Clinical trials: Infection and Inflammatory Reaction
SIRS, Sepsis
Prevalence and Outcome of Hypermetabolism in Initial Prevalence and Outcome of Hypermetabolism in Initial Phase of Intensive Care Unit Patient: a Prospective Observational Study
Patients in critical illness frequently present hypermetabolism， which can extremely increase the rest energy expenditure（REE）. We hypothesize that if we alleviate the extremely increased REE will improve ICU patients' outcome
- Conditions
- SIRS, Sepsis, Septic Shock
- Trial name
- NCT02002676
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Nanjing University School of Medicine
Uveitis
Daclizumab and Sirolimus to Treat Uveitis
This study will examine whether the combination of the drugs daclizumab and sirolimus can effectively treat adults with uveitis, an eye inflammation.
- Trial name
- NCT00078689
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Eye Institute (NEI)
Sepsis Newborn, Sepsis
A Multi-center Quasi-experimental Study in Northern Italy to Evaluate the Impact of Sepsis Bundle in Obstetric Settings: the SOS Study
Despite advances in the diagnosis and treatment of sepsis, the studies available in the literature report very high maternal and fetal/neonatal mortality and morbidity in cases of sepsis occurring during pregnancy or the…
- Trial name
- NCT07375108
- Testing
- microbiological results from blood cultures or other materials.
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Sepsis, Primary Myopathies
Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
The primary aim of the project is to apply the non-invasive stimulated muscle force assessment system to i) intensive care unit patients and ii) patients with primary myopathy or subclinic myopathy (e.g., Duchenne muscular…
- Trial name
- NCT00735384
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
COVID-19, Chronic Heart Failure
Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.
Aim of this prospective, interventional, single-center, randomized study is to evaluate the efficacy and safety of intermittent hypoxic-hyperoxic training (IHHT) as a rehabilitation method in patients with cardiovascular…
- Conditions
- COVID-19, Chronic Heart Failure, Hypertension, Arrhythmia
- Trial name
- NCT05379608
- Testing
- Intermittent hypoxic-hyperoxic training, Intermittent hypoxic-hyperoxic training/control
- Where
- Russia
- Volunteers
- 43 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Severe Sepsis, Organ Failure
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure
This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis patients, 30 non-septic patients with organ failure, 30 healthy subjects.
- Trial name
- NCT00361725
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Feeding; Difficult, Newborn, Growth Failure
Prophylactic Probiotics to Extremely Low Birth Weight Prematures
Mortality and incidence of severe complications is still high among extremely premature infants. Common causes of severe complications in this population are poor nutrition, necrotizing enterocolitis, and severe infections.
- Conditions
- Feeding; Difficult, Newborn, Growth Failure, Necrotizing Enterocolitis, Sepsis
- Trial name
- PROPEL (NCT01603368)
- Testing
- Lactobacillus reuteri
- Where
- 2 sites in Sweden
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Ostergotland County Council, Sweden
Chronic Hepatitis b, Viremia
Adaptability of an Undetectable = Untransmissible Model for HBV
Persons with chronic hepatitis B (HBV) infection and active viremia are infectious and may transmit virus to others through blood/body fluid exposure.
- Trial name
- NCT07449091
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Skin Diseases, Bacterial
A Study of the Safety and Effectiveness of Levofloxacin Compared to Ticarcillin/Clavulanate Alone or Followed by Amoxicillin/Clavulanate in the Treatment of Complicated Skin Infections
The purpose of this study is to compare the safety and effectiveness of levofloxacin (an antibiotic) with ticarcillin/clavulanate alone or followed by amoxicillin/clavulanate in the treatment of complicated skin infections.
- Trial name
- NCT00249197
- Testing
- levofloxacin
- Volunteers
- 413 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Early-Onset Neonatal Sepsis
PROcalcitonin and Presepsin-guided Decision for Antibiotic Prophylaxis of EOS
The goal of this randomized controlled study is to compare the outcome of preterm infants who will receive the standard antibiotic prophylaxis for EOS or Procalcitonin/Presepsin-guided antibiotic prophylaxis of early onset sepsis…
- Trial name
- PROPOSE (NCT05796115)
- Testing
- Procalcitonin/Presepsin guided antibiotic prophylaxis for EOS, Antibiotic prophylaxis for EOS
- Volunteers
- 266 people
- Sponsor
- University of Florence
Covid-19
CLBS119 for Repair of COVID-19 Induced Pulmonary Damage
This clinical trial will explore the safety and potential efficacy of CLBS119 for the repair of COVID-19 induced pulmonary damage in adults.
- Trial name
- NCT04522817
- Testing
- CLBS119
- Where
- United States
- Sponsor
- Lisata Therapeutics, Inc.
Severe Sepsis, Septic Shock
International Multicentre Prevalence Study on Sepsis
To mark 10 years of the Surviving Sepsis Campaign (SSC), and timed to coincide with World Sepsis Day, on September 13, 2013, the SSC, ESICM and SCCM will be conducting an international point prevalence study of severe sepsis and…
- Trial name
- IMPRESS (NCT01943747)
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- European Society of Intensive Care Medicine
Erythema Migrans
Cytokines and Chemokines in Erythema Migrans
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with erythema migrans to gain better insight into pathogenesis of early Lyme borreliosis…
- Trial name
- NCT02147249
- Testing
- antibiotic treatment
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Sepsis
Pasteurization of Mother's Own Milk for Preterm Infants
We hypothesize that short term infection-related benefits of human milk feeding are decreased by the process of pasteurization. Primary objective of the study is to compare the incidence of late-onset sepsis in very low birth…
- Trial name
- NCT01580826
- Testing
- pasteurization of mother's own milk
- Where
- Belgium
- Volunteers
- 303 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Abscess
Antibiotic Therapy After Incision and Drainage for Abscess
Background: Skin abscesses are a growing problem in the general pediatric population around the world. While the standard treatment for an abscess/boil is incision and drainage, many physicians also prescribe antibiotics, despite…
- Trial name
- NCT00900510
- Testing
- Incision and drainage, Trimethoprim/Sulfamethoxazole (Bactrim)
- Where
- United States
- Sponsor
- Wake Forest University
Sepsis, Septic Shock
Dose-response Study of Arginine Supplementation in Severe Sepsis
Pilot data in patients and data from pig studies indicate that arginine-NO metabolism is impaired in sepsis with changes in splanchnic metabolism and function, and reduced survival at low nitrate levels.
- Trial name
- NCT01775020
- Testing
- L-arginine
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Bacteremia, Fungemia
Rapid Identification and Susceptibility Testing of Pathogens From Blood Cultures
Would rapid identification of bacteria and rapid detection of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE) (using an FDA-cleared assay) in positive blood culture bottles improve patient care…
- Conditions
- Bacteremia, Fungemia, Bloodstream Infection
- Trial name
- NCT01898208
- Testing
- FilmArray testing, Antimicrobial Stewardship, Bacterial culture
- Where
- United States
- Volunteers
- 743 people
- Sponsor
- Mayo Clinic
Septic Shock, Antibiotic Resistant Infection
Pharmacokinetics of High-dose Tigecycline in Critically Ill Patients
The objective of this study is to describe the pharmacokinetics of tigecycline in critically ill patients receiving continuous venovenous haemodialysis (CVVHD) and to evaluate the frequency of pharmacokinetic/pharmacodynamic…
- Conditions
- Septic Shock, Antibiotic Resistant Infection, Critical Illness
- Trial name
- NCT03034174
- Where
- Poland
- Volunteers
- 37 people
- Sponsor
- Medical University of Lublin
Pneumonia
A Study of the Safety and Effectiveness of Levofloxacin Compared With Ceftriaxone Sodium or Cefuroxime Axetil in the Treatment of Adults With Pneumonia
The purpose of this study is evaluation of the safety and effectiveness of levofloxacin, an antibiotic, compared with ceftriaxone sodium or cefuroxime axetil in the treatment of adults with pneumonia.
- Trial name
- NCT00257049
- Testing
- levofloxacin
- Volunteers
- 604 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Hypovolemia, Sepsis
A Prospective Observational Study of the Expectations and Physiological Effects of Fluid Bolus Therapy
This prospective observational study aims to (i) asses intensive care doctors trigger for and the expected physiological response to a fluid bolus and (ii) evaluate the patient's actual physiological response to a single fluid…
- Conditions
- Hypovolemia, Sepsis, Post-operative Hypovolemia, Fluid Therapy
- Trial name
- NCT03178578
- Where
- 3 sites in Australia, Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
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