Clinical trials: Infection of Bloodstream
Pneumonia - Bacterial, Urinary Tract Infection Bacterial
Clinical Impact of a Machine Learning Decision Support System for Empirical Antibiotic Therapy
The goal of this quasi-experimental study is to analyze if a Machine Learning Clinical Decision Support System can improve the empirical antibiotic treatment in patients with pneumonia, urinary tract infection and / or sepsis.
- Conditions
- Pneumonia - Bacterial, Urinary Tract Infection Bacterial, Bloodstream Infection
- Trial name
- NCT07762378
- Testing
- Machine Learning Decision Support System
- Volunteers
- 486 people
- Sponsor
- Instituto de Investigación Sanitaria Gregorio Marañón
Falls Injury, Readmission Rates
Duke Virtual IntEgrated Workflow
This quality improvement initiative aims to evaluate the implementation, utilization, and impact of virtual care technologies and workflows being implemented at Duke University Health System (DUHS).
- Conditions
- Falls Injury, Readmission Rates, CLABSI - Central Line Associated Bloodstream Infection, Catheter Associated Urinary Tract Infection
- Trial name
- Duke VIEW (NCT07406074)
- Testing
- Co-Care
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Duke University
Hepatitis C, Chronic, Non-Alcoholic Fatty Liver Disease
Intra-Individual Reproducibility of the Non-Invasive Assessment of the Portal Circulation
HepQuant tests are new liver tests that are being developed to accurately measure liver function with sensitivity and specificity while being safe and non-invasive.
- Trial name
- Repro (NCT01579162)
- Testing
- Cholate-24-13C (IND 65121) & Cholate-2,2,4,4-d4 (IND 65123)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- HepQuant, LLC
HIV
Sildenafil to Treat HIV-Associated Pulmonary Hypertension
This study will examine how blood pressure in the lungs is controlled in healthy people, people with HIV and people with HIV and pulmonary artery hypertension (high blood pressure in the lungs, also called PAH).
- Trial name
- NCT00327080
- Testing
- MRI, L-NMMA, Acetylcholine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bloodstream Infection, Sepsis
Granzyme A in Patients With E. Coli Bacteremic Urinary Tract Infections
Background: Survival in Granzyme A gene (gzmA) knocked-out mice was significantly longer than in wild-type mice in a murine peritonitis model (cecal ligation puncture).
- Conditions
- Bloodstream Infection, Sepsis, Pathogenesis, Escherichia Coli Bacteremia
- Trial name
- GABEC (NCT03991793)
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Bloodstream Infection, Pneumonia - Bacterial
Combination vs. Monotherapy for Stenotrophomonas Maltophilia Infections
The goal of this multicentre observational study is to analyse the treatment strategies and the outcomes for patients with S. maltophilia infections using target trial emulation methodology.
- Conditions
- Bloodstream Infection, Pneumonia - Bacterial, S Maltophilia Infections
- Trial name
- EMULATE-Sm (NCT07593547)
- Where
- Spain
- Volunteers
- 1,718 people
- Sponsor
- Instituto de Investigación Sanitaria Gregorio Marañón
Sepsis, Acute Circulatory Failure
Systems Analysis of Antigen Presenting Cells in Human Sepsis
Sepsis is a common life-threatening inflammatory response to infection and is the leading cause of death in the intensive care unit.
- Trial name
- DENDRISEPSIS (NCT03788772)
- Testing
- Multiple blood sampling, Simple blood sampling
- Where
- France
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Catheter-Related Infections
Efficacy and Safety of Peripherally Inserted Central Venous Catheters
Central venous access is critical for administering intravenous medications, parenteral nutrition, and fluid therapy in intensive care units (ICUs).
- Conditions
- Critical Illness, Catheter-Related Infections, Upper Extremity Deep Vein Thrombosis, Catheter Obstruction
- Trial name
- NCT07834996
- Volunteers
- 60 people
- Sponsor
- Assiut University
Catheterization, Central Venous, Catheter-Associated Infections
Prevention of Catheter-Associated Infection With the Skin Disinfectant Octenidine Dihydrochloride
Health-care-acquired infections are of tremendous importance for patients, especially catheter-associated infections. More than 40% of all bloodstream infections are associated with central venous catheters (CVC; catheters which…
- Conditions
- Catheterization, Central Venous, Catheter-Associated Infections, Bacterial Infections, Bacteremia
- Trial name
- NCT00515151
- Testing
- 0.1% Octenidine with 30% 1-propanol and 45% 2-propanol, 74% Ethanol with 10% 2-propanol
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital Freiburg
Blood Stream Infection, Blood Stream Infections
Evaluation of Diagnostic Accuracy and Clinical Performance of the UllCORE Bloodstream Infection (BSI) Test
This study is designed to evaluate the clinical performance of the UllCORE Bloodstream Infection (BSI) Test, an investigational molecular diagnostic test intended to detect microorganisms and selected antimicrobial resistance…
- Conditions
- Blood Stream Infection, Blood Stream Infections, Sepsis, Fungemia
- Trial name
- B-RAPID (NCT07859852)
- Testing
- UllCORE BSI Test
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 1,500 people
- Sponsor
- Deepull Diagnostics S.L.
Infectious Diseases and Manifestations
Cohort of the Specialist Network Infectious Diseases
This observational study aims to collect standardized clinical data and biosamples from adults in university hospitals across Germany.
- Trial name
- SNID (NCT06879184)
- Where
- Germany
- Volunteers
- 15,000 people
- Sponsor
- Goethe University
Central Venous Catheter Related Infections
Comparison of Central Venous Catheters With Silver Nanoparticles Versus Conventional Catheters
Bloodstream infections are common in Intensive Care Units (ICUs). The need of a central venous line increases the risk of bacteremia and central venous catheter (CVC) related infections.
- Trial name
- NanoAgCVC (NCT00337714)
- Testing
- CVC impregnated with silver nanoparticles (AgTive®), CVC cannulation
- Where
- Italy
- Volunteers
- 472 people
- Sponsor
- Catholic University of the Sacred Heart
Bacterial Infections
Quinolone Resistance in Bloodstream Isolates of Escherichia Coli
This proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of E. coli. Additionally, the adequacy of empiric antibiotic therapy for E. coli bloodstream infections will be assessed.
- Trial name
- NCT00449735
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Pittsburgh
Shock, Cardiovascular Diseases
Impact of Endothelial and Leukocyte Senescence in Circulatory Shock States
Circulatory shocks (CS) are life-threatening, acute organ dysfunction. Advances in critical care medicine have decreased early hospital mortality, increasing the number of surviving patients.
- Conditions
- Shock, Cardiovascular Diseases, Infection
- Trial name
- Seneshock (NCT03559569)
- Testing
- Biological samples will be done to evaluate the endothelial and leukocyte senescence.
- Where
- France
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Acute Myeloid Leukemia
Study of Periodontitis and Blood Stream Infection in AML Patients Receiving Chemotherapy
This is a prospective, observational study to establish the connection between periodontitis and BSI in AML patients planning to receive intensive chemotherapy.
- Trial name
- NCT04858594
- Testing
- Planned Chemotherapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Enterobacteriaceae Infections, Bloodstream Infection
Antibiotic Treatment Duration (7 vs 14 Days) Comparison in Blood Stream Infection Causes by Enterobacteriaceae
The antimicrobial crisis is a real problem. Infections produced by multiresistant bacteria are becoming more and more frequent, and available antimicrobial agents are usually scarce.
- Trial name
- SHORTEN (NCT02400268)
- Testing
- 7 days course of antibiotic treatment, 14 days course of antibiotic treatment
- Where
- 4 sites in Spain
- Volunteers
- 238 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Gram-Negative Bacterial Infections
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants
The primary purpose of this study is to understand the pharmacokinetics (PK) of single and multiple doses of cefiderocol in children from birth to less than 3 months of age with suspected or confirmed aerobic Gram-negative…
- Trial name
- NCT06086626
- Testing
- Cefiderocol, Standard of Care
- Where
- 4 sites in United States, South Africa and 1 more
- Volunteers
- 30 people
- Sponsor
- Shionogi
Acute Lymphoblastic Leukemia, Bloodstream Infection
The Role of NK Cells to Detect Blood Infection in ALL.
1. Assess possibility of prediction of blood stream infections in ALL patients by profiling of NK cells using flow cytometry. 2. Assess the role of NK cells in development of drug resistance post chemotherapy.
- Trial name
- NCT06160115
- Testing
- Flow cytometry
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bloodstream Infection
Next Generation Pathogen Sequencing for Prediction of Adverse Events
The majority of children and adolescents diagnosed with cancer will experience one or more episodes of fever or infection during their course of therapy.
- Trial name
- NCT03226158
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- St. Jude Children's Research Hospital
Candidiasis
Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis
The purpose of this study is to further evaluate the safety and effectiveness of intravenous anidulafungin (Eraxis™) in patients with a diagnosis of candidemia or invasive candidiasis, which is a fungus infection of the blood or…
- Trial name
- NCT00496197
- Testing
- Eraxis (anidulafungin), Diflucan (fluconazole), Vfend (voriconazole)
- Where
- 43 sites in United States, South Korea
- Volunteers
- 282 people
- Sponsor
- Pfizer