Clinical trials: Infection Surgical Wound
Infection Control / Methods, Surgical Site Infection (SSI)
Preoperative Clindamycin Vaginal Cream Versus Vaginal Cleansing With Povidone-iodine on Postoperative Infections After Cesarean Section
To evaluate the effects of preoperative prophylactic administration of clindamycin vaginal cream compared to preoperative vaginal cleansing using a 10% povidone-iodine solution on postpartum infectious morbidity.
- Trial name
- SSI (NCT07474194)
- Testing
- Clindamycin vaginal cream, Vaginal preparation with povidone- iodide solution 10 %
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Beni-Suef University
Wound Infection, Surgical Site Infection
Prophylactic Closed Incision Negative Pressure Wound Therapy on Abdominal Wounds - Clinical and Economic Perspectives
This study evaluates whether specialist negative pressure dressings reduce the risk of wound infections after operations when compared to conservative dressings, and if one negative pressure dressings works better than another.
- Conditions
- Wound Infection, Surgical Site Infection, Surgical Wound, Surgical Incision
- Trial name
- ProNounCE (NCT04110353)
- Testing
- Wound dressings: Conservative dressings, Wound dressings: Prevena dressings, Wound dressings: ciVAC dressings
- Sponsor
- Imperial College London
Surgical Site Infection
Comparison of Iodine + Isopropyl Alcohol Versus Iodine + Antimicrobial Sealant for Skin Preparation
The purpose if this study is to determine whether a microbial sealant (iodine + cyanoacrylate) [InteguSEAL®, Kimberly-Clark] reduces surgical site infections when compared to iodine and isopropyl alcohol (povacrylex in isopropyl…
- Trial name
- NCT01110772
- Testing
- 2-octyl cyanoacrylate [InteguSEAL®], Iodine povacrylex in isopropyl alcohol [Duraprep®, 3M]
- Where
- Mexico
- Volunteers
- 1,200 people
- Sponsor
- National Institute of Cancerología
Nurse's Role, Surgical Site Infection
Effectiveness of the Decolonization Circuit of S. Aureus, Reducing Infection in Primary Arthroplasty of the Lower Limb
Lower limb joint replacement surgery is one of the most prevalent globally. In our center, more than 400 lower limb arthroplasties (LLA) are performed annually.
- Conditions
- Nurse's Role, Surgical Site Infection, Patient Satisfaction
- Trial name
- NCT05158322
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Corporacion Parc Tauli
Wound Heal, Periprosthetic Joint Infection
Closed Incisional Negative Pressure Wound Therapy in Post-surgical Wound Care of Patients With Periprosthetic Joint Infection
In the proposed study, we will apply Prevena on the surgical wound right after closure of the wound in the operating theater. Prevena will be used for 7 days, unless there is ongoing infection or much wound drainage that requires…
- Trial name
- NCT05357287
- Testing
- PREVENA incision management system
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Postoperative Infection
RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section
Background Women undergoing Caesarean Section (CS) have an increased risk of postpartum infections compared to women undergoing vaginal delivery. In Denmark the incidence of post-CS infections is 7-10%.
- Trial name
- APIPICS (NCT02009098)
- Testing
- Cefuroxime
- Where
- 3 sites in Denmark
- Sponsor
- Odense University Hospital
Infection, Surgical Site
IO vs IV Vancomycin in Tourniquetless TKA
Purpose of this study is to compare the efficacy of intravenous and intraosseous antibiotic administration techniques during tourniquetless total knee arthroplasty.
- Trial name
- NCT05705843
- Testing
- Intraosseous Vancomycin Injection, Intravenous Vancomycin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Infections
Role of Oxidized Regenerated Cellulose (ORC) Applied to "Dirty" Surgical Wounds
The purpose of this study is to determine whether oxidized regenerated cellulose (ORC) is effective to reduce the risk of surgical site infections (SSI).
- Trial name
- ORC (NCT00947089)
- Testing
- oxidized regenerated cellulose (Fibrillar SURGICEL), iodoform gauze
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- Catholic University of the Sacred Heart
Post-operative Infections
Reduction in IV Associated Contamination
The purpose of this study is to investigate whether implementing a novel syringe and IV stopcock cap system impregnated with alcohol will reduce IV catheter bacterial contamination and infections in patients.
- Trial name
- NCT01426217
- Testing
- Passive Bundle PSI (Problem Solving Innovations) Medical HubScrub, PSI Medical DocIt
- Where
- United States
- Volunteers
- 594 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Surgery, Biliary Disease
Bile Duct Injury Digestif
Data accumulated from medical record collected from January 2008 until December 2018
- Conditions
- Surgery, Biliary Disease, Bile Duct Injury, Sepsis
- Trial name
- NCT04582240
- Testing
- no intervention
- Volunteers
- 24 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Surgical Wound Infection, Postoperative Wound Infection
Study Evaluating Severe Surgical Site Infections (SSIs) Following Contaminated Or Dirty-infected Abdominal Surgery
This is an observational study to evaluate the relative importance of the known risk factors for severe surgical site infections (SSIs) on the development of the more severe SSI cases, and to describe the demographic, clinical…
- Trial name
- EURIDICE (NCT00906074)
- Testing
- Elective or emergency abdominal surgery
- Volunteers
- 180 people
- Sponsor
- Pfizer
Surgical Site Infection, Breast Reconstruction
Surgical Site Infection and Antibiotic Use Study
This study is a prospective, multi-institutional, noninferiority, randomized control trial that will compare the efficacy of two antibiotic treatments in preventing SSI in patients receiving immediate breast reconstruction with…
- Conditions
- Surgical Site Infection, Breast Reconstruction, Antibiotic Use
- Trial name
- ASSERT (NCT04631185)
- Testing
- Single pre-operative dose of intravenous antibiotics with intraoperative redosing, One week of post-operative antibiotics
- Where
- 5 sites in United States
- Volunteers
- 235 people
- Sponsor
- The Plastic Surgery Foundation
Skin Diseases, Surgical Site Infection
Surgical Hand Antisepsis With Propan-ol-1 60% Per Rubbing and Scrubbing
The present study evaluates the effects of to compare bactericidal efficacy using the reference antiseptic product propan-ol-1 60% using the hand rub method versus hand scrub method in order to test if pass the standard european…
- Trial name
- NCT04446923
- Testing
- Hand antisepsis by scrub
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Ankle Fractures
Factors Influencing the Risk of Surgical Site Infections and Wound Complications in Operatively Treated Ankle Fractures in the Elderly
This study is to analyse risk factors for wound complications or surgical site infections and to analyse whether risk factors for wound complications or surgical site infections are also factors for other complications.
- Trial name
- NCT04379791
- Testing
- Data collection from routine medical records
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Infection, Surgical Site
Povidone-Iodine and Ozonated Distilled Water Irrigation in the Management of Maxillofacial Space Infections
Maxillofacial space infections are among the most common infections encountered in oral and maxillofacial surgery and may progress to severe, life-threatening complications if not properly managed, making their treatment a…
- Trial name
- NCT07904143
- Testing
- Incision and drainage + Povidone-iodine irrigation, Incision and drainage + ozonated distilled
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University
Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS)
Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2
VISION-2 is an international, multi-site, prospective observational cohort study of 20,000 patients undergoing noncardiac surgery.
- Conditions
- Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS), Sepsis, Infection Without Sepsis
- Trial name
- VISION-2 (NCT07300579)
- Testing
- Continuous vital signs measurement device
- Where
- 3 sites in Canada
- Volunteers
- 20,000 people
- Sponsor
- Hamilton Health Sciences Corporation
Wound Complication, Cardiac Surgery
Effectiveness of Topical Vancomycin in Reducing Sternal Wound Infections Post-Cardiac Surgery
Title: The Role of Vancomycin Powder in Reducing Sternal Wound Infections Following Cardiac Surgery: A Randomized Controlled Trial Introduction: Sternal wound infections (SWIs) are significant complications in cardiac surgery…
- Trial name
- NCT06651268
- Testing
- while Group B (vancomycin group, n=12) had vancomycin powder applied during closure. T
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Liaquat National Hospital & Medical College
Surgical Site Infection, Surgical Wound Infection
ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions
ROSSINI 2 is a phase III, multi-arm, multi-stage (MAMS) pragmatic, blinded (patient and outcome assessor), multicentre, randomised controlled trial (RCT) with an internal pilot, to evaluate the use of several in-theatre…
- Conditions
- Surgical Site Infection, Surgical Wound Infection, Surgery--Complications, Surgery
- Trial name
- ROSSINI 2 (NCT03838575)
- Testing
- 2% alcoholic chlorhexidine skin prep (SKIN PREP), Iodophor Antimicrobial Incise Drapes (DRAPE), Gentamicin-impregnated implants/ sponges (SPONGE)
- Where
- 2 sites in United Kingdom
- Volunteers
- 6,610 people
- Sponsor
- University of Birmingham
Infection of Total Hip Joint Prosthesis
Evaluating Advantages of Prevena After Hip and Knee Arthroplasty
Determine the extent to which application of the Prevena vacuum system to clean surgical incisions immediately following surgical procedure (total hip or total knee arthroplasty) will reduce the rates of: readmission to hospital…
- Trial name
- NCT01854138
- Testing
- Prevena Incision Management System
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- ProMedica Health System
Diet, Healthy, Food
The PASTDUe Nutrition Ecosystem Project (PASTDUe)
This is a research study to determine if a particular method of providing nutrition improves the clinical outcomes of patients in the intensive care unit (ICU) who have undergone abdominal surgery and would require nutrition…
- Conditions
- Diet, Healthy, Food, Nutrition, Intensive Care
- Trial name
- PASTDUe (NCT05127109)
- Testing
- Nutrition Ecosystem pathway, Comparator
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
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