Clinical trials: Infection Surgical Wound
Thyroid Diseases, Wound Healing
Safety and Efficacy of NTP in Thyroid Surgery: Pilot Study on Morbidity Prevention and Adjuvant Oncological Control
The goal of this clinical trial is to evaluate the therapeutic efficacy and safety of non-thermal plasma (NTP) as an adjuvant treatment for surgical bed decontamination and accelerated tissue repair in patients undergoing total…
- Conditions
- Thyroid Diseases, Wound Healing, Thyroidectomy, Surgical Wound Infection
- Trial name
- NCT07382973
- Testing
- Atmospheric Pressure Non-Thermal Plasma, Standard Surgical Wound Care Protocol
- Where
- Mexico
- Volunteers
- 26 people
- Sponsor
- National Institute of Nuclear Research - Mexico
Surgical Site Infection
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
The purpose of this study is to see whether applying povidone iodine (PVI) to the noses of patients undergoing lower extremity (leg, ankle, or foot) orthopedic fixation procedures of high-energy lower extremity fractures (HELEF)…
- Trial name
- POTENT (NCT05763602)
- Testing
- povidone-iodine topical ointment
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Loreen Herwaldt
Infection, Bacterial, Wound Infection
DACC in the REduction of Surgical Site INfection
Surgical site infection is an infection at a place in the body where surgery has taken place, and has been reported in around 5% of people undergoing an operation. In vascular surgery, infection rates are as high as 30%.
- Conditions
- Infection, Bacterial, Wound Infection, Wound Infection, Surgical, Surgical Incision
- Trial name
- DRESSINg (NCT02992951)
- Testing
- DACC-Coated Post Operative Dressing
- Where
- United Kingdom
- Volunteers
- 722 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Surgical Site Infection (SSI), Central Nervous System Tumor
A Clinical Prediction Model for Surgical Site Infection After Central Nervous System Tumor Surgery
1. Study Background For patients undergoing brain or spinal tumor surgery, postoperative surgical wound infection (known as "surgical site infection," SSI) is a recognized risk.
- Trial name
- NCT07378683
- Testing
- ML-Based Enhanced Intervention Package for SSI Prevention, Standard Postoperative Care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ming Yang
Surgical Site Infection (SSI), Mediastinitis
Use of Platelet-Rich Plasma to Reduce Sternal Wound Complications After CABG With Median Sternotomy
The goal of this clinical trial is to learn whether applying autologous platelet-rich plasma (PRP) to the sternal wound during heart surgery improves wound healing and reduces complications after surgery.
- Conditions
- Surgical Site Infection (SSI), Mediastinitis, Delayed Wound Healing
- Trial name
- NCT07352020
- Testing
- Autologous Platelet-Rich Plasma (PRP) Application, Standard Sternal Wound Closure
- Where
- Pakistan
- Volunteers
- 98 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Mandible Fracture, Post-operative Antibiotics
The MANTRA Trial (MANdibular TRauma and Antibiotic Use)
1. FULL TITLE OF THE PROJECT Should we use post-operative antibiotics following surgery for patients with mandible fractures? The MANTRA trial (MANdibular TRauma and Antibiotic use) 2.
- Trial name
- MANTRA (NCT05964140)
- Testing
- Different post-operative antibiotic regimens following surgical treatment of mandible fractures
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,841 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Pre-surgical Anxiety, Blood Glucose Concentration
Vis Pre Surgery Medical Food Validation Study
A pre-market, confirmatory, prospective, interventional, clinical investigation to confirm the clinical safety and performance profile of Vis Pre-surgeryTM that the medical food will reduce pre and post-surgical complications…
- Conditions
- Pre-surgical Anxiety, Blood Glucose Concentration, Blood Cortisol Levels, Electrolyte Levels
- Trial name
- NCT07359222
- Testing
- Pre-surgical medical food
- Where
- India
- Volunteers
- 67 people
- Sponsor
- TM Nutrition LLC
Surgical Wound Infection, Hematoma
Comparing Outcomes Of Single Layer Versus Multilayer Leg Closure Techniques Following Great Saphenous Vein Harvesting For CABG
This study aims to address the knowledge gap by comparing the outcomes of single-layer and multi-layer leg closure techniques following great saphenous vein harvesting for Coronary artery bypass grafting. Research question: 1.
- Conditions
- Surgical Wound Infection, Hematoma, Seroma Following Procedure, Prolonged Hospital Stay
- Trial name
- CABG (NCT07355452)
- Testing
- Multi-layer closure (MLC), singlelayer closure for leg wound
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Varicocele
Comparison of Open Versus Laparoscopic High Ligation Varicocelectomy For The Treatment Of Varicocele
Varicocele is a common condition in which veins around the testis become enlarged, and it may be associated with scrotal discomfort and reduced fertility.
- Trial name
- NCT07353164
- Testing
- Open high ligation varicocelectomy, Laparoscopic high ligation varicocelectomy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Lahore General Hospital
Inguinal Hernia, Hydroceles
Prevention of Surgical Site Infection in Open Paediatric Groin Surgeries Using Intravenous Prophylactic Antibiotics and Antimicrobial-coated Sutures
The goal of this clinical trial is to learn if the use of prophylactic antibiotics and antimicrobial-coated sutures can prevent surgical site infection in children undergoing open groin surgeries.
- Conditions
- Inguinal Hernia, Hydroceles, Surgical Site Infection
- Trial name
- NCT07346742
- Testing
- Antimicrobial-coated sutures, Intravenous Cefuroxime
- Where
- Nigeria
- Volunteers
- 174 people
- Sponsor
- Olawumi Olajide
Elective Abdominal Surgery
Comparison of the Risk of Surgical Site Infections Between Dressings Stopped at Postoperative Day 1 vs Dressings Stopped at Postoperative Day 6+/-1 After Elective Abdominal Surgery
The daily changing of postoperative dressings is a widespread practice, often continuing until the 5th-7th day after surgery. In theory, dressings aim to reduce the risk of superficial surgical site infections (SSIs).
- Trial name
- PAN-STOP (NCT06569862)
- Testing
- Postoperative day 1 dressing, Postoperative day 6+/-1 dressing
- Where
- France
- Volunteers
- 1,288 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Incisional Hernia/Prevention and Control, Surgical Site Infection (SSI)
Comparison of Small-bite Versus Conventional Midline Fascial Closure in Abdominal Surgeries
This study investigates how different incision and fascial closure (suture) techniques used in abdominal surgery are associated with the development of incisional hernia, a common long-term complication after laparotomy.
- Trial name
- NCT07340918
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Staphylococcus Aureus Colonization, Surgical Site Infections
Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
The purpose of the study is to determine the effectiveness, safety, and health-care utilization and costs of a preoperative Staphylococcus aureus (SA) screening and decolonization bundle, (5 days of nasal mupirocin ointment…
- Conditions
- Staphylococcus Aureus Colonization, Surgical Site Infections, Healthcare Associated Infections
- Trial name
- NCT06378359
- Testing
- Screening and decolonization for SA carriers with the 3 drug bundle, No screening for SA, no screening
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Minnesota
Tissue Expander Based Breast Reconstruction
Local Antibiotic Concentrations With Tissue Expanders in Breast Reconstruction
Infections after tissue expander breast reconstruction can lead to pain, additional surgeries, and loss of the reconstruction. This study will compare two types of antibiotic carriers used during surgery to help lower the risk of…
- Trial name
- NCT07339215
- Testing
- Antibiotic loaded calcium sulfate beads, Polymethylmethacrylate antibiotic disc
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Gynecological Surgery
Assessment of Changes in Vaginal Microbiota Profiles Before and After Vaginal Urogynecologic Surgery
Several studies have shown interactions between vaginal microbiota and post-surgical evolution. A study conducted by our team showed a tendency for patients with complications to have a greater diversity of vaginal microbiota.
- Trial name
- VAGIBIOTE (NCT04301401)
- Testing
- Vaginal swabs, Stool samples, Urine samples
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Surgical Site Infection, Cesarean Section; Infection
Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections
This will be a single-center randomized control trial comparing the efficacy of two different formulations of Chlorhexidine surgical skin preparation in preventing cesarean section wound infections.
- Trial name
- NCT05920122
- Testing
- 2% Chlorhexidine gluconate with 70% alcohol, 4% Chlorhexidine Gluconate aqueous solution
- Where
- United States
- Volunteers
- 1,398 people, healthy volunteers welcome
- Sponsor
- Hyagriv Simhan
Surgical Site Infection, Dementia
Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial
Prophylactic TxA administration in patients undergoing major gastrointestinal surgery reduces the incidence of delirium after surgery when compared with placebo.
- Conditions
- Surgical Site Infection, Dementia, Cognition
- Trial name
- TRIGS-D (NCT05470816)
- Testing
- Tranexamic Acid 100Mg/ml Inj Vial 10ml
- Where
- Australia
- Volunteers
- 826 people
- Sponsor
- Bayside Health
Pilonidal Sinus Disease, Sacrococcygeal Pilonidal Sinus
Primary Closure vs Open Technique for Pilonidal Sinus
The purpose of this randomized controlled trial is to compare two commonly used surgical techniques for the treatment of pilonidal sinus disease: excision with primary closure and excision with open (lay-open) technique.
- Conditions
- Pilonidal Sinus Disease, Sacrococcygeal Pilonidal Sinus, Chronic Infected Sinus Tract, Post-surgical Wound Healing
- Trial name
- NCT07311707
- Testing
- Primary Suturing of Surgical Wound, Open Surgical Wound Management
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Teaching Hospital
Surgical Site Infection
Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation
A surgical site infection (SSI) is an infection that occurs after a surgical procedure. Despite a variety of infection prevention strategies, SSIs still occur often and impose a significant burden on patients and the healthcare…
- Trial name
- NCT04548661
- Testing
- Intraoperative incisional wound irrigation with povidone-iodine solution, Intraoperative incisional wound irrigation with saline
- Where
- 13 sites in Canada
- Volunteers
- 2,701 people
- Sponsor
- Sunnybrook Health Sciences Centre
Incisional Hernia, Surgical Site Infection
Prophylactic Mesh Reinforcement for Stoma Closure
In the current work we are aiming to compare between the mesh-reinforced stoma closure and the anatomical closure in terms of the risk of developing surgical site incisional hernia (SSIH),incidence of surgical site infection …
- Conditions
- Incisional Hernia, Surgical Site Infection, Postoperative Pain, Hospital Stay, Length of Stay in Hospital From Surgery to Discharge
- Trial name
- OASIS (NCT06157645)
- Testing
- Prolene mesh
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Assiut University