Clinical trials: Infections, Coronavirus
Heparin Overdose of Undetermined Intent, COVID-19
Unfractionated Heparin in COVID-19 and Non-COVID-19 Patients
The majority of ICU patients with COVID-19 show profound activation of coagulation, potentially resulting in thromboembolic events.
- Trial name
- NCT05509647
- Testing
- Unfractionated heparin
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Leiden University Medical Center
Coronavirus
Telephony Or Videophony for Isolated elDerly in Maine-Et-Loire 49 During COVID-19
The current health crisis at COVID-19 is forcing us to profoundly rethink our social organizations, especially towards our most fragile seniors.
- Trial name
- TOVID-49 (NCT04333849)
- Where
- France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Angers
COVID-19 Pandemic
Elevated Liver Enzymes as a Predictor of Acute Kidney Injury in Hospitalized Patients With COVID-19
In critically ill patients, AKI is a common complication of COVID-19 infection, occurring in 23% to 43% of cases, and was correlated with poor clinical outcomes.
- Trial name
- COVID-19 (NCT05157152)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Thrombosis, Nadroparin
Nadroparin Pharmacokinetics in Different Stages of COVID-19
Objective: The risk of thrombotic complications in critical COVID-19 patients remains extremely high, and multicenter trials failed to prove the survival benefit of escalated doses of low molecular weight heparins (LMWH) in this…
- Conditions
- Thrombosis, Nadroparin, COVID-19, Mechanical Ventilation
- Trial name
- NCT05621915
- Testing
- Nadroparin
- Where
- Poland
- Volunteers
- 43 people
- Sponsor
- Medical University of Lublin
Covid19
Phase 3 Inhaled Novaferon Study in Hospitalized Patients With Moderate to Severe COVID-19
This study is a randomized, double-blind, multicenter, placebo-controlled trial to evaluate the safety and efficacy of a novel therapeutic agent, Novaferon, in hospitalized adult patients diagnosed with COVID-19.
- Trial name
- NOVATION-1 (NCT04669015)
- Testing
- Novaferon
- Where
- 88 sites in Argentina, Brazil and 10 more
- Volunteers
- 914 people
- Sponsor
- Genova Inc.
Colorectal Neoplasms Malignant
Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread…
- Trial name
- COVID-CRC (NCT04712292)
- Testing
- Surgical procedure for confirmed or suspected colorectal cancer
- Where
- 45 sites in Italy
- Volunteers
- 15,000 people
- Sponsor
- University of Bologna
Severe COVID-19
COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic
Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
- Trial name
- CoVAPid2 (NCT05256511)
- Where
- France
- Sponsor
- University Hospital, Lille
SARS-CoV-2, Covid19
Tomographic Findings in COVID-19 and Influenza
The investigators decided to conduct a longitudinal study that compares the pulmonary tomographic patterns found in patients with viral pneumonia (i.e. influenza H1N1 and SARS-CoV-2) at a regional hospital.
- Conditions
- SARS-CoV-2, Covid19, H1N1 Influenza, Computed Tomography
- Trial name
- TOMOCOVIDMX (NCT04497311)
- Testing
- Thoraxic computed tomography
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Universidad de Guanajuato
SARS-CoV2, COVID-19
Are SARS-CoV-2 Specific Antibodies a Correlate for Protection?
The objectives of this study are (1) to determine the ex vivo neutralizing capacity and the longevity of SARS-CoV-2-specific Ab responses and (2) to measure the memory B-cell responses in a cohort of health care workers (HCW)…
- Trial name
- ImmCoV (NCT04469634)
- Testing
- Assessing antibody responses, neutralizing capacity and memory B-cell function
- Where
- 2 sites in Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Adult Patients With Lesions on Fingers or Toes
Clinical and Mechanistic Study of Patients (With COVID-19 or Not) With a Recent Acrosyndrome
The recent and unexpected occurrence of patients with the development of skin lesions on the hands and/ or feet has been described recently.
- Trial name
- ACROCOVID (NCT04590209)
- Testing
- Blood sampling, Skin biopsy
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid-19 Vaccine
Oxidative Stress Parameters, Trace Element and Quality of Life in Women Before and After Covid-19 Vaccines
There is no effective treatment method for COVID-19 yet. With vaccination being the most effective approach to control the COVID-19 pandemic, vaccines have been developed with many different methods.
- Trial name
- NCT04751721
- Testing
- CoronoVac Vaccine
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
COVID-19 Vaccines
The ARCT-154 Self-Amplifying RNA Vaccine Efficacy Study (ARCT-154-01)
This is a Phase 1/2/3, randomized, placebo-controlled, observer-blind study designed to evaluate the safety, immunogenicity and efficacy of ARCT-154 in adult participants to be enrolled in Vietnam.
- Trial name
- ARCT-154-01 (NCT05012943)
- Testing
- ARCT-154 Self-Amplifying RNA SARS-CoV-2 Vaccine, Astra Zeneca COVID-19 vaccine
- Where
- 3 sites in Vietnam
- Volunteers
- 19,474 people, healthy volunteers welcome
- Sponsor
- Vinbiocare Biotechnology Joint Stock Company
COVID-19
Dietary Intake and Eating Habits During the COVID-19 Pandemic
The COVID-19 pandemic affects eating habits, diet quality and physical activity differently among individuals; it is unclear how these behaviours will evolve as the pandemic continues.
- Trial name
- COVIDiet (NCT04407533)
- Testing
- Diet tracking and survey
- Where
- Canada
- Volunteers
- 2,020 people, healthy volunteers welcome
- Sponsor
- McGill University
Diabetes Mellitus, Type One, Diabetes Mellitus, Type I
Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes
This Phase II RCT using multi-dose Bacillus Calmette-Guérin (BCG) in adults with juvenile or childhood onset diabetes is based on prior clinical trials showing that even with advanced disease and little of no remaining pancreas…
- Conditions
- Diabetes Mellitus, Type One, Diabetes Mellitus, Type I, Autoimmune Diabetes, Covid19
- Trial name
- NCT02081326
- Testing
- Bacillus Calmette-Guérin, Saline injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
COVID-19, Fibrosis
Covid-19 Respiratory Sequelae French Cohort
As the investigators need data on long term outcome of Covid-19, especially respiratory sequelae, a national cohort is required.
- Conditions
- COVID-19, Fibrosis, Cohort, Follow-up
- Trial name
- PNEUMOCOVID (NCT05075785)
- Where
- France
- Volunteers
- 2,933 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
COVID-19 Pandemic, Yoga
Effect of Yoga-based Exercises of Healthcare Workers During COVID-19 Pandemic: Prospective Clinical Trial
To investigate the effect of yoga-based exercises therapy on functional capacity, dyspnea, quality of life, depression, anxiety, and sleep quality in healthcare professionals following COVID-19.
- Conditions
- COVID-19 Pandemic, Yoga, Exercise Therapy, Mind-Body Therapies
- Trial name
- NCT05279443
- Testing
- yoga-based exercises therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ankara City Hospital Bilkent
COVID-19 Infection
A Trial Looking at the Use of Camostat in People Who Have Tested Positive for Coronavirus (COVID-19) (SPIKE-1)
This is a phase II randomised, multicentre, prospective, open label clinical trial. The trial aims to recruit patients who test positive for COVID-19 who have mild symptoms and therefore can treat their symptoms in the community.
- Trial name
- SPIKE-1 (NCT04455815)
- Testing
- Camostat
- Where
- 9 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- Cancer Research UK
Corona Virus Infection
Trial of Treatments for COVID-19 in Hospitalized Adults
DisCoVeRy is a randomized controlled trial among adults (≥18-year-old) hospitalized for COVID-19. This study is an adaptive, randomized, open or blinded, depending on the drug to be evaluated, clinical trial to evaluate the…
- Trial name
- DisCoVeRy (NCT04315948)
- Testing
- Remdesivir, Lopinavir/ritonavir, Interferon Beta-1A
- Where
- 62 sites in Austria, Belgium and 5 more
- Volunteers
- 1,552 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
COVID-19
Counter-Regulatory Hormonal and Stress Systems in Patients With COVID-19
The COVID-19 pandemic is associated with a highly variable presentation, ranging from patients who are asymptomatic or experience only mild symptoms to others with acute respiratory syndrome (ARDS) who require ventilatory support…
- Trial name
- CROSS-CO19 (NCT05736900)
- Testing
- Blood sampling
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COVID-19
Improving COVID-19 Vaccine Uptake Among Black and Latino Youth
Black and Latino youth may be less likely to get the COVID-19 vaccine than White youth. In this study we will work with community members to come up with ways to help Black and Latino families learn more about the COVID-19…
- Trial name
- NCT05293392
- Testing
- Culturally-Tailored COVID-19 Vaccine Uptake Intervention, Standard Care
- Where
- United States
- Volunteers
- 5,792 people
- Sponsor
- Nemours Children's Health System
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