Clinical trials: Infection and Inflammatory Reaction
Sepsis, Septic Shock
Impact of Early Sepsis Care Guided by the National Early Warning Score 2 in the Emergency Department
The goal of this pilot clinical trial is to determine the feasibility of conducting a fully powered type 1 hybrid effectiveness-implementation trial on early sepsis care that is guided by early warning score in adult emergency…
- Trial name
- NEWS-1-TRIPS (NCT05731349)
- Testing
- 2018 Surviving Sepsis Campaign Hour-1 Bundle
- Where
- 4 sites in Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Septic Shock
Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock
The purpose of this trial is to investigate the potential of FE 202158 as a treatment which can stabilize blood pressure for treatment of patients in early septic shock.
- Trial name
- NCT01612676
- Testing
- FE 202158
- Where
- 4 sites in Belgium, Denmark
- Volunteers
- 31 people
- Sponsor
- Ferring Pharmaceuticals
Neonatal SEPSIS
Safety and Efficacy of Oral Bovine Lactoferrin
Oral lactoferrin versus Placebo will be given to preterm neonates
- Trial name
- Lactoferrin (NCT04094597)
- Testing
- Lactoferrin
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sepsis
Pharmacokinetic and Pharmacodynamic Evaluation of Doripenem in Critically Ill Trauma Patients
The study hypothesis is to measure how the drug doripenem is cleared from the body of critically ill trauma patients. The investigators will measure blood drug concentrations and calculate how much the drug distributes in the…
- Trial name
- NCT01027897
- Testing
- Doripenem
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Septic Shock
Utility of Sodium Lactate Infusion During Septic Shock
ULIS-1 is an open-label pilot study concerning utility of molar sodium lactate in fluid balance in septic shock patients
- Trial name
- ULIS1 (NCT03528213)
- Testing
- Sodium Lactate light dose, Sodium Lactate high dose, Normal saline
- Where
- 7 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Lille
COVID-19
Safety and Efficacy of Baricitinib for COVID-19
This study plans to learn more about the effects of a medicine called baricitinib on the progression of COVID-19 (coronavirus disease of 2019), the medical condition caused by the Severe Acute Respiratory Syndrome Coronavirus 2…
- Trial name
- NCT04340232
- Testing
- Baricitinib
- Where
- United States
- Sponsor
- University of Colorado, Denver
Sepsis
Procalcitonin as a Tool to Shorten Antibiotic Therapy in the ICU
Recently, biomarkers like procalcitonin have been studied in order to help physicians to decrease the duration of the antibiotic therapy.
- Trial name
- NCT01494675
- Testing
- procalcitonin measurement
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Hospital Israelita Albert Einstein
Acute Respiratory Distress Syndrome, Corona Virus Infection
Knowledge, Attitude and Practice of Dental Students About COVID-19
Coronavirus disease 2019 (abbreviated "COVID- 19") is a pandemic respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China.
- Conditions
- Acute Respiratory Distress Syndrome, Corona Virus Infection, Acute Lung Injury, Fever
- Trial name
- NCT04449081
- Testing
- Knowledge, Attitude, Practice, Awareness, Preference
- Where
- Malaysia
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Gingival Inflammation in Diabetic Patients
Herbal Periodontal Patch (THPP) for Gingival Inflammation in Diabetics
Diabetes increases the incidence and severity of periodontal inflammation and disease, and periodontal disease causes an increase in the severity of diabetes by worsening glycemic control and increasing insulin resistance.The…
- Trial name
- NCT00731432
- Testing
- Transmucosal Herbal Periodontal Patch (THPP)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Izun Pharma Ltd
Cystic Fibrosis, Allergic Bronchopulmonary Aspergillosis
Mechanisms of Immune Tolerance and Inflammation in Patients With Cystic Fibrosis With ABPA
The goal of this study is to identify the immunological factors that influence a patient's response to the presence of the fungus Aspergillus fumigatus (A. fumigatus) in the lungs.
- Trial name
- ABPA (NCT00585364)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Bacteremia
Rapid Antimicrobial Susceptibility Testing with MIC Directly from Positive Blood Cultures with ASTar
The investigators want to investigate the clinical impact of early antimicrobial susceptibility results for gram negative bacilli isolated from blood cultures on antimicrobial choices and early switches of antimicrobial therapy.
- Trial name
- RASTA (NCT06218277)
- Testing
- ASTAR
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Septic Shock
REmote Ischemic COnditioning in Septic Shock
Septic shock remains a major public health problem in industrialized countries, with a mortality rate as high as 50%, largely related to multiple organ dysfunction.
- Trial name
- RECO-Sepsis (NCT03201575)
- Testing
- Remote Ischemic conditioning, Patients with no remote ischemic conditioning
- Where
- 6 sites in France
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Hysterectomy, Cellulitis
Prevention of Vaginal Cellulitis or Vaginal Cuff Abscess After Laparoscopic Hysterectomy
Operative site infection remains the most common complication after performing a gynecological procedure, and has a great implication in the morbidity and mortality of patients.
- Conditions
- Hysterectomy, Cellulitis, Vaginosis, Abscess
- Trial name
- NCT03917134
- Testing
- cephalosporin + Metronidazole Vaginal
- Where
- 2 sites in Colombia
- Volunteers
- 600 people
- Sponsor
- CES University
Septic Shock, Fluid Resuscitation
Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients
Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable.
- Conditions
- Septic Shock, Fluid Resuscitation, Congestion, Venous
- Trial name
- FLUID-IMPACT (NCT06958809)
- Testing
- Echography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospital Ambroise Paré Paris
Staphylococcus Aureus
A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)
The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of AZD7760 when given as an intravenous infusion to healthy participants (Phase I) or participants with end-stage kidney disease receiving hemodialysis…
- Trial name
- PEAK (NCT06749457)
- Testing
- AZD7760
- Where
- 40 sites in United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Neonatal Sepsis
Frequency and Severity of Thrombocytopenia in Neonatal Sepsis
The aim of our study was to find the frequency of thrombocytopenia and its severity in neonates with sepsis
- Trial name
- NCT05692128
- Testing
- Hematological and chemistry tests
- Volunteers
- 50 people
- Sponsor
- Assiut University
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital
Sepsis
Modulation of Gut Microbiota in Early Sepsis: A Pilot Study
Background Sepsis is a common disease leading to high morbidity and mortality. Gut microbiota and/or gut permeability may play a crucial role in the development of organ dysfunction.
- Trial name
- MGM-sepsis (NCT02469571)
- Testing
- Winclove 607
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Medical University of Graz
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced HIV Infection
The purpose of this study is to determine if infection with Mycobacterium avium complex (MAC) occurs in other parts of the body before it is found in the blood.
- Trial name
- NCT00000895
- Testing
- Nelfinavir mesylate, Nevirapine, Azithromycin
- Where
- 26 sites in United States
- Volunteers
- 85 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Late Onset Neonatal Sepsis, Necrotising Enterocolitis
Lactoferrin Prophylaxis in VLBW and Regulator T-cells
The aim of the study is to evaluate whether oral administration of 200 mg/day lactoferrin (LF) to very low birth weight infants reduces late onset sepsis and necrotising enterocolitis and the effect of LF on regulatory T cells.
- Conditions
- Late Onset Neonatal Sepsis, Necrotising Enterocolitis, Very Low Birth Weight Infants
- Trial name
- NCT01287507
- Testing
- Lactoferrin (bovine origin)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara University
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