Clinical trials: Infection and Inflammatory Reaction
Lung Neoplasm, Adult ALL
LUS to Assess Lung Injury After Lung Lobectomy
The purpose of the study is to assess whether lung ultrasound is able to detect lung injury after lung resection surgery.
- Conditions
- Lung Neoplasm, Adult ALL, Lung Injury, Lung Inflammation
- Trial name
- OPEN THORUS (NCT04755478)
- Testing
- Thoracotomy, VATS
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital General Universitario de Valencia
Septic Shock, Pediatric Critical Illness
Randomized Control Study in REsuscitation of SEpsis Trial
Crystalloids vs. Synthetic Plasma for Fluid Resuscitation in Children with Sepsis - REsuscitation of SEpsis Trial (RESET): A Comparative and Feasibility Study This research study, called the REsuscitation of SEpsis Trial (RESET)…
- Trial name
- RESET (NCT07035509)
- Testing
- Pharmaceutical fresh frozen plasma, Normal Saline, Ringer lactate (RL)
- Where
- Colombia
- Volunteers
- 150 people
- Sponsor
- Fundación Cardioinfantil Instituto de Cardiología
Gingivitis
Effect of Nigella Sativa Toothpaste on Salivary Biomarkers in Patients With Gingivitis
This study evaluated the effects of Nigella sativa toothpaste on salivary inflammatory biomarkers (IL-1β, PGE2, and MMP-8) in Indonesian Army personnel with gingivitis.
- Trial name
- NS-GINGIVITIS (NCT07447349)
- Testing
- Nigella sativa toothpaste
- Where
- Indonesia
- Volunteers
- 100 people
- Sponsor
- Universitas Airlangga
Wound Infection, Abscess
Oritavancin Versus IV Vancomycin for the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infection
The purpose of this Phase 3 trial is to evaluate the efficacy, safety, and tolerability of oritavancin in ABSSSIs, including those caused by MRSA and to evaluate the potential economic benefit of oritavancin administered as a…
- Conditions
- Wound Infection, Abscess, Systemic Inflammation, Cellulitis
- Trial name
- SOLO II (NCT01252732)
- Testing
- Single-Dose IV Oritavancin Diphosphate, IV Vancomycin
- Where
- United States
- Volunteers
- 1,019 people
- Sponsor
- Melinta Therapeutics, Inc.
Critical Illness, Sepsis
ICU Admission Diagnoses and ICU Mortality
This retrospective cohort study will evaluate whether syndromic clinical diagnoses present at ICU admission are associated with ICU mortality, independent of physiologic severity scores.
- Conditions
- Critical Illness, Sepsis, Septic Shock, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT07369206
- Where
- Turkey (Türkiye)
- Volunteers
- 1,248 people
- Sponsor
- Ataturk University
Uveitis
Efficacy and Safety of Adalimumab in Patients With Active Uveitis
A study comparing the safety and efficacy of adalimumab compared with placebo in patients with active uveitis.
- Trial name
- VISUAL l (NCT01138657)
- Testing
- Adalimumab, Prednisone
- Volunteers
- 239 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Bacteremia, Endocarditis
An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures
Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens.
- Trial name
- NCT06422221
- Testing
- Clindamycin, Doxycycline
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Santiago de Compostela
Sepsis
Curcumin in Critically Ill Patients With Sepsis
Sepsis is a life-threatening condition that occurs when the body's response to an infection becomes overwhelming and damages its own organs.
- Trial name
- NCT07436130
- Testing
- Curcumin
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Hospital Civil de Guadalajara
Sepsis
Sepsis Multiomic Analysis & Risk sTratification in China
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and delayed diagnosis remains a major driver of mortality, while traditional biomarkers (PCT, CRP, lactate) have limited early…
- Trial name
- China SMART-1 (NCT07599644)
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- Yuebei People's Hospital
Sepsis
Cortisol Control of Human Inflammatory Responses to Endotoxin
The purpose of the research is to study a common and dangerous medical condition called 'septic shock' that often occurs in critically ill patients.
- Trial name
- NCT00396344
- Testing
- Çontrol, Hydrocortisone
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Sepsis
Zinc and Inflammation in Sepsis
The purpose of the proposed project is to investigate measures of zinc status in relation to oxidative stress and inflammation in patients with sepsis.
- Trial name
- NCT01328509
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- University of Aberdeen
SIRS, Sepsis
Urinary Proteomics Analysis for Sepsis and Prognosis
As a noninvasive examination, urinary proteomics is a very useful tool to identify renal disease. The purpose of the present study was to find differential proteins among patient with SIRS and sepsis(included survivors and…
- Trial name
- NCT01493492
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Infection, Bacteremia
Pharmacodynamic Parameters of Two Different Doses of Cefepime
Pharmacokinetics is the study of the disposition of drugs in the body, while pharmacodynamics considers the interaction of the drug at the site of infection over time.
- Conditions
- Infection, Bacteremia, Pneumonia
- Trial name
- NCT00177736
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Pittsburgh
Urinary Tract Infection, Cellulitis
Perspectives on Antibiotics and Tracking Symptoms in Children
The study will assess families' perspectives and decision-making regarding the duration of oral antibiotic courses prescribed to children (4-17 years) who present with uncomplicated bacterial infections at the Royal Children's…
- Conditions
- Urinary Tract Infection, Cellulitis, Impetigo, Pharyngitis
- Trial name
- PATSy (NCT07093749)
- Testing
- Garmin Smartwatch
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Murdoch Childrens Research Institute
Severe Septic Syndrome, Septic Shock
Community Acquired Sepsis Cohort
The aim of this project is to constitute a prospective cohort of all the patients presenting to the adult emergencies of the University Hospital Centre (CHU) of Rennes for a septic syndrome of community origin.
- Trial name
- CASC (NCT03280992)
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Rennes University Hospital
Sepsis, Norepinephrine
Cerebral Pulsatility Index Compared To Mean Arterial Blood Pressure Guided Protocol In Sepsis Induced Encephalopathy:
The aim of our study is to compare between transcranial doppler pulsatility index and mean arterial blood pressure in guiding management of sepsis induced encephalopathy.
- Conditions
- Sepsis, Norepinephrine, Encephalopathy
- Trial name
- NCT05842616
- Testing
- Transcranial doppler pulsatility index guided protocol, Mean arterial blood pressure guided protocol
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Tanta University
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Severe Sepsis
The Efficacy of Si-Ni-Tang (a Chinese Herbal Formula) for Severe Sepsis
The purpose of this study is to evaluate the efficacy of Si-Ni-Tang (a Chinese Herbal Formula documented in Shang Han Lun) in treating severe sepsis.
- Trial name
- NCT02777606
- Testing
- Si-Ni-Tang
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Sepsis, Severe Sepsis
Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study
The primary objective is to demonstrate that the plasma inducible nitric oxide synthase (iNOS) assay (PliNOSa® test) has an acceptable relative risk ratio for predicting the onset of sepsis within 72 hours of testing when…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PliNOSa® Test (NCT01371929)
- Volunteers
- 166 people
- Sponsor
- Research & Diagnostic Antibodies
Malaria
Blood-Stage Plasmodium Vivax Cell Bank
Background: Malaria is caused by a parasite (a type of germ called P. vivax) that is carried by mosquitoes. The disease is transmitted to people when they are bitten by infected mosquitoes.
- Trial name
- NCT05095272
- Testing
- HMPBS02-Pv
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.