Clinical trials: Infections, Coronavirus
Covid19, Pneumonia, Viral
Aralast NP With Antiviral Treatment and Standard of Care Versus Antiviral Treatment With Standard of Care in Hospitalized Patients With Pneumonia and COVID-19 Infection
This is a Randomized, Open-Label Study of the Efficacy and Safety of Aralast NP Infusion Therapy with Antiviral Treatment and standard of care versus Antiviral Treatment and standard of care (control group) in Hospitalized…
- Trial name
- NCT04675086
- Testing
- alpha1-proteinase inhibitor, Antiviral Agents
- Where
- United States
- Sponsor
- Blessing Corporate Services, Inc
Patients With COVID-19 Pneumonia Will Allow to Detect an Absolute Reduction in the Rate of Respiratory-failure
Defibrotide in COVID-19 Pneumonia
Phase II, prospective, interventional, single-arm, multicentric, open label trial, with a parallel retrospective collection of data on not treated patients from IRCCS, San Raffaele Scientific Institute included in the…
- Trial name
- DEFI-VID19 (NCT04335201)
- Testing
- Defibrotide Injection
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
COVID-19, SARS-CoV-2 Infection
Nasal and Pulmonary Nitric Oxide Output in COVID-19 Infection
A Study of the relation of COVID-19 infection and its severity to upper and lower airway nitric oxide, upper airway viral load and lung function.
- Trial name
- NCT04728919
- Where
- Finland
- Volunteers
- 82 people
- Sponsor
- Tampere University Hospital
Venous Thromboembolism, covid19
Hemostasis and Inflammation in COVID-19 Patients With Venous and Arterial Thrombotic Complications
The study is aimed at assessing the role of the activity of high-risk markers of thrombotic events (MCP-1, MIP1α, IP-10, phosphatedylserine, calreticulin) on the development of thrombotic complications in patients with COVID -19.
- Conditions
- Venous Thromboembolism, covid19, Thrombosis
- Trial name
- NCT05143567
- Testing
- standard of care anticoagulation in absence of thrombotic complications, standard of care anticoagulation in presence of thrombotic complications, standard of care anticoagulation in combination with elastic compression
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Ryazan State Medical University
COVID-19, Patient Discharge
Symptom Clusters and Risk Factors of COVID-19 Patients
Aim and objectives: To clarify the types, composition, distribution characteristics and risk factors of symptom clusters experienced by discharged patients with COVID-19, to lay the foundation for effective symptom management.
- Conditions
- COVID-19, Patient Discharge, Symptoms and Signs
- Trial name
- NCT05556707
- Where
- China
- Volunteers
- 384 people
- Sponsor
- RenJi Hospital
Nitric Oxide, COVID-19
Inhaled NO in Surgical Patients With Recent COVID-19 Infection
The aim of this study is to evaluate the effect of perioperative inhalation of NO on reducing the incidence of postoperative pulmonary complications in patients with recent COVID-19 infection, and to evaluate whether inhaled NO…
- Conditions
- Nitric Oxide, COVID-19, Surgery, Postoperative Complications
- Trial name
- INORDINATE (NCT05721144)
- Testing
- Nitric Oxide Gas
- Where
- China
- Volunteers
- 660 people
- Sponsor
- Xijing Hospital
Severe COVID-19 Disease
RAPA-501-Allo Therapy of COVID-19-ARDS
The first-in-human Phase 1 study component will evaluate two dose levels of RAPA-501-ALLO off the shelf cells in patients with COVID-19-related ARDS, with key endpoints of safety, biologic and potential disease-modifying effects.
- Trial name
- NCT04482699
- Testing
- RAPA-501-Allo off-the-shelf Therapy of COVID-19
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rapa Therapeutics LLC
Patient Preference, COVID-19
Patients' Experiences in a Medicalized Hotel for COVID-19 Acute Care Support
The 11th March 2020, the World Health Organization (WHO) declared the novel coronavirus Covid-19 as a pandemic. Urgent reorganization was required to give answers to the needs of this new illness.
- Trial name
- NCT04503434
- Where
- Spain
- Volunteers
- 517 people
- Sponsor
- Hospital Clinic of Barcelona
SARS-CoV-2 Infection, COVID-19
Evaluation of a Screening Program for SARS-CoV-2 Infection in the General Population Based on the Use of New Detection Approaches or for Diagnostic Orientation on Saliva
The investigators hypothesize that detection of SARS-CoV2 on saliva samples will increase the performance of the screening program compared to the reference strategy (RT-PCR on a nasopharyngeal swab).
- Trial name
- SALICOV (NCT04578509)
- Testing
- Nasopharyngeal swab, Saliva sample, axillary sweat sample
- Where
- France
- Volunteers
- 5,197 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma, COPD
MUlti-nuclear MR Imaging Investigation of Respiratory Disease-associated CHanges in Lung Physiology
Lung magnetic resonance imaging (MRI) with proton and inhaled inert gases has demonstrated a clinical ability to provide valuable structural and functional information in lung disease.
- Conditions
- Asthma, COPD, Covid19, Long COVID
- Trial name
- MURDOCH (NCT04872309)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Coronavirus Disease 2019 (COVID-19) Pneumonia
Phase 3 Study to Evaluate Efficacy and Safety of Lenzilumab in Patients With COVID-19
The primary objective of this study is to assess whether the use of lenzilumab in addition to current standard of care can alleviate the immune-mediated cytokine release syndrome (CRS) and improve ventilator-free survival in…
- Trial name
- NCT04351152
- Testing
- Lenzilumab, Standard of Care
- Where
- 29 sites in United States, Brazil
- Volunteers
- 520 people
- Sponsor
- Humanigen, Inc.
Acute Respiratory Failure, COVID-19
REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
The worldwide COVID-19 pandemic has led to a dramatic increase in the number of patients hospitalized in intensive care units for an acute respiratory failure in all countries.
- Conditions
- Acute Respiratory Failure, COVID-19, Trauma, Stroke
- Trial name
- REHSCU (NCT04611425)
- Testing
- Remimazolam
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Covid19
Clinical Characteristics of Deceased With COVID-19
This study aims to describe the clinical characteristics of patients who died from COVID-19 in the largest hospital in Bangladesh to understand the risk associated with COVID-19 related mortality in this region.
- Trial name
- COVID-19 (NCT04874792)
- Where
- Bangladesh
- Volunteers
- 282 people
- Sponsor
- Dhaka Medical College
COVID-19 Pneumonia
Clinical, Molecular and Functional Biomarkers for PROgnosis, Pathomechanisms and Treatment Strategies of COVID-19
The aim of the joint project PROVID is to contribute to better outcome prediction for COVID-19 patients, to better clinical management, and to the development of new therapies.
- Trial name
- NCT04977934
- Where
- 5 sites in Austria, Germany
- Volunteers
- 94 people
- Sponsor
- Charite University, Berlin, Germany
Covid19, Hemodynamic Instability
Hemodynamic Impact on Critical Care Patients With Lung Damage Secondary to COVID-19
The aim of the present work is to describe the hemodynamic effects shown in patients with ARDS secondary to SARS-CoV-2 infection
- Conditions
- Covid19, Hemodynamic Instability, ARDS, Human
- Trial name
- NCT04556864
- Where
- 5 sites in Spain
- Volunteers
- 67 people
- Sponsor
- Juan Victor Lorente
SARS-CoV-2 Infection, Acute Kidney Injury
Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection
An interventional clinical trial using oral nicotinamide riboside (NR) in hospitalized patients with COVID-19 infection and acute kidney injury to determine the effect of NR on whole blood nicotinamide adenine dinucleotide (NAD+)…
- Trial name
- NIRVANA (NCT04818216)
- Testing
- Nicotinamide riboside
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI
The overarching goal of this study is to develop PET/MR techniques for the diagnosis of neuropsychiatric post-acute sequelae (PASC) of SARS-CoV-2.
- Trial name
- NCT05615415
- Testing
- PET Tracer, MRI Tracer, 3T PET/MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
COVID-19
ApTOLL for the Treatment of COVID-19
There is a clear and urgent medical need of developing new medicinal products for COVID-19 since there are poor pharmacological tools to block the progression of patients to cytokine storm syndrome (CSS).
- Trial name
- NCT05293236
- Testing
- ApTOLL, Saline
- Where
- 4 sites in Spain
- Volunteers
- 5 people
- Sponsor
- Macarena Hernández Jiménez
Bariatric Surgery Candidate, Covid19
Obesity Surgery During 2020 Italian Pandemic
The first person-to-person Coronavirus disease (COVID-19) transmission in Italy was reported on Feb 21st, 2020, causing one of the most massive outbreak in Europe so far that stopped immediately all elective surgical procedures.
- Conditions
- Bariatric Surgery Candidate, Covid19, Complication of Surgical Procedure, Pneumonia, Viral
- Trial name
- NCT04480034
- Testing
- Bariatric procedures
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- University of Roma La Sapienza
SARS-CoV 2, COVID-19
Test and Treat COVID 65plus+
Patients over equal or older than 65 yearswill be treated with a hydroxychloroquine versus placebo reduced loading dose of 600mg on the first day followed with 400mg/day divided in 2x200mg for 6 more days resulting in a total…
- Trial name
- COVID65plus (NCT04351516)
- Testing
- Hydroxychloroquine
- Where
- 2 sites in Germany
- Sponsor
- University Hospital Tuebingen
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