Clinical trials: Infection and Inflammatory Reaction
Sepsis
Effect of Montelukast Versus Co Enzyme in Sepsis
Sepsis is a leading cause of morbidity and mortality in intensive care units. Sepsis is a life-threatening organ dysfunction linked to a dysregulated host response to infection.
- Trial name
- NCT05293132
- Testing
- Montelukast Sodium 10 mg, Co-Enzyme Q10, Standard Treatment
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Cardiac Output, LIDCO Rapid, Septic Shock
Validation of Uncalibrated Cardiac Output Measurement With LiDCOrapid in the Resuscitation of Critically Ill Patients With Septic Shock: A Prospective Cross-sectional Study.
Transthoracic echocardiography (TTE) has been used as a reference technique for CO measurement and its accuracy has been adequate for many clinical uses. TTE is painless, safe and non-invasive.
- Trial name
- NCT04705493
- Testing
- fluid resuscitation with crystalloid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cytokine Storm, COVID-19
Early Treatment of Cytokine Storm Syndrome in Covid-19
This proposal addresses the problem of preventing the very high mortality and morbidity associated with the development of Cytokine Storm Syndrome (CSS) associated respiratory failure in Covid-19 infection.
- Trial name
- NCT04362111
- Testing
- Anakinra, Normal saline
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Alabama at Birmingham
Staphylococcal Infections, Osteomyelitis
Ceftriaxone as Home IV for Staph Infections
Patients who are admitted to hospital with serious infections, such as those in bone, joints or spine, require a long course of intravenous (IV) antibiotics.
- Conditions
- Staphylococcal Infections, Osteomyelitis, CNS Infection, Septic Arthritis
- Trial name
- NCT04141787
- Testing
- Ceftriaxone, Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
- Where
- 2 sites in Canada
- Volunteers
- 310 people
- Sponsor
- Vancouver Island Health Authority
Sepsis
Electroencephalographic Patterns of Septic Patients and Its Correlation With Cognitive Outcomes
The investigators evaluated the electroencephalographic pattern by the Sinek and Young scales during ICU stay and its correlation with cognitive impairment determined by the Montreal Cognitive Assessment (MOCA) in septic patients…
- Trial name
- NCT05448534
- Testing
- Eletroencephalography
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Hospital Sao Domingos
Septic Shock
Microcirculation After MAP Increase in Septic Shock Patients With Previous Hypertension
The optimal levels of mean arterial pressure that must be achieved in septic shock are subject of debate. Studies tried to correlate blood pressure increase in patients with septic shock with microcirculation.
- Trial name
- NCT02519699
- Testing
- norepinephrine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Shock, Septic
Tryptophan, Serotonin and Kynurenine in Septic Shock
Septic shock is a major cause of mortality and morbidity worldwide. Serotonin (5-HT) is released by activated platelets into the circulation, and is mediator of endothelial dysfunction.
- Trial name
- TSK (NCT00684736)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Versailles Hospital
Sepsis
Personalized Immunotherapy in Sepsis
Αim of ImmunoSep is to assess whether personalized adjunctive immunotherapy directed against a state of either fulminant hyper-inflammation or immunoparalysis is able to change sepsis outcomes.
- Trial name
- ImmunoSep (NCT04990232)
- Testing
- Anakinra or rhIFNγ
- Where
- 35 sites in Germany, Greece and 4 more
- Volunteers
- 280 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Febrile Neutropenia (FN), Sepsis
Prophylaxis of Febrile Neutropenia With Lactoferrin in Oncohematologic Children Undergoing Induction Chemotherapy
Test, in a randomized phase II trial, the safety and efficacy of lactoferrin prophylaxis in preventing the occurrence of febrile neutropenia and sepsis, with particular regard to forms due to multidrug-resistant Gram-negative…
- Conditions
- Febrile Neutropenia (FN), Sepsis, Chemotherapy Treatment
- Trial name
- Lactoferrin (NCT07113314)
- Testing
- Lactoferrin Bovine
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Autoimmune Diseases, Infection
the Influence of Remote Ischemic Preconditioning on Inflammation During Human Endotoxemia
In a wide range of auto-inflammatory and infectious diseases attenuation of the immune response could be beneficial. Remote ischemic preconditioning (RIPC) has been identified as a means of protecting patients undergoing cardiac…
- Trial name
- RISPENDO (NCT02602977)
- Testing
- Multiple-dose Remote Ischemic Preconditioning, Single-dose Remote Ischemic Preconditioning, LPS infusion
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Bacteremia Associated With Intravascular Line, Ventilator Associated Pneumonia
Simplified Selective Digestive Tract Decontamination for the Prevention of Intensive Care Unit Acquired Infections
A simplified graded gut decontamination protocol combined with rigorous bi-weekly screening and appropriate bacterial prophylaxis, will lead to a 25% reduction in the acquisition of blood stream infections and to a 25% reduction…
- Conditions
- Bacteremia Associated With Intravascular Line, Ventilator Associated Pneumonia, Bacteremia
- Trial name
- SDDICU (NCT01798537)
- Testing
- Neomycin Colistin Nystatin Vancomycin
- Where
- Israel
- Volunteers
- 2,400 people
- Sponsor
- Rambam Health Care Campus
Antibiotic Stewardship, Neonatal Sepsis, Late-Onset
Vancomycin Reduction Practices (VRP) in the NICU
This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs).
- Conditions
- Antibiotic Stewardship, Neonatal Sepsis, Late-Onset, Vancomycin
- Trial name
- NCT06772675
- Testing
- External Facilitation
- Where
- 13 sites in United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
Septic Shock
Dexmedetomidine on Microcirculation in Septic Shock
Dexmedetomidine was found might be beneficial to sepsis. Dexmedetomidine were found to improve microcirculation in sepsis animal studies and non-sepsis patients.
- Trial name
- NCT02270281
- Testing
- Dexmedetomidine 0.7 Mcg/kg/h
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Southeast University, China
Congenital Heart Disease, Viremia
Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and Diabetes
Beyond EV-B, there are clinical observations to implicate other viruses in birth defects, including CHD. Since the Rubella epidemic of 1960s', however, viruses have received little attention and certainly no comprehensive study…
- Conditions
- Congenital Heart Disease, Viremia, Virus Diseases, Enterovirus
- Trial name
- CHARMED (NCT04769167)
- Testing
- Stool and Blood Specimen Collection, Follow-up Medical Record Review
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Bile Duct Stricture, Choledocholithiasis
Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatography).
The aim of this study is to prospectively evaluate the frequency of bacteremia after ERCP/cholangioscopy using the Spyglass Direct Visualization System.
- Trial name
- NCT01414400
- Testing
- Blood draw for culture
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Stanford University
Septic Shock, Nonchemotherapy Drug-induced Neutropenia
Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia
Septic shock remains a significant clinical problem associated with high rates of mortality among neutropenic patient despite antimicrobial therapy and supportive care.
- Conditions
- Septic Shock, Nonchemotherapy Drug-induced Neutropenia, Neutropenia After Chemotherapy in Oncohematological Patients, Neutropenia in Patients With Aplastic Anemia
- Trial name
- NCT01849237
- Testing
- Mesenchymal stromal cells, Standard therapy of septic shock
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- National Research Center for Hematology, Russia
Septic Shock, Shock
Balanced Crystalloid vs. Saline in Children With Septic Shock
Fluid resuscitation is the cornerstone of pediatric shock management; current practices of fluid resuscitation in children are not evidence based.
- Trial name
- NCT02835157
- Testing
- Balanced crystalloid solution, 0.9%sodium chloride
- Where
- 4 sites in India
- Volunteers
- 708 people
- Sponsor
- All India Institute of Medical Sciences
Infection, Bacterial, Burns
ICIS in Burn Patients Compared to Other Inflammatory Markers
The current markers of inflammation that govern antibiotic treatment have their significant limitations, especially in patients with burns.
- Conditions
- Infection, Bacterial, Burns, Inflammation
- Trial name
- ICARUS (NCT04894500)
- Testing
- Flow fluorescence cytometry
- Where
- Czechia
- Volunteers
- 97 people
- Sponsor
- Charles University, Czech Republic
Neonatal Sepsis
Treatment Outcome With Antibiotic Use and Its Resistance Pattern Among Patient With Neonatal Sepsis
Determine Treatment outcome with antibiotic use and its resistance pattern among neonatal sepsis patients
- Trial name
- NCT05742477
- Testing
- Antibiotic
- Volunteers
- 100 people
- Sponsor
- Assiut University
COVID-19, Outcome, Fatal
Critically Ill ICU Patients Under Casirivimab- and/or Tocilizumab Application
In a retrospective observational study, critically ill COVID-19 patients admitted to the ICU with the CoV-2 delta-variant between august 2021 and february 2022 were evaluated (ethics application nr.
- Conditions
- COVID-19, Outcome, Fatal, Tocilizumab, Interleukin 6
- Trial name
- CasiTocCOVID (NCT06233357)
- Testing
- treated without (N), with casirivimab / imdevimab (C) or tocilizumab (T), solely, or in combination of both (C + T)
- Where
- Germany
- Volunteers
- 95 people
- Sponsor
- University of Ulm
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