Clinical trials: Infection Surgical Wound
Ankle Fractures
Cryotherapy Reduces Time to Surgery and Local Complication in Patients With Ankle Fractures
Ankle fractures are common injuries and cryotherapy is routinely used to reduce pain, swelling and local skin complications, both before and after surgery. However, the results on ankle surgery are contradictory.
- Trial name
- Cryotherapy (NCT06396364)
- Testing
- Cryotherapy
- Where
- 2 sites in Italy
- Volunteers
- 169 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini
Postoperative Infection
RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section
Background Women undergoing Caesarean Section (CS) have an increased risk of postpartum infections compared to women undergoing vaginal delivery. In Denmark the incidence of post-CS infections is 7-10%.
- Trial name
- APIPICS (NCT02009098)
- Testing
- Cefuroxime
- Where
- 3 sites in Denmark
- Sponsor
- Odense University Hospital
Surgical Site Infections
PVP Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site
Prospective cluster-randomized multicenter cross-over trial to prove non-inferiority of PI compared to CHX in preoperative skin antisepsis
- Trial name
- PICASSo (NCT03685604)
- Testing
- CHX disinfection, PI Disinfection
- Where
- 3 sites in Switzerland
- Volunteers
- 3,321 people
- Sponsor
- University Hospital, Basel, Switzerland
Surgical Site Infection
Use of 2% Chlorhexidine Cloths Reduce Surgical Site Infections
Use of 2% chlorhexidine gluconate cloths pre-operatively and daily post-operatively jaw line to toes will decrease surgical site infections (SSI) by 30% when compared to patients who receive routine standard of care (use of…
- Trial name
- NCT02385708
- Testing
- 2% Chlorohexidine Gluconate Standard of Care, 2% Chlorohexidine Gluconate Chin to Toe
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Vanderbilt University
Healing Surgical Wounds
Local Wound Infiltration Versus Caudal Block on Wound Infection and Healing in Paediatrics Inguinal Herniotomy
The aim of the present study is to assess effect of local wound infiltration in comparison with caudal block by bupivacaine 0.25% after inguinal herniotomy in pediatrics on: Wound infection and healing (primary outcome) and…
- Trial name
- NCT03563625
- Testing
- Caudal block, Wound infiltration, Bupivacaine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- University of Alexandria
Surgical Site Infection, SCIP
Use of a Microbial Sealant to Reduce Surgical Site Infections.
Surgical site infections (SSI) are costly complications that may cause significant morbidity and increase the cost of care, particularly in colorectal surgery.
- Trial name
- Integuseal (NCT02241915)
- Testing
- Open Colorectal Surgery, Laparoscopic Surgery
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Circulatory Shock, Sepsis
Shock and Acute Conditions OutcOmes Platform
In-hospital mortality of patients admitted in the intensive care unit (ICU) for circulatory shock remains high (between 20 and 40%).
- Conditions
- Circulatory Shock, Sepsis, Cardiogenic Shock, Major Trauma
- Trial name
- ShockCO-OP (NCT06376318)
- Testing
- Inotrope, Mechanical circulatory support, anti-bodies
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Surgical Site Infection
Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine and Nasal Mupirocin
We hypothesize the application of mupirocin or povidone-iodine to the nares is equally effective in short term Staphylococcus aureus(SA)suppression.
- Trial name
- NCT01313182
- Testing
- mupirocin calcium ointment, 2%, 3M Skin and Nasal Antiseptic
- Where
- United States
- Volunteers
- 1,874 people
- Sponsor
- Solventum US LLC
Abscess, Wound Infection
Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections
The primary object is to compare the early clinical efficacy (after 48-72 hours of therapy) of dalbavancin to the comparator regimen (vancomycin with the option to switch to oral linezolid) for the treatment of patients with a…
- Conditions
- Abscess, Wound Infection, Surgical Site Infection, Cellulitis
- Trial name
- NCT01339091
- Testing
- Dalbavancin, Vancomycin / Linezolid
- Where
- 91 sites in United States, Canada and 6 more
- Volunteers
- 573 people
- Sponsor
- Durata Therapeutics Inc., an affiliate of Allergan plc
Incisional Hernia, Ventral Hernia
Risk Factors for Mesh Infection After Abdominal Wall Reconstruction
Abdominal wall reconstruction (AWR) with mesh is the standard repair for ventral, incisional, parastomal and complex abdominal wall defects, but mesh-related infection remains one of its most serious complications - prolonging…
- Conditions
- Incisional Hernia, Ventral Hernia, Parastomal Hernia, Abdominal Wall Defect
- Trial name
- NCT07725718
- Where
- Egypt
- Volunteers
- 420 people
- Sponsor
- Minia University
Surgical Wound Infection
Comparison of Surgical Site Infection Rate Between Primary, Delayed Primary and Vacuum Assisted Closures.
The objective of the study is to compare infection rates between primary, delayed primary and vacuum assisted closures in contaminated and dirty/infected laparotomy wounds.
- Trial name
- NCT02649543
- Testing
- Primary Closure, Vacuum Assisted Closure, Delayed Primary Closure
- Where
- Mexico
- Volunteers
- 81 people
- Sponsor
- Eduardo Flores Villalba
Surgical Site Infection, Colon Surgery
Gut Decolonisation With Neomycin/Metronidazole or Rifaximin Before Colon Surgery
The goal of this clinical trial is to find out if a gut cleaning using Rifaximin works as well as the usual treatment with Neomycin and Metronidazole to prevent infections after colon surgery.
- Conditions
- Surgical Site Infection, Colon Surgery, Surgical Site Infections
- Trial name
- NeoRiDe (NCT07180615)
- Testing
- Rifaximin (Xifaxan), Metronidazole, Neomycin Sulfate
- Where
- 4 sites in Switzerland
- Volunteers
- 458 people
- Sponsor
- Universität Luzern
Appendicitis
Comparative Study of Harmonic Scalpel vs. Suture Ligation for Appendix Base During Laparoscopic Appendectomy
This study is a comparative study between use of suture ligation vs harmonic scalpel for sealing and cutting the base of appendix.
- Trial name
- HASSEL (NCT07049965)
- Testing
- Suture ligation, Harmonic Scalpel
- Where
- India
- Volunteers
- 60 people
- Sponsor
- GSVM Medical College
Surgical Site Infection, Post-Op Infection
Analysis of Risk Factors for Surgical Site Infections in Patients With Acute Abdomen at Hospital of State University of Haiti
The purpose of this study is to identify the risk factors associated with surgical site infection.
- Trial name
- NCT06480344
- Where
- Haiti
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Haiti
Deep Surgical Site Infection, Spine Surgery
Risk Factors Associated With Infection After Spine Surgery
Surgical site infection (SSI), particularly deep SSI, is one of the most serious complications after spinal surgery. evaluating the risk of SSI and, correspondingly, prescription of prophylactic measures are extremely important…
- Trial name
- NCT05740865
- Testing
- open posterior instrumented thoracolumbar surgery
- Where
- China
- Volunteers
- 3,419 people
- Sponsor
- Xuanwu Hospital, Beijing
Wound Healing Complication, Oral Surgery
Comparison of Three Types of Sutures in Oral Surgery. Study of Bacterial Colonization, Tissue Reaction and Clinical Characteristics: Randomized Clinical Study
Considering the wide variety of surgical sutures currently marketed in the field of Dentistry, it was decided to conduct a study comparing the microbial adhesion and antibacterial activity of three different types of sutures used…
- Conditions
- Wound Healing Complication, Oral Surgery, Third Molar Extraction, Oral Infection
- Trial name
- NCT06864559
- Testing
- To Compare 3 different suture materials used in oral surgery
- Volunteers
- 24 people
- Sponsor
- Universidad de Granada
Sternal Wound Infection, Sternal Non-union
Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and Pain
The goal of this study is to evaluate sternal osteosynthesis, chest wall pain and return to normal activity in open heart surgery patients who had their breast bone closed either with wires or plates.
- Conditions
- Sternal Wound Infection, Sternal Non-union, Pain, Mediastinitis
- Trial name
- RESTORE (NCT00819286)
- Testing
- SternaLock Rigid Fixation Plates, wire (control)
- Where
- 6 sites in United States, Germany
- Volunteers
- 140 people
- Sponsor
- Zimmer Biomet
Craniotomy Surgery, Preventive Health Care
The Effect of Bundle Application on Surgical Site Infection
Surgical site infections (SSI) are the most common complications after surgical operations and are in the top three in Healthcare Associated Infections (HIE).
- Trial name
- NCT06724354
- Testing
- The Surgical Site Infections Precaution Package Form includes the parameters that should be applied to patients before, during and after surgery.
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Surgical Site Infection
Effect of Prophylactic Prosthesis Placement With Versus Without Omega-3 at the Umbilical Trocar Level on Surgical Site Infection and Herniation After Laparoscopic Cholecystectomy in Patients With Risk Factors.
TITLE: Effect of prophylactic prosthesis placement with versus without omega-3 at the umbilical trocar level on surgical site infection and herniation after laparoscopic cholecystectomy in patients with risk factors.
- Trial name
- NCT04345809
- Testing
- MESH WHIT OMEGA-3, MESH WITHOUT OMEGA-3
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Wound; Head, Multiple, Wound; Head, Scalp
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Infection
- Trial name
- FTFDT3 (NCT03872544)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
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