Clinical trials: Infections, Coronavirus
Covid19
Prophylaxis for COVID-19: Ivermectin in Close Contacts of COVID-19 Cases (IVERNEX-TUC)
Randomized controlled clinical trial on using oral ivermectin in COVID-19 prophylaxis supplying the drug to close contacts of confirmed cases.
- Trial name
- IVERNEX-TUC (NCT04894721)
- Testing
- Ivermectin
- Where
- Argentina
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Ministry of Public Health, Argentina
COVID-19
Epidemiological Observation From a Smartphone Self-monitoring Application for Suspected COVID-19 Patients' Triage
A coronavirus pandemic began on 12/31/2020 with the first Chinese patient. As of 3/16/2020, the epidemic affects more than 100 countries with 169,000 official infections and 6,500 deaths.
- Trial name
- COVID CALL 15 (NCT04331171)
- Testing
- Web application users
- Where
- France
- Volunteers
- 12,000,000 people, healthy volunteers welcome
- Sponsor
- Weprom
SARS-CoV2 Infection
The School SPIT Study - Elementary Schools in High COVID-19 Incidence Regions
This study will conduct an evaluation of a program that is being implemented SickKids / Toronto Public Health that provides take-home saliva testing kits in schools.
- Trial name
- NCT05055492
- Testing
- Take home saliva kits
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
COVID-19
Safety, Tolerability, and Pharmacokinetics Study of Human Monoclonal Antibody BRII-198
This is a phase 1 study in which healthy adult volunteers will receive BRII-198 or placebo and will be assessed for safety, tolerability, and pharmacokinetics.
- Trial name
- NCT04479644
- Testing
- BRII-198
- Where
- China
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Brii Biosciences Limited
COVID-19, Healthy
A Nasal Treatment for COVID-19
The goal of this study is to test an investigational new inhaled medication called Optate.
- Trial name
- COVD-TX (NCT05799521)
- Testing
- Optate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
COVID, Personal Protective Equipment
The New Silicone N99 Half-Piece Respirator
Filter facepiece respirator (FFR) is a critical equipment to prevent the transmission of respiratory tract infection disease especially the dreadful corona virus 2(SARs-CoV-2).The N95 mask is the prototype of high efficiency…
- Trial name
- NCT04454606
- Testing
- Fit test, Filtration Test
- Where
- Thailand
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Mindfulness, Randomized Controlled Trial
Mindful Prevention of Psychopathology in Healthcare Workers During the COVID-19 Crisis (COVID-19 MindPreP)
The current study will be a randomized controlled trial (RCT) investigating an adapted online Mindfulness-Based Stress Reduction (MBSR) program versus daily online self-help mindfulness exercises, in preventing incident/prevalent…
- Conditions
- Mindfulness, Randomized Controlled Trial, Psychopathology, Health Personnel
- Trial name
- NCT04720404
- Testing
- Mindfulness-Based Stress Reduction, Self-help mindfulness/compassion exercises, Support as usual
- Where
- Netherlands
- Volunteers
- 201 people
- Sponsor
- Radboud University Medical Center
Covid19
Blood Coagulation Abnormalities in COVID-19 (Corona Virus Disease-19) Patients
The role of the coagulation parameters in predicting the severity of COVID-19 disease will be assessed
- Trial name
- NCT04982263
- Testing
- Blood coagulation profile
- Where
- 2 sites in Egypt
- Volunteers
- 125 people
- Sponsor
- Sohag University
COVID-19
Pharmacologic Ascorbic Acid as an Activator of Lymphocyte Signaling for COVID-19 Treatment
There are currently no approved therapies for patients with coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- NCT04363216
- Testing
- Ascorbic Acid
- Volunteers
- 66 people
- Sponsor
- Thomas Jefferson University
Coronavirus Disease (COVID)19
D-dimer Adjusted Versus Therapeutic Dose Low-molecular-weight Heparin in Patients With COVID-19 Pneumonia
evaluation of the efficacy and safety of D-dimer adjusted heparin versus therapeutic dose heparin in patients with COVID-19 Pneumonia.
- Trial name
- NCT04584580
- Testing
- low-molecular-weight heparin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV 2 Infection), Hospitalized Patients
Antibodies Responses to COVID-19 Infection in Hospitalized Patients
1.5. Why this clinical study? The prevalence of seropositivity following SARS-CoV 2 infection might have its own potential benefits in terms of predicting the end of pandemic and the validity of herd immunity.
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV 2 Infection), Hospitalized Patients, Laboratory-confirmed SARS-CoV 2 Infection
- Trial name
- No-SARS (NCT04520880)
- Testing
- Testing procedure for Binding antibodies, Neutralizing antibodies
- Where
- Saudi Arabia
- Volunteers
- 158 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
COVID-19
A Clinical Trial of the Efficacy and Safety of Levilimab (BCD-089) in Patients With Severe COVID-19
The objective: to study the efficacy and safety of levilimab in subjects with severe COVID-19.
- Trial name
- CORONA (NCT04397562)
- Testing
- Levilimab
- Where
- 16 sites in Russia
- Volunteers
- 206 people
- Sponsor
- Biocad
Perinatal Anxiety, Covid19
Augmented CBGT for Perinatal Anxiety During a Global Pandemic (COVID-19)
This study will evaluate the effectiveness of an augmented version of our current evidence-based Cognitive Behavioural Group Therapy (CBGT) for perinatal anxiety protocol with cognitive and behavioural strategies composed of…
- Trial name
- NCT04495803
- Testing
- Cognitive Behavioural Group Therapy for Perinatal Anxiety
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- St. Joseph's Healthcare Hamilton
COVID-19 Infection, Cancer Patients
COVID19-Convalescent Plasma for Treating Patients With Active Symptomatic COVID 19 Infection (FALP-COVID)
COVID-19 infection has spread worldwide causing several deaths in few months Convalescent Plasma from COVID 19 donors has shown huge activity in small series from Chinese patients and currently many centers from USA and the…
- Conditions
- COVID-19 Infection, Cancer Patients, General Population
- Trial name
- FALP-COVID (NCT04384588)
- Testing
- Convalescent Plasma from COVID-19 donors
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Fundacion Arturo Lopez Perez
Scleroderma, Scleroderma, Systemic
Evaluation of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Together Program
Contagious disease outbreaks, such as the coronavirus disease 2019 (COVID-19) outbreak, and associated restrictions to prevent spread can lead to negative psychological outcomes, including loneliness, depression, and anxiety…
- Conditions
- Scleroderma, Scleroderma, Systemic, Systemic Sclerosis
- Trial name
- SPIN-CHAT (NCT04335279)
- Testing
- SPIN-CHAT Program
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- Lady Davis Institute
COVID-19 Pneumonia
"Clinical Characteristics, Comorbidities and Outcome of Critically Sick Patients With COVID-19
COVID-19, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), is a multisystem disease which primarily involves the respiratory tract.
- Trial name
- NCT05249803
- Testing
- Patients with COVID-19 Pneumonia
- Where
- Pakistan
- Volunteers
- 133 people
- Sponsor
- FMH College of Medicine and Dentistry
COVID-19
Evaluation of Molecular Point-of-care Xpert® Xpress SARS-CoV-2 Detection Implementation in Resource-limited Settings
This study evaluated the diagnostic accuracy and effectiveness of POC viral load (VL) assay in improving the availability of SARS-CoV-2 detection for COVID-19 patient management in decentralised healthcare facilities of…
- Trial name
- EXPERT-CoV-2 (NCT05514886)
- Testing
- Gene Expert molecular Point-of-Care (POC) (Xpert® Xpress SARS-CoV-2/Flu/RSV test
- Where
- Tanzania
- Volunteers
- 3,429 people
- Sponsor
- National Institute for Medical Research, Tanzania
Cancer
Booster Dose Trial
The goal of this study is to assess the safety and effectiveness of COVID vaccine booster doses in patients with cancer who have not developed an antibody after the U.S.
- Trial name
- NCT05016622
- Testing
- BNT162b2 vaccine
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Montefiore Medical Center
Novel Coronavirus Pneumonia, Pneumonia
A Study to Evaluate the Efficacy and Safety of Pirfenidone With Novel Coronavirus Infection
The acute lung injury caused by SARS and 2003 were both related to the inflammatory cytokine storm in patients. The biochemical test showed abnormal increase in related indicators such as interleukin-8, and CT images showed a…
- Conditions
- Novel Coronavirus Pneumonia, Pneumonia, Pirfenidone
- Trial name
- NCT04282902
- Testing
- pirfenidone
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Huilan Zhang
Covid19, SARS-CoV Infection
SARS-CoV-2 Human Challenge Characterisation Study
This is a dose optimisation study in healthy adults aged 18-30 who will be experimentally inoculated with SARS-CoV-2. The aim is to cause PCR-confirmed upper respiratory infection in the majority of challenged individuals with…
- Conditions
- Covid19, SARS-CoV Infection, Corona Virus Infection, Coronavirus
- Trial name
- NCT04865237
- Testing
- SARS-CoV-2 Virus 1x10^1 TCID50, Remdesivir, SARS-CoV-2 Virus 1x10^2 TCID50
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Imperial College London
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