Clinical trials: Infection in ICU
Acute Kidney Injury, Sepsis
Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury
The goal of this clinical trial is to learn if adding the iron-binding drug MEX-CD1 to dialysis fluid can help remove excess iron in adults with sepsis-associated acute kidney injury (AKI) requiring dialysis who are in the…
- Trial name
- IRON-IC (NCT07236463)
- Testing
- Continuous veino-veinous dialysis with iron-chelator supplemented dialysate
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Quality of Life, Long-term Outcomes
Quality of Life and Patient-centered Outcomes After ICU Admission for COVID-19
Patients suffering from pneumonia due to SARS-CoV-2 infection, after admission to the Intensive Care Unit (ICU), are susceptible to development of various functional sequelae, increased risk of chronic diseases, increased…
- Conditions
- Quality of Life, Long-term Outcomes, Coronavirus Infection, Morality
- Trial name
- NCT04416464
- Testing
- COVID-19 Pneumonia
- Where
- 3 sites in Portugal
- Volunteers
- 280 people
- Sponsor
- Universidade do Porto
Infections
Effect of Antibiotic Rotation in the ICU on the Prevalence of Antibiotic Resistant Gram-negative Colonisation
The SATURN ICU-trial studies the effect of antibiotic rotation on the prevalence of antibiotic resistant Gram-negative colonisation.
- Trial name
- SATURN (NCT01293071)
- Testing
- Antibiotic rotation
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- UMC Utrecht
Candidiasis
Pharmacokinetics of Fluconazole IV as Prophylaxis or Therapy to ICU Patients
The pharmacokinetics of fluconazole are expected to be different in ICU patients compared to non-ICU patients. The investigators will determine fluconazole and free fluconazole concentrations in 20 ICU patients, who will get…
- Trial name
- PACIFIC (NCT02666716)
- Testing
- fluconazole
- Where
- 3 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
VAP - Ventilator Associated Pneumonia
The Effectiveness of the Modified Bundle in the Prevention of VAP.
Ventilator-associated pneumonia (VAP) is an important cause of prolonged intensive care unit and hospital length of stay, healthcare costs and mortality in mechanically ventilated patients.
- Trial name
- VAP (NCT04038814)
- Testing
- Routine prevention of VAP, Modified prevention of VAP
- Where
- Poland
- Volunteers
- 386 people
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
Sepsis
Procalcitonin as a Tool to Shorten Antibiotic Therapy in the ICU
Recently, biomarkers like procalcitonin have been studied in order to help physicians to decrease the duration of the antibiotic therapy.
- Trial name
- NCT01494675
- Testing
- procalcitonin measurement
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Hospital Israelita Albert Einstein
Septic Shock, Sepsis
Sepsis in the ICU-II
Sepsis-induced cardiac dysfunction (SIMD) is a well-known phenomenon yet its diagnosis remains elusive with no accepted definition, or defining pathophysiological mechanism associated with this disease.
- Conditions
- Septic Shock, Sepsis, Cardiomyopathies, Organ Failure, Multiple
- Trial name
- NCT04695119
- Testing
- Exposure is septic shock (defined according to Sepsis-III) and standard treatment according to departmental protocols.
- Where
- 4 sites in France, Sweden
- Volunteers
- 379 people
- Sponsor
- Linkoeping University
Hospital Acquired Infection
Effect of Copper Impregnated Textiles on Healthcare Associated Infections and Antibiotic Use
This is a prospective Infection Control study comparing rates of antibiotic usage and infections in the General Intensive Care Unit (GICU) in beds with copper impregnated linens versus regular linens.
- Trial name
- NCT02351895
- Testing
- Copper impregnated linen
- Where
- United States
- Volunteers
- 1,302 people
- Sponsor
- Eastern Virginia Medical School
Septic Shock, Sepsis
Observed Pharmacokinetic of Piperacillin/Tazobactam Compared to Amikacin in ICU
The pharmacokinetics of antimicrobials is profoundly modified in Intensive care unit (ICU) patients. To adapt the treatment, it is recommended to measure blood levels of antibiotics.
- Conditions
- Septic Shock, Sepsis, Sepsis Syndrome
- Trial name
- OPTIMA (NCT03990467)
- Testing
- Plasma dosage of amikacin, piperacillin and tazobactam
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Ventilator Associated Pneumonia
Effect of a Constructivist Educational Program on Preventing Ventilator-Associated Pneumonia in Intensive Care Units
This study is designed to investigate the impact of a constructivist education program on nurses and cleaning personnel regarding the preventive care bundle for the prevention of ventilator-associated pneumonia in the intensive…
- Trial name
- NCT07102407
- Testing
- Contructivist, Routine training
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Karaman Training and Research Hospital
Intensive Care Units, Shock, Septic
Fluid Overload Quantification in Septic Shock
Fluid management in septic shock patients remain a great challenge. Insufficient fluid filling lead to hypovolemia, organ failure and increased death, whereas fluid overload was associated to an increased morbidity and mortality…
- Trial name
- FOTOShock (NCT04114162)
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
ICU Patients, Under Mechanical Ventilation
Syndrome and Aspiration Pneumonia in Intensive Care
Inhalation is a common condition in patients with impaired their awareness requiring protection of the upper airway by endotracheal intubation. This inhalation may lead to chemical pneumonitis and/or bacterial pneumonia.
- Conditions
- ICU Patients, Under Mechanical Ventilation, In State of Coma (Define by Glasgow ≤ 8), No Antibiotic Treatment
- Trial name
- SPIRE (NCT01881672)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Cardiac Arrest, Sepsis
Repository for Sepsis and Postresuscitation Samples
The objective of this study is to find a new therapeutic strategy by investigating the serial serum samples of patients with sepsis or postresuscitation state.
- Trial name
- NCT01670383
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Hospital
Infection in ICU
Antibiotic Therapy for Hospital-Acquired Infections in ICU Patients
Antibiotic Therapy for Hospital-Acquired Infections in ICU Patients. A prospective, observational, multicenter study (ANTHICUS).
- Trial name
- ANTHICUS (NCT00543894)
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Septic Shock, Mechanical Ventilation Complication
Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients
Sedation and analgesia in patients with sepsis and hemodynamic instability may be challenging in the ICU. Opioids and propofol can further exacerbate tissue infusion in septic shock by reducing cardiac contractility, increasing…
- Trial name
- NCT05839366
- Testing
- Esketamine, Saline, Remifentanil + propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Septic Shock
Thyroid and Adrenal Disorders in ICU
A dysregulated host response to infection results in organ failure and sepsis, a potentially fatal illness. Sepsis killed about 11 million people worldwide in 2017 and had a death rate close to 20 %
- Trial name
- NCT07245550
- Testing
- Blood sampling
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Sepsis, Disease of Diaphragm
Ultrasound Diaphragmatic Thickening to Monitor Its Dysfunction in Patients With Sepsis
Diaphragmatic dysfunction is associated with sepsis severity and pejorative prognosis. Aim of this study is to assess diaphragmatic function with the Diaphragmatic Thickening Fraction (DTF) ultrasound measure in patients with…
- Conditions
- Sepsis, Disease of Diaphragm, Defect of Diaphragm, Intensive Care Neuropathy
- Trial name
- US-Diamonds (NCT02474797)
- Testing
- Diaphragmatic ultrasonography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Hôpital Saint-Joseph
ICU Patients Requiring a Central Venous Access
Chlorhexidine vs Povidone Iodine in Alcoholic Solutions for Prevention of Central Venous Catheter Infection
The best antiseptic solution for cateheter care remains unknown.High concentration in aquous solution or low concentration in alcoholic solution of chlorhexidine actbetter than povidone iodine in aquous solutions.
- Trial name
- NCT00259350
- Testing
- Skin disinfection
- Where
- France
- Volunteers
- 520 people
- Sponsor
- Poitiers University Hospital
COVID-19
Ramipril for the Treatment of COVID-19
In this study we propose to treat 560 patients with ramipril or placebo for 14 days. After an initial evaluation for COVID-19 status, medical history, and symptom assessment, patients will receive either 2.5 mg/day of ramipril or…
- Trial name
- RAMIC (NCT04366050)
- Testing
- Ramipril 2.5 MG Oral Capsule
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of California, San Diego
Covid19
Long Term Outcome in ICU Treated COVID-19: Return to Work
Return to work (not being on sick leave) within one year after intensive care unit (ICU) admission with Coronavirus disease 2019 (COVID-19) will be assessed.
- Trial name
- NCT05054608
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 13,537 people
- Sponsor
- Uppsala University