Clinical trials: Infection Wound
Acute Brain Injury
The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT)
This trial in brain-injured patients will test which of the following will lead to better patient outcomes: (1) an airway management pathway consisting of daily assessments and removal of the breathing tube as soon as patients…
- Trial name
- NCT04291235
- Testing
- Airway Management Pathway, Usual Care
- Where
- 14 sites in Canada
- Volunteers
- 332 people
- Sponsor
- Sunnybrook Health Sciences Centre
Anastomotic Leak, Surgical Site Infection
Bowel Prep vs Non-Bowel Prep for Laparoscopic Colorectal Surgery
Research Question: Are anastomotic leak and surgical site infection rates equivalent in patients having laparoscopic bowel resections without bowel preparation vs those having bowel preparation? Bowel preparation is a distressing…
- Trial name
- NCT00643084
- Testing
- low residue diet/no standard bowel preparation, standard bowel preparation
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Hamilton Health Sciences Corporation
Fracture Related Infection
Incidence of Fracture-Related Infection Among Adult Trauma Patients Undergoing Operative Fracture Fixation A Prospective Cohort Study at the Orthopaedic and Trauma Surgery Unit, Assiut University Hospital
Fracture-related infection (FRI) is an infection occurring after operative or non-operative management of a fracture, and it represents one of the most serious complications encountered in orthopaedic trauma surgery.
- Trial name
- NCT07853404
- Volunteers
- 375 people
- Sponsor
- Assiut University
Acute Kidney Failure, Acute Kidney Insufficiency
Kidney Precision Medicine Project (KPMP) - COVID-19 Protocol
Since its inception, KPMP has developed sophisticated protocols for collection and analysis of human kidney tissue, and for collection of biofluids.
- Conditions
- Acute Kidney Failure, Acute Kidney Insufficiency, Acute Renal Failure, Acute Renal Injury
- Trial name
- NCT05384899
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Washington
HIV Infections, Opioid Use
Trauma Intervention to Optimize PrEP Among Women Who Inject Drugs
The goal of this randomized controlled trial is to test the effectiveness of "TIARAS," a trauma intervention designed to reduce HIV acquisition risk among women who inject drugs (WWID).
- Conditions
- HIV Infections, Opioid Use, Trauma, Psychological
- Trial name
- TIARAS (NCT05192434)
- Testing
- Expressive Writing, Contingency Management
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Drexel University
Diabetic Foot Ulcer, Surgical Wound
The Effect of Natrox® Oxygen Wound Therapy on the Healing Rate of Chronic Diabetic Foot Ulcers
A Multicentre Randomized Controlled Trial to Investigate the Effect of Natrox Topical Oxygen Wound Therapy on the Healing rates of Diabetic Foot Ulcers.
- Trial name
- NCT03905863
- Testing
- Natrox® Oxygen Wound Therapy
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 145 people
- Sponsor
- Inotec AMD Limited
Heart Attack, Cardiac Arrest
Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys
Based on limited published epidemiological data, up to an alarming 1 in 50 surgical inpatients die within 30 postoperative days.
- Conditions
- Heart Attack, Cardiac Arrest, Congestive Heart Failure, Atrial Fibrillation
- Trial name
- SATISFY-SOS (NCT02032030)
- Where
- United States
- Volunteers
- 73,952 people
- Sponsor
- Washington University School of Medicine
Sepsis, Trauma Related Injuries
Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies
In order to better determine which therapy is best for patiënts which present with organ falure during the course of their stay in the intesive care unit (ICU) , one has to determine which underlying mechanism is causing this…
- Conditions
- Sepsis, Trauma Related Injuries, Subarachnoid Haemorrhage (SAH)
- Trial name
- ICU-FERRO (NCT06928649)
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- University Hospital, Antwerp
Tuberculosis Infection
Analysis of Liver Injury Risk Factors in a Multiethnic Population Treated With Antituberculosis Drugs
Tuberculosis (TB) is the world's second leading cause of death from a single infectious agent after COVID-19. In 2022, TB was estimated to have affected 10.6 million people, of whom 1.3 million died because of it, despite the…
- Trial name
- TUBILI (NCT06539455)
- Testing
- standard anti-TB treatment
- Where
- Italy
- Volunteers
- 127 people
- Sponsor
- Stefania Cheli
End-Stage Renal Disease, Kidney Failure
Eculizumab for Prevention and Treatment of Kidney Graft Reperfusion Injury
Study of eculizumab ability to correct the reperfusion injury of the kidney allograft.
- Conditions
- End-Stage Renal Disease, Kidney Failure, Graft Reperfusion Injury
- Trial name
- NCT01756508
- Testing
- eculizumab
- Where
- Russia
- Volunteers
- 57 people
- Sponsor
- Russian Academy of Medical Sciences
Surgical Site Infections
Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting
The hypothesis is that application of Mupirocin to the nose before and after coronary artery bypass grafting surgery will reduce the incidence of surgical site infections.
- Trial name
- MIR-CABG (NCT01949935)
- Testing
- Mupirocin
- Where
- Canada
- Volunteers
- 974 people
- Sponsor
- Horizon Health Network
Mediastinitis
Infectious Mediastinitis Among the Strasbourg Universitary Hospital
Mediastinitis are rare but serious infections, with mortality rates varying from 6 to 30% according to the literature. They are essentially linked to surgical management (cardio-thoracic in particular), but some forms can be…
- Trial name
- MEDIASTINITIS (NCT05001308)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Antibiotic Side Effect, Eyelid; Wound
Topical Antibiotic Prophylaxis for Eyelids
The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery.
- Conditions
- Antibiotic Side Effect, Eyelid; Wound, Eyelid Diseases, Surgical Wound Infection
- Trial name
- NCT03199911
- Testing
- Topical Antibiotic Product, Topical Non-Antibiotic Ointment
- Where
- United States
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Irrigation Solution, Chronic Wound
Effectiveness and Safety of Using Prontosan to Treat Bacterial Biofilm
The goal of this prospective, multi-center, randomized, parallel-controlled, open-label clinical study is to evaluate the effectiveness and safety of Prontosan wound irrigation solution comparing with Normal Saline on the removal…
- Conditions
- Irrigation Solution, Chronic Wound, Pressure Injury, Diabetic Foot Ulcer
- Trial name
- NCT06185465
- Testing
- Prontosan Wound Irrigation Solution, Normal Saline
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- The First Hospital of Jilin University
Skin and Subcutaneous Tissue Bacterial Infections, Wound Infection
A Study of Safety, Tolerability, and Efficacy of AFN-12520000 in the Treatment of Acute Bacterial Skin and Skin Structure Infections Due to Staphylococci
The purpose of the study is to determine the safety, tolerability and effectiveness of AFN-12520000 for in the treatment of Staphylococcal infections of the skin.
- Conditions
- Skin and Subcutaneous Tissue Bacterial Infections, Wound Infection, Cutaneous Abscess, Burn Infection
- Trial name
- NCT01519492
- Testing
- AFN-12520000
- Where
- 14 sites in United States, Canada
- Volunteers
- 103 people
- Sponsor
- Affinium Pharmaceuticals, Ltd
Septic Shock, Acute Kidney Injury
Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock
Although norepinephrine is commonly used and is the recommended agent for the treatment of hypotension in volume-resuscitated hyperdynamic septic shock, Low doses of vasopressin may be added to norepinephrine to maintain arterial…
- Trial name
- NCT04302584
- Testing
- norepinephrine / Vasopressin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Mechanical Ventilation, Tracheal Intubation
Simple Mechanical Device to Control Pressure in the Balloon of the Endotracheal Tube to Prevent Ventilator-acquired Pneumonia
Hypothesis: Nosten® device is able to reduce the time of underinflated balloon and removes excess pressure. This device may thus reduce the risk of ventilator-acquired pneumonia (VAP) and early tracheal lesions resulting from…
- Conditions
- Mechanical Ventilation, Tracheal Intubation, Ventilator-acquired Pneumonia, Intubation -Related Tracheal Lesions
- Trial name
- PAV-PROTECT (NCT02514655)
- Testing
- Nosten® pressure control (it's not an antibiotic, but simple device), Manual pressure control
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Wound Complication
Comparing Wound Complications After Elective Abdominal Surgery Using Two Closure Techniques
Wound complications, increased hospital stays and post-operative morbidity are all common following abdominal surgery. Abdominal closure complications are strongly associated with the closure technique and material used.
- Trial name
- COFACTOR (NCT03527433)
- Testing
- New closure technique
- Where
- Lebanon
- Volunteers
- 274 people
- Sponsor
- American University of Beirut Medical Center
COVID-19
Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine
This is a double blind, placebo controlled study in approximately 2,000 health care workers at risk for being exposed to COVID-19.
- Trial name
- HERO-HCQ (NCT04334148)
- Testing
- Hydroxychloroquine
- Where
- 34 sites in United States
- Volunteers
- 1,360 people, healthy volunteers welcome
- Sponsor
- Adrian Hernandez
Hydrocephalus, Ventriculoperitoneal Shunt
Clinical Observation of V-P Shunt and Application of "Three-step Disinfection" to Reduce Post-operative Infection Rate
A randomized, single blind, parallel controlled, multicenter clinical study was performed in which patients who had undergone a cerebrospinal fluid to peritoneal shunt that met the criteria were divided into two groups (test and…
- Trial name
- NCT04785248
- Testing
- Three-step disinfection
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Baiyun Liu
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