Clinical trials: Infection of Bloodstream
Septic Shock, Norepinephrine Adverse Reaction
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit
This is a single-center study retrospectively evaluating a local clinical routine to administer norepinephrine in midline catheters, with regard to complications and patient outcomes
- Conditions
- Septic Shock, Norepinephrine Adverse Reaction, Hypotension and Shock
- Trial name
- NCT06121115
- Testing
- Norepinephrine
- Where
- Sweden
- Volunteers
- 473 people
- Sponsor
- Region Skane
Bloodstream Infection (BSI)
Prolonged Cardiopulmonary Bypass Time as Predictive Factor for in Hospital Infection
This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.
- Trial name
- NCT04548167
- Where
- Switzerland
- Volunteers
- 7,064 people
- Sponsor
- University Hospital, Basel, Switzerland
Carbapenem-resistant Enterobacteriaceae
The Population Pharmacokinetics Study of Tigecycline and Pharmacokinetics- Pharmacodynamics Index in Patients With Carbapenem Resistant Enterobacteriaceae Bloodstream Infection
Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent global public health problem. Patients who were infected caused by CRE bloodstream infection were high mortality up to 40%.
- Trial name
- NCT06049771
- Testing
- Collect blood sample
- Where
- Thailand
- Volunteers
- 72 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Catheter-related Infections
Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI
This is a Phase 3, multi-center, randomized, open-label, assess-blind study to determine the efficacy and safety of MLT, a novel antibiotic lock therapy that combines minocycline with edetate disodium in 25% ethanol solution as…
- Trial name
- NCT02901717
- Testing
- Mino-Lok, Antibiotic lock
- Where
- 22 sites in United States, Puerto Rico
- Volunteers
- 144 people
- Sponsor
- Leonard-Meron Biosciences, Inc.
Central Venous Catheter, Midline Catheter
CVCs Versus Midline Catheters
The goal of this clinical trial is to learn if midline catheters can reduce adverse patient outcomes in adult patients requiring a single vasopressor.
- Conditions
- Central Venous Catheter, Midline Catheter, Complication of Catheter
- Trial name
- NCT06884176
- Testing
- Ultrasound Guided Central Venous Catheter, Ultrasound Guided Midline Catheter
- Sponsor
- Albert Einstein College of Medicine
Sepsis, Severe, Acute Kidney Injury
MR-Evaluation of Renal Function In Septic Patients
A study of renal blood flow and renal oxygenation measured by magnetic resonance after a standardized fluid challenge in critically ill, resuscitated, patients with sepsis due to COVID-19 or other agents.
- Conditions
- Sepsis, Severe, Acute Kidney Injury, COVID-19
- Trial name
- MERSEP (NCT02765191)
- Testing
- Plasma expansion with Ringer's Acetate
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Uppsala University
Central Line-associated Bloodstream Infection (CLABSI)
The Association Between Chlorhexidine Bathing and Central Line-Associated Infections in Medical Intensive Care Units
We conducted a retrospective observational cohort study assessing the relationship between regular bathing using 2% CHG wipes every other day and the occurrence of central line-associated infections (CLABSI) in patients within…
- Trial name
- NCT05919966
- Testing
- Chlorhexidine bathing
- Where
- Taiwan
- Volunteers
- 6,930 people
- Sponsor
- National Taiwan University Hospital
Line Insertion Site, Central Line-associated Bloodstream Infection (CLABSI)
Umbilical Cord Care for the Prevention of Colonization
Umbilical catheters are necessary for many infants admitted to the Newborn Intensive Care Unit (NICU)and utilized when indicated for up to 7 to 14 days.
- Trial name
- NCT01893060
- Testing
- Povidone-Iodine, Chlorhexidine gluconate, Pluronic Cream
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Catheter-related Bloodstream Infection
Expanded Access Program for Patients at Risk for Catheter-related Infections Who Are Not Eligible for DefenCath® Clinical Trials
The EAP for DefenCath is designed to provide access to a broader population of adult and pediatric patients using catheters for various serious medical conditions.
- Trial name
- NCT06707480
- Testing
- Taurolidine and Heparin
- Sponsor
- CorMedix Therapeutics
Hemodynamics Instability
Non-invasive Goal-directed thErapy oN cIrcUlatory Shock
Circulatory shock occurs when the oxygen supply to the tissues decreases, leading to cellular damage and affecting about one-third of patients admitted to Intensive Care Units (ICUs).
- Trial name
- GENIUS (NCT05336357)
- Testing
- Goal-Directed Therapy
- Where
- Brazil
- Volunteers
- 380 people
- Sponsor
- University of Sao Paulo
Staphylococcus Aureus
Impact of 18 FDG PET/CT on the Management of Patients With Staphylococcus Aureus Bloodstream Infection
S. aureus bloodstream infection (SAB) is a severe disease associated with a 30% case-fatality rate at 12 weeks. Severity of this disease is related to the high prevalence of staphylococcal Deep Foci of Infection (SA-DFI), which…
- Trial name
- TEPSTAR (NCT03419221)
- Testing
- PET/CT Positron emission tomography (PET) using small radiotracers, a special camera and a computer to evaluate organ and tissue functions, Patients' routine care with performance of explorations based on anamnesis and clinical symptoms
- Where
- France
- Volunteers
- 291 people
- Sponsor
- University Hospital, Montpellier
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia
This phase III trial compares the effect of xylitol dental wipes to dental wipes without xylitol for the reduction of bloodstream infection in children with acute myeloid leukemia (AML).
- Trial name
- NCT07022678
- Testing
- Best Practice, Biospecimen Collection, Cytarabine
- Where
- 39 sites in United States
- Volunteers
- 556 people
- Sponsor
- Children's Oncology Group
Nosocomial Infections, Bloodstream Infection
Surveillance for Nosocomial Infections in Pediatric Cancer Patients
The Oncoped 2006 study implements a multicenter prospective surveillance module for nosocomial infections in pediatric cancer patients.
- Conditions
- Nosocomial Infections, Bloodstream Infection, Invasive Aspergillosis
- Trial name
- Oncoped2006 (NCT00843804)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bonn
Bloodstream Infections
Clinical Impact of Rapid Identification of Positive Blood Cultures vs. Internal Laboratory Standard
In this before-after study, different new methods for bacterial species identification from positive blood cultures will be compared towards historic controls.
- Trial name
- NCT04156633
- Testing
- conventional identification method: biochemical profiling or MALDI-TOF MS, new identification method: Biofire FilmArray© BCID panel, new identification method: metagenomic WGS
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- University Hospital, Basel, Switzerland
Staphylococcus Aureus Infection
Probability of Target Attainment With Standard Intermittent Bolus Administration of Cefazolin in Patients With Complicated Infections Caused by Staphylococcus Aureus
Given the paucity of pharmacological data on cefazolin treatment of Methicillin-susceptible S. aureus (MSSA) complicated S. aureus infection (CSAI), the primary purpose of this study is to investigate the probability of…
- Trial name
- TARGET II (NCT04503252)
- Testing
- Blood samples for the measurement of the concentration of cefazolin, S. aureus culture isolate, structured telephone interview
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Central Venous Catheter Thrombosis, Central Venous Catheter Related Bloodstream Infection
CLiCK in the Critical Care Unit
Insertion of a central venous access device (CVAD) allows clinicians to easily access the circulation of a patient to administer life-saving interventions.
- Conditions
- Central Venous Catheter Thrombosis, Central Venous Catheter Related Bloodstream Infection, Catheter Complications, Catheter Blockage
- Trial name
- CLiCK (NCT04548713)
- Testing
- 4% EDTA, Saline
- Where
- 6 sites in Canada
- Volunteers
- 1,449 people
- Sponsor
- Fraser Health
Carbapenem-Resistant Enterobacteriaceae Infection
Efficacy and Safety of Colistimethate Sodium for Injection in The Treatment of Carbapenem-Resistant Enterobacteriaceae Infection
Colistin can be used to treat the infection caused by carbapenem-resistant enterobacteriaceae(CRE). In China, patients diagnosed with Hospital-acquired-pneumonia (HAP)or bloodstream infection caused by CRE are recruited, and…
- Trial name
- NCT06051513
- Testing
- treatment with or without colistin
- Where
- 15 sites in China
- Volunteers
- 404 people
- Sponsor
- Southeast University, China
Bile Duct Stricture, Choledocholithiasis
Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatography).
The aim of this study is to prospectively evaluate the frequency of bacteremia after ERCP/cholangioscopy using the Spyglass Direct Visualization System.
- Trial name
- NCT01414400
- Testing
- Blood draw for culture
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Stanford University
Staphylococcus Aureus
Mupirocin-Iodophor ICU Decolonization Swap Out Trial
The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the non-inferiority of two decolonization regimens: Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in…
- Trial name
- NCT03140423
- Testing
- Arm 1. Routine Care (Mupirocin/CHG), Arm 2. Iodophor/CHG Decolonization
- Where
- 137 sites in United States
- Volunteers
- 353,323 people
- Sponsor
- Harvard Pilgrim Health Care
Catheter-Related Infections, Catheter Complications
Impact of Tubing Colonization on the Incidence of Central Venous Catheter Infection
The objective of this study is to assess the relationship between infusion system colonization (ramps or multi-lumen devices) and the occurrence of CVC infection/colonization.
- Conditions
- Catheter-Related Infections, Catheter Complications, Catheter Infection, Catheter-related Bloodstream Infection
- Trial name
- CRIC (NCT06019897)
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers