infection
ChatGPT-4 for Surgical Site Infection Detection From Electronic Health Records After Colorectal Surgery.
Epidemiological surveillance is one of the eight core components of the World Health Organization Infection Prevention and Control Programmes. These include surveillance programmes for surgical site infection (SSI).
- Trial name
- Infect-IA-3 (NCT06626399)
- Testing
- Diagnosis of SSI
- Where
- Spain
- Volunteers
- 1,100 people
- Sponsor
- Hospital de Granollers