Clinical trials: Infection Prophylaxis
Pre-Exposure Prophylaxis of HIV Infection
Study of Lenacapavir Taken Twice a Year for HIV Pre-Exposure Prophylaxis (PrEP)
The goals of this clinical study are to learn more about the study drug lenacapavir (LEN), by comparing the consistent and continuous use of LEN and emtricitabine/tenofovir disoproxil fumarate (coformulated; Truvada®) (F/TDF)…
- Trial name
- PURPOSE 5 (NCT06513312)
- Testing
- Lenacapavir Injection, Lenacapavir Tablet, Emtricitabine/tenofovir disoproxil fumarate (F/TDF)
- Where
- 14 sites in France, United Kingdom
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
HIV Infections, Tuberculosis
Tuberculosis Prevention for HIV Infected Adults
This study compares three different tuberculosis (TB) prevention regimens against the standard regimen of 6 months of isoniazid. It is being conducted in Soweto, South Africa.
- Trial name
- NCT00057122
- Testing
- Isoniazid, Rifapentine, Rifampin
- Where
- South Africa
- Volunteers
- 1,148 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stigma, Social, Drug Abuse Illicit
Lower Intersecting HIV-related Stigmas to Facilitate Treatment as Prevention (LIFT)
The purpose of this study is to reduce HIV transmission risk among people who inject drugs (PWID) through a multilevel intervention known as LIFT.
- Conditions
- Stigma, Social, Drug Abuse Illicit, HIV (Human Immunodeficiency Virus)
- Trial name
- LIFT (NCT07541131)
- Testing
- LIFT for People Who Use Drugs, LIFT for MMT Providers
- Where
- Kyrgyzstan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Covid19
SARS-CoV-2 Pre-exposure Prophylaxis With Ivermectin Retrospective Cohort Study
This observational study, a multicenter retrospective cohort database study, carried out in two medical centers, Centro Medico Bournigal (CMBO) in Puerto Plata and Centro Medico Punta Cana (CMPC) in Punta Cana, Dominican…
- Trial name
- NCT04832945
- Testing
- Ivermectin 6 Mg Oral Tablet
- Where
- 2 sites in Dominican Republic
- Volunteers
- 713 people, healthy volunteers welcome
- Sponsor
- Grupo Rescue S.A.S República Dominicana
White Spot Lesion of Tooth, Gingival Inflammation
EFFECTIVENESS of WATER FLOSS in PLAQUE REMOVAL and PREVENTION of WHITE SPOT LESIONS in ORTHODONTIC PATIENTS: a RANDOMISED CONTROLLED CLINICAL TRIAL
This clinical trial aims to learn if water floss is as efficient as other interdental cleaning tools and can prevent plaque accumulation and white spot lesions (WSLs) in orthodontic patients.
- Conditions
- White Spot Lesion of Tooth, Gingival Inflammation, Gingival Bleeding, Dental Plaque
- Trial name
- WATER FLOSS (NCT06752291)
- Testing
- water flosser
- Where
- Malaysia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Anthrax
VELOCITY: An Anthrax Vaccine Clinical Study
This study is designed to evaluate the lot consistency (using three consecutively manufactured lots), safety, and ability of the AV7909 anthrax vaccine to generate an immune response in healthy adults and compare the response to…
- Trial name
- NCT03877926
- Testing
- AV7909, BioThrax
- Where
- 35 sites in United States
- Volunteers
- 3,689 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Novel 2009 Influenza H1N1, Influenza, Human
Tolerability and Immunogenicity Study of FLUVAL P H1N1 Flu Vaccine of Omninvest in Children and Adolescents
This is a single-blind, reference drug controlled study to assess safety and tolerability of FLUVAL P H1N1 monovalent influenza vaccine (whole virus, inactivated, adjuvanted with alumn phosphate gel) containing 6 mcgHA per 0.5mL…
- Trial name
- NCT01407978
- Testing
- Vaccination with Fluval P monovalent influenza vaccine, Vaccination with Fluval AB, Vaccination with Fluval AB Novo
- Where
- Hungary
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Fluart Innovative Vaccine Ltd, Hungary
COVID-19
Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19
The HCW Prophylaxis (HCWP) Study, single, open and off label intervention study. Up to 350 participants will be assigned to group that takes HCQ or group that opts to not take study medication.
- Trial name
- NCT04435808
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
HIV-1-infection, Antenatal Care
An Integrated Strategy to Support Antiretroviral Therapy and Pre-exposure Prophylaxis Adherence for HIV Prevention in Pregnant and Breastfeeding Women
This study is composed of two parallel, pilot randomized groups that will obtain preliminary data about the the acceptability, fidelity, and clinical outcomes associated with a multi-component adherence support strategy for HIV…
- Trial name
- NCT04330989
- Testing
- iNSC and Adherence supporter training
- Where
- Malawi
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Common Cold, Gastroenteritis
Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers
We hypothesize the herbal preparation will enhance the preschoolers' immune response and when taken prophylactically for 12 weeks will decrease episodes of upper respiratory infections and gastroenteritis in the active versus the…
- Trial name
- NCT00231218
- Testing
- dietary supplement--echinacea, propolis, and vitamin c
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Diphtheria, Tetanus
REVAXIS® Versus DT Polio® as a Second Booster in 6 Year-old Children
Primary objective: To demonstrate the non inferiority between REVAXIS® and DT Polio® when given as a second booster to healthy 6 year-old children . Secondary objectives: Additional immunogenicity assessments.
- Conditions
- Diphtheria, Tetanus, Poliomyelitis
- Trial name
- NCT00447525
- Testing
- REVAXIS®, DT-Polio®
- Where
- 64 sites in France
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Covid19, SARS (Severe Acute Respiratory Syndrome)
Safety and Efficacy of Hydroxychloroquine for the Treatment & Prevention of Coronavirus Disease 2019 (COVID-19) Caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Coronavirus Disease 2019 (COVID-19) (previously called 2019-nCOV acute respiratory disease) is caused by SARS-CoV-2, a positive-sense single-stranded RNA virus of the coronavirus family.
- Trial name
- NCT04590274
- Testing
- Hydroxychloroquine, Vitamins and Minerals, Azithromycin
- Volunteers
- healthy volunteers welcome
- Sponsor
- International Brain Research Foundation
Ventilator-associated Pneumonia
Medico-economic Study of the Subglottic Secretions Drainage in Prevention of Ventilator-associated Pneumonia (DEMETER)
In France, despite the implementation of bundles to prevent Ventilator-Associated Pneumonia (VAP) in the last decades, the VAP incidence remains high above 10 per cent.
- Trial name
- DEMETER (NCT02515617)
- Testing
- Endotracheal tubes not allowing SSD, Endotracheal tubes allowing SSD
- Where
- 25 sites in Belgium, France and 2 more
- Volunteers
- 2,577 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Pyelonephritis, Renal Scars
A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux
The aim of this study is to assess the effectiveness of antibiotic prophylaxis in preventing pyelonephritis and in avoiding the appearance of new scars in a sample of children under 36 months with vesico-ureteral reflux (VUR).
- Trial name
- NCT00382343
- Testing
- Sulfamethoxazole/trimethoprim
- Where
- 7 sites in Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS Burlo Garofolo
HIV, Sexually Transmitted Infections
Multicomponent Intervention to Reduce Sexual Risk and Substance Use
The objective is to expand and refine an intervention for transgender women (TW) into a 7-session individual- and group-based intervention that is scalable for community settings to reduce sexual risk and substance use and to…
- Conditions
- HIV, Sexually Transmitted Infections, Substance Use
- Trial name
- NCT01880489
- Testing
- MI + CBST Intervention
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
HIV Infections, Gonorrhea
Effectiveness of HIV/Sexually Transmitted Infection Training for Physicians in China
This study will evaluate the effectiveness of a physician training program, the Ai Shi Zi program, in improving HIV/sexually transmitted infection diagnosis, treatment, and management by Chinese physicians and in reducing the…
- Conditions
- HIV Infections, Gonorrhea, Chlamydia
- Trial name
- NCT00644150
- Testing
- Physician Ai Shi Zi training, Standard care, Patient risk-reduction counseling
- Where
- China
- Volunteers
- 1,373 people
- Sponsor
- University of California, Los Angeles
Healthy
VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases
This protocol will screen healthy normal volunteers for participation in studies of vaccines under development at NIAID's Vaccine Research Center. Of interest are vaccines for: Newly identified infectious diseases such as SARS.
- Trial name
- NCT00068926
- Where
- 2 sites in United States
- Volunteers
- 958 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy
This study is an investigation to compare the efficacy of two different intermittent sulfadoxine/pyrimethamine (SP) treatment regimens and intermittent sulfadoxine/pyrimethamine (SP) + artesunate (SP/AS) treatment of HIV negative…
- Trial name
- NCT00164255
- Testing
- sulfadoxine/pyrimethamine, sulfadoxine/pyrimethamine plus artesunate
- Where
- 2 sites in Tanzania
- Volunteers
- 1,614 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Human Papillomavirus-Related Cervical Carcinoma
Single Dose of Cervarix Vaccine in Girls or Three Doses of Gardasil Vaccine in Women for the Prevention of Human Papillomavirus Infection, the PRIMAVERA-ESCUDDO Trial
This phase IIIb trial compares a single dose of the Cervarix vaccine in girls to 3 doses of the Gardasil vaccine in young women for the prevention of human papillomavirus (HPV) infection.
- Trial name
- PRIMAVERA (NCT03728881)
- Testing
- Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine, Recombinant Human Papillomavirus Bivalent Vaccine
- Where
- Costa Rica
- Volunteers
- 1,240 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Dengue
Educational Intervention to Promote Control Behaviors and Prevention of Dengue
This study will assess the effect of an educational nursing intervention in adults to promote dengue control and prevention behaviors, in comparison with the usual strategy of a health service provider institution.
- Trial name
- NCT05321264
- Testing
- Educational nursing intervention
- Where
- Colombia
- Volunteers
- 116 people
- Sponsor
- Universidad de Antioquia
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