Clinical trials: Infections, Coronavirus
COVID-19
Efficacy,Immunogenicity and Safety of COVID-19 Vaccine , Inactivated Booster Dose in Adults Aged 18 Years and Above
This is a multi-center, case-driven, randomized, double-blinded, and placebo-controlled Phase Ⅲb clinical trial of COVID-19 Vaccine manufactured by Sinovac Research \& Development Co., Ltd.The purpose of this study is to evaluate…
- Trial name
- NCT05156632
- Testing
- Medium-dosage COVID-19 Vaccine,Inactivated, High-dosage COVID-19 Vaccine,Inactivated
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sinovac Research and Development Co., Ltd.
COVID-19 (SARS-CoV-2 Infection)
Use of a Cysteine-rich Whey Protein Isolate in Post COVID-19 Cognitive Impairment
Abstract Background: Post-COVID-19 cognitive impairment (PCCI), characterized by deficits in attention, memory, and executive functioning, remains a major challenge among patients with long COVID.
- Trial name
- NCT07184398
- Testing
- Intervention with Consolidated Cysteine (Immunocal) 20 g per day, Cognitive rehabilitation workshops
- Where
- Colombia
- Volunteers
- 120 people
- Sponsor
- Universidad Libre seccional Cali
COVID-19
Reactogenicity and Immunogenicity of Third Dose Vaccine Booster Following Two Doses of Inactivated Vaccines
It is a prospective open-labeled study, We intended to recruit the participants who completed 2 doses of inactivated COVID-19 vaccine 4-8 months before, and volunteered to receive the third dose of vaccine (inactivated vaccine…
- Trial name
- NCT05095298
- Testing
- Vaccine, COVID19
- Where
- 2 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
COVID-19 Infections
Monitoring the IgG/IgM Antibodies in COVID-19 Patients
The COVID-19 was declared a global pandemic by WHO more than a year ago, and the world is still experiencing a state of global emergency.
- Trial name
- NCT04810117
- Testing
- Serodiagnosis of IgG and IgM
- Where
- 2 sites in Pakistan
- Volunteers
- 373 people
- Sponsor
- University of Sargodha
Covid19
Convalescent Plasma in the Early Treatment of High-Risk Patients With SARS-CoV-2 (COVID-19) Infection
This study proposes to evaluate the therapeutic efficacy, immunologic effects and normalization of laboratory parameters for patients at high risk for mortality when infected by SARS-CoV-2 (COVID-19) when administered one unit…
- Trial name
- NCT04513158
- Testing
- Convalescent Plasma
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Joseph M. Flynn, D.O., MPH
SARS CoV 2 Infection, Vaccination Reaction
Evaluation of Post-vaccination Anti-SARS-CoV-2 Serological Response in Health Care Workers With a History of COVID-19.
Since the beginning of 2020, a major pandemic due to the new emerging coronavirus (SARS-CoV-2) has been spreading around the world.
- Trial name
- VACCICOVID (NCT04934215)
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Fondation Hôpital Saint-Joseph
COVID-19
Compassionate Use of REGN-COV2 for the Treatment of COVID-19
Compassionate Use requests will be considered for individuals who test positive for SARS-CoV-2 and where there is reasonable basis to believe that the patient is infected with a susceptible variant.
- Trial name
- NCT04617535
- Testing
- REGN10933+REGN10987 combination therapy
- Sponsor
- Regeneron Pharmaceuticals
COVID-19
Current Pharmacological Practices in Severe COVID-19
The investigators aim to understand the variation in pharmacological therapies for the management of severe coronavirus disease 2019 (COVID-19) in India and compare it to the recent available evidence.
- Trial name
- NCT04691921
- Testing
- Current clinical practices of participating physicians
- Where
- India
- Volunteers
- 1,055 people
- Sponsor
- NMC Specialty Hospital
COVID-19, COVID Long-Haul
Comprehensive Imaging Exam of Convalesced COVID-19 Patients
COVID-19 is a systemic inflammatory disease involving many organs including the lungs, vascular system liver and myocardium that lead to severe pathologies.
- Trial name
- NCT05920616
- Testing
- Magnetic Resonance Imaging, Ultra-High Resolution Computed Tomography (CT) Scan
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Johns Hopkins University
Solid Organ Transplant Recipients, Autoimmune Diseases
Mass Evaluation of Lateral Flow Immunoassays for the Detection of SARS-CoV-2 (Covid-19) Antibodies
DESIGN Observational epidemiological study AIMS - To determine: 1. The proportion of immunosuppressed people who have detectable SARS-CoV-2 antibodies following a primary vaccine course (3 doses), and the demographic, disease…
- Conditions
- Solid Organ Transplant Recipients, Autoimmune Diseases, Haematological Malignancies
- Trial name
- MELODY (NCT05148806)
- Testing
- self-administered lateral flow assays
- Where
- 4 sites in United Kingdom
- Volunteers
- 28,411 people
- Sponsor
- Imperial College London
Covid19
Post-COVID-Health Study: Multidimensional Health Status of COVID-19 Survivors One Year After a SARS-CoV-2 Infection
This study assesses the multidimensional health status of COVID-19 survivors one-year post-infection using validated subjective and objective measures.
- Trial name
- NCT04794985
- Where
- 3 sites in Netherlands
- Volunteers
- 140 people
- Sponsor
- Maastricht University Medical Center
Abdominal Aortic Aneurysm, COVID-19
AAA Rupture Risk Assessment in COVID-19 Pandemic
The acute phase of the COVID-19 pandemic requires a redefinition of healthcare system to increase the number of available intensive care units for COVID-19 patients.
- Trial name
- NCT05197543
- Testing
- Biomechanical rupture risk assessment
- Where
- Czechia
- Volunteers
- 102 people
- Sponsor
- Masaryk University
Coronavirus Infection, COVID19
Prediction Models for Diagnosis and Prognosis of Severe COVID-19
Clinical observation has found that COVID-19 patients often present inconsistency of clinical features, nucleic acid of the SARS-CoV-2 and imaging findings, which brings challenges to the management of patients.The quantitative…
- Trial name
- NCT04525287
- Where
- 6 sites in China
- Volunteers
- 617 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronavirus Infections
French COVID Cohort
Infectious disease is the single biggest cause of death worldwide. New infectious agents, such as the SARS, MERS and other novel coronavirus, novel influenza viruses, viruses causing viral haemorrhagic fever (e.g.
- Trial name
- FrenchCOVID (NCT04262921)
- Where
- 98 sites in France
- Volunteers
- 4,415 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
COVID 19, SARS-CoV 2
Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation
The purpose of this prospective, Phase 2, multicenter, blinded, randomized placebo controlled study is to demonstrate that early treatment with mavrilimumab prevents progression of respiratory failure in patients with severe…
- Conditions
- COVID 19, SARS-CoV 2, Pneumonia
- Trial name
- NCT04492514
- Testing
- Mavrilimumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Kristin Hudock
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
The Effect of Listening to Music During CPAP on the Agitation Levels and Compliance.
Aim: This study was conducted to determine the effect of listening to music during CPAP on the agitation levels of intensive care patients who underwent CPAP due to COVID-19 and their compliance with the treatment.
- Trial name
- NCT05102084
- Testing
- Listening to music with a bluetooth headset to patients receiving CPAP support
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- SÜMEYYE BİLGİLİ
COVID-19
The COVID-19 Mobile Health Study (CMHS)
This study evaluates a brand-new cell phone-based auto-diagnosis system, which is based on the clinical guidelines, clinical experience, and statistic training model.
- Trial name
- CMHS (NCT04275947)
- Testing
- nCapp, a cell phone-based auto-diagnosis system
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Chinese Alliance Against Lung Cancer
COVID 19 Disease
Tafenoquine in Patients With Mild to Moderate COVID-19
A clinical study to assess the efficacy and safety of oral tafenoquine compared to placebo in patients with mild to moderate COVID 19 disease.
- Trial name
- NCT04533347
- Testing
- Tafenoquine Oral Tablet
- Where
- 10 sites in United States
- Volunteers
- 86 people
- Sponsor
- 60 Degrees Pharmaceuticals LLC
Headache, Migraine
New-onset Severe Headache After Covid-19 Vaccine
Hypotheses: 1. Severe new-onset headache after Covid-19 vaccine occur in a minor subset of vaccinated individuals. 2. Immunological reactivity with activation of trigeminal nociceptors can be among the mechanisms in severe…
- Conditions
- Headache, Migraine, COVID-19
- Trial name
- CovaxHEAD (NCT05235776)
- Testing
- observation
- Where
- 10 sites in Norway
- Volunteers
- 63 people
- Sponsor
- Oslo University Hospital
Psychological Burnout
Effects of Mindfulness Practice on Healthcare Workers
This study aims to examine the effects of mindfulness practice administered using a mobile app on psychological health among health care workers in Singapore.
- Trial name
- NCT04936893
- Testing
- Mindfulness Practice, Cognitive training
- Where
- Singapore
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
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