Clinical trials: Infection Surgical Wound
Infection, Surgery
Topical Vancomycin for Neurosurgery Wound Prophylaxis
This study is a collaboration between New York Presbyterian (NYP)-Columbia and NYP-Cornell that seeks to evaluate the use of topical vancomycin and its reduction on surgical site infection (SSI) in neurosurgical procedures.
- Conditions
- Infection, Surgery, Nervous System Diseases
- Trial name
- Vanguard (NCT02284126)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 1,103 people
- Sponsor
- Columbia University
Surgical Site Infections, Post Operative Complication
2% Chlorhexidine Gluconate Skin Cloths to Prevent SSI in Spine Surgery Patients
Surgical site infection (SSI) following spinal surgery is a frequent complication and results in higher morbidity, mortality and healthcare costs.
- Trial name
- DeSSI (NCT02490631)
- Testing
- 2% chlorhexidine gluconate cloths
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Vanderbilt University
Spinal Fusion, Spinal Stenosis
Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery
Deep surgical site infection (DSSI) is one of the most challenging complications for spinal surgeons and can lead to a poor clinical outcome.
- Conditions
- Spinal Fusion, Spinal Stenosis, Spondylolisthesis
- Trial name
- NCT03883022
- Testing
- with U-VANCO (vancomycin hydrochloride), without U-VANCO (vancomycin hydrochloride)
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pancreatic Disease, Pancreatic Neoplasms
Early (4 Days) Versus Standard Drainage of the Abdominal Cavity After Pancreaticoduodenectomy
Around two thousand pancreaticoduodenectomy (PD) are performed each year in France. This intervention is associated with a high rate of postoperative complications including: pancreatic fistulas (PF); surgical site infections…
- Trial name
- DRAINAGE DPC (NCT01368094)
- Testing
- Drain removal at D4, Standard drain removal
- Where
- 5 sites in France
- Volunteers
- 141 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Orthopedic Surgery
Biofilm Formation and Antibiotic Sensitivity Patterns
Detection of bacteria that form biofilm and its sensitivity to antibiotics in patients with surgical site infection after orthopedic surgery.
- Trial name
- NCT05181163
- Testing
- swab
- Volunteers
- 100 people
- Sponsor
- Sohag University
Elective Surgery, High Risk
General Decolonization With Octenisan® Set Before Elective Orthopedic Surgery
The general decolonization of the human body surface by industrial antiseptic agents, before elective surgery is recommended by the World Health Organization (WHO).
- Conditions
- Elective Surgery, High Risk, Prevention of Surgical Site Infections, Randomized-controlled Trial
- Trial name
- BALGDEC (NCT05647252)
- Testing
- Whole Body and nasal decolonization with octenidin (Octenisan Set), Questionnaire for study participants immediately after the decolonization
- Where
- 2 sites in Switzerland
- Volunteers
- 1,086 people
- Sponsor
- Balgrist University Hospital
Peripheral Vascular Disease, Claudication
Oral Nutritional Supplement in Reducing Surgical Site Infections
The study aims to evaluate the efficacy of an arginine enriched oral nutritional supplement in the prevention of wound complications in the the wounds of patients post lower limb revascularization.
- Trial name
- NCT02475525
- Testing
- Arginine enriched oral nutritional supplement
- Where
- Ireland
- Volunteers
- 6 people
- Sponsor
- University of Limerick
Wound Infection, Fractures, Open
Tobramycin Injection to Prevent Infection in Open Fractures
The goal of open extremity fracture (OEF) treatment is to promote fracture healing and restore function while preventing the development of infection.
- Conditions
- Wound Infection, Fractures, Open, Surgical Site Infection
- Trial name
- NCT04964947
- Testing
- Tobramycin Injection
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- Massachusetts General Hospital
Periimplantitis, Dental Plaque
Antimicrobial Activity of Two Mouthwashes
This is a three arm randomized trial. The aim is to evaluate the antimicrobial activity of chlorhexidine and polyhexamethylene biguanide oral antiseptics on the microorganisms of the oral cavity.
- Conditions
- Periimplantitis, Dental Plaque, Periodontal Diseases, Caries
- Trial name
- NCT02375178
- Testing
- chlorhexidine, Polyhexamethylene biguanide, Sterile saline solution
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Acute Lithiasic Cholecystitis Grade I or II, Symptoms Lasting for Less Than 5 Days
Place of Antibiotics in the Postoperative Acute Lithiasic Cholecystitis
Assess whether postoperative antibiotics after cholecystectomy for acute lithiasic cholecystitis little or moderately severe, is effective and therefore justified.
- Conditions
- Acute Lithiasic Cholecystitis Grade I or II, Symptoms Lasting for Less Than 5 Days, Required Cholecystectomy, Preoperative Amoxicillin Clavulanic Acid for at Most 5 Days
- Trial name
- ABCAL (NCT01015417)
- Testing
- Amoxicillin clavulanic acid, No medication
- Where
- 21 sites in France
- Volunteers
- 414 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Rectal Cancer, Retention, Urinary
Incidence of Acute Urine Retention: Randomized Clinical Trial Comparing Early, Mid or Late Urinary Catheter Removal in Patients With Rectal Resection
DESIGN: Randomized, open-label and parallel clinical trial, assigned to early, mid, or late withdrawal of urinary catheter with a 1: 1: 1 allocation ratio.
- Conditions
- Rectal Cancer, Retention, Urinary, Urinary Tract Infections, Surgical Site Infection
- Trial name
- RAOREC (NCT04751149)
- Testing
- Removal of Urinary Catheter
- Where
- Spain
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Hospital Donostia
Surgical Wound Infection
Alexis O-Ring Wound Retractor for the Prevention of Post-cesarean Surgical Site Infections
Post cesarean section surgical site infection (SSI) is a common complication that can affect patient recovery and overall outcome.
- Trial name
- Alexis (NCT03365219)
- Testing
- Alexis O-Ring Wound Retractor, Standard Surgical Retractors
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Breast Cancer, Surgical Site Infection
NPWT for Abdominal Incisions in DIEP Reconstructions: A RCT
The current study is a single center randomized control trial that will examine the effect of closed incision negative pressure wound therapy (ciNPT) versus conventional dressing on abdominal incision in a deep inferior…
- Conditions
- Breast Cancer, Surgical Site Infection, Wound Dehiscence
- Trial name
- NPWTinDIEP (NCT05338281)
- Testing
- Negative Pressure Wound Therapy
- Where
- Canada
- Sponsor
- Western University, Canada
Surgical Site Infections
Prevention of Infections in Cardiac Surgery (PICS) Prevena Study
This vanguard study will be conducted at two study sites in Canada. It is a cluster randomized trial to test a combination of two antibiotics for antibiotic prophylaxis as compared to routine prophylaxis with one single…
- Trial name
- PICS-Prevena (NCT03402945)
- Testing
- Prevena, Cefazolin, Vancomycin
- Where
- 2 sites in Canada
- Volunteers
- 4,107 people
- Sponsor
- Population Health Research Institute
Surgical Site Infection, Superficial Surgical Site Infection
Clipping Versus No Hair Removal and the Risk of Surgical Site Infections
The objective of this study is to determine whether hair clipping is non-inferior to no hair removal in preventing superficial, deep, and organ space surgical site infections (SSI) in patients undergoing various general surgical…
- Conditions
- Surgical Site Infection, Superficial Surgical Site Infection, Deep Surgical Site Infection, Organ/Space Surgical Site Infection
- Trial name
- NCT00975377
- Testing
- Hair clipping
- Where
- United States
- Volunteers
- 1,678 people
- Sponsor
- Gundersen Lutheran Medical Foundation
Surgery, Nasal Disease
Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections
This is a randomised, unblinded interventional device proof of concept pilot trial in which patients undergoing nasal surgery will be selected for either photodisinfection therapy (PDT) with the Steriwave™ ND System, or control…
- Conditions
- Surgery, Nasal Disease, Light; Therapy, Complications
- Trial name
- LIGHT (NCT06731881)
- Testing
- Nasal PDT, Photosensitizer formulation only, Standard follow-up
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Lumbar Vertebrae, Surgical Site Infection
Dixon MRI Imaging Histology for Predicting Postoperative Infection in Posterior Lumbar Fusion for Myasthenia Gravis
Sarcopenia is an age-related condition that manifests itself as a persistent decrease in muscle mass and function, which may lead to decreased physical function, increased risk of disease, and reduced quality of life.
- Conditions
- Lumbar Vertebrae, Surgical Site Infection, Radiomics
- Trial name
- NCT06805643
- Volunteers
- 1,300 people
- Sponsor
- The First People's Hospital of Yunnan
Sternal Fracture, Sternal Wound Infection
Sternal Wound Infection in Patients Undergone Sternal Fixation Using Locking Compression Plates
Sternal Wound Infection (SWI) in open heart surgery is one of the most annoying and avoidable complications that one encounters during work.
- Conditions
- Sternal Fracture, Sternal Wound Infection, Surgical Site Infection
- Trial name
- NCT05040399
- Testing
- Locking Compression Plates, Sternal Wires
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Assiut University
Laceration of Skin, Injury Skin
Assessment of DAFILON® Suture Material for Skin Closure
In this non-interventional study (NIS) a polyamide non-absorbable suture (Dafilon®) will be evaluated for skin closure in adult and pediatric patients.
- Trial name
- SKINDA (NCT04617041)
- Where
- 2 sites in Germany, Spain
- Volunteers
- 115 people
- Sponsor
- Aesculap AG
Surgical Wound Infection, Spinal Deformity
Comparison of Antibiotic Protocols in Spine Patients With Postoperative Drains
In spine surgery, postoperative spinal drains are often utilized to prevent fluid buildup around the spinal cord. The purpose of this study is to determine whether postoperative antibiotic treatment continued for the duration of…
- Conditions
- Surgical Wound Infection, Spinal Deformity, Spinal Degeneration
- Trial name
- NCT01608854
- Testing
- Antibiotic Protocol
- Where
- United States
- Volunteers
- 539 people
- Sponsor
- NYU Langone Health
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