Clinical trials: Infection Hip
Infection, Hip Joint Replacement
Cementless One-stage Revision of the Chronic Infected Hip Arthroplasty
The investigators hypothesise that cementless one-stage exchange revision surgery can be performed in patients with chronically infected hip replacement with substantial benefits for the patients, in terms of fast rehabilitation…
- Trial name
- CORIHA (NCT01015365)
- Testing
- Cementless one-stage surgical revision
- Where
- 8 sites in Denmark
- Volunteers
- 56 people
- Sponsor
- University of Aarhus
Bone and Joint Infection, Bacterial Infections
Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection
This study concerns patients having had an infection on their prosthesis (hip, knee,..) and for whom a 2-step exchange of prosthesis has been done.
- Conditions
- Bone and Joint Infection, Bacterial Infections, EPIDEMIOLOGY
- Trial name
- NCT03627000
- Testing
- failure after reimplantation
- Volunteers
- 114 people
- Sponsor
- Hospices Civils de Lyon
Infection, Arthroplasty
Effect of Prophylactic Antibiotics on Intra-Operative Culture Results
Subjects will be consented and then determined randomly whether they will receive antibiotics prior to their surgery or during their surgery.
- Trial name
- NCT01174212
- Testing
- Prophylactic Antibiotics, Control Antibiotics
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Rush University Medical Center
Prosthetic Joint Infection
Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI)
This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.
- Trial name
- ACTIVE2 (NCT05269134)
- Testing
- Bacteriophage
- Where
- 10 sites in United States
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Prosthesis-related Infections
European Prosthetic Joint Infection Cohort Study- Hip, Knee and Shoulder Prosthetic Joint Infection
The purpose of the study is to compare different approaches for the treatment of prosthetic joint revisions and to optimize the outcomes in patients with prosthetic joint infections (PJI) by improving the treatment concept of PJI.
- Trial name
- EPJIC (NCT02424903)
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Pro-Implant Foundation
Surgical Site Infection, Hip Fractures
Wound Contamination During Orthopaedic Surgery
In the present study we will compare bacteriological findings and the incidence of SSI in relation to laminar airflow (LAF) ventilated ORs, conventional (also called displacement or mixed) ventilated ORs and conventional…
- Conditions
- Surgical Site Infection, Hip Fractures, Orthopedic Disorder, Implant Infection
- Trial name
- Clean Care (NCT04676841)
- Testing
- Conventional ventilation + instrumental tables with integrated laminar airflow, Conventional ventilation + standard instrumental tables, Laminar airflow ventilation + standard instrumental tables
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Vastra Gotaland Region
Total Hip Arthroplasty (THA), Antibiotic Prophylaxis
Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.
Prosthetic Joint Infection (PJI) is a significant issue in joint replacement surgeries, causing additional surgeries and substantial healthcare costs.
- Conditions
- Total Hip Arthroplasty (THA), Antibiotic Prophylaxis, Revision Arthroplasty, Total Knee Arthroplasty
- Trial name
- REVISE (NCT07053943)
- Where
- Netherlands
- Volunteers
- 70,000 people
- Sponsor
- JointResearch
Prosthetic Joint Infection
Bacteriophage Therapy in Patients With Prosthetic Joint Infections
This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.
- Trial name
- NCT04787250
- Testing
- Phage Therapy, Two-Stage Exchange Arthroplasty
- Where
- United States
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Osteomyelitis, Bone Infection
Clinical Effectiveness of S53P4 Bioactive Glass in Treatment of Long-bone Chronic Osteomyelitis
This clinical trial studies the clinical effectiveness of S53P4 bioactive glass (BAG) as a bacterial growth inhibiting bone graft substitute in a one-stage or two-stage surgical procedure for treatment of chronic long bone…
- Conditions
- Osteomyelitis, Bone Infection, Non-Union Fracture, Bone Infection of Lower Leg
- Trial name
- NCT04945434
- Testing
- S53P4 bioactive glass (BonAlive)
- Volunteers
- 78 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Arthroplasty, Hip Replacement, Infection, Postoperative Wound
Efficacy of Surgical Skin Preparation Solutions in Hip Arthroplasty Surgery
This study will assess the efficacy of two of the most commonly used surgical skin-preparation solutions: Chloraprep (chlorhexidine-alcohol) and Duraprep (iodine-alcohol) at eliminating bacteria from the hip site by evaluating…
- Trial name
- NCT03393819
- Testing
- DuraPrep, ChloraPrep
- Volunteers
- 105 people
- Sponsor
- Lakehead University
Peri-Prosthetic Joint Infection
IP-coated Revision Hip Implants
The primary aim of the clinical investigation is to demonstrate the efficacy of a silver-based antimicrobial coating on hip implants in the reduction of periprosthetic infections in revision hip arthroplasty due to periprosthetic…
- Trial name
- HIPrevision (NCT06737809)
- Testing
- IP Plasmafit® Revision cup (and stem) system
- Where
- 2 sites in Germany, Poland
- Volunteers
- 268 people
- Sponsor
- Aesculap AG
Hip Osteoarthritis, Knee Osteoarthritis
Acceptance and Commitment Therapy Delivered by Automated Software Messaging
This study aims to 1) observe the course of pain, 2) mental status, and 3) possible effect of a behavioral intervention delivered via an automated mobile phone messaging robot in patients were indicated and/or scheduled to…
- Conditions
- Hip Osteoarthritis, Knee Osteoarthritis, Mental Stress, Coronavirus
- Trial name
- NCT04329897
- Testing
- Software Messaging
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Infections Joint Prosthetic
Egyptian Arthroplasty Surgeons' Antibiotics Usage Awareness
Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are procedures successfully applied to manage various end-stage chronic hip and knee diseases, such as osteoarthritis, rheumatoid arthritis, and femoral head…
- Trial name
- NCT06451224
- Testing
- Questionnaire
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- South Valley University
Infection
The Effect of Oral Antibiotics on Synovial Fluid and Differential for the Diagnosis of Infection
Periprosthetic joint infection following total hip or knee arthroplasty is a rare but potentially devastating complication. Accurate diagnosis of these infections remains one of the most challenging undertakings in orthopaedics.
- Trial name
- NCT03551847
- Testing
- Antibiotic, No antibiotics
- Where
- United States
- Sponsor
- Rush University Medical Center
Infection and Inflammatory Reaction
Pending Failure in Hard-hard Total Hip Arthroplasty
During last 6 years approximately 10.000 ceramic balls and 5.000 ceramic liners have been implanted in the region Emilia-Romagna in Italy (4 million Every single year approximately 60.000 hip prostheses are implanted in Italy.
- Trial name
- PF (NCT02427984)
- Testing
- Metal ions dosage and evaluation of local/systemic reaction, Noise registration and metal ions determination, Metal ions dosage, evaluation of local/systemic reaction, noise registration
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- Istituto Ortopedico Rizzoli
Degenerative Osteoarthritis, Rheumatic Arthritis
CoreHip - Post Market Clinical Follow-Up Study
The study is designed as a prospective, non-interventional multicentre cohort study. The product under Investigation will be used in Routine clinical practice and according to the authorized Instructions for Use (IfU).
- Conditions
- Degenerative Osteoarthritis, Rheumatic Arthritis, Fractures, Hip, Necrosis, Femur Head
- Trial name
- NCT03685110
- Testing
- CoreHip Total Hip Arthroplasty
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 248 people
- Sponsor
- Aesculap AG
Acute Pediatric Septic Hip Infection
Use of Arthroscopy in Treatment of Acute Pediatric Septic Hip Infection
Acute septic hip infection in pediatric population is a true orthopedic surgical emergency that require early diagnosis and prompt management.
- Trial name
- NCT06505720
- Testing
- Arthroscopic management of acute pediatric septic hip infecion, Open debridement of acute pediatric septic hip
- Volunteers
- 62 people
- Sponsor
- Hesham Mohamed Elbaseet
Total Hip Replacement, Arthroplasty Complications
REVISITS: Revision Single or Two Stage Surgery
Hip replacement surgery is common, with over 60,000 cases in Canada annually. After hip replacement, about 1-2% patients develop a deep infection in their artificial hip implant, called a periprosthetic joint infection (PJI).
- Trial name
- REVISITS (NCT03741296)
- Testing
- Single stage revision, Two-stage revision
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Infection of Total Hip Joint Prosthesis, Implants
Immunology of Failing Metal-on-Metal Hip Replacement
Metal-on-metal total hip replacement (MoM THR) has been targeted at younger patients with anticipated long-term survival since the bearing surfaces wear less than the traditional metal-on-plastic (MoP) replacements.
- Trial name
- NCT01517737
- Where
- 2 sites in United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Anemia, Hematologic Diseases
Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease
The purpose of this study is to compare liberal red blood cell transfusion therapy with restrictive red blood cell transfusion therapy in surgical patients with cardiovascular disease or risk factors.
- Conditions
- Anemia, Hematologic Diseases, Cardiovascular Diseases, Heart Diseases
- Trial name
- FOCUS (NCT00071032)
- Testing
- Liberal (10 g/dL) Transfusion Strategy, Restrictive (Symptomatic) Transfusion Strategy
- Where
- United States
- Volunteers
- 2,016 people
- Sponsor
- Rutgers, The State University of New Jersey