Clinical trials: Infection Prevention
Urinary Tract Infection, Asymptomatic Bacteriuria
Perioperative Fosfomycin in the Prophylaxis of Urinary Tract Infection in Kidney Transplant Recipients
A clinical controlled, randomized and double blind trial that included adult patients (≥18 years) receiving kidney transplantation (KT) at the INCMNSZ.
- Trial name
- PERIFOS (NCT03235947)
- Testing
- Fosfomycin disodium, Trimethoprim / Sulfamethoxazole
- Where
- Mexico
- Volunteers
- 82 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Central Nervous System Infections
Effect of a Bundle of Interventions on the Outcomes of Patients With Intracranial Devices (ICP Monitor e EVD)
Non-randomized clinical trial conducted in the adult ICUs of Brazilian hospitals participating in the IMPACTO MR Platform, involving adult patients using an intracranial pressure monitoring catheter device or external ventricular…
- Trial name
- NCT06412549
- Testing
- Health care practices and routines
- Volunteers
- 1,300 people
- Sponsor
- Beneficência Portuguesa de São Paulo
HIV Infections
Education Program to Promote Female Condom Use
The female condom offers women a potentially important option for HIV prevention. This study will develop and evaluate a health education program to increase female condom use among ethnically diverse women.
- Trial name
- NCT00062634
- Testing
- Female condom skills training
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV Preexposure Prophylaxis
Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024)
The main purpose of the study is to evaluate the safety and tolerability of oral Islatravir (ISL) once monthly (QM) as Preexposure Prophylaxis (PrEP) in cisgender men who have sex with men (MSM) and transgender women (TGW) who…
- Trial name
- Impower-024 (NCT04652700)
- Testing
- ISL, FTC/TDF, FTC/TAF
- Where
- 25 sites in United States, Brazil and 5 more
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Safety of the CytaCoat LIP Foley Catheter, Tolerability of the CytaCoat LIP Foley Catheter
Evaluation of Safety and Performance of the CytaCoat Lubricious Infection Prevention (LIP) Foley Catheter
The goal of this pilot safety and tolerability study is to determine whether the novel CytaCoat LIP (Lubricious Infection Prevention) Foley catheter is safe to use in patients during short term use.
- Trial name
- NCT06242600
- Testing
- Drainage of the bladder by indwelling Foley catheter
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- CytaCoat AB
HIV, Homosexuality
Factors Affecting the Intention to Take nPEP Among Thai MSM
The potential participants will be informed of the study details, including the study objectives. Once they have read the study information sheet and have a good understanding of the study, those who intend to participate in the…
- Trial name
- NCT02107911
- Where
- Thailand
- Volunteers
- 450 people
- Sponsor
- SEARCH Research Foundation
Human Papillomavirus Infection, Human Papillomavirus-Related Cervical Carcinoma
Comparing One or Two Doses of the Human Papillomavirus Vaccine for the Prevention of Human Papillomavirus Infection, ESCUDDO Study
This phase IV trial investigates whether one dose of a human papillomavirus vaccine works as well as two doses in preventing human papillomavirus (HPV) infection. Certain types of HPV cause almost all cases of cervical cancer.
- Trial name
- ESCUDDO (NCT03180034)
- Testing
- Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed, Questionnaire Administration, Recombinant Human Papillomavirus Bivalent Vaccine
- Where
- Costa Rica
- Volunteers
- 27,945 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Surgical Site Infection
Air Barrier System for the Prevention of Surgical Site Infection
Airborne particles are present in all indoor environments including the operating room. Most of these particles come from the surgical staff moving around in the room, positioning of the patient during surgery, and the movement…
- Trial name
- ABS (NCT01610271)
- Testing
- Air Barrier System
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Nimbic Systems, LLC
HIV Prevention, HIV Infections
Rectal Microbicide Safety and Acceptability Trial of Topically Applied Tenofovir Compared With Oral Tablet
To date, the majority of microbicide research has focused on the assessment of the safety and effectiveness of vaginal microbicides used for the prevention of HIV transmission via the vaginal compartment.
- Trial name
- RMP02-MTN006 (NCT00984971)
- Testing
- Tenofovir, Open label tenofovir tablet
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- CONRAD
Hospital-acquired Pneumonia
0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia
Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among…
- Trial name
- NCT04403971
- Testing
- 0.12% Chlorhexidine Oral Liquid Product, Listerine Oral Liquid Product, Normal Saline Product
- Where
- Taiwan
- Volunteers
- 103 people
- Sponsor
- National Cheng-Kung University Hospital
Viral Infection
ARMS - Rapidly Generated Multivirus-Specific CTLs for Prophylaxis & Treatment of EBV, CMV, Adenovirus, HHV6 & BK Virus
The subjects eligible for this trial have a type of blood cell cancer, other blood disease or a genetic disease for which they will receive a stem cell transplant.
- Trial name
- ARMS (NCT01570283)
- Testing
- Multivirus-specific T cells Dose Level 1, Multivirus-specific T cells Dose Level 2, Multivirus-specific T cells Dose Level 3
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- AlloVir
Sexually Transmitted Infection, Hiv
A Comprehensive HIV Prevention Package for South African Adolescent Girls and Young Women: IMARA SA
Programs which go beyond individual-level behavior change to reduce HIV and STI infections among adolescent girls and young women in sub-Saharan Africa are essential to meet global HIV targets.
- Trial name
- IMARA-SA pilot (NCT05504954)
- Testing
- IMARA-SA (intervention group), Health promotion control group
- Where
- South Africa
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Endophthalmitis
Evaluation of Efficacy and Safety of Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis.
There has thus far been only one randomized and masked clinical trial in the world to evaluate the efficacy of the intraoperative intracameral injection of antibiotics with the objective of preventing endophthalmitis following…
- Trial name
- NCT02770729
- Testing
- Moxifloxacin, No injection of moxifloxacin
- Where
- Brazil
- Volunteers
- 3,640 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Surgical Wound Infection, Surgical Site Infection
Assessing Parenteral Antibiotics Versus Single-time Intra-operative Intra-dermal Antibiotic Administration for Prevention of SSI
The purpose of the study is to study the incidence of surgical site infection when patients are given local versus parenteral antibiotics
- Trial name
- NCT04975945
- Testing
- Ceftriaxone Sodium
- Where
- India
- Sponsor
- The Grant Medical College & Sir J.J. Group of Hospitals
Papillomavirus Infections, Uterine Cervical Neoplasms
Improving HPV Vaccination Coverage Among Adolescent Girls in Mali and Côte d'Ivoire Through Community Health Worker Follow-up
The goal of this trial is to learn if a community health worker (CHW) follow-up program can improve HPV vaccination coverage among adolescent girls in Mali and Côte d'Ivoire.
- Trial name
- NCT07807202
- Testing
- HPV vaccination pro-active community-based follow-up model, Standard community mobilization
- Where
- 2 sites in Côte d’Ivoire, Mali
- Volunteers
- 17,188 people
- Sponsor
- Arsène Brunelle Sandie
Urinary Tract Infections, Urinary Tract Infection (UTI)
Alternative Prophylaxis in Female Recurrent Urinary Tract Infections
Urological pathogens are effected by rising antimicrobial resistance rates due to the frequent use of antimicrobials for treatment and prophylaxis.
- Trial name
- AlP-FrUiT (NCT04095572)
- Testing
- intravesical instillation with HA-CS, intravesical instillation of sterile purified water
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Complicated Intraabdominal Infections
CABI: Antibiotic Duration for Complicated Intra-ABdominal Infection
Complicated intra-ABdominal Infections (CABIs) are abdominal infections where there is an abscess inside the abdomen, or a hole (perforation) in an abdominal organ such that infected material e.g.
- Trial name
- CABI (NCT03265834)
- Testing
- < 10 days of antibiotics, 28 days of antibiotics
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Leeds
Post-exposure Prophylaxis, Sexually Transmitted Diseases
Pharmacokinetic Characterization of a Single 200 mg Dose of Doxycycline in Post-exposure Prophylaxis (PEP) of Sexually Transmitted Infections in Different Biological Compartments
Post-exposure prophylaxis (PEP) using doxycycline 200 mg within 24 hours of unprotected sexual intercourse to prevent sexually transmitted infections has demonstrated a reduction in the incidence of chlamydial and syphilis…
- Conditions
- Post-exposure Prophylaxis, Sexually Transmitted Diseases, Doxycycline
- Trial name
- DOXY-PK (NCT06007534)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections
An Affect Management Intervention for Juvenile Offenders
Adolescents are at risk for HIV because of sexual and drug behavior initiated during this developmental period. Adolescents in the juvenile justice system are at increased risk for HIV due to higher rates of substance use and…
- Trial name
- NCT00748800
- Testing
- Affect Management, General Health Promotion
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Covid19
Prophylaxis for COVID-19: Ivermectin in Close Contacts of COVID-19 Cases (IVERNEX-TUC)
Randomized controlled clinical trial on using oral ivermectin in COVID-19 prophylaxis supplying the drug to close contacts of confirmed cases.
- Trial name
- IVERNEX-TUC (NCT04894721)
- Testing
- Ivermectin
- Where
- Argentina
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Ministry of Public Health, Argentina