Clinical trials: Infection in ICU
Ventilator Associated Pneumonia ( VAP)
Impact of Oral Care on Ventilator Associated Pneumonia
The goal of this clinical trial was to find out whether cleaning the mouths of children in the Pediatric Intensive Care Unit (PICU) with toothbrushing and chlorhexidine lowers the chance of getting lung infections in patients on…
- Trial name
- OH-VAP (NCT07287566)
- Testing
- Toothbrushing + Chlorhexidine, Routine oral care + Chlorohexidine
- Where
- Egypt
- Volunteers
- 118 people
- Sponsor
- Ain Shams University
Infectious Disease Transmission
Effectiveness of Chlorhexidine Bathing in the Neonatal Intensive Care Unit
This is a prospective, controlled; crossover study of daily bathing with no-rinse, 2% chlorhexidine gluconate (CHG) impregnated washcloths versus bathing with water/soap or water according to gestational age and weight (e.g.
- Trial name
- NCT02537964
- Testing
- washcloths impregnated with 2% chlorhexidine gluconate
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Shaare Zedek Medical Center
Sepsis, Severe, Sepsis
Multiple Biomarkers in ICU Sepsis Patients
Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality.
- Conditions
- Sepsis, Severe, Sepsis, Septic Shock, AKI
- Trial name
- NCT03802136
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhongnan Hospital
Antibiotic Resistant Infection, Liver Cirrhoses
Antibiotic-resistant Bacterial Infection of Hepatic Patients
the investigators want to identify the microbial profile, antibiotic resistant bacteria in hepatic patients with infections in Liver ICU, and explore risk factors and outcomes in those patients with antibiotic resistant bacteria.
- Trial name
- NCT03855709
- Testing
- microbiological culture and sensetivity
- Volunteers
- 200 people
- Sponsor
- Assiut University
Sepsis, Primary Myopathies
Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
The primary aim of the project is to apply the non-invasive stimulated muscle force assessment system to i) intensive care unit patients and ii) patients with primary myopathy or subclinic myopathy (e.g., Duchenne muscular…
- Trial name
- NCT00735384
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Multivisceral Failure Syndrome, Monovisceral Failure
Measurement of Intestinal Permeability in Intensive Care Patients With Single or Multiple Organ Failure
Multivisceral failure syndrome (MVFS) in humans is associated with a very high risk of mortality, ranging between 30 and 50%. This syndrome is associated with significant systemic inflammation and a high risk of bacteremia, the…
- Conditions
- Multivisceral Failure Syndrome, Monovisceral Failure, Infection in ICU
- Trial name
- BLUE-REA (NCT06845865)
- Testing
- enteric dyed solution
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Shock, Sepsis
Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO
The purpose of this study is To assess the value of dynamics (SVV, PPV) and static indices (GEDVI, ITBVI, CVP) of preload and its combination with contractility (CI,SV, ventricular power, dP/dtmax, CFI, GEF) and lung water…
- Conditions
- Shock, Sepsis, Systemic Inflammatory Response Syndrome, Low Cardiac Output
- Trial name
- PreloaDren (NCT01157299)
- Where
- 7 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario La Paz
Respiratory Insufficiency, Metabolic Disease
Is Venous to Arterial Conversion (v-TAC) of Blood Gas Reliable in Critical Ill Patients in the ICU?
Objective: Arterial blood gas (ABG) is essential in the clinical assessment of potential acutely ill patients venous to arterial conversion (v-TAC), a mathematical method, has recently been developed to convert peripheral venous…
- Conditions
- Respiratory Insufficiency, Metabolic Disease, Acidosis, Alkalosis
- Trial name
- NCT03309423
- Testing
- venous to arterial conversion (v-TAC)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aalborg University
Osteoarticular Infection, Intensive Care Patients
OsteoArticular Sepsis in Intensive Care unitS
This is an ambispective observational study of patients admitted to intensive care with a diagnosis of joint prosthesis infection (mainly knee and hip prostheses).
- Conditions
- Osteoarticular Infection, Intensive Care Patients, Prosthetic Joint Infection
- Trial name
- OASIS (NCT06627842)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Septic Shock
Early Goal-directed Therapy and Myocardial Dysfunction
The cardiovascular system plays a central role in the pathophysiology and prognosis of sepsis, yet the correct hemodynamic management of septic patients is still vigorously debated.
- Conditions
- Sepsis, Septic Shock, Myocardial Dysfunction
- Trial name
- SEPT-MD (NCT01312688)
- Testing
- Early Goal Directed Hemodynamic Therapy in Sepsis
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Covid19
Impact of Steroids on Inflammatory Response in Covid-19
we designed this study to observe the efficacy and safety of dexamethasone versus methylprednisolone in covid-19 diseased patients upon monitoring the inflammatory response and to compare the outcome when these steroids will be…
- Trial name
- NCT04909918
- Testing
- Dexamethasone, Methylprednisolone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Septic Shock, Fluid Therapy
Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
The purpose of the study is to determine if a protocol that assesses patients' daily fluid intake and output can decrease the overall amount of fluid patients receive during the first five days in the ICU.
- Conditions
- Septic Shock, Fluid Therapy, Hypotension
- Trial name
- NCT02473718
- Testing
- Fluid minimization protocol, Ultrasound
- Volunteers
- 82 people
- Sponsor
- Washington University School of Medicine
Pneumonia
Anaerobic Antibiotic Usage for Pneumonia in the Medical Intensive Care Unit
Observation of prescription usage of anaerobic antibiotics for patients admitted to the ICU with pneumonia.
- Trial name
- NCT03046082
- Testing
- Antibiotics
- Volunteers
- 192 people
- Sponsor
- Henry Ford Health System
COVID-19, Critical Illness
Epidemiological and Clinical Characteristics of Critically Ill Patients With COVID-19
Objective of this observational multicentric retrospective-prospective study is to describe the number and the characteristics of patients with Reverse Transcription Polymerase Chain Reaction (RT-PCR) for SARS-CoV2 positivity…
- Trial name
- 2019nCoV_ICU (NCT04388670)
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Policlinico Hospital
COVID-19, Palliative Care
Palliative Care in Patients With COVID-19: Analysis of Costs of Hospitalization in Wards and Intensive Care Units
The confrontation of COVID-19 foreshadowed a serious crisis of scarce health resources worldwide. To assist in this confrontation, the Palliative Care Scientific Technical Core of the Clinical Hospital, School of Medicine, Sao…
- Trial name
- NCT05897229
- Testing
- Analysis of costs with patient care during hospitalization
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo General Hospital
Pulmonary Thromboembolism
Thromboembolic Events in Severe COVID-19 Patients
The main objective of this study is to describe the incidence of thromboembolic events in a population of patients hospitalized in intensive care units in France for severe COVID-19.
- Trial name
- COVICLOT (NCT04405869)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Pregnancy, Postpartum
Organ Dysfunction Score for Obstetric Patients
The goal of this observational study is to develop and evaluate an organ dysfunction score adapted to pregnancy and early puerperium (SOFA-OBS) that also incorporates a non-invasive tool to evaluate respiratory function (pulse…
- Conditions
- Pregnancy, Postpartum, Organ Dysfunction, Critical Care, Intensive Care
- Trial name
- SOFA-OBS (NCT07068022)
- Testing
- Organ dysfunction score adjusted to obstetric patients (SOFA-OBS)
- Where
- 18 sites in Argentina, Ecuador and 2 more
- Volunteers
- 130 people
- Sponsor
- Daniela Vasquez
Artificial Intelligence, Septic Shock
Artificial Intelligence for Sepsis Prediction in ICU
The development of sepsis prediction model in line with Chinese population, and extended to clinical, assist clinicians for early identification, early intervention, has a good application prospect.
- Conditions
- Artificial Intelligence, Septic Shock, Intensive Care Unit Psychosis
- Trial name
- AICUSepsis (NCT04913181)
- Testing
- Artificial intelligence sepsis prediction model
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Peripheral Artery Disease, Peripheral Artery Occlusion
Peripheral Artery Disease and Sepsis Outcomes
The peripheral artery disease (PAD) prevalence is high in the elderly, the diabetic patients, and the patients receiving hemodialysis.
- Conditions
- Peripheral Artery Disease, Peripheral Artery Occlusion, Sepsis, Diagnosis
- Trial name
- NCT03372330
- Testing
- Standard care for sepsis and PAD, Standard care for sepsis
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Invasive Fungal Infection
Pharmacokinetics and Pharmacodynamics of Caspofungin (Cancidas ®) and Drug Tolerance of Fungi to Patients With an Invasive Fungal Infection in the Intensive Care Unit
To investigate pharmacokinetics(PK) and pharmacodynamics(PD) of Caspofungin in ICU patients after received a loading dose of 70mg followed by 50mg (35mg if Child-Pugh score is 7-9), 40 patients will be recruited.
- Trial name
- NCT02510053
- Testing
- Caspofungin
- Volunteers
- 40 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University