Clinical trials: Infections, Coronavirus
COVID-19
A Multicentre Open-label Two-arm Randomised Superiority Clinical Trial of Azithromycin Versus Usual Care In Ambulatory COVID19 (ATOMIC2)
A multi-centre open-label two-arm randomised superiority clinical trial of two weeks of oral Azithromycin 500mg once daily versus usual care in adult patients presenting to secondary care with clinically-diagnosed COVID-19 but…
- Trial name
- ATOMIC2 (NCT04381962)
- Testing
- Azithromycin Capsule
- Where
- 5 sites in United Kingdom
- Volunteers
- 298 people
- Sponsor
- University of Oxford
Pregnancy Related, COVID
Hydroxychloroquine Efficacy and Safety in Preventing SARS-CoV-2 Infection and COVID-19 Disease Severity During Pregnancy and Postpartum
It still unclear how SARS-CoV-2 affects pregnant women and their offspring, as well as which factors may influence obstetrical disease and outcomes, including the timing of maternal viral exposure by gestational age, the effects…
- Conditions
- Pregnancy Related, COVID, Covid-19
- Trial name
- COVID-Preg (NCT04410562)
- Testing
- Hydroxychloroquine
- Where
- 9 sites in Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Covid19
Changing of Trace Element, Homocysteine, Oxidative Stress Parameters and Physical Activity Levels in Covid-19
With the rapid spread of COVID-19 (SARS-CoV-2) disease all over the world and the announcement of a pandemic, researches on many different drug approaches have begun and these researches continue today.
- Trial name
- NCT04694703
- Testing
- Covid-19 group
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Izmir Bakircay University
COVID-19, SARS-CoV2 Infection
Asymptomatic and Pre-symptomatic Transmission of SARS-CoV-2 in a Community Congregant Setting
The overall aim of this study is to measure how transmission of COVID-19 occurs in communities - including the role of super spreaders and/or identifying conditions that may increase transmission risk, with a focus on congregant…
- Trial name
- NCT05145803
- Testing
- Polyvinylalcohol strip [diagnostic]
- Where
- 6 sites in United States
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Colorado School of Public Health
Sars-CoV2
Hydroxychloroquine or Diltiazem-Niclosamide for the Treatment of COVID-19
No optimal antiviral intervention has been yet validated to treat COVID-19 disease. Comorbidities, such as older age, obesity, diabetes, history of cardiovascular diseases are associated with poor prognosis.
- Trial name
- HYdILIC (NCT04372082)
- Testing
- Standard of care (SOC), Hydroxychloroquine, Association of diltiazem and niclosamide
- Sponsor
- University Hospital, Lille
SARS CoV 2 Infection, COVID-19
Diagnosis of Respiratory Viruses in Children With Rhinoswab Junior
A study to investigate Rhinoswab as an alternative method to combined throat and deep nasal (CTDN) swab for respiratory sample collection in children who present to the Royal Children's Hospital (RCH) for viral testing.
- Trial name
- NCT05043623
- Testing
- Rhinoswab Junior, Combined nose and throat swab, Saliva swab
- Where
- Australia
- Volunteers
- 339 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
COVID-19
Tocilizumab for Prevention of Respiratory Failure in Patients With Severe COVID-19 Infection
The purpose of this study is to find out whether the study drug tocilizumab is an effective treatment for COVID-19 infection.
- Trial name
- NCT04377659
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Covid19, Thrombosis
Apixaban for PrOphyLaxis of thromboemboLic Outcomes in COVID-19
Randomized, double-blinded, placebo-controlled trial comparing oral anticoagulation with placebo for community-dwelling patients with symptomatic COVID-19 infection and risk factors for thrombosis.
- Trial name
- APOLLO (NCT04746339)
- Testing
- Apixaban 2.5 MG
- Where
- 4 sites in Brazil
- Volunteers
- 411 people
- Sponsor
- Brazilian Clinical Research Institute
Long Haul COVID, Postural Orthostatic Tachycardia Syndrome
Ivabradine for Long-Term Effects of COVID-19 With POTS Cohort
The purpose of the study is three-fold. The primary aim is to identify the proportion of Long-Haul COVID (LHC) and non-LHC volunteers with relevant symptoms actually have postural orthostatic tachycardia syndrome (POTS).
- Trial name
- COVIVA (NCT05481177)
- Testing
- Ivabradine
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Uniformed Services University of the Health Sciences
Tuberculosis
Evaluation of Tuberculosis Treatment Outcomes
Tuberculosis (TB) is an infectious disease caused by Mycobacterium species grouped in the Mycobacterium tuberculosis complex. TB remains a major global health problem, despite the fact that there are drugs that can eradicate the…
- Trial name
- CLIO-TB (NCT06942975)
- Testing
- Patients with turberculosis
- Where
- Italy
- Volunteers
- 111 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Coronavirus Infection
Efficacy of Probiotics in the Treatment of Hospitalised Patients With Novel Coronavirus Infection
The treatment of the new coronavirus infection (COVID-19) and COVID-19-associated diarrhoea and liver injury remains challenging. Optimizing treatment approaches for COVID-19 remains an issue.
- Trial name
- NCT04854941
- Testing
- Probiotics
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
COVID-19, Venous Thromboembolism
Prevalence and Severity of Venous Thromboembolism in a General Population During the COVID-19 Pandemic
The purpose of this study is to investigate the prevalence of venous thromboembolism in a regional health care system (Region Östergötland, Sweden) before and during the SARS-COV-2 pandemic.
- Conditions
- COVID-19, Venous Thromboembolism, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- NCT04400877
- Testing
- Diagnostic examination for venous thromboembolism
- Where
- Sweden
- Volunteers
- 7,795 people
- Sponsor
- University Hospital, Linkoeping
Acute Respiratory Distress Syndrome, Corona Virus Infection
Knowledge, Attitude and Practice of Dental Students About COVID-19
Coronavirus disease 2019 (abbreviated "COVID- 19") is a pandemic respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China.
- Conditions
- Acute Respiratory Distress Syndrome, Corona Virus Infection, Acute Lung Injury, Fever
- Trial name
- NCT04449081
- Testing
- Knowledge, Attitude, Practice, Awareness, Preference
- Where
- Malaysia
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
COVID 19
AiM COVID for Covid 19 Tracking and Prediction
University of Warwick (Coventry, UK) and NTUU "Igor Sikorsky" Kyiv Polytechnic Institute (Kyiv, Ukraine), together with ClickMedix LLC, have developed an app and a chatbot "AiM COVID" for efficient monitoring and mitigation of…
- Trial name
- NCT04354753
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aarogyam UK
Covid-19
Relationship Between Social Status and Use of Healthcare Services During the Confinement Period Linked to the COVID-19 Epidemic
Epidemics have always affected the most disadvantaged social categories more intensely. This social inequality is expressed in the use of care and emergencies: greater frequency but also greater seriousness.
- Trial name
- NCT04703777
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Mental Health, COVID-19
Leveraging Community Health Workers to Combat COVID-19 and Mental Health Misinformation in Haiti, Malawi, and Rwanda
Partners In Health (PIH), in collaboration with Harvard Medical School, aims to develop and evaluate an SMS-based intervention for Community Health Workers (CHWs) to combat COVID-19 and mental health-related misinformation in…
- Conditions
- Mental Health, COVID-19, Misinformation
- Trial name
- NCT05997511
- Testing
- Card-Sorting Activity (Pre-intervention design), SMS Crafting (Pre-intervention design), SMS Messaging
- Where
- 3 sites in Haiti, Malawi and 1 more
- Volunteers
- 5,109 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
COVID-19 Infection, COVID-19-Associated Acute Respiratory Distress Syndrome
Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia
This is a phase I trial followed by a phase II randomized trial. The purpose of phase I study is the feasibility of treating patients with acute respiratory distress syndrome (ARDS) related to COVID-19 infection (COVID-19) with…
- Conditions
- COVID-19 Infection, COVID-19-Associated Acute Respiratory Distress Syndrome, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT04565665
- Testing
- Best Practice, Mesenchymal Stem Cell
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- M.D. Anderson Cancer Center
Covid19
Core Warming in COVID-19 Patients Undergoing Mechanical Ventilation
The purpose of the proposed pilot study is to determine if core warming improves respiratory physiology of mechanically ventilated patients with COVID-19, allowing earlier weaning from ventilation, and greater overall survival.
- Trial name
- NCT04494867
- Testing
- Core Warming, Standard of Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sharp HealthCare
Metabolic Syndrome, Emotional Eating
The Relationship Between COVID-19 Anxiety Level and Emotional Eating in Individuals With Metabolic Syndrome
The aim was to determine the coronavirus anxiety levels and emotional eating status of cases with diagnosis of MetS according to diagnostic criteria published by the International Diabetic Federation (IDF) in 2005 and healthy…
- Conditions
- Metabolic Syndrome, Emotional Eating, COVID-19
- Trial name
- COVID-19 (NCT04912934)
- Testing
- A survey form was applied to individuals included in the study face-to-face.
- Where
- Turkey (Türkiye)
- Volunteers
- 214 people
- Sponsor
- Ordu University
SARS-CoV-2, COVID-19
VA Remote and Equitable Access to COVID-19 Healthcare Delivery (VA-REACH TRIAL)
We propose a 3-arm RCT to determine the efficacy of hydroxychloroquine or azithromycin in treating mild to moderate COVID-19 among Veterans in the outpatient setting.
- Trial name
- VA-REACH (NCT04363203)
- Testing
- Hydroxychloroquine, Azithromycin
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Salomeh Keyhani MD
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