Clinical trials: Infection Prophylaxis
Ocular Infection and Inflammation
Non-Inferiority of Gatifloxacin/Prednisolone Association vs Isolated Administration in Prevention of Ocular Infection/Inflammation
The purpose of the study is to evaluate the safety and tolerance of the 0.3% gatifloxacin and 1.0% prednisolone acetate association in eye drops in the prevention of infection and inflammation after refractive surgery (Lasik) and…
- Trial name
- NCT01218737
- Testing
- 0.3% gatifloxacin and 1.0% prednisolone acetate association, isolated 0.3% gatifloxacin and 1.0% prednisolone acetate
- Where
- Brazil
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Influenza
Tolerability and Safety Study of FLUVAL P Monovalent Influenza Vaccine in Children
To determine the tolerability and safety of FLUVAL P monovalent influenza vaccine in children.
- Trial name
- NCT01100294
- Testing
- Vaccination with FLUVAL P
- Where
- Hungary
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fluart Innovative Vaccine Ltd, Hungary
Sepsis
Effect of Taurolidin on Prevention of Bloodstream Infection
Home parenteral nutrition (HPN) is a validated technique for patients with various intestinal disease leading to chronic malabsorption or obstruction, whatever the aetiology.
- Trial name
- Nutrilock (NCT00545831)
- Testing
- Taurolidine, Physiologic Serum
- Where
- 7 sites in France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Rouen
Stress Disorders, Post-Traumatic, Sexually Transmitted Infection (STI) Prevention
Cognitive Processing Therapy to Treat PTSD and Sexually Transmitted Infections Among Men Who Have Sex With Men
Gay, bisexual, queer, and other men who have sex with men (GBM) continue to bear a disproportionate burden of the sexually transmitted and blood-borne infections (STBBI), largely attributable to efficient transmission during…
- Trial name
- CPT-T (NCT06463431)
- Testing
- Cognitive Processing Therapy
- Where
- 2 sites in Canada
- Volunteers
- 56 people
- Sponsor
- Toronto Metropolitan University
Hematopoietic Stem Cell Transplantation
PTCy-ATG vs ATG in Haploidentical HSCT for Acute Graft-versus-host Disease Prophylaxis
The granulocyte colony-stimulating factor (G-CSF)+antithymocyte globulin (ATG)-based protocols and posttransplantation cyclophosphamide (PTCy) protocols have been widely used for graft-versus-host disease (GVHD) prophylaxis in…
- Trial name
- NCT03689465
- Testing
- ATG, CTX, Mycophenolate Mofetil
- Where
- 7 sites in China
- Volunteers
- 260 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Urinary Tract Infection
Can Probiotics be Used in the Prevention of Recurrent UTI in Paediatric Neurogenic Bladder
Although clean intermittent catheterization (CIC) remains the mainstay to ensure complete low-pressure bladder emptying in neurogenic bladder (NB) patients, this forms a vehicle for bacterial entry and colonization of the urinary…
- Trial name
- NCT02044965
- Testing
- Antibiotic, Probiotic
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- London Health Sciences Centre
Malaria in Pregnancy
Assessment of Sulphadoxine-pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Malawi
The purpose of this study is to determine the efficacy and effectiveness of sulphadoxine-pyrimethamine intermittent preventive treatment in pregnancy for reducing malaria-associated morbidity in pregnant women in Malawi.
- Trial name
- NCT01120145
- Where
- Malawi
- Volunteers
- 1,410 people
- Sponsor
- Centers for Disease Control and Prevention
Ocular Toxoplasmosis
Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis
The investigators study aims to determine the effect of prophylactic therapy with Trimethoprim-sulfamethoxazole on the recurrences of toxoplasma retinochoroiditis gondii.
- Trial name
- ISROT (NCT01449877)
- Testing
- Trimethoprim-Sulfamethoxazole
- Where
- Brazil
- Volunteers
- 141 people
- Sponsor
- University of Campinas, Brazil
Yellow Fever
Trial of Yellow Fever Inactivated Vaccine
The Phase 1 trial is a single-center, randomized, double blind, placebo-controlled, dose-ranging out-patient study designed to provide the first clinical data on the safety, tolerability and immunogenicity of XRX-001 inactivated…
- Trial name
- NCT00995865
- Testing
- XRX-001 Inactivated yellow fever vaccine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Hiv, Sexually Transmitted Diseases
Evaluation of Implementation of Pre-exposure Prophylaxis (PrEP) in Norway
Despite the significant preventive efforts to reduce HIV infections in the past decades, the incidence in MSM has plateaued at a higher level after the turn of the millennium.
- Conditions
- Hiv, Sexually Transmitted Diseases, Mental Health Wellness 1
- Trial name
- NCT03436407
- Where
- 9 sites in Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Post-exposure Prophylaxis, Sexually Transmitted Diseases
Pharmacokinetic Characterization of a Single 200 mg Dose of Doxycycline in Post-exposure Prophylaxis (PEP) of Sexually Transmitted Infections in Different Biological Compartments
Post-exposure prophylaxis (PEP) using doxycycline 200 mg within 24 hours of unprotected sexual intercourse to prevent sexually transmitted infections has demonstrated a reduction in the incidence of chlamydial and syphilis…
- Conditions
- Post-exposure Prophylaxis, Sexually Transmitted Diseases, Doxycycline
- Trial name
- DOXY-PK (NCT06007534)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Relapsed Refractory Multiple Myeloma (RRMM)
Phase II Trials of Letermovir Prophylaxis in Patients With RRMM Undergoing Elranatamab Therapy
This is an open-label, single arm, multicenter study to evaluate the efficacy of letermovir in the prevention of clinically significant CMV infection in adult, CMV-seropositive relapsed/refractory MM patients undergoing BsAbs…
- Trial name
- OPTIMUS-EL (NCT06920251)
- Testing
- Letermovir
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Taurolidine, Lock Solution
Efficacy of Taurolidine Containing Lock Solution for Prevention of Central Venous Catheter Infection in ICU Patients
This study aimed to assess effectiveness of a taurolidine based lock solution in preventing the infections of central venous catheter (CVC) in intensive care unit (ICU) cases.
- Conditions
- Taurolidine, Lock Solution, Prevention, Central Venous Catheter Infection
- Trial name
- NCT07366372
- Testing
- Saline, Tigecycline and heparin, Taurolidine-citrate-heparin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Healthy Volunteers
Study To Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in African Population
This study will test a new drug (MAM01) to find which doses are safe and could help prevent people from getting malaria for at least 4 months. The study will take place in parts of Africa where malaria is common.
- Trial name
- NCT06408857
- Testing
- MAM01 300 mg SC, MAM01 300 mg IM, MAM01 2000 mg IV
- Where
- 2 sites in Uganda
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Gates Medical Research Institute
Central Nervous System (CNS) Infection, Encephalitis
Establishment of Prevention and Control System of Central Nervous System Infection
Central nervous system (CNS) infection is a common nervous system acute and severe disease, mainly manifested as encephalitis, meningitis and meningoencephalitis, but also manifested as brain abscess and brain granuloma et al.
- Conditions
- Central Nervous System (CNS) Infection, Encephalitis, Meningitis
- Trial name
- NCT04722328
- Testing
- CSF metagenomic next generation sequencing (mNGS)
- Where
- China
- Volunteers
- 715 people
- Sponsor
- Xuanwu Hospital, Beijing
Human Immunodeficiency Virus (HIV)
ComBaCaL HIV Prevention TwiCs
This cluster-randomized intervention is embedded in the ComBaCaL (Community-Based Chronic disease care Lesotho) cohort study (EKNZ ID AO_2022-00058, clinicaltrials.gov ID NCT05596773, Lesotho NH-REC ID 210-2022), a platform for…
- Trial name
- CoPrev (NCT07581600)
- Testing
- CoPrev model, Referral to the nearest responsible health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Kidney Stone, Infection
Novel Antimicrobial Solution to Prevent Infections
Ureteroscopy is the most common surgical treatment for kidney stones. Although rare, sepsis after ureteroscopy can be a life-threatening complication, occuring in <3% of patients.
- Conditions
- Kidney Stone, Infection, Infection Associated With Catheter, Sepsis
- Trial name
- NCT07881822
- Testing
- antimicrobial irrigation
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Cystic Fibrosis
Evaluation of the Emission Distance of P. Aeruginosa From the Respiratory Tract of People With Cystic Fibrosis
It is well known that an association exists between the acquisition of some respiratory pathogens and prognosis of CF people. About 57 % of patients has a lung infection due to P.aeruginosa (PA).
- Trial name
- NCT00531531
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- University of Florence
Anemia
Efficacy of Iron Fortified Complementary Food and IPT of Malaria in Young Children in Côte d'Ivoire
The proposed project is aimed at testing two interventions, namely a highly bioavailable iron compound and a combination of SP plus amodiaquine for intermittent preventive treatment (IPT) of malaria, to reduce anaemia in very…
- Trial name
- NCT01634945
- Testing
- SP/amodiaquine, FeFum fortified porridge, SP/Amodiaquine + FeFum fortified porridge
- Where
- Côte d’Ivoire
- Volunteers
- 629 people
- Sponsor
- Swiss Federal Institute of Technology
Benign Prostatic Hyperplasia, Urinary Tract Infections
Role of Prophylactic Postoperative Antibiotics in HoLEP
The purpose of this study is to investigate whether prescribing a 3-day course of antibiotics after Holmium laser enucleation of the prostate (HoLEP) reduces the risk of urinary tract infection.
- Trial name
- NCT05274672
- Testing
- Nitrofurantoin, Cephalexin, Sulfamethoxazole Trimethoprim Combination
- Where
- 2 sites in United States
- Sponsor
- Baylor Research Institute
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