Clinical trials: Infection Prophylaxis
Infection
Infection Prevention After TKA With or Without Vancomycin
Prospective, Randomized, Double Blinded Trial Comparing Clinical, Radiological and Laboratory Outcomes in prevention of infection after Total Knee Arthroplasty With or Without Vancomycin.
- Trial name
- TKA_Vanco (NCT05461651)
- Testing
- Knee arthroplasty
- Where
- Poland
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
HIV/AIDS
Access to PrEP for MSM: Acceptability and Feasibility in Community-based Clinics in West Africa (CohMSM-PrEP)
This demonstration project will assess the acceptability and feasibility of pre-exposure prophylaxis (PrEP) for men who have sex with men (MSM) as part of a comprehensive HIV prevention package in community-based clinics in West…
- Trial name
- CohMSM-PrEP (NCT03459157)
- Testing
- HIV prevention package including PrEP
- Where
- 4 sites in Burkina Faso, Côte d’Ivoire and 2 more
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Skin Flora Infection
Antimicrobial Activity of IV Clear™ Dressing - Prevention of Antimicrobial Regrowth
The purpose of this study is to assess the surface cutaneous antimicrobial activity of IV Clear™ Dressing, Tegaderm CHG™ Dressing and a Silicone Vehicle Control Dressing.
- Trial name
- NCT01368120
- Testing
- IV Clear™ Dressing, Tegaderm CHG™, Silicone Vehicle Control Dressing
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Covalon Technologies Inc.
HIV/AIDS, Adherence, Medication
Interventions to Improve the HIV PrEP Cascade Among Methamphetamine Users
Despite increasing knowledge about and use of PrEP nationally, HIV continues to have disproportionate impact among cisgender men and transgender persons who have sex with men and transgender persons (MSM/TG), with methamphetamine…
- Conditions
- HIV/AIDS, Adherence, Medication, Drug Use
- Trial name
- NCT03584282
- Testing
- Text Messaging, Peer Navigation
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Washington
Diarrhea
ETEC Logistics Trial (TREK)
This is a multicenter, double-blind, randomized, placebo-controlled field trial to evaluate the epidemiology of natural infection with ETEC occurring after transcutaneous immunization in a field setting.
- Trial name
- Trek (NCT00516659)
- Testing
- Heat-Labile Enterotoxin of Escherichia coli (LT)
- Where
- 19 sites in United States, Guatemala and 1 more
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Intercell USA, Inc.
HIV Infections, Sexually Transmitted Diseases
HIV and STD Prevention for High-Risk, Inner-City, African American Youth
This study will evaluate the joint and separate effectiveness of two HIV/STD prevention programs in providing protection against acquiring STDs and maintaining safer sex behavior.
- Trial name
- NCT00353405
- Testing
- Social Skills Training, Mass media, Control
- Where
- 4 sites in United States
- Volunteers
- 1,650 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Stress Ulcer Prophylaxis
Re-Evaluating the Inhibition of Stress Erosions: Gastrointestinal Bleeding Prophylaxis In ICU
The purpose of the this Pilot Trial is to determine the feasibility of conducting a large randomized controlled trial (RCT), that aims to examine the efficacy and safety of using pantoprazole compared to placebo for stress ulcer…
- Trial name
- REVISE (NCT02290327)
- Testing
- Pantoprazole
- Where
- 10 sites in Australia, Canada and 1 more
- Volunteers
- 91 people
- Sponsor
- McMaster University
Site Infection
Incidence of Ssi After c.s
aim of the work is to evaluate adherence to preoperative , intraoperative, and postoperative infection preventive measures during cesarean section and to assess it s impact on the incidence of surgical site infection and maternal…
- Trial name
- NCT07476261
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Assiut University
End Stage Renal Failure on Dialysis
Hemodialysis Infection Prevention Using Polysporin Ointment With Shower Technique in Satellite Centres Pilot Study
Background: The investigators developed a Shower Technique protocol (STP) for hemodialysis (HD) patients with healed central venous catheter (CVC) exit sites, designed to permit showering but not increase infection risk.
- Trial name
- HIPPO-SAT (NCT02002169)
- Testing
- Shower Technique Protocol, Standard CVC Care
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- University Health Network, Toronto
Pre-Eclampsia
Impact of Antichlamydial Treatment on the Rate of Preeclampsia
This randomized, double blinded controlled trial included 1200 healthy primigravidae who attended an outpatient clinic at 16-20weeks of pregnancy.
- Trial name
- NCT03233880
- Testing
- Azithromycin 1gm
- Where
- Egypt
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Rabies
Immunogenicity and Safety of Different Dosages of Rabies Vaccine (Serum-free Vero Cell)
To describe the immunogenicity and safety of two dosages of Sinovac rabies vaccine, as well as compared the differences with the marked WHO PQ rabies vaccine Verorab® in a post-exposure prophylaxis (PEP) schedule.
- Trial name
- NCT07055880
- Testing
- Rabies Vaccine (Serum-free Vero Cell), Freeze-dried, Verorab®
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Cervical Cancer, HPV Infection
HPV DNA Self-sampling in a General Practitioner's Office.
One of the limitations of organized cervical screening in the Czech Republic is the lack of participation in preventive gynecological examinations.
- Conditions
- Cervical Cancer, HPV Infection, Precancerous Lesion
- Trial name
- ASTRA (NCT06253169)
- Testing
- HPV DNA self-test
- Where
- 2 sites in Czechia
- Volunteers
- 2,000 people
- Sponsor
- Patient Organization Veronica
HIV Infections, Sexually Transmitted Diseases
A Peer-Oriented HIV Prevention Outreach Program for Individuals at High Risk for HIV and Other STIs
This study will determine the effectiveness of a peer outreach intervention in preventing HIV infection in adults at high risk for contracting HIV and other sexually transmitted diseases (STDs).
- Trial name
- NCT00183456
- Testing
- Peer-oriented intervention, Group cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
COVID-19
Ivermectin for Post Exposure Prophylaxis of Covid-19
Post exposure prophylaxis of healthy contacts is among the measures used for outbreak control of several infectious diseases (e.g., pandemic influenza).
- Trial name
- I-CPEP (NCT05231603)
- Testing
- Ivermectin
- Where
- 10 sites in Malaysia
- Volunteers
- 50 people
- Sponsor
- Clinical Research Centre, Malaysia
COVID-19
Safe and Timely Cessation of Isolation of Patients With COVID-19 (The SCIP-COVID-19) Study
Rationale: In the treatment, care and isolation of COVID-19 patients, one of the most important issues is determining the duration of infectiousness.
- Trial name
- SCIP-COVID19 (NCT05346042)
- Testing
- duration infectiousness
- Where
- Netherlands
- Volunteers
- 7,000 people
- Sponsor
- Anne Voor in 't holt
Paediatric Kidney or Liver Transplantation, Chronic Kidney Disease
Prevention of Human Papillomavirus (HPV) Infection in Paediatric Kidney and Liver Transplant Recipients and in Paediatric Patients With Advanced Chronic Kidney Disease
Due to their immunosuppressive therapy, solid-organ transplant (SOT) recipients bear a 10 to 100 times higher risk of human papillomavirus (HPV)-associated malignancies than healthy individuals.
- Trial name
- NCT03100682
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- University Hospital Heidelberg
Cholestasis in Newborn
Parenteral Nutrition Cycling for Prevention of Cholestatic Syndrome in Newborn
Background: Despite the use of parenteral nutrition cycling (PNC) in neonatal intensive care units (NICU), there is limited evidence regarding the benefits in relation to the nutrición parenteral total (NPT) in term and late…
- Trial name
- NCT06366880
- Testing
- Parenteral nutrition cycling
- Where
- Mexico
- Volunteers
- 66 people
- Sponsor
- Hospital Pediátrico de Sinaloa
Cancer
Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation
RATIONALE: White blood cells from donors who have been exposed to cytomegalovirus may be able to help prevent this infection from occurring in patients who are undergoing bone marrow or peripheral stem cell transplantation.
- Trial name
- NCT00002673
- Testing
- infection prophylaxis and management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fred Hutchinson Cancer Center
Adenovirus Infection
Administration of Virus-Specific Cytotoxic T-Lymphocytes
The main purpose of this study is to see if these T-lymphocytes are safe. To make these Ad-specific T lymphocytes the investigators will obtain blood from the stem cell donor and transfer Ad into another type of blood cell…
- Trial name
- LYPTAIST (NCT00590083)
- Testing
- CTL administration
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- Baylor College of Medicine
Recurrent Urinary Tract Infection, Vaginal Atrophy
Prevention of Recurrent UTI Using Vaginal Testosterone Versus Placebo Placebo
Women over the age of 60 years have an estimated 10 to 15 % risk of recurrent urinary tract infections (UTI). This is believed to be due to hormonally induced changes in the vaginal flora associated with menopause.
- Conditions
- Recurrent Urinary Tract Infection, Vaginal Atrophy, Postmenopausal Disorder
- Trial name
- PIVoT (NCT04807894)
- Testing
- Vaginal Cream with Applicator
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Jefferson Drapkin
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