Clinical trials: Infection Prophylaxis
Infertility, Female, Recurrent Implantation Failure
Short Course Rifapentine and Isoniazid for the Preventive Treatment for Latent Genital Tuberculosis
The purpose of this study is to assess the efficacy, safety and tolerability of the 1-month regimen of three times weekly rifapentine plus isoniazid in improving fertility outcome in recurrent implantation failure (RIF) patients…
- Conditions
- Infertility, Female, Recurrent Implantation Failure, Genital Tuberculoses, Female, Genital Tuberculosis, Latent
- Trial name
- SCRIPT-LGTB (NCT04528277)
- Testing
- rifapentine plus isoniazid
- Where
- China
- Volunteers
- 1,050 people
- Sponsor
- Huashan Hospital
COVID-19 Respiratory Infection, SARS-CoV-2 Acute Respiratory Disease
Photodynamic Therapy for COVID-19 Prevention
This is a single-center open-label study to evaluate antimicrobial photodynamic therapy (aPDT) for upper airway decolonization in patients presenting with SARS-CoV-2 positive antigen test with mild or no symptoms of COVID-19.
- Trial name
- NCT05184205
- Testing
- Nasal Photodisinfection
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Ondine Biomedical Inc.
HIV Infections
Effectiveness of Communication Technology in Disseminating HIV Prevention Training to Non-governmental Organizations
This study will compare the effectiveness of face-to-face training versus Web-based training seminars in disseminating HIV prevention interventions to nongovernmental organizations in Eastern Europe and Central Asia.
- Trial name
- NCT00698529
- Testing
- Face-to-face training, Distance training, Popular Opinion Leader (POL)
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Covid19
Prophylaxis of COVID-19 Disease With Ivermectin in COVID-19 Contact Persons [German: Prophylaxe Der COVID-19-Erkrankung Mit Ivermectin Bei COVID-19 Kontaktpersonen]
The Prevent-COVID study is a prospective, multicenter, randomized, two-armed, placebo-controlled, double-blind, interventional study in which the efficacy and safety of ivermectin in COVID-19 post-exposure prophylaxis (PEP) is…
- Trial name
- NCT05060666
- Testing
- Ivermectin
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Infectopharm Arzneimittel GmbH
COVID 19, Immunomediated Inflammatory Disease in Treatment With Biological Agents and / or Jak Inhibitors
Randomized, Controlled, Double-blind Clinical Trial Comparing the Efficacy and Safety of Chemoprophylaxis With Hydroxychloroquine in Patients Under Biological Treatment and / or JAK Inhibitors in the Prevention of SARS-CoV-2 Infection
The investigators plan to evaluate a strategy of chemoprophylaxis with hydroxyloquine (HCQ) against COVID-19 infection in patients diagnosed with an immunomediated inflammatory disease who are following a treatment with…
- Trial name
- NCT04330495
- Testing
- Hidroxicloroquina, Control group
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder
RATIONALE: Cyclosporine eye drops may prevent graft-versus-host disease of the eye in patients who have undergone donor stem cell transplant for hematologic cancer or bone marrow failure disorder.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00755040
- Testing
- cyclosporine ophthalmic emulsion
- Where
- 5 sites in United States
- Volunteers
- 164 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
HIV Infections
Impact of a Telenovela/Soap Opera for HIV Prevention in Latinas
Latinas continue to be affected disproportionally by HIV in the United States (US). Often, Latinas are not aware of their HIV status.
- Trial name
- NCT05929482
- Testing
- Infección de Amor (Infectious Love)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Idiopathic Overactive Bladder, Postoperative Urinary Tract Infection
Antibiotic Prophylaxis for Bladder Botox
Injection of Botox into the bladder is a common treatment for overactive bladder. Postoperative bladder infection is one of the more frequently reported complications of this procedure.
- Trial name
- NCT04444440
- Testing
- Ciprofloxacin
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- University of Alberta
Tuberculosis, HIV I Infection
ThiPhiSA: New Pathways to Prevention From Community TB Screening in South Africa
This study will compare community-delivered, multi-month dispensing of tuberculosis preventive therapy (TPT) to standard-of-care clinic-based TPT delivery in a population of South African adults who are recommended to receive TB…
- Trial name
- ThiPhiSA (NCT06214910)
- Testing
- Community-delivered TB preventive therapy (TPT) - 3 months weekly isoniazid plus rifapentine (3HP), Clinic-link TPT
- Where
- South Africa
- Volunteers
- 301 people
- Sponsor
- University of Washington
COVID, Vitamin D Deficiency
Vitamin D Levels in SARS-CoV-2: Do Current Adequacy Thresholds Reflect Clinical Risk? Insights From a Large Turkish Cohort
Blood vitamin D levels may be associated with severity of viral infections. To find out If there is a statistically significant relation between blood 25-hydroxy vitamin D (25(OH)D) levels and disease severity, patients with…
- Trial name
- NCT04394390
- Testing
- vitamin d
- Where
- Turkey (Türkiye)
- Volunteers
- 1,100 people
- Sponsor
- Bursa City Hospital
Covid19
Study of DS-5670a (COVID-19 Vaccine) in Japanese Healthy Adults and Elderly Subjects
This study will assess the safety, tolerability and immunogenicity of DS-5670a (COVID-19 Vaccine) and determine the recommended dose in Japanese healthy adults and elderly participants.
- Trial name
- NCT04821674
- Testing
- DS-5670a
- Where
- Japan
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo Co., Ltd.
Covid-19
Prevention and Treatment for COVID -19 (Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2) Associated Severe Pneumonia in the Gambia
The trial aims to assess the impact of cheap, licenced and widely available investigational products on the natural history of SARS-CoV-2 infection in 2 groups of patients - those with mild or moderate pneumonia (Cohort 1) and…
- Trial name
- PaTS-COVID (NCT04703608)
- Testing
- Ivermectin, ASP
- Where
- The Gambia
- Volunteers
- 1,200 people
- Sponsor
- London School of Hygiene and Tropical Medicine
COVID-19
Dapsone Coronavirus SARS-CoV-2 Trial (DAP-CORONA) COVID-19
This is a multi-center, randomized, triple-blind, placebo-controlled (RCT) study to evaluate the efficacy and safety of Dapsone in older adults, and/or in adult patients (≥40yrs of age) with at least one high-risk comorbidity…
- Trial name
- DAP-CORONA (NCT04935476)
- Testing
- Dapsone 85 mg PO BID
- Where
- 7 sites in United States, Canada
- Volunteers
- 3,000 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
HIV/AIDS, Gonorrhea
A Pragmatic Trial of Two Strategies for Implementing an Effective eHealth HIV Prevention Program (Keep It Up! 3.0)
This study evaluates and compares two implementation strategies of an online HIV prevention intervention: Strategy 1 in which community-based organizations apply, and are selected, for funding to deliver Keep It Up! through…
- Conditions
- HIV/AIDS, Gonorrhea, Chlamydia
- Trial name
- NCT03896776
- Testing
- Keep It Up! 3.0
- Where
- United States
- Volunteers
- 2,249 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cancer, COVID
Early Treatment With Ivermectin and LosarTAN for Cancer Patients With COVID-19 Infection
Ivermectin plus losartan as prophilaxy to severe events in patients with cancer with recent diagnosis of COVID-19
- Conditions
- Cancer, COVID, Coronavirus Infection
- Trial name
- TITAN (NCT04447235)
- Testing
- Ivermectin, Losartan
- Where
- Brazil
- Volunteers
- 77 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
HIV/AIDS
Biomedical HIV/AIDS Prevention Program Yunnan
B-HAPPY is an implementation project to study the process by which pre-exposure prophylaxis (PrEP) is introduced and integrated into a specific international health system facing high rates of HIV incidence among men who have sex…
- Trial name
- B-HAPPY (NCT03992274)
- Testing
- Enhanced implementation of PrEP
- Where
- China
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Columbia University
Bacterial Vaginosis
Photobiomodulation With Blue LED in Recurrent Bacterial Vaginosis
Introduction: Bacterial vaginosis (BV) is the most prevalent vaginal dysbiosis in women of reproductive age and is associated with adverse gynecological and obstetric outcomes; therefore, its diagnosis and appropriate treatment…
- Trial name
- NCT07835815
- Testing
- Metronidazole, Blue Light-Emitting Diode (LED)
- Volunteers
- 40 people
- Sponsor
- Patricia Lordelo
Malaria in Pregnancy, HIV Infections
Influence of Chloroquine on HIV Viral Load Among Pregnant Women in Uganda
There is conflicting evidence regarding the influence of HIV infection on the success of malaria prevention in pregnancy and effect on pregnancy outcome.
- Trial name
- NCT00132535
- Testing
- sulfadoxine-pyrimethamine intermittent preventive treatment, chloroquine
- Where
- Uganda
- Volunteers
- 2,548 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Non Communicable Diseases, Non Communicable Chronic Diseases
Behavioral Interventions as Primary Prevention for Non-Communicable Diseases Among Young People
In consistence of North Africa vision to decrease incidence of NCDs in different population type investigators decide to give more concerns to youth (young old) who are the main human power to build future.
- Trial name
- NCT07528625
- Testing
- health education of preventive tools for developing chronic diseases
- Where
- Egypt
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Deraya University
Cancer, Covid19
COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial;
A multi-centre Australian trial with four arms aims to evaluate several different immune modulating drugs for prevention and treatment of COVID-19 specifically in the cancer population.
- Conditions
- Cancer, Covid19, Respiratory Viral Infection
- Trial name
- C-SMART (NCT04534725)
- Testing
- Interferon alfa, Selinexor, Lenzilumab
- Where
- 5 sites in Australia
- Volunteers
- 441 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
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