Clinical trials: Infection and Inflammatory Reaction
Sepsis Newborn, Malaria
Immune Dysfunction in Newborn Sepsis
The aim of the project is to study neonatal immune dysfunction associated to the risk of newborn sepsis in a malaria endemic area in Benin.
- Conditions
- Sepsis Newborn, Malaria, Immune Responses
- Trial name
- RECIPAL (NCT03780712)
- Testing
- Non applicable
- Volunteers
- 585 people
- Sponsor
- BioMérieux
Septic Shock
Comparison of ECMO Use and Conventional Treatment in Adults With Septic Shock
Although few cases reported successful treatment of septic shock using extracorporeal membrane oxygenation (ECMO) in adults, no studies compared ECMO to conventional treatment (without ECMO) as treatment for adults with septic…
- Trial name
- NCT01685112
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury, Probiotics
Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients
Septic acute kidney injury is a condition associated with highly related to inflammatory molecules. Prebiotics and probiotics have shown to improve inflammatory cascade in animal model; In this study, the investigators propose…
- Conditions
- Acute Kidney Injury, Probiotics, Sepsis
- Trial name
- NCT03877081
- Testing
- Probiotics
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Hospital Civil de Guadalajara
Septic Shock, Cardiomyopathy
Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock
The aim of this study is to investigate the effects milrinon and levosimandan on n heart function in septic cardiomyopathy and how norepinephrine affects the left and right ventricular function in patients with septick shock…
- Trial name
- SCLM (NCT02640846)
- Testing
- Norepinephrine, Milrinone, Levosimendan
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Bacterial Infections, Bacteremia
Validation Study of Combined Positron Emission Tomography/Computer Tomography to Diagnose Infection and Inflammation
The overall aim is to validate the current use of FDG PET/CT for the diagnosis of infection and inflammation and examine the usefulness of PET/CT applying also other tracers.
- Conditions
- Bacterial Infections, Bacteremia, Gram-Positive Bacterial Infections, Inflammation
- Trial name
- PIN-UP (NCT00835783)
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Odense University Hospital
Sepsis, Vancomycin Treatment
A New Protocol for Continuous Vancomycin Infusion Dosing.
This observational study prospectively collect data on chosen dosing, renal function, measured plasma concentrations and adherence to the recommended clinical protocl for ICU patients treated with continuous vancomycin infusion.
- Trial name
- CVIP (NCT05143645)
- Testing
- Plasma vancoymcin measurements
- Where
- Sweden
- Volunteers
- 101 people
- Sponsor
- Karolinska University Hospital
Gram Negative Septic Shock
Endotoxin in Gram-negative Septic Shock
The purpose of this observational study is to determine whether endotoxin levels and/or their trends can be considered predictive of morbility or mortality in septic shock caused by gram-negative bacteria, searching also for a…
- Trial name
- NCT01602354
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Septic Shock
Fluid Responseveness in Sepsis and Its Correlation to CVP
Introduction Aim of the work Patients and methods Type of study Exclusion criteria Statistical analysis Research ethics Reference
- Trial name
- NCT05612529
- Testing
- US , Echocardiography
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Septic Shock
Midodrine Use in Septic Shock
The investigators aim to perform a randomized, double-blind, placebo-controlled trial to investigate the efficacy of midodrine in decreasing time to IV vasopressor liberation in patients with septic shock.
- Trial name
- NCT03706053
- Testing
- Midodrine Hydrochloride
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Sepsis
Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial)
MODIFY is a randomized, open-labeled, and prospective study that will be conducted in multiple Intensive Care Units (ICUs) and departments of Internal Medicine across Greece.
- Trial name
- MODIFY (NCT05909683)
- Testing
- Change of antimicrobials based on BCID2 and Reveal Rapid AST tests. Stop of antimicrobials based on PCT results., Standard of Care
- Where
- 15 sites in Greece
- Volunteers
- 190 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Endothelial Dysfunction
The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains.
The study aimed to check the influence of timing and composition of diet on markers of gut injury, endotoxemia and stress.
- Trial name
- NCT06403241
- Testing
- 2000 meter ergometer test
- Where
- Poland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Sepsis
SepsisFLAGS ( FLuidAndGender)
In this single-center study the investigators will analyze gender differences among patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years.
- Trial name
- FLAGS (NCT03811483)
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Karolinska Institutet
Sepsis, Blood Purification
Blood Purification in Septic Children
In septic shock, dysregulated host responses to pathogens lead to cytokine storms that damage host tissues and organs, further contributing to the development of organ dysfunction and increased mortality.
- Trial name
- NCT05595239
- Testing
- blood purification(CVVH), blood purification(TPE+CVVH), blood purification(HP+CVVH)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Children's Hospital of Fudan University
Empyema
Thoracoscopy Versus Fibrinolysis in Children With Empyema
The null hypothesis is that patients receiving either thoracoscopy or fibrinolysis for empyema recover in the same amount of time.
- Trial name
- NCT00323531
- Testing
- Chest tube with tPA infusion for 3 days, VATS decortication
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Children's Mercy Hospital Kansas City
Staphylococcus Aureus Bacteremia
Clinical Trial Comparing Safety and Pharmacokinetics of Standard Antibiotic Therapy, Plus Aurexis® or Placebo, for Treatment of Staphylococcus Aureus Bacteremia (SAB)
Hospitalized patients at least 18 years of age, with Staphylococcus aureus bacteremia (SAB) will be enrolled into the study and receive one dose of Aurexis® intravenously on Study Day 1, and will be followed until Study Day 57.
- Trial name
- NCT00198302
- Testing
- Aurexis®
- Volunteers
- 60 people
- Sponsor
- Bristol-Myers Squibb
Pneumonia, Necrotizing Soft Tissue Infection
The Role of Circadian Clock Proteins in Innate and Adaptive Immunity
Our data suggest that modulating the characteristics of light carries the potential to modify the host response to injury and critical illness and thus, improve outcome.
- Conditions
- Pneumonia, Necrotizing Soft Tissue Infection, Intraabdominal Infections, Infection Joint
- Trial name
- NCT03482245
- Testing
- Blue Light
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Washington University School of Medicine
Postoperative Abdominal Wall Wound Complications, Surgical Wound Infection
Arterial Stiffness During Negative Pressure Wound Therapy for Abdominal Wall Wounds
WALLAS is a small observational study of 30 adults with complex wounds in the abdominal wall after surgery. All participants will receive negative pressure wound therapy (NPWT) because their treating team considers it…
- Conditions
- Postoperative Abdominal Wall Wound Complications, Surgical Wound Infection, Surgical Wound Dehiscence, Mesh-Associated Wound Complications
- Trial name
- WALLAS (NCT07907705)
- Testing
- Negative Pressure Wound Therapy (NPWT)
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Dávid Ágoston Kovács
Severe Sepsis or Septic Shock
Effects of Early Exercise Rehabilitation on Long-term Functional Recovery in Patients With Severe Sepsis
We hypothesized that early exercise rehabilitation for patients with severe sepsis or septic shock would decrease their functional disability and cognitive impairment.
- Trial name
- NCT01845766
- Testing
- exercise rehabilitation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Mycoses
Effect of Inflammation on Pharmacokinetics of Posaconazole
Posaconazole plasma concentration and inflammatory markers will be determined in all samples available from routine analysis.
- Trial name
- NCT02492802
- Testing
- posaconazole
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- University Medical Center Groningen
Septic Shock, Sepsis
Effects of Paroxetine on Cardiovascular Function in Septic Patients
It is known that septic shock is characterized by arterial hypotension, decreased peripheral vascular resistance and hyporeactivity to vasoconstrictor agents, with NO being an important mediator of this organ dysfunction.
- Trial name
- NCT05725837
- Testing
- Paroxetine
- Where
- 2 sites in Brazil
- Volunteers
- 130 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.