Clinical trials: Infection and Inflammatory Reaction
Endotoxemia, Metabolic Syndrome
Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health
The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's propensity to develop obesity…
- Conditions
- Endotoxemia, Metabolic Syndrome, Glucose Metabolism Disorders, Insulin Resistance
- Trial name
- Phenulin (NCT03800277)
- Testing
- Cranberry, Agaves
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Laval University
Sepsis, Severe, Septic Shock
High-dose Intravenous Vitamin C in Patients With Septic Shock
Despite promising observational and phase 1 data, the therapeutic potential of vitamin C for the management of septic shock has not borne out in recent large multi-centre randomized controlled trials.
- Trial name
- HIGH-VIS (NCT04796636)
- Testing
- Sodium Ascorbate
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Septic Shock, Sepsis
Examination of ADMA Serum Level and DDAH II
Examination of ADMA (Asymmetric-Dimethylarginine)-serum level and DDAH II (Dimethylarginine Dimethylaminohydrolase)- Polymorphism in patients with severe Sepsis and septic shock as prognostic value.
- Trial name
- ADSeS (NCT01632059)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Parapneumonic Pleural Effusion, Empyema
Clinical Trial Corticoids For Empyema And Pleural Effusion In Children
STUDY JUSTIFICATION 1. Scientific evidence of the usefulness of corticosteroid use for infectious diseases: Corticosteroids along with antibiotic use improve survival in some infectious processes provide long term benefits and…
- Trial name
- CORTEEC (NCT01261546)
- Testing
- Dexamethasone
- Where
- 8 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Infanta Sofia
Staphylococcus Aureus, Bacteremia
Echocardiography Versus no Echocardiography in S. Aureus Bacteraemia and VIRSTA Score < 3
Staphylococcus aureus is the most frequent cause of both healthcare-associated and community-acquired bloodstream infections worldwide.
- Conditions
- Staphylococcus Aureus, Bacteremia, Infective Endocarditis
- Trial name
- VIRSTA-VAL (NCT06457386)
- Testing
- systematic echocardiography, no echocardiography arm
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Use of Neurostimulation As a Tool for Reconditioning the Neuromuscular System of Patients Admitted to the ICU for Septic Shock
Patients hospitalized in the ICU are likely to develop sarcopenia due to a progressive and generalized decrease in muscle mass that is responsible for generalized muscle weakness known as resuscitation neuromyopathy.
- Trial name
- STIMUREA (NCT05257759)
- Testing
- Usual care, Electrostimulation, Evaluation of the neuromuscular system
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Critical Illness, Intensive Care Unit Delirium
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis.
- Conditions
- Critical Illness, Intensive Care Unit Delirium, Neurocognitive Deficit, Microbiome,immune Function, Critically Ill
- Trial name
- MS-ICU (NCT06749483)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Suture, Complication, Wound
Split Scar Study to Assess Cosmetic Outcome From Differing Suture Spacing
The investigators wish to determine how suture spacing (5 mm vs. 10 mm) affects cosmetic outcome and development of "train tracking" in wounds.
- Conditions
- Suture, Complication, Wound, Wound Complication, Wound Dehiscence
- Trial name
- SFD (NCT03284983)
- Testing
- Suture spacing for wound closure
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Silver Falls Dermatology
Sepsis, Disease of Diaphragm
Ultrasound Diaphragmatic Thickening to Monitor Its Dysfunction in Patients With Sepsis
Diaphragmatic dysfunction is associated with sepsis severity and pejorative prognosis. Aim of this study is to assess diaphragmatic function with the Diaphragmatic Thickening Fraction (DTF) ultrasound measure in patients with…
- Conditions
- Sepsis, Disease of Diaphragm, Defect of Diaphragm, Intensive Care Neuropathy
- Trial name
- US-Diamonds (NCT02474797)
- Testing
- Diaphragmatic ultrasonography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Sepsis
Xuanbai Yiqi Decoction for Sepsis: A Randomized Controlled Trial
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Multiple organ dysfunction syndrome (MODS) is the leading cause of sepsis-related death.
- Trial name
- TCM-CIM-SEPSIS (NCT07902024)
- Testing
- Xuanbai Chengqi Decoction, Xuanbai Chengqi Decoction; Forest-Cultivated Ginseng, Xuanbai Yiqi Decoction
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Periodontitis, Cardiovascular Diseases
Periodontal and Cardiovascular Diseases Project
The purpose of this study is to investigate whether basic periodontal therapy aim to reduce subgingival levels of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, has an impact on the vascular function of…
- Trial name
- NCT02716259
- Testing
- Scaling and root planing, Supragingival prophylaxis
- Where
- 2 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Universidad Complutense de Madrid
Newborn Sepsis
Clinical Criteria for a Pathogen in Term Newborn Suspected of Neonatal Sepsis
Neonatal early onset sepsis (EOS) diagnosis is difficult due to lack of sensivity and specificity markers. The investigators conduced a restrospectif study to all term born infants born between 1 january and 31 December 2013 and…
- Trial name
- IMF-NN (NCT03623503)
- Testing
- Observational study
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Renal Dysfunction, Sepsis
Comparison Between HA330 Hemoperfusion Filter Hemodialysis and Conventional High-Flux Hemodialysis Filter
The purpose of this study is to compare the effectiveness between conventional hemodialysis and hemodialysis using hemoperfusion adsorbents in renal dysfunction caused by sepsis
- Conditions
- Renal Dysfunction, Sepsis, Hemodialysis
- Trial name
- NCT05941624
- Testing
- Ha-330 Hemoperfusion Filter Hemodialysis, Conventional Hemodialysis
- Where
- Indonesia
- Volunteers
- 33 people
- Sponsor
- Universitas Indonesia
Septic Shock
UK ANDROMEDA-Shock-2 RCT
The purpose of the trial is to test if a strategy of resuscitation guided by capillary refill time and individualised clinical hemodynamic phenotyping can improve important clinical outcomes within 28 days in septic shock…
- Trial name
- NCT06366854
- Testing
- Personalised fluid and haemodynamic resuscitation
- Volunteers
- 25 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Sepsis, Septic Shock
A STUDY BEFORE/AFTER THE IMPLEMENTATION OF AN ANTI-INFECTIOUS PRESCRIPTION AID
Anti-infective strategy is a major public health problem. This is a before-and-after study of an anti-infectious prescription tool with a comparison of mortality at 30 days (then 3 and 6 months) between the two inclusion phases…
- Trial name
- NCT05140213
- Testing
- Anti-infectious prescription support tool
- Where
- France
- Volunteers
- 371 people
- Sponsor
- University Hospital, Montpellier
Sepsis
The Degree, Duration and Frequency of Insulin Resistance in Non-operated Patients With Sepsis
Surgery induces insulin resistance lasting for 2-3 weeks. We wanted to elucidate if stress-metabolic, medical conditions carry the same effect.
- Trial name
- NCT04969159
- Testing
- no intervention
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Jens Rikardt Andersen
Sepsis, Respiratory Failure
Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating CfDNA/NETs in Subjects with Sepsis
This is a prospective, multinational, multicentre, randomised, parallel-group, open-label study to assess the safety, tolerability and performance of the NucleoCapture extracorporeal apheresis device in the reduction of…
- Trial name
- NUC-CAP (NCT05647096)
- Testing
- NucleoCapture device
- Where
- 9 sites in Germany, Switzerland and 1 more
- Volunteers
- 73 people
- Sponsor
- Santersus AG
Neuropsychiatric Disorders, Neuroinflammatory Disorders
A Longitudinal Natural History Study of Immune Biomarkers in Neuropsychiatric Illness
Background: Some brain or mental health conditions may be caused when a person s immune system attacks their own body. These are called immunologic neuropsychiatric disorders.
- Conditions
- Neuropsychiatric Disorders, Neuroinflammatory Disorders, Post-Infectious Neuropsychiatric Disorders
- Trial name
- NCT07877246
- Where
- 3 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Mental Health (NIMH)
Acute-On-Chronic Liver Failure, Sepsis
Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis
This study aims to evaluate the efficacy and safety of the double plasma cytokine adsorption system with sequential low-dose plasma exchange (DPCAS+LPE) in patients with acute-on-chronic liver failure (ACLF) complicated by…
- Trial name
- NCT06562803
- Testing
- double plasma cytokine adsorption system with sequential low-dose plasma exchange, plasma exchange
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Sepsis, Acute Renal Failure
The Membrane Adsorbing OXiris Filter in Septic Patients With AKI
Patients with Sepsis / Septic Shock and AKI are submitted to Continuous Renal Replacement Therapy with the oXiris filter . The pro- inflammatory mediators , the endotoxin , interleukin 10 , the main cardiorespiratory indices and…
- Trial name
- MOSAKI (NCT03914586)
- Testing
- oXiris filter
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- FRANCO TURANI
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